Showing entry for Nuclear cap-binding protein subunit 2



                       
General Target Information
BXGT IdBXGT010927
Protein NameNuclear cap-binding protein subunit 2
Uniport IdP52298
GeneNCBP2
Gene Id22916
DomainRRM_1
Pfam PF00076  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.2 Translation hsa03013 RNA transport
2. Genetic Information Processing 2.2 Translation hsa03015 mRNA surveillance pathway
2. Genetic Information Processing 2.1 Transcription hsa03040 Spliceosome
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006370 7-methylguanosine mRNA capping
Biological Process GO:0008543 fibroblast growth factor receptor signaling pathway
Biological Process GO:0031047 gene silencing by RNA
Biological Process GO:0008334 histone mRNA metabolic process
Biological Process GO:0031124 mRNA 3'-end processing
Biological Process GO:0045292 mRNA cis splicing, via spliceosome
Biological Process GO:0006406 mRNA export from nucleus
Biological Process GO:0000398 mRNA splicing, via spliceosome
Biological Process GO:0051168 nuclear export
Biological Process GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Biological Process GO:0031442 positive regulation of mRNA 3'-end processing
Biological Process GO:0046833 positive regulation of RNA export from nucleus
Biological Process GO:0098789 pre-mRNA cleavage required for polyadenylation
Biological Process GO:0006446 regulation of translational initiation
Biological Process GO:0006405 RNA export from nucleus
Biological Process GO:0016070 RNA metabolic process
Biological Process GO:0008380 RNA splicing
Biological Process GO:0006408 snRNA export from nucleus
Biological Process GO:0042795 snRNA transcription by RNA polymerase II
Biological Process GO:0006369 termination of RNA polymerase II transcription
Biological Process GO:0006366 transcription by RNA polymerase II
Biological Process GO:0006368 transcription elongation from RNA polymerase II promoter
molecular function GO:0003729 mRNA binding
molecular function GO:0000340 RNA 7-methylguanosine cap binding
molecular function GO:0003723 RNA binding
molecular function GO:0000339 RNA cap binding
molecular function GO:0017069 snRNA binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005845 mRNA cap binding complex
cellular component GO:0005846 nuclear cap binding complex
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0034518 RNA cap binding complex
Reactome
Pathway Id Pathway Name
R-HSA-111367 SLBP independent Processing of Histone Pre-mRNAs
R-HSA-112382 Formation of RNA Pol II elongation complex
R-HSA-113418 Formation of the Early Elongation Complex
R-HSA-1226099 Signaling by FGFR in disease
R-HSA-1266738 Developmental Biology
R-HSA-159227 Transport of the SLBP independent Mature mRNA
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-162582 Signal Transduction
R-HSA-162587 HIV Life Cycle
R-HSA-162599 Late Phase of HIV Life Cycle
R-HSA-162906 HIV Infection
R-HSA-1643685 Disease
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat
R-HSA-167158 Formation of the HIV-1 Early Elongation Complex
R-HSA-167169 HIV Transcription Elongation
R-HSA-167172 Transcription of the HIV genome
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat
R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript
R-HSA-1839126 FGFR2 mutant receptor activation
R-HSA-190236 Signaling by FGFR
R-HSA-191859 snRNP Assembly
R-HSA-194441 Metabolism of non-coding RNA
R-HSA-376176 Signaling by ROBO receptors
R-HSA-422475 Axon guidance
R-HSA-5654738 Signaling by FGFR2
R-HSA-5655253 Signaling by FGFR2 in disease
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
R-HSA-5663205 Infectious disease
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6803529 FGFR2 alternative splicing
R-HSA-6807505 RNA polymerase II transcribes snRNA genes
R-HSA-72086 mRNA Capping
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72165 mRNA Splicing - Minor Pathway
R-HSA-72172 mRNA Splicing
R-HSA-72187 mRNA 3'-end processing
R-HSA-72202 Transport of Mature Transcript to Cytoplasm
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA
R-HSA-73856 RNA Polymerase II Transcription Termination
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-75067 Processing of Capped Intronless Pre-mRNA
R-HSA-75955 RNA Polymerase II Transcription Elongation
R-HSA-77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
R-HSA-77595 Processing of Intronless Pre-mRNAs
R-HSA-8851708 Signaling by FGFR2 IIIa TM
R-HSA-8953854 Metabolism of RNA
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-927802 Nonsense-Mediated Decay (NMD)
R-HSA-9675108 Nervous system development
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0376705 BXGD008009 Viral Load result
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1836230 BXGD014099 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO
C1836231 BXGD014100 HIV-1, RESISTANCE TO
C1836232 BXGD014101 ACQUIRED IMMUNODEFICIENCY SYNDROME, PROGRESSION TO
C1836233 BXGD014102 AIDS, PROGRESSION TO
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein