Showing entry for Geranylgeranyl transferase type-1 subunit beta


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011001
Protein NameGeranylgeranyl transferase type-1 subunit beta
Uniport IdP53609
GenePGGT1B
Gene Id5229
DomainPrenyltrans
Pfam PF00432  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process
Biological Process GO:0045787 positive regulation of cell cycle
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0018344 protein geranylgeranylation
Biological Process GO:0018342 protein prenylation
Biological Process GO:0034097 response to cytokine
molecular function GO:0004662 CAAX-protein geranylgeranyltransferase activity
molecular function GO:0008144 drug binding
molecular function GO:0019840 isoprenoid binding
molecular function GO:0042277 peptide binding
molecular function GO:0004661 protein geranylgeranyltransferase activity
molecular function GO:0008270 zinc ion binding
cellular component GO:0005953 CAAX-protein geranylgeranyltransferase complex
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0009319 BXGD000596 Colitis Digestive System Diseases
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024312 BXGD001766 Lymphopenia Immune System Diseases; Hemic and Lymphatic Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0220620 BXGD004299 Gastrointestinal Carcinoid Tumor Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0280100 BXGD006713 Solid Neoplasm Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C4703473 BXGD023650 Atherosclerotic lesion Cardiovascular Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0015355 Lauric anhydride 382.34
BXGC0024941 Itaconic anhydride 112.02
BXGC0045257 Lonafarnib 636.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein