Showing entry for Excitatory amino acid transporter 4


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010652
Protein NameExcitatory amino acid transporter 4
Uniport IdP48664
GeneSLC1A6
Gene Id6511
DomainSDF
Pfam PF00375  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.6 Nervous system hsa04721 Synaptic vesicle cycle
5. Organismal Systems 5.6 Nervous system hsa04724 Glutamatergic synapse
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0015810 aspartate transmembrane transport
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:0014047 glutamate secretion
Biological Process GO:0006811 ion transport
Biological Process GO:0098712 L-glutamate import across plasma membrane
Biological Process GO:0015813 L-glutamate transmembrane transport
Biological Process GO:0042391 regulation of membrane potential
molecular function GO:0005314 high-affinity glutamate transmembrane transporter activity
molecular function GO:0015183 L-aspartate transmembrane transporter activity
molecular function GO:0046872 metal ion binding
cellular component GO:0098978 glutamatergic synapse
cellular component GO:0005794 Golgi apparatus
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0099056 integral component of presynaptic membrane
cellular component GO:0045111 intermediate filament cytoskeleton
cellular component GO:0016020 membrane
cellular component GO:0098796 membrane protein complex
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-112310 Neurotransmitter release cycle
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-210500 Glutamate Neurotransmitter Release Cycle
R-HSA-382551 Transport of small molecules
R-HSA-425393 Transport of inorganic cations/anions and amino acids/oligopeptides
R-HSA-425407 SLC-mediated transmembrane transport
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0014550 BXGD000930 Myoclonic Epilepsy Nervous System Diseases
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0028968 BXGD002103 Olivopontocerebellar Atrophies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0041696 BXGD002932 Unipolar Depression Mental Disorders
C0752123 BXGD010671 Spinocerebellar Ataxia Type 5 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C4317123 BXGD022727 Myoclonic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0006162 L-Glutamic acid 147.13
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein