Showing entry for ATP-dependent RNA helicase A


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT012970
Protein NameATP-dependent RNA helicase A
Uniport IdQ08211
GeneDHX9
Gene Id1660
DomainDEAD; dsrm; HA2; Helicase_C; OB_NTP_bind
Pfam PF00270   PF00035   PF04408   PF00271   PF07717  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0000380 alternative mRNA splicing, via spliceosome
Biological Process GO:0034622 cellular protein-containing complex assembly
Biological Process GO:0071360 cellular response to exogenous dsRNA
Biological Process GO:0071356 cellular response to tumor necrosis factor
Biological Process GO:0070934 CRD-mediated mRNA stabilization
Biological Process GO:0032508 DNA duplex unwinding
Biological Process GO:0006260 DNA replication
Biological Process GO:0006353 DNA-templated transcription, termination
Biological Process GO:0039695 DNA-templated viral transcription
Biological Process GO:0044806 G-quadruplex DNA unwinding
Biological Process GO:0006954 inflammatory response
Biological Process GO:0045087 innate immune response
Biological Process GO:0000398 mRNA splicing, via spliceosome
Biological Process GO:0051028 mRNA transport
Biological Process GO:0001649 osteoblast differentiation
Biological Process GO:2000767 positive regulation of cytoplasmic translation
Biological Process GO:0045739 positive regulation of DNA repair
Biological Process GO:0045740 positive regulation of DNA replication
Biological Process GO:2000373 positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
Biological Process GO:0048146 positive regulation of fibroblast proliferation
Biological Process GO:2000637 positive regulation of gene silencing by miRNA
Biological Process GO:0050729 positive regulation of inflammatory response
Biological Process GO:0045089 positive regulation of innate immune response
Biological Process GO:0032727 positive regulation of interferon-alpha production
Biological Process GO:0032728 positive regulation of interferon-beta production
Biological Process GO:0032741 positive regulation of interleukin-18 production
Biological Process GO:0032755 positive regulation of interleukin-6 production
Biological Process GO:0051092 positive regulation of NF-kappaB transcription factor activity
Biological Process GO:1905698 positive regulation of polysome binding
Biological Process GO:0060760 positive regulation of response to cytokine stimulus
Biological Process GO:0046833 positive regulation of RNA export from nucleus
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:1904469 positive regulation of tumor necrosis factor secretion
Biological Process GO:0032481 positive regulation of type I interferon production
Biological Process GO:0050434 positive regulation of viral transcription
Biological Process GO:1904973 positive regulation of viral translation
Biological Process GO:1903608 protein localization to cytoplasmic stress granule
Biological Process GO:0070269 pyroptosis
Biological Process GO:2000765 regulation of cytoplasmic translation
Biological Process GO:0050691 regulation of defense response to virus by host
Biological Process GO:0050684 regulation of mRNA processing
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0048511 rhythmic process
Biological Process GO:0010501 RNA secondary structure unwinding
Biological Process GO:0070922 small RNA loading onto RISC
Biological Process GO:0030423 targeting of mRNA for destruction involved in RNA interference
molecular function GO:0033679 3'-5' DNA/RNA helicase activity
molecular function GO:0043138 3'-5' DNA helicase activity
molecular function GO:0034458 3'-5' RNA helicase activity
molecular function GO:0016887 ATPase activity
molecular function GO:0005524 ATP binding
molecular function GO:0031490 chromatin DNA binding
molecular function GO:0003677 DNA binding
molecular function GO:0003678 DNA helicase activity
molecular function GO:0003688 DNA replication origin binding
molecular function GO:0003690 double-stranded DNA binding
molecular function GO:0003725 double-stranded RNA binding
molecular function GO:0061676 importin-alpha family protein binding
molecular function GO:0046872 metal ion binding
molecular function GO:0003729 mRNA binding
molecular function GO:0017111 nucleoside-triphosphatase activity
molecular function GO:0047429 nucleoside-triphosphate diphosphatase activity
molecular function GO:1905538 polysome binding
molecular function GO:1990841 promoter-specific chromatin binding
molecular function GO:0001069 regulatory region RNA binding
molecular function GO:1905172 RISC complex binding
molecular function GO:0003723 RNA binding
molecular function GO:0003724 RNA helicase activity
molecular function GO:0070063 RNA polymerase binding
molecular function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
molecular function GO:0000993 RNA polymerase II complex binding
molecular function GO:0001085 RNA polymerase II transcription factor binding
molecular function GO:0035613 RNA stem-loop binding
molecular function GO:1990825 sequence-specific mRNA binding
molecular function GO:1990518 single-stranded 3'-5' DNA helicase activity
molecular function GO:0003697 single-stranded DNA binding
molecular function GO:0003727 single-stranded RNA binding
molecular function GO:0035197 siRNA binding
molecular function GO:0003713 transcription coactivator activity
molecular function GO:0003712 transcription coregulator activity
molecular function GO:0045142 triplex DNA binding
cellular component GO:0015629 actin cytoskeleton
cellular component GO:0005813 centrosome
cellular component GO:0070937 CRD-mediated mRNA stability complex
cellular component GO:0005737 cytoplasm
cellular component GO:0036464 cytoplasmic ribonucleoprotein granule
cellular component GO:0005829 cytosol
cellular component GO:0016020 membrane
cellular component GO:0016604 nuclear body
cellular component GO:0097165 nuclear stress granule
cellular component GO:0005730 nucleolus
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0005726 perichromatin fibrils
cellular component GO:0042788 polysomal ribosome
cellular component GO:0005844 polysome
cellular component GO:0032991 protein-containing complex
cellular component GO:1990904 ribonucleoprotein complex
cellular component GO:0016442 RISC complex
cellular component GO:0070578 RISC-loading complex
Reactome
Pathway Id Pathway Name
R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-1810476 RIP-mediated NFkB activation via ZBP1
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA
R-HSA-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72172 mRNA Splicing
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA
R-HSA-8953854 Metabolism of RNA
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011311 BXGD000714 Dengue Fever Infections
C0011633 BXGD000742 Dermatomyositis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0014057 BXGD000880 Japanese Encephalitis Infections; Nervous System Diseases
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024286 BXGD001756 Lymphogranuloma Venereum Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024530 BXGD001783 Malaria Infections
C0027149 BXGD001979 Myxoma Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0041296 BXGD002903 Tuberculosis Infections
C0042769 BXGD002999 Virus Diseases Infections
C0043119 BXGD003029 Werner Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0149925 BXGD003387 Small cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0241868 BXGD005118 acute aortic dissection Cardiovascular Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0276289 BXGD006418 Zika Virus Infection Infections
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0454568 BXGD008837 Transcortical sensory dysphasia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0751651 BXGD010539 Mitochondrial Diseases Nutritional and Metabolic Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C2062441 BXGD016897 Influenza A
C3536893 BXGD019076 Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor Neoplasms
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4727916 BXGD023877 H3N2 influenza
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein