adisease

Showing entry for Lymphopenia

General Disease Information
BXGD Id	BXGD001766
Disease Name	Lymphopenia
Disease CUI Id	C0024312
MeSH Codes	C20 C15
Disease Class Name	Immune System Diseases; Hemic and Lymphatic Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id	HP:0002715 HP:0001871
Human Phenotype Ontology Term	Abnormality of the immune system; Abnormality of blood and blood-forming tissues
Disease Ontology Id	DOID:7
Disease Ontology Class Name	disease of anatomical entity
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00214	BXGT003897	Galectin-8	3964	reviewed	Signaling
O14746	BXGT004091	Telomerase reverse transcriptase	7015	reviewed	Enzyme
O15353	BXGT004155	Forkhead box protein N1	8456	reviewed
O15496	BXGT004175	Group 10 secretory phospholipase A2	8399	reviewed	Enzyme
O43914	BXGT004635	TYRO protein tyrosine kinase-binding protein	7305	reviewed
O95267	BXGT005368	RAS guanyl-releasing protein 1	10125	reviewed	Enzyme modulator
O95470	BXGT005382	Sphingosine-1-phosphate lyase 1	8879	reviewed
O95644	BXGT005389	Nuclear factor of activated T-cells, cytoplasmic 1	4772	reviewed	Transcription factor
O95786	BXGT005396	Probable ATP-dependent RNA helicase DDX58	23586	reviewed
O95819	BXGT005398	Mitogen-activated protein kinase kinase kinase kinase 4	9448	reviewed	Kinase
P00325	BXGT005498	Alcohol dehydrogenase 1B	125	reviewed	Enzyme
P00441	BXGT005540	Superoxide dismutase [Cu-Zn]	6647	reviewed	Enzyme
P00491	BXGT005555	Purine nucleoside phosphorylase	4860	reviewed	Enzyme
P00533	BXGT005575	Epidermal growth factor receptor	1956	reviewed	Kinase
P00736	BXGT005632	Complement C1r subcomponent	715	reviewed	Enzyme
P00813	BXGT005667	Adenosine deaminase	100	reviewed	Enzyme
P01024	BXGT005719	Complement C3	718	reviewed	Enzyme modulator
P01308	BXGT005749	Insulin	3630	reviewed
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P01589	BXGT005773	Interleukin-2 receptor subunit alpha	3559	reviewed	Receptor
P01730	BXGT005781	T-cell surface glycoprotein CD4	920	reviewed
P01911	BXGT005816	HLA class II histocompatibility antigen, DRB1-15 beta chain	3123	reviewed	Immune response
P01920	BXGT005817	HLA class II histocompatibility antigen, DQ beta 1 chain	3119	reviewed	Immune response
P02741	BXGT005936	C-reactive protein	1401	reviewed
P03372	BXGT006059	Estrogen receptor	2099	reviewed	Nuclear receptor
P04150	BXGT006154	Glucocorticoid receptor	2908	reviewed	Nuclear receptor
P05091	BXGT006312	Aldehyde dehydrogenase, mitochondrial	217	reviewed	Enzyme
P05231	BXGT006345	Interleukin-6	3569	reviewed
P06239	BXGT006427	Tyrosine-protein kinase Lck	3932	reviewed	Kinase
P06276	BXGT006430	Cholinesterase	590	reviewed
P07339	BXGT006604	Cathepsin D	1509	reviewed	Enzyme
P08246	BXGT006756	Neutrophil elastase	1991	reviewed	Enzyme
P08575	BXGT006793	Receptor-type tyrosine-protein phosphatase C	5788	reviewed	Enzyme
P08637	BXGT006802	Low affinity immunoglobulin gamma Fc region receptor III-A	2214	reviewed	Cell adhesion
P09429	BXGT006889	High mobility group protein B1	3146	reviewed	Nucleic acid binding
P10145	BXGT007542	Interleukin-8	3576	reviewed	Signaling
P10323	BXGT007557	Acrosin	49	reviewed	Enzyme
P10415	BXGT007567	Apoptosis regulator Bcl-2	596	reviewed	Signaling
P10747	BXGT007609	T-cell-specific surface glycoprotein CD28	940	reviewed
P11586	BXGT007723	C-1-tetrahydrofolate synthase, cytoplasmic	4522	reviewed	Enzyme
P12268	BXGT007783	Inosine-5'-monophosphate dehydrogenase 2	3615	reviewed	Enzyme
P12821	BXGT007849	Angiotensin-converting enzyme	1636	reviewed	Enzyme
P13501	BXGT007917	C-C motif chemokine 5	6352	reviewed	Signaling
P15056	BXGT008075	Serine/threonine-protein kinase B-raf	673	reviewed	Kinase
P15153	BXGT008090	Ras-related C3 botulinum toxin substrate 2	5880	reviewed	Enzyme modulator
P15498	BXGT008133	Proto-oncogene vav	7409	reviewed
P16410	BXGT008224	Cytotoxic T-lymphocyte protein 4	1493	reviewed
P16871	BXGT008269	Interleukin-7 receptor subunit alpha	3575	reviewed	Receptor
P17735	BXGT008335	Tyrosine aminotransferase	6898	reviewed
P17812	BXGT008345	CTP synthase 1	1503	reviewed	Enzyme
P18887	BXGT008437	DNA repair protein XRCC1	7515	reviewed
P19838	BXGT008526	Nuclear factor NF-kappa-B p105 subunit	4790	reviewed	Transcription factor
P20062	BXGT008543	Transcobalamin-2	6948	reviewed
P20839	BXGT008608	Inosine-5'-monophosphate dehydrogenase 1	3614	reviewed	Enzyme
P21453	BXGT008654	Sphingosine 1-phosphate receptor 1	1901	reviewed	G-protein coupled receptor
P24298	BXGT008960	Alanine aminotransferase 1	2875	reviewed	Enzyme
P24530	BXGT008975	Endothelin receptor type B	1910	reviewed	G-protein coupled receptor
P27986	BXGT009216	Phosphatidylinositol 3-kinase regulatory subunit alpha	5295	reviewed	Kinase
P28070	BXGT009230	Proteasome subunit beta type-4	5692	reviewed
P29597	BXGT009367	Non-receptor tyrosine-protein kinase TYK2	7297	reviewed	Kinase
P29965	BXGT009388	CD40 ligand	959	reviewed	Signaling
P31785	BXGT009577	Cytokine receptor common subunit gamma	3561	reviewed	Signaling
P33527	BXGT009728	Multidrug resistance-associated protein 1	4363	reviewed	Transporter
P40763	BXGT010202	Signal transducer and activator of transcription 3	6774	reviewed	Nucleic acid binding
P40933	BXGT010209	Interleukin-15	3600	reviewed
P42224	BXGT010286	Signal transducer and activator of transcription 1-alpha/beta	6772	reviewed	Nucleic acid binding
P43403	BXGT010385	Tyrosine-protein kinase ZAP-70	7535	reviewed	Kinase
P48551	BXGT010645	Interferon alpha/beta receptor 2	3455	reviewed	Receptor
P49917	BXGT010765	DNA ligase 4	3981	reviewed
P51617	BXGT010868	Interleukin-1 receptor-associated kinase 1	3654	reviewed	Kinase
P51692	BXGT010885	Signal transducer and activator of transcription 5B	6777	reviewed	Nucleic acid binding
P52333	BXGT010928	Tyrosine-protein kinase JAK3	3718	reviewed	Kinase
P53609	BXGT011001	Geranylgeranyl transferase type-1 subunit beta	5229	reviewed	Enzyme
P54819	BXGT011084	Adenylate kinase 2, mitochondrial	204	reviewed	Kinase
P60033	BXGT011286	CD81 antigen	975	reviewed
P60568	BXGT011315	Interleukin-2	3558	reviewed
P60709	BXGT011322	Actin, cytoplasmic 1	60	reviewed	Cellular structure
P61011	BXGT011346	Signal recognition particle 54 kDa protein	6729	reviewed	Nucleic acid binding
P61073	BXGT011352	C-X-C chemokine receptor type 4	7852	reviewed	G-protein coupled receptor
P78556	BXGT011849	C-C motif chemokine 20	6364	reviewed	Signaling
Q00653	BXGT012541	Nuclear factor NF-kappa-B p100 subunit	4791	reviewed	Transcription factor
Q01959	BXGT012624	Sodium-dependent dopamine transporter	6531	reviewed	Transporter
Q05655	BXGT012832	Protein kinase C delta type	5580	reviewed	Kinase
Q06187	BXGT012860	Tyrosine-protein kinase BTK	695	reviewed	Kinase
Q07108	BXGT012919	Early activation antigen CD69	969	reviewed
Q07817	BXGT012941	Bcl-2-like protein 1	598	reviewed	Signaling
Q07820	BXGT012942	Induced myeloid leukemia cell differentiation protein Mcl-1	4170	reviewed	Signaling
Q12866	BXGT013273	Tyrosine-protein kinase Mer	10461	reviewed	Kinase
Q13043	BXGT013307	Serine/threonine-protein kinase 4	6789	reviewed	Kinase
Q13191	BXGT013325	E3 ubiquitin-protein ligase CBL-B	868	reviewed	Enzyme
Q13315	BXGT013339	Serine-protein kinase ATM	472	reviewed	Kinase
Q13426	BXGT013353	DNA repair protein XRCC4	7518	reviewed
Q13535	BXGT013370	Serine/threonine-protein kinase ATR	545	reviewed	Kinase
Q15746	BXGT013591	Myosin light chain kinase, smooth muscle	4638	reviewed	Kinase
Q5Y7D3	BXGT015912	HLA class II histocompatibility antigen DQ beta chain	3119	unreviewed
Q8IU54	BXGT018331	Interferon lambda-1	282618	reviewed
Q8N6T7	BXGT018525	NAD-dependent protein deacetylase sirtuin-6	51548	reviewed	Epigenetic regulator
Q8NHV1	BXGT018570	GTPase IMAP family member 7	168537	reviewed
Q96AZ6	BXGT019621	Interferon-stimulated gene 20 kDa protein	3669	reviewed
Q96EB6	BXGT019646	NAD-dependent protein deacetylase sirtuin-1	23411	reviewed	Epigenetic regulator
Q96Q11	BXGT019713	CCA tRNA nucleotidyltransferase 1, mitochondrial	51095	reviewed
Q96RJ3	BXGT019729	Tumor necrosis factor receptor superfamily member 13C	115650	reviewed
Q99558	BXGT019934	Mitogen-activated protein kinase kinase kinase 14	9020	reviewed	Kinase
Q99836	BXGT019970	Myeloid differentiation primary response protein MyD88	4615	reviewed	Enzyme modulator
Q99972	BXGT019979	Myocilin	4653	reviewed	Cellular structure
Q9BZS1	BXGT020203	Forkhead box protein P3	50943	reviewed
Q9NRA0	BXGT021183	Sphingosine kinase 2	56848	reviewed	Kinase
Q9NYA1	BXGT021254	Sphingosine kinase 1	8877	reviewed	Kinase
Q9NZQ7	BXGT021281	Programmed cell death 1 ligand 1	29126	reviewed	Receptor
Q9P2W7	BXGT021306	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1	27087	reviewed	Enzyme
Q9UBC3	BXGT021650	DNA (cytosine-5)-methyltransferase 3B	1789	reviewed
Q9UER7	BXGT021672	Death domain-associated protein 6	1616	reviewed
Q9UGN5	BXGT021688	Poly [ADP-ribose] polymerase 2	10038	reviewed
Q9Y275	BXGT022223	Tumor necrosis factor ligand superfamily member 13B	10673	reviewed
Q9Y2Q3	BXGT022242	Glutathione S-transferase kappa 1	373156	reviewed
P16284	BXGT022972	Platelet endothelial cell adhesion molecule	5175	reviewed	Cell adhesion
Q13432	BXGT024144	Protein unc-119 homolog A	9094	reviewed	Receptor
P29590	BXGT024350	Protein PML	5371	reviewed
P31358	BXGT025061	CAMPATH-1 antigen	1043	reviewed
Q96MS0	BXGT025241	Roundabout homolog 3	64221	reviewed	Receptor
Q96SD1	BXGT025929	Protein artemis	64421	reviewed
P11836	BXGT025994	B-lymphocyte antigen CD20	931	reviewed	Receptor

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}