Showing entry for Hydroxymethylglutaryl-CoA synthase, cytoplasmic


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT012599
Protein NameHydroxymethylglutaryl-CoA synthase, cytoplasmic
Uniport IdQ01581
GeneHMGCS1
Gene Id3157
DomainHMG_CoA_synt_C; HMG_CoA_synt_N
Pfam PF08540   PF01154  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00072 Synthesis and degradation of ketone bodies
1. Metabolism 1.5 Amino acid metabolism hsa00280 Valine, leucine and isoleucine degradation
1. Metabolism 1.1 Carbohydrate metabolism hsa00650 Butanoate metabolism
1. Metabolism 1.9 Metabolism of terpenoids and polyketides hsa00900 Terpenoid backbone biosynthesis
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
5. Organismal Systems 5.2 Endocrine system hsa03320 PPAR signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006084 acetyl-CoA metabolic process
Biological Process GO:0007420 brain development
Biological Process GO:0071397 cellular response to cholesterol
Biological Process GO:0071372 cellular response to follicle-stimulating hormone stimulus
Biological Process GO:0071404 cellular response to low-density lipoprotein particle stimulus
Biological Process GO:0006695 cholesterol biosynthetic process
Biological Process GO:0010142 farnesyl diphosphate biosynthetic process, mevalonate pathway
Biological Process GO:0006629 lipid metabolic process
Biological Process GO:0001889 liver development
Biological Process GO:0008584 male gonad development
Biological Process GO:0045540 regulation of cholesterol biosynthetic process
Biological Process GO:0019216 regulation of lipid metabolic process
Biological Process GO:0042493 response to drug
Biological Process GO:0009645 response to low light intensity stimulus
Biological Process GO:0014074 response to purine-containing compound
Biological Process GO:0046690 response to tellurium ion
Biological Process GO:0033197 response to vitamin E
molecular function GO:0008144 drug binding
molecular function GO:0004421 hydroxymethylglutaryl-CoA synthase activity
molecular function GO:0016853 isomerase activity
molecular function GO:0043177 organic acid binding
molecular function GO:0042803 protein homodimerization activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF)
R-HSA-191273 Cholesterol biosynthesis
R-HSA-1989781 PPARA activates gene expression
R-HSA-2426168 Activation of gene expression by SREBF (SREBP)
R-HSA-400206 Regulation of lipid metabolism by PPARalpha
R-HSA-556833 Metabolism of lipids
R-HSA-8957322 Metabolism of steroids
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0025202 BXGD001832 melanoma Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0037926 BXGD002712 Compression of spinal cord Nervous System Diseases; Wounds and Injuries
C0206624 BXGD004190 Hepatoblastoma Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0376634 BXGD008006 Craniofacial Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein