Showing entry for Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010698
Protein NameProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Uniport IdP49354
GeneFNTA
Gene Id2339
DomainPPTA
Pfam PF01239  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.9 Metabolism of terpenoids and polyketides hsa00900 Terpenoid backbone biosynthesis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0045213 neurotransmitter receptor metabolic process
Biological Process GO:0090045 positive regulation of deacetylase activity
Biological Process GO:0090044 positive regulation of tubulin deacetylation
Biological Process GO:0018343 protein farnesylation
Biological Process GO:0018344 protein geranylgeranylation
Biological Process GO:0022400 regulation of rhodopsin mediated signaling pathway
Biological Process GO:0071340 skeletal muscle acetylcholine-gated channel clustering
Biological Process GO:0007179 transforming growth factor beta receptor signaling pathway
molecular function GO:0030548 acetylcholine receptor regulator activity
molecular function GO:0043014 alpha-tubulin binding
molecular function GO:0004662 CAAX-protein geranylgeranyltransferase activity
molecular function GO:0008017 microtubule binding
molecular function GO:0004660 protein farnesyltransferase activity
molecular function GO:0004661 protein geranylgeranyltransferase activity
molecular function GO:0004663 Rab geranylgeranyltransferase activity
molecular function GO:0030971 receptor tyrosine kinase binding
cellular component GO:0005953 CAAX-protein geranylgeranyltransferase complex
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005875 microtubule associated complex
cellular component GO:0005886 plasma membrane
cellular component GO:0005965 protein farnesyltransferase complex
Reactome
Pathway Id Pathway Name
R-HSA-109581 Apoptosis
R-HSA-111465 Apoptotic cleavage of cellular proteins
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-162582 Signal Transduction
R-HSA-168256 Immune System
R-HSA-2187338 Visual phototransduction
R-HSA-2514856 The phototransduction cascade
R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade
R-HSA-372790 Signaling by GPCR
R-HSA-388396 GPCR downstream signalling
R-HSA-418594 G alpha (i) signalling events
R-HSA-5357801 Programmed Cell Death
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-5683057 MAPK family signaling cascades
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-75153 Apoptotic execution phase
R-HSA-9607240 FLT3 Signaling
R-HSA-9648002 RAS processing
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0004277 Acetic acid 60.05
BXGC0015355 Lauric anhydride 382.34
BXGC0024941 Itaconic anhydride 112.02
BXGC0045257 Lonafarnib 636.05
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein