Showing entry for Rap guanine nucleotide exchange factor 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013402
Protein NameRap guanine nucleotide exchange factor 1
Uniport IdQ13905
GeneRAPGEF1
Gene Id2889
DomainRasGEF; RasGEF_N
Pfam PF00617   PF00618  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04015 Rap1 signaling pathway
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04510 Focal adhesion
5. Organismal Systems 5.6 Nervous system hsa04722 Neurotrophin signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04910 Insulin signaling pathway
6. Human Diseases 6.2 Cancers: Specific types hsa05211 Renal cell carcinoma
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0090630 activation of GTPase activity
Biological Process GO:0000186 activation of MAPKK activity
Biological Process GO:0001568 blood vessel development
Biological Process GO:0098609 cell-cell adhesion
Biological Process GO:0071320 cellular response to cAMP
Biological Process GO:1990090 cellular response to nerve growth factor stimulus
Biological Process GO:0019221 cytokine-mediated signaling pathway
Biological Process GO:0061028 establishment of endothelial barrier
Biological Process GO:0090090 negative regulation of canonical Wnt signaling pathway
Biological Process GO:0070373 negative regulation of ERK1 and ERK2 cascade
Biological Process GO:2000178 negative regulation of neural precursor cell proliferation
Biological Process GO:0051898 negative regulation of protein kinase B signaling
Biological Process GO:0046580 negative regulation of Ras protein signal transduction
Biological Process GO:0038180 nerve growth factor signaling pathway
Biological Process GO:0048008 platelet-derived growth factor receptor signaling pathway
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:1905451 positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis
Biological Process GO:0043547 positive regulation of GTPase activity
Biological Process GO:0010976 positive regulation of neuron projection development
Biological Process GO:0046579 positive regulation of Ras protein signal transduction
Biological Process GO:0032486 Rap protein signal transduction
Biological Process GO:1901888 regulation of cell junction assembly
Biological Process GO:0046328 regulation of JNK cascade
Biological Process GO:0007165 signal transduction
Biological Process GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
molecular function GO:0005085 guanyl-nucleotide exchange factor activity
molecular function GO:0017034 Rap guanyl-nucleotide exchange factor activity
molecular function GO:0017124 SH3 domain binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005769 early endosome
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0030670 phagocytic vesicle membrane
cellular component GO:0032991 protein-containing complex
Reactome
Pathway Id Pathway Name
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-166520 Signaling by NTRKs
R-HSA-166520 Signaling by NTRKs
R-HSA-168256 Immune System
R-HSA-169893 Prolonged ERK activation events
R-HSA-169893 Prolonged ERK activation events
R-HSA-170968 Frs2-mediated activation
R-HSA-170968 Frs2-mediated activation
R-HSA-186763 Downstream signal transduction
R-HSA-186797 Signaling by PDGF
R-HSA-187037 Signaling by NTRK1 (TRKA)
R-HSA-187037 Signaling by NTRK1 (TRKA)
R-HSA-187687 Signalling to ERKs
R-HSA-187687 Signalling to ERKs
R-HSA-449147 Signaling by Interleukins
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-HSA-6806834 Signaling by MET
R-HSA-8875555 MET activates RAP1 and RAC1
R-HSA-8875878 MET promotes cell motility
R-HSA-9006335 Signaling by Erythropoietin
R-HSA-9006335 Signaling by Erythropoietin
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9027284 Erythropoietin activates RAS
R-HSA-9027284 Erythropoietin activates RAS
R-HSA-912631 Regulation of signaling by CBL
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0005890 BXGD000345 Body Height
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0221238 BXGD004415 Mesangial proliferative glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0685938 BXGD009829 Malignant neoplasm of gastrointestinal tract Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332309 BXGD012521 Anti-Basement Membrane Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0004275 Acetaldehyde 44.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein