Showing entry for Beta-secretase 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011201
Protein NameBeta-secretase 1
Uniport IdP56818
GeneBace1
Gene Id23821
DomainAsp
Pfam PF00026  
OrganismMus musculus (Mouse)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0050435 amyloid-beta metabolic process
Biological Process GO:0042987 amyloid precursor protein catabolic process
Biological Process GO:1904646 cellular response to amyloid-beta
Biological Process GO:0071280 cellular response to copper ion
Biological Process GO:0071287 cellular response to manganese ion
Biological Process GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
Biological Process GO:0006509 membrane protein ectodomain proteolysis
Biological Process GO:0007613 memory
Biological Process GO:0050804 modulation of chemical synaptic transmission
Biological Process GO:0043525 positive regulation of neuron apoptotic process
Biological Process GO:0060134 prepulse inhibition
Biological Process GO:0006508 proteolysis
Biological Process GO:0048167 regulation of synaptic plasticity
Biological Process GO:2000300 regulation of synaptic vesicle exocytosis
Biological Process GO:0010288 response to lead ion
Biological Process GO:0009314 response to radiation
molecular function GO:0001540 amyloid-beta binding
molecular function GO:0004190 aspartic-type endopeptidase activity
molecular function GO:0004175 endopeptidase activity
molecular function GO:0019899 enzyme binding
molecular function GO:0008233 peptidase activity
cellular component GO:0030424 axon
cellular component GO:0009986 cell surface
cellular component GO:0031410 cytoplasmic vesicle
cellular component GO:0030659 cytoplasmic vesicle membrane
cellular component GO:0030425 dendrite
cellular component GO:0005769 early endosome
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005768 endosome
cellular component GO:0005794 Golgi apparatus
cellular component GO:0098686 hippocampal mossy fiber to CA3 synapse
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005770 late endosome
cellular component GO:0005764 lysosome
cellular component GO:0016020 membrane
cellular component GO:0045121 membrane raft
cellular component GO:0005771 multivesicular body
cellular component GO:0043025 neuronal cell body
cellular component GO:0005886 plasma membrane
cellular component GO:0055037 recycling endosome
cellular component GO:0008021 synaptic vesicle
cellular component GO:0005802 trans-Golgi network
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0023512 Ampelopsin C 680.2
BXGC0033310 Epigalocatechin Gallate 458.08
BXGC0050641 (?)-Davidiol A 680.2
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein