adisease

Showing entry for Cystic Fibrosis

General Disease Information
BXGD Id	BXGD000683
Disease Name	Cystic Fibrosis
Disease CUI Id	C0010674
MeSH Codes	C16 C06 C08
Disease Class Name	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id
Human Phenotype Ontology Term
Disease Ontology Id	DOID:630
Disease Ontology Class Name	genetic disease
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
A0A024RAV5	BXGT000013	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b	3845	unreviewed
F7VJQ1	BXGT003310	Alternative prion protein	5621	reviewed
O00141	BXGT003882	Serine/threonine-protein kinase Sgk1	6446	reviewed	Kinase
O00187	BXGT003890	Mannan-binding lectin serine protease 2	10747	reviewed	Enzyme
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O00329	BXGT003909	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	5293	reviewed	Kinase
O00602	BXGT003940	Ficolin-1	2219	reviewed	Signaling
O14745	BXGT004090	Na(+)/H(+) exchange regulatory cofactor NHE-RF1	9368	reviewed
O14920	BXGT004110	Inhibitor of nuclear factor kappa-B kinase subunit beta	3551	reviewed	Kinase
O15118	BXGT004127	NPC intracellular cholesterol transporter 1	4864	reviewed	Transporter
O15123	BXGT004130	Angiopoietin-2	285	reviewed	Signaling
O15151	BXGT004132	Protein Mdm4	4194	reviewed	Nucleic acid binding
O15438	BXGT004168	Canalicular multispecific organic anion transporter 2	8714	reviewed	Transporter
O15440	BXGT004170	Multidrug resistance-associated protein 5	10057	reviewed	Transporter
O15553	BXGT004181	Pyrin	4210	reviewed
O15554	BXGT004182	Intermediate conductance calcium-activated potassium channel protein 4	3783	reviewed	Ion channel
O43451	BXGT004594	Maltase-glucoamylase, intestinal	8972	reviewed	Enzyme
O43570	BXGT004601	Carbonic anhydrase 12	771	reviewed
O60218	BXGT004858	Aldo-keto reductase family 1 member B10	57016	reviewed	Enzyme
O60603	BXGT004887	Toll-like receptor 2	7097	reviewed
O60760	BXGT004899	Hematopoietic prostaglandin D synthase	27306	reviewed
O60885	BXGT004906	Bromodomain-containing protein 4	23476	reviewed	Epigenetic regulator
O75015	BXGT005095	Low affinity immunoglobulin gamma Fc region receptor III-B	2215	reviewed	Cell adhesion
O75251	BXGT005107	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	374291	reviewed
O75460	BXGT005127	Serine/threonine-protein kinase/endoribonuclease IRE1	2081	reviewed	Kinase
O75469	BXGT005128	Nuclear receptor subfamily 1 group I member 2	8856	reviewed	Nuclear receptor
O75663	BXGT005143	TIP41-like protein	261726	reviewed
O75751	BXGT005150	Solute carrier family 22 member 3	6581	reviewed	Transporter
O75762	BXGT005151	Transient receptor potential cation channel subfamily A member 1	8989	reviewed	Ion channel
O75844	BXGT005156	CAAX prenyl protease 1 homolog	10269	reviewed	Enzyme
O76074	BXGT005174	cGMP-specific 3',5'-cyclic phosphodiesterase	8654	reviewed
O94925	BXGT005342	Glutaminase kidney isoform, mitochondrial	2744	reviewed	Enzyme
O95398	BXGT005378	Rap guanine nucleotide exchange factor 3	10411	reviewed	Enzyme modulator
O95750	BXGT005395	Fibroblast growth factor 19	9965	reviewed	Signaling
O96017	BXGT005415	Serine/threonine-protein kinase Chk2	11200	reviewed	Kinase
O96020	BXGT005416	G1/S-specific cyclin-E2	9134	reviewed	Enzyme modulator
P00390	BXGT005526	Glutathione reductase, mitochondrial	2936	reviewed	Enzyme
P00439	BXGT005539	Phenylalanine-4-hydroxylase	5053	reviewed
P00505	BXGT005560	Aspartate aminotransferase, mitochondrial	2806	reviewed
P00533	BXGT005575	Epidermal growth factor receptor	1956	reviewed	Kinase
P00734	BXGT005630	Prothrombin	2147	reviewed	Enzyme
P00742	BXGT005636	Coagulation factor X	2159	reviewed	Enzyme
P00747	BXGT005639	Plasminogen	5340	reviewed	Enzyme
P00749	BXGT005641	Urokinase-type plasminogen activator	5328	reviewed	Enzyme
P00813	BXGT005667	Adenosine deaminase	100	reviewed	Enzyme
P00973	BXGT005711	2'-5'-oligoadenylate synthase 1	4938	reviewed	Enzyme
P01009	BXGT005714	Alpha-1-antitrypsin	5265	reviewed	Enzyme modulator
P01011	BXGT005715	Alpha-1-antichymotrypsin	12	reviewed	Enzyme modulator
P01023	BXGT005718	Alpha-2-macroglobulin	2	reviewed	Enzyme modulator
P01024	BXGT005719	Complement C3	718	reviewed	Enzyme modulator
P01042	BXGT005722	Kininogen-1	3827	reviewed	Enzyme modulator
P01106	BXGT005730	Myc proto-oncogene protein	4609	reviewed	Transcription factor
P01116	BXGT005733	GTPase KRas	3845	reviewed	Enzyme modulator
P01133	BXGT005736	Pro-epidermal growth factor	1950	reviewed
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01189	BXGT005742	Pro-opiomelanocortin	5443	reviewed
P01236	BXGT005744	Prolactin	5617	reviewed	Signaling
P01270	BXGT005746	Parathyroid hormone	5741	reviewed
P01275	BXGT005747	Glucagon	2641	reviewed
P01308	BXGT005749	Insulin	3630	reviewed
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01574	BXGT005768	Interferon beta	3456	reviewed
P01579	BXGT005770	Interferon gamma	3458	reviewed
P01583	BXGT005771	Interleukin-1 alpha	3552	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P01889	BXGT005809	HLA class I histocompatibility antigen, B-7 alpha chain	3106	reviewed
P01909	BXGT005815	HLA class II histocompatibility antigen, DQ alpha 1 chain	3117	reviewed	Immune response
P01911	BXGT005816	HLA class II histocompatibility antigen, DRB1-15 beta chain	3123	reviewed	Immune response
P01920	BXGT005817	HLA class II histocompatibility antigen, DQ beta 1 chain	3119	reviewed	Immune response
P02545	BXGT005889	Prelamin-A/C	4000	reviewed
P02649	BXGT005909	Apolipoprotein E	348	reviewed
P02724	BXGT005934	Glycophorin-A	2993	reviewed
P02741	BXGT005936	C-reactive protein	1401	reviewed
P02768	BXGT005955	Serum albumin	213	reviewed	Transporter
P02774	BXGT005959	Vitamin D-binding protein	2638	reviewed	Transporter
P02787	BXGT005962	Serotransferrin	7018	reviewed	Enzyme
P03372	BXGT006059	Estrogen receptor	2099	reviewed	Nuclear receptor
P03905	BXGT006113	NADH-ubiquinone oxidoreductase chain 4	4538	reviewed	Enzyme
P03956	BXGT006120	Interstitial collagenase	4312	reviewed	Enzyme
P04004	BXGT006125	Vitronectin	7448	reviewed
P04040	BXGT006132	Catalase	847	reviewed	Enzyme
P04054	BXGT006136	Phospholipase A2	5319	reviewed	Enzyme
P04062	BXGT006140	Lysosomal acid glucosylceramidase	2629	reviewed
P04083	BXGT006147	Annexin A1	301	reviewed
P04150	BXGT006154	Glucocorticoid receptor	2908	reviewed	Nuclear receptor
P04156	BXGT006156	Major prion protein	5621	reviewed
P04271	BXGT006177	Protein S100-B	6285	reviewed	Calcium-binding protein
P04275	BXGT006180	von Willebrand factor	7450	reviewed	Enzyme modulator
P04629	BXGT006239	High affinity nerve growth factor receptor	4914	reviewed	Kinase
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P04792	BXGT006264	Heat shock protein beta-1	3315	reviewed
P04818	BXGT006269	Thymidylate synthase	7298	reviewed	Enzyme
P05089	BXGT006310	Arginase-1	383	reviewed	Enzyme
P05109	BXGT006318	Protein S100-A8	6279	reviewed	Calcium-binding protein
P05121	BXGT006320	Plasminogen activator inhibitor 1	5054	reviewed	Enzyme modulator
P05156	BXGT006329	Complement factor I	3426	reviewed
P05164	BXGT006333	Myeloperoxidase	4353	reviewed	Enzyme
P05177	BXGT006336	Cytochrome P450 1A2	1544	reviewed	Enzyme
P05231	BXGT006345	Interleukin-6	3569	reviewed
P05362	BXGT006350	Intercellular adhesion molecule 1	3383	reviewed
P05787	BXGT006385	Keratin, type II cytoskeletal 8	3856	reviewed
P06702	BXGT006476	Protein S100-A9	6280	reviewed	Calcium-binding protein
P06731	BXGT006488	Carcinoembryonic antigen-related cell adhesion molecule 5	1048	reviewed
P06865	BXGT006516	Beta-hexosaminidase subunit alpha	3073	reviewed	Enzyme
P07093	BXGT006544	Glia-derived nexin	5270	reviewed	Enzyme modulator
P07225	BXGT006572	Vitamin K-dependent protein S	5627	reviewed
P07384	BXGT006619	Calpain-1 catalytic subunit	823	reviewed	Enzyme
P07477	BXGT006629	Trypsin-1	5644	reviewed	Enzyme
P07550	BXGT006636	Beta-2 adrenergic receptor	154	reviewed	G-protein coupled receptor
P07711	BXGT006661	Cathepsin L1	1514	reviewed	Enzyme
P07741	BXGT006666	Adenine phosphoribosyltransferase	353	reviewed
P07858	BXGT006689	Cathepsin B	1508	reviewed	Enzyme
P07900	BXGT006696	Heat shock protein HSP 90-alpha	3320	reviewed	Chaperone
P07996	BXGT006710	Thrombospondin-1	7057	reviewed
P08047	BXGT006720	Transcription factor Sp1	6667	reviewed	Nucleic acid binding
P08100	BXGT006725	Rhodopsin	6010	reviewed	G-protein coupled receptor
P08151	BXGT006731	Zinc finger protein GLI1	2735	reviewed
P08183	BXGT006741	ATP-dependent translocase ABCB1	5243	reviewed	Transporter
P08185	BXGT006742	Corticosteroid-binding globulin	866	reviewed	Enzyme modulator
P08236	BXGT006752	Beta-glucuronidase	2990	reviewed
P08246	BXGT006756	Neutrophil elastase	1991	reviewed	Enzyme
P08253	BXGT006757	72 kDa type IV collagenase	4313	reviewed	Enzyme
P08311	BXGT006762	Cathepsin G	1511	reviewed	Enzyme
P08397	BXGT006768	Porphobilinogen deaminase	3145	reviewed	Enzyme
P08514	BXGT006781	Integrin alpha-IIb	3674	reviewed
P08581	BXGT006794	Hepatocyte growth factor receptor	4233	reviewed	Kinase
P08637	BXGT006802	Low affinity immunoglobulin gamma Fc region receptor III-A	2214	reviewed	Cell adhesion
P08684	BXGT006812	Cytochrome P450 3A4	1576	reviewed	Enzyme
P08697	BXGT006815	Alpha-2-antiplasmin	5345	reviewed	Enzyme modulator
P08758	BXGT006821	Annexin A5	308	reviewed
P08842	BXGT006830	Steryl-sulfatase	412	reviewed	Enzyme
P09211	BXGT006869	Glutathione S-transferase P	2950	reviewed
P09237	BXGT006874	Matrilysin	4316	reviewed	Enzyme
P09429	BXGT006889	High mobility group protein B1	3146	reviewed	Nucleic acid binding
P09455	BXGT006890	Retinol-binding protein 1	5947	reviewed
P09466	BXGT006892	Glycodelin	5047	reviewed	Enzyme
P09488	BXGT006899	Glutathione S-transferase Mu 1	2944	reviewed
P09601	BXGT006909	Heme oxygenase 1	3162	reviewed
P09848	BXGT006929	Lactase-phlorizin hydrolase	3938	reviewed	Enzyme
P09936	BXGT006943	Ubiquitin carboxyl-terminal hydrolase isozyme L1	7345	reviewed	Enzyme
P09958	BXGT006950	Furin	5045	reviewed	Enzyme
P0CG48	BXGT007468	Polyubiquitin-C	7316	reviewed	Nucleic acid binding
P10145	BXGT007542	Interleukin-8	3576	reviewed	Signaling
P10147	BXGT007543	C-C motif chemokine 3	6348	reviewed	Signaling
P10415	BXGT007567	Apoptosis regulator Bcl-2	596	reviewed	Signaling
P10599	BXGT007583	Thioredoxin	7295	reviewed
P10809	BXGT007617	60 kDa heat shock protein, mitochondrial	3329	reviewed
P11021	BXGT007644	Endoplasmic reticulum chaperone BiP	3309	reviewed
P11166	BXGT007661	Solute carrier family 2, facilitated glucose transporter member 1	6513	reviewed	Transporter
P11226	BXGT007675	Mannose-binding protein C	4153	reviewed	Receptor
P11473	BXGT007709	Vitamin D3 receptor	7421	reviewed	Nuclear receptor
P12004	BXGT007766	Proliferating cell nuclear antigen	5111	reviewed	Nucleic acid binding
P12318	BXGT007799	Low affinity immunoglobulin gamma Fc region receptor II-a	2212	reviewed	Cell adhesion
P12724	BXGT007837	Eosinophil cationic protein	6037	reviewed
P12821	BXGT007849	Angiotensin-converting enzyme	1636	reviewed	Enzyme
P13501	BXGT007917	C-C motif chemokine 5	6352	reviewed	Signaling
P13569	BXGT007923	Cystic fibrosis transmembrane conductance regulator	1080	reviewed	Ion channel
P14174	BXGT007991	Macrophage migration inhibitory factor	4282	reviewed
P14210	BXGT007994	Hepatocyte growth factor	3082	reviewed	Enzyme
P14410	BXGT008009	Sucrase-isomaltase, intestinal	6476	reviewed	Enzyme
P14555	BXGT008020	Phospholipase A2, membrane associated	5320	reviewed	Enzyme
P14618	BXGT008027	Pyruvate kinase PKM	5315	reviewed	Kinase
P14679	BXGT008039	Tyrosinase	7299	reviewed	Enzyme
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P14902	BXGT008065	Indoleamine 2,3-dioxygenase 1	3620	reviewed
P15311	BXGT008106	Ezrin	7430	reviewed	Cellular structure
P15336	BXGT008109	Cyclic AMP-dependent transcription factor ATF-2	1386	reviewed	Transcription factor
P15531	BXGT008136	Nucleoside diphosphate kinase A	4830	reviewed	Kinase
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P15813	BXGT008158	Antigen-presenting glycoprotein CD1d	912	reviewed
P15848	BXGT008162	Arylsulfatase B	411	reviewed
P15884	BXGT008166	Transcription factor 4	6925	reviewed	Transcription factor
P15941	BXGT008176	Mucin-1	4582	reviewed
P16050	BXGT008184	Arachidonate 15-lipoxygenase	246	reviewed	Enzyme
P16109	BXGT008194	P-selectin	6403	reviewed
P16157	BXGT008203	Ankyrin-1	286	reviewed
P16278	BXGT008213	Beta-galactosidase	2720	reviewed	Enzyme
P16442	BXGT008227	Histo-blood group ABO system transferase	28	reviewed	Enzyme
P17252	BXGT008294	Protein kinase C alpha type	5578	reviewed	Kinase
P17342	BXGT008302	Atrial natriuretic peptide receptor 3	4883	reviewed
P17405	BXGT008304	Sphingomyelin phosphodiesterase	6609	reviewed	Enzyme
P17643	BXGT008323	5,6-dihydroxyindole-2-carboxylic acid oxidase	7306	reviewed	Enzyme
P17676	BXGT008327	CCAAT/enhancer-binding protein beta	1051	reviewed	Transcription factor
P17735	BXGT008335	Tyrosine aminotransferase	6898	reviewed
P17861	BXGT008348	X-box-binding protein 1	7494	reviewed
P17936	BXGT008357	Insulin-like growth factor-binding protein 3	3486	reviewed	Enzyme modulator
P17948	BXGT008358	Vascular endothelial growth factor receptor 1	2321	reviewed	Kinase
P18089	BXGT008379	Alpha-2B adrenergic receptor	151	reviewed	G-protein coupled receptor
P19021	BXGT008449	Peptidyl-glycine alpha-amidating monooxygenase	5066	reviewed	Enzyme
P19320	BXGT008470	Vascular cell adhesion protein 1	7412	reviewed
P19438	BXGT008480	Tumor necrosis factor receptor superfamily member 1A	7132	reviewed
P19838	BXGT008526	Nuclear factor NF-kappa-B p105 subunit	4790	reviewed	Transcription factor
P19883	BXGT008528	Follistatin	10468	reviewed	Enzyme modulator
P20160	BXGT008548	Azurocidin	566	reviewed	Enzyme
P20309	BXGT008562	Muscarinic acetylcholine receptor M3	1131	reviewed	G-protein coupled receptor
P20810	BXGT008602	Calpastatin	831	reviewed
P21266	BXGT008632	Glutathione S-transferase Mu 3	2947	reviewed
P21333	BXGT008638	Filamin-A	2316	reviewed
P21579	BXGT008665	Synaptotagmin-1	6857	reviewed	Transporter
P21796	BXGT008690	Voltage-dependent anion-selective channel protein 1	7416	reviewed
P21802	BXGT008691	Fibroblast growth factor receptor 2	2263	reviewed	Kinase
P21980	BXGT008715	Protein-glutamine gamma-glutamyltransferase 2	7052	reviewed	Enzyme
P22083	BXGT008727	Alpha-(1,3)-fucosyltransferase 4	2526	reviewed	Enzyme
P22303	BXGT008751	Acetylcholinesterase	43	reviewed	Enzyme
P22309	BXGT008753	UDP-glucuronosyltransferase 1-1	54658	reviewed
P22455	BXGT008772	Fibroblast growth factor receptor 4	2264	reviewed	Kinase
P22894	BXGT008815	Neutrophil collagenase	4317	reviewed	Enzyme
P23193	BXGT008834	Transcription elongation factor A protein 1	6917	reviewed	Nucleic acid binding
P23297	BXGT008848	Protein S100-A1	6271	reviewed	Calcium-binding protein
P23975	BXGT008935	Sodium-dependent noradrenaline transporter	6530	reviewed	Transporter
P24158	BXGT008951	Myeloblastin	5657	reviewed	Enzyme
P24298	BXGT008960	Alanine aminotransferase 1	2875	reviewed	Enzyme
P24530	BXGT008975	Endothelin receptor type B	1910	reviewed	G-protein coupled receptor
P24855	BXGT008998	Deoxyribonuclease-1	1773	reviewed
P25024	BXGT009005	C-X-C chemokine receptor type 1	3577	reviewed	G-protein coupled receptor
P25025	BXGT009006	C-X-C chemokine receptor type 2	3579	reviewed	G-protein coupled receptor
P25101	BXGT009018	Endothelin-1 receptor	1909	reviewed	G-protein coupled receptor
P25774	BXGT009066	Cathepsin S	1520	reviewed	Enzyme
P27169	BXGT009161	Serum paraoxonase/arylesterase 1	5444	reviewed
P27361	BXGT009176	Mitogen-activated protein kinase 3	5595	reviewed	Kinase
P27797	BXGT009206	Calreticulin	811	reviewed	Calcium-binding protein
P28161	BXGT009234	Glutathione S-transferase Mu 2	2946	reviewed
P28223	BXGT009239	5-hydroxytryptamine receptor 2A	3356	reviewed	G-protein coupled receptor
P28482	BXGT009263	Mitogen-activated protein kinase 1	5594	reviewed	Kinase
P29033	BXGT009308	Gap junction beta-2 protein	2706	reviewed	Cell-cell junction
P29320	BXGT009332	Ephrin type-A receptor 3	2042	reviewed	Kinase
P29323	BXGT009334	Ephrin type-B receptor 2	2048	reviewed	Kinase
P29466	BXGT009349	Caspase-1	834	reviewed	Enzyme
P29474	BXGT009352	Nitric oxide synthase, endothelial	4846	reviewed
P29475	BXGT009353	Nitric oxide synthase, brain	4842	reviewed
P29965	BXGT009388	CD40 ligand	959	reviewed	Signaling
P30153	BXGT009409	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform	5518	reviewed	Enzyme
P30307	BXGT009421	M-phase inducer phosphatase 3	995	reviewed	Enzyme
P30536	BXGT009435	Translocator protein	706	reviewed
P30626	BXGT009450	Sorcin	6717	reviewed
P30711	BXGT009460	Glutathione S-transferase theta-1	2952	reviewed
P30988	BXGT009491	Calcitonin receptor	799	reviewed	G-protein coupled receptor
P31025	BXGT009500	Lipocalin-1	3933	reviewed	Enzyme
P31391	BXGT009535	Somatostatin receptor type 4	6754	reviewed	G-protein coupled receptor
P31749	BXGT009574	RAC-alpha serine/threonine-protein kinase	207	reviewed	Kinase
P31948	BXGT009590	Stress-induced-phosphoprotein 1	10963	reviewed
P31997	BXGT009593	Carcinoembryonic antigen-related cell adhesion molecule 8	1088	reviewed
P33261	BXGT009707	Cytochrome P450 2C19	1557	reviewed
P33527	BXGT009728	Multidrug resistance-associated protein 1	4363	reviewed	Transporter
P34932	BXGT009772	Heat shock 70 kDa protein 4	3308	reviewed
P34949	BXGT009775	Mannose-6-phosphate isomerase	4351	reviewed	Enzyme
P35222	BXGT009799	Catenin beta-1	1499	reviewed
P35228	BXGT009800	Nitric oxide synthase, inducible	4843	reviewed
P35247	BXGT009804	Pulmonary surfactant-associated protein D	6441	reviewed	Surfactant
P35348	BXGT009814	Alpha-1A adrenergic receptor	148	reviewed	G-protein coupled receptor
P35354	BXGT009816	Prostaglandin G/H synthase 2	5743	reviewed	Enzyme
P35558	BXGT009847	Phosphoenolpyruvate carboxykinase, cytosolic [GTP]	5105	reviewed	Kinase
P35869	BXGT009877	Aryl hydrocarbon receptor	196	reviewed	Transcription factor
P36222	BXGT009914	Chitinase-3-like protein 1	1116	reviewed
P36551	BXGT009927	Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial	1371	reviewed	Enzyme
P37088	BXGT009961	Amiloride-sensitive sodium channel subunit alpha	6337	reviewed	Ion channel
P37231	BXGT009972	Peroxisome proliferator-activated receptor gamma	5468	reviewed	Nuclear receptor
P38398	BXGT010037	Breast cancer type 1 susceptibility protein	672	reviewed	Enzyme
P38936	BXGT010074	Cyclin-dependent kinase inhibitor 1	1026	reviewed
P40199	BXGT010166	Carcinoembryonic antigen-related cell adhesion molecule 6	4680	reviewed
P40763	BXGT010202	Signal transducer and activator of transcription 3	6774	reviewed	Nucleic acid binding
P41143	BXGT010223	Delta-type opioid receptor	4985	reviewed	G-protein coupled receptor
P41231	BXGT010240	P2Y purinoceptor 2	5029	reviewed	G-protein coupled receptor
P41240	BXGT010242	Tyrosine-protein kinase CSK	1445	reviewed	Kinase
P41594	BXGT010266	Metabotropic glutamate receptor 5	2915	reviewed	G-protein coupled receptor
P42224	BXGT010286	Signal transducer and activator of transcription 1-alpha/beta	6772	reviewed	Nucleic acid binding
P42226	BXGT010288	Signal transducer and activator of transcription 6	6778	reviewed	Nucleic acid binding
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42338	BXGT010303	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	5291	reviewed	Kinase
P42345	BXGT010304	Serine/threonine-protein kinase mTOR	2475	reviewed	Kinase
P42574	BXGT010317	Caspase-3	836	reviewed	Enzyme
P42858	BXGT010341	Huntingtin	3064	reviewed
P43220	BXGT010367	Glucagon-like peptide 1 receptor	2740	reviewed	G-protein coupled receptor
P43246	BXGT010371	DNA mismatch repair protein Msh2	4436	reviewed	Nucleic acid binding
P45983	BXGT010494	Mitogen-activated protein kinase 8	5599	reviewed	Kinase
P45984	BXGT010495	Mitogen-activated protein kinase 9	5601	reviewed	Kinase
P46108	BXGT010509	Adapter molecule crk	1398	reviewed
P47712	BXGT010577	Cytosolic phospholipase A2	5321	reviewed	Enzyme
P47900	BXGT010595	P2Y purinoceptor 1	5028	reviewed	G-protein coupled receptor
P48029	BXGT010606	Sodium- and chloride-dependent creatine transporter 1	6535	reviewed	Transporter
P48147	BXGT010620	Prolyl endopeptidase	5550	reviewed	Enzyme
P48506	BXGT010635	Glutamate--cysteine ligase catalytic subunit	2729	reviewed	Enzyme
P48736	BXGT010658	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	5294	reviewed	Kinase
P48740	BXGT010659	Mannan-binding lectin serine protease 1	5648	reviewed	Enzyme
P49354	BXGT010698	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	2339	reviewed	Enzyme
P49763	BXGT010737	Placenta growth factor	5228	reviewed	Signaling
P49888	BXGT010756	Estrogen sulfotransferase	6783	reviewed
P49902	BXGT010758	Cytosolic purine 5'-nucleotidase	22978	reviewed	Enzyme
P49913	BXGT010761	Cathelicidin antimicrobial peptide	820	reviewed
P50052	BXGT010768	Type-2 angiotensin II receptor	186	reviewed	G-protein coupled receptor
P51159	BXGT010839	Ras-related protein Rab-27A	5873	reviewed
P51168	BXGT010842	Amiloride-sensitive sodium channel subunit beta	6338	reviewed	Ion channel
P51170	BXGT010843	Amiloride-sensitive sodium channel subunit gamma	6340	reviewed	Ion channel
P51572	BXGT010859	B-cell receptor-associated protein 31	10134	reviewed	Transporter
P51575	BXGT010861	P2X purinoceptor 1	5023	reviewed	Ion channel
P51681	BXGT010878	C-C chemokine receptor type 5	1234	reviewed	G-protein coupled receptor
P51787	BXGT010889	Potassium voltage-gated channel subfamily KQT member 1	3784	reviewed	Ion channel
P51884	BXGT010903	Lumican	4060	reviewed
P52209	BXGT010923	6-phosphogluconate dehydrogenase, decarboxylating	5226	reviewed	Enzyme
P52788	BXGT010953	Spermine synthase	6611	reviewed
P52803	BXGT010958	Ephrin-A5	1946	reviewed	Signaling
P54646	BXGT011062	5'-AMP-activated protein kinase catalytic subunit alpha-2	5563	reviewed	Kinase
P54707	BXGT011068	Potassium-transporting ATPase alpha chain 2	479	reviewed	Transporter
P54762	BXGT011076	Ephrin type-B receptor 1	2047	reviewed	Kinase
P55072	BXGT011103	Transitional endoplasmic reticulum ATPase	7415	reviewed
P55085	BXGT011104	Proteinase-activated receptor 2	2150	reviewed	G-protein coupled receptor
P55957	BXGT011137	BH3-interacting domain death agonist	637	reviewed
P56373	BXGT011164	P2X purinoceptor 3	5024	reviewed	Ion channel
P60022	BXGT011285	Beta-defensin 1	1672	reviewed
P60484	BXGT011307	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	5728	reviewed	Enzyme
P60568	BXGT011315	Interleukin-2	3558	reviewed
P60709	BXGT011322	Actin, cytoplasmic 1	60	reviewed	Cellular structure
P61586	BXGT011375	Transforming protein RhoA	387	reviewed	Enzyme modulator
P62805	BXGT011457	Histone H4	8370	reviewed
P62979	BXGT011476	Ubiquitin-40S ribosomal protein S27a	6233	reviewed	Nucleic acid binding
P63092	BXGT011495	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	2778	reviewed
P63104	BXGT011499	14-3-3 protein zeta/delta	7534	reviewed	Chaperone
P63244	BXGT011510	Receptor of activated protein C kinase 1	10399	reviewed
P68871	BXGT011615	Hemoglobin subunit beta	3043	reviewed
P69905	BXGT011649	Hemoglobin subunit alpha	3040	reviewed
P78536	BXGT011847	Disintegrin and metalloproteinase domain-containing protein 17	6868	reviewed
P80188	BXGT011882	Neutrophil gelatinase-associated lipocalin	3934	reviewed	Enzyme
P80365	BXGT011895	Corticosteroid 11-beta-dehydrogenase isozyme 2	3291	reviewed	Enzyme
P80511	BXGT011914	Protein S100-A12	6283	reviewed	Calcium-binding protein
P81172	BXGT011935	Hepcidin	57817	reviewed
P84022	BXGT012027	Mothers against decapentaplegic homolog 3	4088	reviewed	Transcription factor
P98160	BXGT012228	Basement membrane-specific heparan sulfate proteoglycan core protein	3339	reviewed	Enzyme modulator
P98170	BXGT012231	E3 ubiquitin-protein ligase XIAP	331	reviewed	Enzyme modulator
Q00613	BXGT012540	Heat shock factor protein 1	3297	reviewed	Transcription factor
Q01970	BXGT012627	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	5331	reviewed	Enzyme
Q02156	BXGT012639	Protein kinase C epsilon type	5581	reviewed	Kinase
Q02643	BXGT012660	Growth hormone-releasing hormone receptor	2692	reviewed	G-protein coupled receptor
Q02809	BXGT012674	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	5351	reviewed	Enzyme
Q03518	BXGT012723	Antigen peptide transporter 1	6890	reviewed	Transporter
Q04206	BXGT012754	Transcription factor p65	5970	reviewed	Transcription factor
Q05655	BXGT012832	Protein kinase C delta type	5580	reviewed	Kinase
Q06609	BXGT012884	DNA repair protein RAD51 homolog 1	5888	reviewed
Q07869	BXGT012945	Peroxisome proliferator-activated receptor alpha	5465	reviewed	Nuclear receptor
Q08881	BXGT013012	Tyrosine-protein kinase ITK/TSK	3702	reviewed	Kinase
Q09428	BXGT013036	ATP-binding cassette sub-family C member 8	6833	reviewed	Transporter
Q12778	BXGT013263	Forkhead box protein O1	2308	reviewed
Q12809	BXGT013267	Potassium voltage-gated channel subfamily H member 2	3757	reviewed	Ion channel
Q12830	BXGT013268	Nucleosome-remodeling factor subunit BPTF	2186	reviewed
Q13155	BXGT013320	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2	7965	reviewed
Q13231	BXGT013329	Chitotriosidase-1	1118	reviewed
Q13255	BXGT013332	Metabotropic glutamate receptor 1	2911	reviewed	G-protein coupled receptor
Q13283	BXGT013334	Ras GTPase-activating protein-binding protein 1	10146	reviewed	Nucleic acid binding
Q13501	BXGT013365	Sequestosome-1	8878	reviewed
Q13510	BXGT013367	Acid ceramidase	427	reviewed	Enzyme
Q13946	BXGT013406	High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	5150	reviewed
Q14116	BXGT013442	Interleukin-18	3606	reviewed
Q14289	BXGT013459	Protein-tyrosine kinase 2-beta	2185	reviewed	Kinase
Q14315	BXGT013460	Filamin-C	2318	reviewed
Q14457	BXGT013472	Beclin-1	8678	reviewed	Enzyme modulator
Q14790	BXGT013505	Caspase-8	841	reviewed	Enzyme
Q15080	BXGT013535	Neutrophil cytosol factor 4	4689	reviewed
Q15109	BXGT013537	Advanced glycosylation end product-specific receptor	177	reviewed	Receptor
Q15118	BXGT013540	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	5163	reviewed	Kinase
Q15125	BXGT013543	3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	10682	reviewed	Enzyme
Q15185	BXGT013549	Prostaglandin E synthase 3	10728	reviewed	Chaperone
Q15746	BXGT013591	Myosin light chain kinase, smooth muscle	4638	reviewed	Kinase
Q15758	BXGT013594	Neutral amino acid transporter B(0)	6510	reviewed	Transporter
Q15848	BXGT013609	Adiponectin	9370	reviewed
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	4780	reviewed	Enzyme
Q16348	BXGT013627	Solute carrier family 15 member 2	6565	reviewed	Transporter
Q16539	BXGT013634	Mitogen-activated protein kinase 14	1432	reviewed	Kinase
Q16651	BXGT013649	Prostasin	5652	reviewed	Enzyme
Q16665	BXGT013653	Hypoxia-inducible factor 1-alpha	3091	reviewed	Transcription factor
Q16666	BXGT013654	Gamma-interferon-inducible protein 16	3428	reviewed	Transcription factor
Q16698	BXGT013659	2,4-dienoyl-CoA reductase, mitochondrial	1666	reviewed	Enzyme
Q30201	BXGT014297	Hereditary hemochromatosis protein	3077	reviewed
Q5Y7D3	BXGT015912	HLA class II histocompatibility antigen DQ beta chain	3119	unreviewed
Q6EIG7	BXGT016267	C-type lectin domain family 6 member A	93978	reviewed	Receptor
Q6NYC1	BXGT016436	Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6	23210	reviewed	Receptor
Q6QHF9	BXGT016497	Peroxisomal N(1)-acetyl-spermine/spermidine oxidase	196743	reviewed
Q6UWV6	BXGT016569	Ectonucleotide pyrophosphatase/phosphodiesterase family member 7	339221	reviewed
Q76MJ5	BXGT016871	Serine/threonine-protein kinase/endoribonuclease IRE2	10595	reviewed	Kinase
Q86V24	BXGT017615	Adiponectin receptor protein 2	79602	reviewed	Receptor
Q8IXJ6	BXGT018362	NAD-dependent protein deacetylase sirtuin-2	22933	reviewed	Epigenetic regulator
Q8N8N7	BXGT018529	Prostaglandin reductase 2	145482	reviewed	Enzyme
Q8NBJ7	BXGT018537	Inactive C-alpha-formylglycine-generating enzyme 2	25870	reviewed
Q8NBK3	BXGT018538	Formylglycine-generating enzyme	285362	reviewed
Q8TD43	BXGT018806	Transient receptor potential cation channel subfamily M member 4	54795	reviewed	Ion channel
Q8TDS5	BXGT018813	Oxoeicosanoid receptor 1	165140	reviewed	G-protein coupled receptor
Q8TDV0	BXGT018815	Probable G-protein coupled receptor 151	134391	reviewed	G-protein coupled receptor
Q92793	BXGT019374	CREB-binding protein	1387	reviewed
Q92835	BXGT019382	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1	3635	reviewed
Q92945	BXGT019397	Far upstream element-binding protein 2	8570	reviewed	Enzyme
Q92993	BXGT019403	Histone acetyltransferase KAT5	10524	reviewed
Q96D31	BXGT019635	Calcium release-activated calcium channel protein 1	84876	reviewed	Ion channel
Q96D42	BXGT019636	Hepatitis A virus cellular receptor 1	26762	reviewed
Q96EB6	BXGT019646	NAD-dependent protein deacetylase sirtuin-1	23411	reviewed	Epigenetic regulator
Q96G91	BXGT019663	P2Y purinoceptor 11	5032	reviewed	G-protein coupled receptor
Q96J66	BXGT019680	ATP-binding cassette sub-family C member 11	85320	reviewed	Transporter
Q96P20	BXGT019704	NACHT, LRR and PYD domains-containing protein 3	114548	reviewed
Q96PD4	BXGT019705	Interleukin-17F	112744	reviewed
Q99572	BXGT019935	P2X purinoceptor 7	5027	reviewed	Ion channel
Q99581	BXGT019937	Protein FEV	54738	reviewed	Transcription factor
Q99798	BXGT019962	Aconitate hydratase, mitochondrial	50	reviewed	Enzyme
Q99808	BXGT019964	Equilibrative nucleoside transporter 1	2030	reviewed	Transporter
Q99836	BXGT019970	Myeloid differentiation primary response protein MyD88	4615	reviewed	Enzyme modulator
Q99873	BXGT019972	Protein arginine N-methyltransferase 1	3276	reviewed	Epigenetic regulator
Q99895	BXGT019974	Chymotrypsin-C	11330	reviewed
Q99933	BXGT019976	BAG family molecular chaperone regulator 1	573	reviewed
Q9BYT8	BXGT020190	Neurolysin, mitochondrial	57486	reviewed	Enzyme
Q9BYW2	BXGT020192	Histone-lysine N-methyltransferase SETD2	29072	reviewed	Epigenetic regulator
Q9GZX6	BXGT020428	Interleukin-22	50616	reviewed
Q9H1D0	BXGT020445	Transient receptor potential cation channel subfamily V member 6	55503	reviewed	Ion channel
Q9H227	BXGT020447	Cytosolic beta-glucosidase	57733	reviewed	Enzyme
Q9H4A3	BXGT020473	Serine/threonine-protein kinase WNK1	65125	reviewed	Kinase
Q9H9B1	BXGT020501	Histone-lysine N-methyltransferase EHMT1	79813	reviewed	Epigenetic regulator
Q9HBA0	BXGT020516	Transient receptor potential cation channel subfamily V member 4	59341	reviewed	Ion channel
Q9HCG7	BXGT020533	Non-lysosomal glucosylceramidase	57704	reviewed
Q9HD26	BXGT020540	Golgi-associated PDZ and coiled-coil motif-containing protein	57120	reviewed
Q9NP55	BXGT021141	BPI fold-containing family A member 1	51297	reviewed
Q9NP58	BXGT021143	ATP-binding cassette sub-family B member 6, mitochondrial	10058	reviewed	Transporter
Q9NP99	BXGT021148	Triggering receptor expressed on myeloid cells 1	54210	reviewed
Q9NPH2	BXGT021158	Inositol-3-phosphate synthase 1	51477	reviewed
Q9NR71	BXGT021180	Neutral ceramidase	56624	reviewed
Q9NR96	BXGT021181	Toll-like receptor 9	54106	reviewed
Q9NRA0	BXGT021183	Sphingosine kinase 2	56848	reviewed	Kinase
Q9NWM0	BXGT021232	Spermine oxidase	54498	reviewed
Q9NZ45	BXGT021269	CDGSH iron-sulfur domain-containing protein 1	55847	reviewed
Q9NZJ4	BXGT021274	Sacsin	26278	reviewed
Q9NZJ5	BXGT021275	Eukaryotic translation initiation factor 2-alpha kinase 3	9451	reviewed	Kinase
Q9NZQ7	BXGT021281	Programmed cell death 1 ligand 1	29126	reviewed	Receptor
Q9UBC3	BXGT021650	DNA (cytosine-5)-methyltransferase 3B	1789	reviewed
Q9UBL9	BXGT021656	P2X purinoceptor 2	22953	reviewed	Ion channel
Q9UBN7	BXGT021658	Histone deacetylase 6	10013	reviewed	Epigenetic regulator
Q9UEW8	BXGT021675	STE20/SPS1-related proline-alanine-rich protein kinase	27347	reviewed	Kinase
Q9UH03	BXGT021690	Neuronal-specific septin-3	55964	reviewed	Enzyme modulator
Q9UI42	BXGT021713	Carboxypeptidase A4	51200	reviewed	Enzyme
Q9UKV0	BXGT021750	Histone deacetylase 9	9734	reviewed	Epigenetic regulator
Q9UKV5	BXGT021751	E3 ubiquitin-protein ligase AMFR	267	reviewed
Q9ULV1	BXGT021764	Frizzled-4	8322	reviewed	G-protein coupled receptor
Q9UM07	BXGT021771	Protein-arginine deiminase type-4	23569	reviewed
Q9UN76	BXGT021781	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	11254	reviewed	Transporter
Q9UNI1	BXGT021788	Chymotrypsin-like elastase family member 1	1990	reviewed	Enzyme
Q9UNQ0	BXGT021792	ATP-binding cassette sub-family G member 2	9429	reviewed	Transporter
Q9Y275	BXGT022223	Tumor necrosis factor ligand superfamily member 13B	10673	reviewed
Q9Y2Q3	BXGT022242	Glutathione S-transferase kappa 1	373156	reviewed
Q9Y2R2	BXGT022243	Tyrosine-protein phosphatase non-receptor type 22	26191	reviewed
Q9Y316	BXGT022252	Protein MEMO1	51072	reviewed
Q9Y3B4	BXGT022255	Splicing factor 3B subunit 6	51639	reviewed
Q9Y5S1	BXGT022300	Transient receptor potential cation channel subfamily V member 2	51393	reviewed	Ion channel
Q9Y5Y6	BXGT022308	Suppressor of tumorigenicity 14 protein	6768	reviewed	Enzyme
Q9Y6F1	BXGT022328	Protein mono-ADP-ribosyltransferase PARP3	10039	reviewed
P04439	BXGT022649	HLA class I histocompatibility antigen, A-3 alpha chain	3105	reviewed
Q92847	BXGT022673	Growth hormone secretagogue receptor type 1	2693	reviewed	G-protein coupled receptor
P00738	BXGT022874	Haptoglobin	3240	reviewed	Enzyme
P16284	BXGT022972	Platelet endothelial cell adhesion molecule	5175	reviewed	Cell adhesion
P19875	BXGT023294	C-X-C motif chemokine 2	2920	reviewed	Signaling
Q16552	BXGT023419	Interleukin-17A	3605	reviewed
P00395	BXGT023596	Cytochrome c oxidase subunit 1	4512	reviewed	Enzyme
P16615	BXGT023653	Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	488	reviewed	Transporter
P40198	BXGT023750	Carcinoembryonic antigen-related cell adhesion molecule 3	1084	reviewed
P35523	BXGT023831	Chloride channel protein 1	1180	reviewed	Ion channel
P15260	BXGT023924	Interferon gamma receptor 1	3459	reviewed	Receptor
Q9BQQ3	BXGT024065	Golgi reassembly-stacking protein 1	64689	reviewed
Q9UKP6	BXGT024239	Urotensin-2 receptor	2837	reviewed	G-protein coupled receptor
P08123	BXGT024477	Collagen alpha-2(I) chain	1278	reviewed
P16104	BXGT024571	Histone H2AX	3014	reviewed	Nucleic acid binding
P38646	BXGT024954	Stress-70 protein, mitochondrial	3313	reviewed
P98082	BXGT025047	Disabled homolog 2	1601	reviewed	Signaling
P25090	BXGT025102	N-formyl peptide receptor 2	2358	reviewed	G-protein coupled receptor
A8K7I4	BXGT025277	Calcium-activated chloride channel regulator 1	1179	reviewed	Ion channel
O14649	BXGT025486	Potassium channel subfamily K member 3	3777	reviewed	Ion channel
Q7LBE3	BXGT026071	Solute carrier family 26 member 9	115019	reviewed	Transporter
P51798	BXGT026083	H(+)/Cl(-) exchange transporter 7	1186	reviewed	Ion channel
Q8N122	BXGT026091	Regulatory-associated protein of mTOR	57521	reviewed
P00403	BXGT026137	Cytochrome c oxidase subunit 2	4513	reviewed	Enzyme
P09471	BXGT026153	Guanine nucleotide-binding protein G(o) subunit alpha	2775	reviewed	Enzyme modulator

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}