adisease

Showing entry for Werner Syndrome

General Disease Information
BXGD Id	BXGD003029
Disease Name	Werner Syndrome
Disease CUI Id	C0043119
MeSH Codes	C16 C18
Disease Class Name	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id
Human Phenotype Ontology Term
Disease Ontology Id	DOID:630
Disease Ontology Class Name	genetic disease
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00748	BXGT003942	Cocaine esterase	8824	reviewed	Enzyme
O14746	BXGT004091	Telomerase reverse transcriptase	7015	reviewed	Enzyme
O15527	BXGT004176	N-glycosylase/DNA lyase	4968	reviewed
O60240	BXGT004860	Perilipin-1	5346	reviewed
O94762	BXGT005329	ATP-dependent DNA helicase Q5	9400	reviewed	Enzyme
P00519	BXGT005570	Tyrosine-protein kinase ABL1	25	reviewed	Kinase
P00747	BXGT005639	Plasminogen	5340	reviewed	Enzyme
P01106	BXGT005730	Myc proto-oncogene protein	4609	reviewed	Transcription factor
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01583	BXGT005771	Interleukin-1 alpha	3552	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P02461	BXGT005880	Collagen alpha-1(III) chain	1281	reviewed
P02545	BXGT005889	Prelamin-A/C	4000	reviewed
P02647	BXGT005908	Apolipoprotein A-I	335	reviewed
P02724	BXGT005934	Glycophorin-A	2993	reviewed
P02751	BXGT005943	Fibronectin	2335	reviewed	Signaling
P02786	BXGT005961	Transferrin receptor protein 1	7037	reviewed	Enzyme
P04040	BXGT006132	Catalase	847	reviewed	Enzyme
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P05121	BXGT006320	Plasminogen activator inhibitor 1	5054	reviewed	Enzyme modulator
P05362	BXGT006350	Intercellular adhesion molecule 1	3383	reviewed
P06213	BXGT006425	Insulin receptor	3643	reviewed	Kinase
P06746	BXGT006496	DNA polymerase beta	5423	reviewed	Enzyme
P09874	BXGT006934	Poly [ADP-ribose] polymerase 1	142	reviewed
P10644	BXGT007597	cAMP-dependent protein kinase type I-alpha regulatory subunit	5573	reviewed
P11166	BXGT007661	Solute carrier family 2, facilitated glucose transporter member 1	6513	reviewed	Transporter
P11362	BXGT007693	Fibroblast growth factor receptor 1	2260	reviewed	Kinase
P12004	BXGT007766	Proliferating cell nuclear antigen	5111	reviewed	Nucleic acid binding
P12821	BXGT007849	Angiotensin-converting enzyme	1636	reviewed	Enzyme
P16157	BXGT008203	Ankyrin-1	286	reviewed
P17540	BXGT008315	Creatine kinase S-type, mitochondrial	1160	reviewed	Kinase
P17936	BXGT008357	Insulin-like growth factor-binding protein 3	3486	reviewed	Enzyme modulator
P23396	BXGT008863	40S ribosomal protein S3	6188	reviewed	Nucleic acid binding
P27695	BXGT009199	DNA-(apurinic or apyrimidinic site) lyase	328	reviewed
P28482	BXGT009263	Mitogen-activated protein kinase 1	5594	reviewed	Kinase
P29466	BXGT009349	Caspase-1	834	reviewed	Enzyme
P31260	BXGT009519	Homeobox protein Hox-A10	3206	reviewed
P35557	BXGT009846	Glucokinase	2645	reviewed	Kinase
P35968	BXGT009887	Vascular endothelial growth factor receptor 2	3791	reviewed	Kinase
P37231	BXGT009972	Peroxisome proliferator-activated receptor gamma	5468	reviewed	Nuclear receptor
P38398	BXGT010037	Breast cancer type 1 susceptibility protein	672	reviewed	Enzyme
P39748	BXGT010134	Flap endonuclease 1	2237	reviewed	Enzyme
P40692	BXGT010195	DNA mismatch repair protein Mlh1	4292	reviewed	Nucleic acid binding
P42345	BXGT010304	Serine/threonine-protein kinase mTOR	2475	reviewed	Kinase
P46063	BXGT010501	ATP-dependent DNA helicase Q1	5965	reviewed	Enzyme
P46108	BXGT010509	Adapter molecule crk	1398	reviewed
P49917	BXGT010765	DNA ligase 4	3981	reviewed
P49959	BXGT010766	Double-strand break repair protein MRE11	4361	reviewed
P51812	BXGT010893	Ribosomal protein S6 kinase alpha-3	6197	reviewed	Kinase
P54132	BXGT011032	Bloom syndrome protein	641	reviewed
P60709	BXGT011322	Actin, cytoplasmic 1	60	reviewed	Cellular structure
P60953	BXGT011342	Cell division control protein 42 homolog	998	reviewed	Enzyme modulator
P62714	BXGT011451	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	5516	reviewed
P63000	BXGT011481	Ras-related C3 botulinum toxin substrate 1	5879	reviewed	Enzyme modulator
P63165	BXGT011506	Small ubiquitin-related modifier 1	7341	reviewed
Q06609	BXGT012884	DNA repair protein RAD51 homolog 1	5888	reviewed
Q08211	BXGT012970	ATP-dependent RNA helicase A	1660	reviewed	Enzyme
Q08945	BXGT013014	FACT complex subunit SSRP1	6749	reviewed
Q13155	BXGT013320	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2	7965	reviewed
Q13315	BXGT013339	Serine-protein kinase ATM	472	reviewed	Kinase
Q13472	BXGT013360	DNA topoisomerase 3-alpha	7156	reviewed	Enzyme
Q13535	BXGT013370	Serine/threonine-protein kinase ATR	545	reviewed	Kinase
Q14191	BXGT013452	Werner syndrome ATP-dependent helicase	7486	reviewed	Enzyme
Q15848	BXGT013609	Adiponectin	9370	reviewed
Q16539	BXGT013634	Mitogen-activated protein kinase 14	1432	reviewed	Kinase
Q7L5Y1	BXGT016996	Mitochondrial enolase superfamily member 1	55556	reviewed	Enzyme
Q8IW19	BXGT018351	Aprataxin and PNK-like factor	200558	reviewed
Q8N6T7	BXGT018525	NAD-dependent protein deacetylase sirtuin-6	51548	reviewed	Epigenetic regulator
Q92698	BXGT019362	DNA repair and recombination protein RAD54-like	8438	reviewed
Q93062	BXGT019456	RNA-binding protein with multiple splicing	11030	reviewed	Nucleic acid binding
Q96FI4	BXGT019658	Endonuclease 8-like 1	79661	reviewed
Q9NR56	BXGT021179	Muscleblind-like protein 1	4154	reviewed	Nucleic acid binding
Q9UGP5	BXGT021689	DNA polymerase lambda	27343	reviewed	Enzyme
Q9UQ84	BXGT021807	Exonuclease 1	9156	reviewed	Enzyme
Q9Y3Z3	BXGT022268	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1	25939	reviewed
Q01995	BXGT022678	Transgelin	6876	reviewed	Cellular structure
P16104	BXGT024571	Histone H2AX	3014	reviewed	Nucleic acid binding
P51608	BXGT025073	Methyl-CpG-binding protein 2	4204	reviewed	Epigenetic regulator

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}