Showing entry for Adolescent idiopathic scoliosis


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD008447
Disease NameAdolescent idiopathic scoliosis
Disease CUI IdC0410702
MeSH Codes C05  
Disease Class NameMusculoskeletal Diseases
Semantic TypeAnatomical Abnormality
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id   
Disease Ontology Class Name
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
O00141 BXGT003882 Serine/threonine-protein kinase Sgk1 6446 reviewed Kinase
O00167 BXGT003887 Eyes absent homolog 2 2139 reviewed
O00206 BXGT003894 Toll-like receptor 4 7099 reviewed
O00482 BXGT003929 Nuclear receptor subfamily 5 group A member 2 2494 reviewed Nuclear receptor
O14578 BXGT004072 Citron Rho-interacting kinase 11113 reviewed Kinase
O14595 BXGT004074 Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 10106 reviewed
O14638 BXGT004077 Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 5169 reviewed Enzyme
O14770 BXGT004095 Homeobox protein Meis2 4212 reviewed Enzyme
O15374 BXGT004157 Monocarboxylate transporter 5 9122 reviewed Transporter
O15382 BXGT004160 Branched-chain-amino-acid aminotransferase, mitochondrial 587 reviewed Enzyme
O43896 BXGT004632 Kinesin-like protein KIF1C 10749 reviewed Cellular structure
O60242 BXGT004861 Adhesion G protein-coupled receptor B3 577 reviewed G-protein coupled receptor
O60260 BXGT004864 E3 ubiquitin-protein ligase parkin 5071 reviewed Enzyme
O60294 BXGT004868 tRNA wybutosine-synthesizing protein 4 9836 reviewed
O60486 BXGT004877 Plexin-C1 10154 reviewed
O60706 BXGT004896 ATP-binding cassette sub-family C member 9 10060 reviewed Transporter
O75129 BXGT005101 Astrotactin-2 23245 reviewed
O75367 BXGT005117 Core histone macro-H2A.1 9555 reviewed Nucleic acid binding
O75469 BXGT005128 Nuclear receptor subfamily 1 group I member 2 8856 reviewed Nuclear receptor
O75676 BXGT005144 Ribosomal protein S6 kinase alpha-4 8986 reviewed Kinase
O75899 BXGT005161 Gamma-aminobutyric acid type B receptor subunit 2 9568 reviewed G-protein coupled receptor
O94788 BXGT005333 Retinal dehydrogenase 2 8854 reviewed Enzyme
P00387 BXGT005525 NADH-cytochrome b5 reductase 3 1727 reviewed
P00533 BXGT005575 Epidermal growth factor receptor 1956 reviewed Kinase
P01023 BXGT005718 Alpha-2-macroglobulin 2 reviewed Enzyme modulator
P01137 BXGT005737 Transforming growth factor beta-1 proprotein 7040 reviewed Signaling
P02774 BXGT005959 Vitamin D-binding protein 2638 reviewed Transporter
P02818 BXGT005969 Osteocalcin 632 reviewed
P03372 BXGT006059 Estrogen receptor 2099 reviewed Nuclear receptor
P05231 BXGT006345 Interleukin-6 3569 reviewed
P07948 BXGT006702 Tyrosine-protein kinase Lyn 4067 reviewed Kinase
P08254 BXGT006758 Stromelysin-1 4314 reviewed Enzyme
P08697 BXGT006815 Alpha-2-antiplasmin 5345 reviewed Enzyme modulator
P08922 BXGT006843 Proto-oncogene tyrosine-protein kinase ROS 6098 reviewed Kinase
P0DMS9 BXGT007507 Transmembrane domain-containing protein TMIGD3 57413 reviewed
P0DP23 BXGT007520 Calmodulin-1 808 reviewed
P0DP24 BXGT007521 Calmodulin-2 808 reviewed
P10275 BXGT007552 Androgen receptor 367 reviewed Nuclear receptor
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P10620 BXGT007590 Microsomal glutathione S-transferase 1 4257 reviewed
P11473 BXGT007709 Vitamin D3 receptor 7421 reviewed Nuclear receptor
P12821 BXGT007849 Angiotensin-converting enzyme 1636 reviewed Enzyme
P14210 BXGT007994 Hepatocyte growth factor 3082 reviewed Enzyme
P16278 BXGT008213 Beta-galactosidase 2720 reviewed Enzyme
P16442 BXGT008227 Histo-blood group ABO system transferase 28 reviewed Enzyme
P17174 BXGT008289 Aspartate aminotransferase, cytoplasmic 2805 reviewed
P18564 BXGT008414 Integrin beta-6 3694 reviewed Receptor
P18850 BXGT008433 Cyclic AMP-dependent transcription factor ATF-6 alpha 22926 reviewed
P19525 BXGT008492 Interferon-induced, double-stranded RNA-activated protein kinase 5610 reviewed Kinase
P23246 BXGT008840 Splicing factor, proline- and glutamine-rich 6421 reviewed Nucleic acid binding
P23381 BXGT008860 Tryptophan--tRNA ligase, cytoplasmic 7453 reviewed Enzyme
P23415 BXGT008864 Glycine receptor subunit alpha-1 2741 reviewed Ion channel
P23468 BXGT008870 Receptor-type tyrosine-protein phosphatase delta 5789 reviewed Enzyme
P24723 BXGT008989 Protein kinase C eta type 5583 reviewed Kinase
P25101 BXGT009018 Endothelin-1 receptor 1909 reviewed G-protein coupled receptor
P26012 BXGT009083 Integrin beta-8 3696 reviewed Receptor
P28300 BXGT009243 Protein-lysine 6-oxidase 4015 reviewed
P30556 BXGT009441 Type-1 angiotensin II receptor 185 reviewed G-protein coupled receptor
P33402 BXGT009722 Guanylate cyclase soluble subunit alpha-2 2977 reviewed
P35222 BXGT009799 Catenin beta-1 1499 reviewed
P35398 BXGT009825 Nuclear receptor ROR-alpha 6095 reviewed Nuclear receptor
P35555 BXGT009845 Fibrillin-1 2200 reviewed Calcium-binding protein
P35754 BXGT009863 Glutaredoxin-1 2745 reviewed
P39086 BXGT010093 Glutamate receptor ionotropic, kainate 1 2897 reviewed Ion channel
P40763 BXGT010202 Signal transducer and activator of transcription 3 6774 reviewed Nucleic acid binding
P41594 BXGT010266 Metabotropic glutamate receptor 5 2915 reviewed G-protein coupled receptor
P42785 BXGT010338 Lysosomal Pro-X carboxypeptidase 5547 reviewed Enzyme
P46939 BXGT010555 Utrophin 7402 reviewed
P48039 BXGT010607 Melatonin receptor type 1A 4543 reviewed G-protein coupled receptor
P48357 BXGT010627 Leptin receptor 3953 reviewed Signaling
P49286 BXGT010691 Melatonin receptor type 1B 4544 reviewed G-protein coupled receptor
P49747 BXGT010732 Cartilage oligomeric matrix protein 1311 reviewed
P49789 BXGT010742 Bis(5'-adenosyl)-triphosphatase 2272 reviewed
P49916 BXGT010764 DNA ligase 3 3980 reviewed Enzyme
P52179 BXGT010921 Myomesin-1 8736 reviewed
P52788 BXGT010953 Spermine synthase 6611 reviewed
P54289 BXGT011040 Voltage-dependent calcium channel subunit alpha-2/delta-1 781 reviewed Ion channel
P55263 BXGT011115 Adenosine kinase 132 reviewed Kinase
P58400 BXGT011235 Neurexin-1-beta 9378 reviewed
P62508 BXGT011431 Estrogen-related receptor gamma 2104 reviewed Nuclear receptor
P84077 BXGT012031 ADP-ribosylation factor 1 375 reviewed
P98160 BXGT012228 Basement membrane-specific heparan sulfate proteoglycan core protein 3339 reviewed Enzyme modulator
Q01484 BXGT012592 Ankyrin-2 287 reviewed
Q02410 BXGT012652 Amyloid-beta A4 precursor protein-binding family A member 1 320 reviewed Transporter
Q02643 BXGT012660 Growth hormone-releasing hormone receptor 2692 reviewed G-protein coupled receptor
Q04446 BXGT012764 1,4-alpha-glucan-branching enzyme 2632 reviewed Enzyme
Q04724 BXGT012778 Transducin-like enhancer protein 1 7088 reviewed Transcription factor
Q05655 BXGT012832 Protein kinase C delta type 5580 reviewed Kinase
Q07343 BXGT012926 cAMP-specific 3',5'-cyclic phosphodiesterase 4B 5142 reviewed
Q07955 BXGT012951 Serine/arginine-rich splicing factor 1 6426 reviewed Nucleic acid binding
Q08499 BXGT012988 cAMP-specific 3',5'-cyclic phosphodiesterase 4D 5144 reviewed
Q08623 BXGT012994 Pseudouridine-5'-phosphatase 8226 reviewed Enzyme
Q13003 BXGT013304 Glutamate receptor ionotropic, kainate 3 2899 reviewed Ion channel
Q13164 BXGT013322 Mitogen-activated protein kinase 7 5598 reviewed Kinase
Q13237 BXGT013331 cGMP-dependent protein kinase 2 5593 reviewed Kinase
Q13586 BXGT013380 Stromal interaction molecule 1 6786 reviewed
Q13627 BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A 1859 reviewed Kinase
Q13936 BXGT013404 Voltage-dependent L-type calcium channel subunit alpha-1C 775 reviewed Ion channel
Q14123 BXGT013445 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C 5137 reviewed
Q14191 BXGT013452 Werner syndrome ATP-dependent helicase 7486 reviewed Enzyme
Q14195 BXGT013453 Dihydropyrimidinase-related protein 3 1809 reviewed Enzyme
Q14449 BXGT013470 Growth factor receptor-bound protein 14 2888 reviewed Receptor
Q14831 BXGT013506 Metabotropic glutamate receptor 7 2917 reviewed G-protein coupled receptor
Q14982 BXGT013518 Opioid-binding protein/cell adhesion molecule 4978 reviewed
Q15031 BXGT013525 Probable leucine--tRNA ligase, mitochondrial 23395 reviewed Enzyme
Q15262 BXGT013555 Receptor-type tyrosine-protein phosphatase kappa 5796 reviewed Enzyme
Q15413 BXGT013568 Ryanodine receptor 3 6263 reviewed Ion channel
Q15746 BXGT013591 Myosin light chain kinase, smooth muscle 4638 reviewed Kinase
Q15848 BXGT013609 Adiponectin 9370 reviewed
Q16659 BXGT013652 Mitogen-activated protein kinase 6 5597 reviewed Kinase
Q16798 BXGT013672 NADP-dependent malic enzyme, mitochondrial 10873 reviewed Enzyme
Q16878 BXGT013687 Cysteine dioxygenase type 1 1036 reviewed
Q53GQ0 BXGT015013 Very-long-chain 3-oxoacyl-CoA reductase 51144 reviewed
Q5VWK5 BXGT015891 Interleukin-23 receptor 149233 reviewed Signaling
Q6IQ22 BXGT016330 Ras-related protein Rab-12 201475 reviewed
Q6XZF7 BXGT016615 Dynamin-binding protein 23268 reviewed
Q7L3T8 BXGT016994 Probable proline--tRNA ligase, mitochondrial 25973 reviewed Enzyme
Q86UX6 BXGT017614 Serine/threonine-protein kinase 32C 282974 reviewed Kinase
Q8IWA4 BXGT018353 Mitofusin-1 55669 reviewed Enzyme
Q8IXI2 BXGT018361 Mitochondrial Rho GTPase 1 55288 reviewed Enzyme modulator
Q8N183 BXGT018497 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 91942 reviewed
Q8N608 BXGT018522 Inactive dipeptidyl peptidase 10 57628 reviewed Enzyme
Q8NFU5 BXGT018564 Inositol polyphosphate multikinase 253430 reviewed Kinase
Q92731 BXGT019366 Estrogen receptor beta 2100 reviewed Nuclear receptor
Q92736 BXGT019367 Ryanodine receptor 2 6262 reviewed Ion channel
Q92784 BXGT019373 Zinc finger protein DPF3 8110 reviewed Enzyme
Q92932 BXGT019395 Receptor-type tyrosine-protein phosphatase N2 5799 reviewed
Q96BI3 BXGT019623 Gamma-secretase subunit APH-1A 51107 reviewed Enzyme modulator
Q96L34 BXGT019689 MAP/microtubule affinity-regulating kinase 4 57787 reviewed Kinase
Q96PR1 BXGT019710 Potassium voltage-gated channel subfamily C member 2 3747 reviewed Ion channel
Q96QU1 BXGT019721 Protocadherin-15 65217 reviewed
Q96RT1 BXGT019736 Erbin 55914 reviewed
Q99653 BXGT019945 Calcineurin B homologous protein 1 11261 reviewed
Q99700 BXGT019949 Ataxin-2 6311 reviewed Nucleic acid binding
Q9BS26 BXGT020120 Endoplasmic reticulum resident protein 44 23071 reviewed
Q9C0B1 BXGT020209 Alpha-ketoglutarate-dependent dioxygenase FTO 79068 reviewed
Q9H008 BXGT020431 Phospholysine phosphohistidine inorganic pyrophosphate phosphatase 64077 reviewed Enzyme
Q9H269 BXGT020450 Vacuolar protein sorting-associated protein 16 homolog 64601 reviewed
Q9H3R0 BXGT020465 Lysine-specific demethylase 4C 23081 reviewed
Q9HAQ2 BXGT020505 Kinesin-like protein KIF9 64147 reviewed Cellular structure
Q9NP56 BXGT021142 cAMP-specific 3',5'-cyclic phosphodiesterase 7B 27115 reviewed
Q9NPH5 BXGT021159 NADPH oxidase 4 50507 reviewed Enzyme
Q9NQX3 BXGT021172 Gephyrin 10243 reviewed
Q9NRM7 BXGT021190 Serine/threonine-protein kinase LATS2 26524 reviewed Kinase
Q9NWB1 BXGT021231 RNA binding protein fox-1 homolog 1 54715 reviewed Nucleic acid binding
Q9UKE5 BXGT021741 TRAF2 and NCK-interacting protein kinase 23043 reviewed Kinase
Q9Y239 BXGT022213 Nucleotide-binding oligomerization domain-containing protein 1 10392 reviewed Enzyme
Q9Y2H1 BXGT022233 Serine/threonine-protein kinase 38-like 23012 reviewed Kinase
Q9Y3I0 BXGT022259 tRNA-splicing ligase RtcB homolog 51493 reviewed
Q9Y6U3 BXGT022341 Adseverin 85477 reviewed Cellular structure
Q9Y6T7 BXGT022665 Diacylglycerol kinase beta 1607 reviewed Enzyme
F1T0I5 BXGT022675 Arylalkylamine N-acetyltransferase (Serotonin N-acetyltransferase) 15 unreviewed
P43146 BXGT022852 Netrin receptor DCC 1630 reviewed
P17752 BXGT023118 Tryptophan 5-hydroxylase 1 7166 reviewed
A9YTQ3 BXGT023537 Aryl hydrocarbon receptor repressor 57491 reviewed Transcription factor
P08123 BXGT024477 Collagen alpha-2(I) chain 1278 reviewed
P0DP25 BXGT024595 Calmodulin-3 808 reviewed
Q99435 BXGT025240 Protein kinase C-binding protein NELL2 4753 reviewed Calcium-binding protein
Q92832 BXGT025242 Protein kinase C-binding protein NELL1 4745 reviewed Calcium-binding protein
Q7Z699 BXGT025789 Sprouty-related, EVH1 domain-containing protein 1 161742 reviewed Receptor
Q9P2E7 BXGT025815 Protocadherin-10 57575 reviewed
P58215 BXGT026106 Lysyl oxidase homolog 3 84695 reviewed
Q96JB6 BXGT026118 Lysyl oxidase homolog 4 84171 reviewed
Q58A45 BXGT026131 PAN2-PAN3 deadenylation complex subunit PAN3 255967 reviewed Kinase
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease