Showing entry for Malignant neoplasm of gastrointestinal tract


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD009829
Disease NameMalignant neoplasm of gastrointestinal tract
Disease CUI IdC0685938
MeSH Codes C06   C04  
Disease Class NameDigestive System Diseases; Neoplasms
Semantic TypeNeoplastic Process
Human Phenotype Ontology Id HP:0025031   HP:0002664  
Human Phenotype Ontology TermAbnormality of the digestive system; Neoplasm
Disease Ontology Id DOID:7   DOID:14566  
Disease Ontology Class Namedisease of anatomical entity; disease of cellular proliferation
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
A0A024RAV5 BXGT000013 V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b 3845 unreviewed
O00182 BXGT003889 Galectin-9 3965 reviewed Signaling
O00329 BXGT003909 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 5293 reviewed Kinase
O00482 BXGT003929 Nuclear receptor subfamily 5 group A member 2 2494 reviewed Nuclear receptor
O14746 BXGT004091 Telomerase reverse transcriptase 7015 reviewed Enzyme
O14965 BXGT004117 Aurora kinase A 6790 reviewed Kinase
O15169 BXGT004134 Axin-1 8312 reviewed
O15492 BXGT004174 Regulator of G-protein signaling 16 6004 reviewed Enzyme modulator
O15527 BXGT004176 N-glycosylase/DNA lyase 4968 reviewed
O43157 BXGT004572 Plexin-B1 5364 reviewed
O43683 BXGT004614 Mitotic checkpoint serine/threonine-protein kinase BUB1 699 reviewed Kinase
O60218 BXGT004858 Aldo-keto reductase family 1 member B10 57016 reviewed Enzyme
O60260 BXGT004864 E3 ubiquitin-protein ligase parkin 5071 reviewed Enzyme
O60462 BXGT004876 Neuropilin-2 8828 reviewed
O60760 BXGT004899 Hematopoietic prostaglandin D synthase 27306 reviewed
O75473 BXGT005129 Leucine-rich repeat-containing G-protein coupled receptor 5 8549 reviewed G-protein coupled receptor
O75475 BXGT005130 PC4 and SFRS1-interacting protein 11168 reviewed Signaling
O75874 BXGT005157 Isocitrate dehydrogenase [NADP] cytoplasmic 3417 reviewed
O75914 BXGT005165 Serine/threonine-protein kinase PAK 3 5063 reviewed Kinase
O95243 BXGT005362 Methyl-CpG-binding domain protein 4 8930 reviewed Enzyme
O95255 BXGT005363 Multidrug resistance-associated protein 6 368 reviewed Transporter
O96017 BXGT005415 Serine/threonine-protein kinase Chk2 11200 reviewed Kinase
P00533 BXGT005575 Epidermal growth factor receptor 1956 reviewed Kinase
P00734 BXGT005630 Prothrombin 2147 reviewed Enzyme
P00751 BXGT005643 Complement factor B 629 reviewed
P01019 BXGT005717 Angiotensinogen 183 reviewed Enzyme modulator
P01106 BXGT005730 Myc proto-oncogene protein 4609 reviewed Transcription factor
P01112 BXGT005732 GTPase HRas 3265 reviewed Enzyme modulator
P01116 BXGT005733 GTPase KRas 3845 reviewed Enzyme modulator
P01133 BXGT005736 Pro-epidermal growth factor 1950 reviewed
P01137 BXGT005737 Transforming growth factor beta-1 proprotein 7040 reviewed Signaling
P01138 BXGT005738 Beta-nerve growth factor 4803 reviewed Signaling
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P02741 BXGT005936 C-reactive protein 1401 reviewed
P02766 BXGT005953 Transthyretin 7276 reviewed Transporter
P02768 BXGT005955 Serum albumin 213 reviewed Transporter
P03372 BXGT006059 Estrogen receptor 2099 reviewed Nuclear receptor
P03956 BXGT006120 Interstitial collagenase 4312 reviewed Enzyme
P04054 BXGT006136 Phospholipase A2 5319 reviewed Enzyme
P04083 BXGT006147 Annexin A1 301 reviewed
P04183 BXGT006166 Thymidine kinase, cytosolic 7083 reviewed Kinase
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 2064 reviewed Kinase
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P04792 BXGT006264 Heat shock protein beta-1 3315 reviewed
P04798 BXGT006265 Cytochrome P450 1A1 1543 reviewed Enzyme
P04818 BXGT006269 Thymidylate synthase 7298 reviewed Enzyme
P05091 BXGT006312 Aldehyde dehydrogenase, mitochondrial 217 reviewed Enzyme
P05181 BXGT006337 Cytochrome P450 2E1 1571 reviewed
P05187 BXGT006339 Alkaline phosphatase, placental type 250 reviewed Enzyme
P05231 BXGT006345 Interleukin-6 3569 reviewed
P06702 BXGT006476 Protein S100-A9 6280 reviewed Calcium-binding protein
P06731 BXGT006488 Carcinoembryonic antigen-related cell adhesion molecule 5 1048 reviewed
P07900 BXGT006696 Heat shock protein HSP 90-alpha 3320 reviewed Chaperone
P08069 BXGT006723 Insulin-like growth factor 1 receptor 3480 reviewed Kinase
P08183 BXGT006741 ATP-dependent translocase ABCB1 5243 reviewed Transporter
P08253 BXGT006757 72 kDa type IV collagenase 4313 reviewed Enzyme
P08254 BXGT006758 Stromelysin-1 4314 reviewed Enzyme
P08581 BXGT006794 Hepatocyte growth factor receptor 4233 reviewed Kinase
P08684 BXGT006812 Cytochrome P450 3A4 1576 reviewed Enzyme
P09211 BXGT006869 Glutathione S-transferase P 2950 reviewed
P09237 BXGT006874 Matrilysin 4316 reviewed Enzyme
P09382 BXGT006882 Galectin-1 3956 reviewed Signaling
P09486 BXGT006897 SPARC 6678 reviewed Signaling
P09488 BXGT006899 Glutathione S-transferase Mu 1 2944 reviewed
P09874 BXGT006934 Poly [ADP-ribose] polymerase 1 142 reviewed
P09917 BXGT006941 Arachidonate 5-lipoxygenase 240 reviewed Enzyme
P09936 BXGT006943 Ubiquitin carboxyl-terminal hydrolase isozyme L1 7345 reviewed Enzyme
P0DN79 BXGT007511 Cystathionine beta-synthase-like protein 875 reviewed
P10145 BXGT007542 Interleukin-8 3576 reviewed Signaling
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P11021 BXGT007644 Endoplasmic reticulum chaperone BiP 3309 reviewed
P11172 BXGT007665 Uridine 5'-monophosphate synthase 7372 reviewed
P11473 BXGT007709 Vitamin D3 receptor 7421 reviewed Nuclear receptor
P11511 BXGT007717 Aromatase 1588 reviewed Enzyme
P11717 BXGT007740 Cation-independent mannose-6-phosphate receptor 3482 reviewed Receptor
P11926 BXGT007760 Ornithine decarboxylase 4953 reviewed Enzyme
P12821 BXGT007849 Angiotensin-converting enzyme 1636 reviewed Enzyme
P12830 BXGT007852 Cadherin-1 999 reviewed
P13569 BXGT007923 Cystic fibrosis transmembrane conductance regulator 1080 reviewed Ion channel
P13688 BXGT007943 Carcinoembryonic antigen-related cell adhesion molecule 1 634 reviewed
P14210 BXGT007994 Hepatocyte growth factor 3082 reviewed Enzyme
P14621 BXGT008028 Acylphosphatase-2 98 reviewed Enzyme
P14780 BXGT008053 Matrix metalloproteinase-9 4318 reviewed Enzyme
P14784 BXGT008054 Interleukin-2 receptor subunit beta 3560 reviewed Receptor
P15056 BXGT008075 Serine/threonine-protein kinase B-raf 673 reviewed Kinase
P15311 BXGT008106 Ezrin 7430 reviewed Cellular structure
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] 3248 reviewed
P15559 BXGT008139 NAD(P)H dehydrogenase [quinone] 1 1728 reviewed
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P15884 BXGT008166 Transcription factor 4 6925 reviewed Transcription factor
P15941 BXGT008176 Mucin-1 4582 reviewed
P16070 BXGT008186 CD44 antigen 960 reviewed
P16152 BXGT008201 Carbonyl reductase [NADPH] 1 873 reviewed
P16442 BXGT008227 Histo-blood group ABO system transferase 28 reviewed Enzyme
P16455 BXGT008229 Methylated-DNA--protein-cysteine methyltransferase 4255 reviewed
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 2321 reviewed Kinase
P18827 BXGT008427 Syndecan-1 6382 reviewed Extracellular structure
P18887 BXGT008437 DNA repair protein XRCC1 7515 reviewed
P19971 BXGT008537 Thymidine phosphorylase 1890 reviewed Enzyme
P20815 BXGT008604 Cytochrome P450 3A5 1577 reviewed Enzyme
P21802 BXGT008691 Fibroblast growth factor receptor 2 2263 reviewed Kinase
P21860 BXGT008698 Receptor tyrosine-protein kinase erbB-3 2065 reviewed Kinase
P22083 BXGT008727 Alpha-(1,3)-fucosyltransferase 4 2526 reviewed Enzyme
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 54658 reviewed
P23219 BXGT008837 Prostaglandin G/H synthase 1 5742 reviewed Enzyme
P23443 BXGT008866 Ribosomal protein S6 kinase beta-1 6198 reviewed Kinase
P23458 BXGT008868 Tyrosine-protein kinase JAK1 3716 reviewed Kinase
P23560 BXGT008883 Brain-derived neurotrophic factor 627 reviewed Signaling
P25103 BXGT009020 Substance-P receptor 6869 reviewed G-protein coupled receptor
P25815 BXGT009074 Protein S100-P 6286 reviewed Calcium-binding protein
P26447 BXGT009114 Protein S100-A4 6275 reviewed Calcium-binding protein
P27037 BXGT009153 Activin receptor type-2A 92 reviewed Kinase
P27361 BXGT009176 Mitogen-activated protein kinase 3 5595 reviewed Kinase
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase 328 reviewed
P28482 BXGT009263 Mitogen-activated protein kinase 1 5594 reviewed Kinase
P29317 BXGT009331 Ephrin type-A receptor 2 1969 reviewed Kinase
P30044 BXGT009395 Peroxiredoxin-5, mitochondrial 25824 reviewed
P30711 BXGT009460 Glutathione S-transferase theta-1 2952 reviewed
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase 207 reviewed Kinase
P31948 BXGT009590 Stress-induced-phosphoprotein 1 10963 reviewed
P32418 BXGT009635 Sodium/calcium exchanger 1 6546 reviewed Transporter
P33261 BXGT009707 Cytochrome P450 2C19 1557 reviewed
P33527 BXGT009728 Multidrug resistance-associated protein 1 4363 reviewed Transporter
P34932 BXGT009772 Heat shock 70 kDa protein 4 3308 reviewed
P35222 BXGT009799 Catenin beta-1 1499 reviewed
P35354 BXGT009816 Prostaglandin G/H synthase 2 5743 reviewed Enzyme
P35520 BXGT009842 Cystathionine beta-synthase 875 reviewed
P35869 BXGT009877 Aryl hydrocarbon receptor 196 reviewed Transcription factor
P36222 BXGT009914 Chitinase-3-like protein 1 1116 reviewed
P36507 BXGT009923 Dual specificity mitogen-activated protein kinase kinase 2 5605 reviewed Kinase
P37173 BXGT009970 TGF-beta receptor type-2 7048 reviewed Kinase
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma 5468 reviewed Nuclear receptor
P38398 BXGT010037 Breast cancer type 1 susceptibility protein 672 reviewed Enzyme
P39748 BXGT010134 Flap endonuclease 1 2237 reviewed Enzyme
P40199 BXGT010166 Carcinoembryonic antigen-related cell adhesion molecule 6 4680 reviewed
P40225 BXGT010168 Thrombopoietin 7066 reviewed
P40692 BXGT010195 DNA mismatch repair protein Mlh1 4292 reviewed Nucleic acid binding
P40763 BXGT010202 Signal transducer and activator of transcription 3 6774 reviewed Nucleic acid binding
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5290 reviewed Kinase
P42338 BXGT010303 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 5291 reviewed Kinase
P42574 BXGT010317 Caspase-3 836 reviewed Enzyme
P42898 BXGT010344 Methylenetetrahydrofolate reductase 4524 reviewed
P43004 BXGT010348 Excitatory amino acid transporter 2 6506 reviewed Transporter
P43246 BXGT010371 DNA mismatch repair protein Msh2 4436 reviewed Nucleic acid binding
P45983 BXGT010494 Mitogen-activated protein kinase 8 5599 reviewed Kinase
P46527 BXGT010525 Cyclin-dependent kinase inhibitor 1B 1027 reviewed
P46531 BXGT010526 Neurogenic locus notch homolog protein 1 4851 reviewed
P46937 BXGT010554 Transcriptional coactivator YAP1 10413 reviewed Enzyme modulator
P48736 BXGT010658 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 5294 reviewed Kinase
P49711 BXGT010728 Transcriptional repressor CTCF 10664 reviewed Transcription factor
P49767 BXGT010739 Vascular endothelial growth factor C 7424 reviewed Signaling
P49841 BXGT010750 Glycogen synthase kinase-3 beta 2932 reviewed Kinase
P49908 BXGT010760 Selenoprotein P 6414 reviewed Extracellular structure
P49959 BXGT010766 Double-strand break repair protein MRE11 4361 reviewed
P51512 BXGT010850 Matrix metalloproteinase-16 4325 reviewed Enzyme
P51787 BXGT010889 Potassium voltage-gated channel subfamily KQT member 1 3784 reviewed Ion channel
P51878 BXGT010902 Caspase-5 838 reviewed Enzyme
P52701 BXGT010943 DNA mismatch repair protein Msh6 2956 reviewed Nucleic acid binding
P53355 BXGT010985 Death-associated protein kinase 1 1612 reviewed Kinase
P54278 BXGT011038 Mismatch repair endonuclease PMS2 5395 reviewed Nucleic acid binding
P60484 BXGT011307 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 5728 reviewed Enzyme
P61073 BXGT011352 C-X-C chemokine receptor type 4 7852 reviewed G-protein coupled receptor
P62820 BXGT011461 Ras-related protein Rab-1A 5861 reviewed
P63092 BXGT011495 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short 2778 reviewed
P78504 BXGT011844 Protein jagged-1 182 reviewed
P98177 BXGT012232 Forkhead box protein O4 4303 reviewed
Q00613 BXGT012540 Heat shock factor protein 1 3297 reviewed Transcription factor
Q00987 BXGT012559 E3 ubiquitin-protein ligase Mdm2 4193 reviewed Nucleic acid binding
Q01082 BXGT012567 Spectrin beta chain, non-erythrocytic 1 6711 reviewed
Q02809 BXGT012674 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 5351 reviewed Enzyme
Q03403 BXGT012712 Trefoil factor 2 7032 reviewed Signaling
Q04912 BXGT012790 Macrophage-stimulating protein receptor 4486 reviewed Kinase
Q07812 BXGT012940 Apoptosis regulator BAX 581 reviewed Signaling
Q08050 BXGT012958 Forkhead box protein M1 2305 reviewed
Q12882 BXGT013276 Dihydropyrimidine dehydrogenase [NADP(+)] 1806 reviewed Enzyme
Q13315 BXGT013339 Serine-protein kinase ATM 472 reviewed Kinase
Q13485 BXGT013363 Mothers against decapentaplegic homolog 4 4089 reviewed Transcription factor
Q13509 BXGT013366 Tubulin beta-3 chain 10381 reviewed Cellular structure
Q13547 BXGT013373 Histone deacetylase 1 3065 reviewed Epigenetic regulator
Q13563 BXGT013377 Polycystin-2 5311 reviewed Ion channel
Q13905 BXGT013402 Rap guanine nucleotide exchange factor 1 2889 reviewed Enzyme modulator
Q14002 BXGT013433 Carcinoembryonic antigen-related cell adhesion molecule 7 1087 reviewed
Q14116 BXGT013442 Interleukin-18 3606 reviewed
Q14790 BXGT013505 Caspase-8 841 reviewed Enzyme
Q15116 BXGT013539 Programmed cell death protein 1 5133 reviewed
Q15562 BXGT013579 Transcriptional enhancer factor TEF-4 8463 reviewed Transcription factor
Q15796 BXGT013599 Mothers against decapentaplegic homolog 2 4087 reviewed Transcription factor
Q15831 BXGT013604 Serine/threonine-protein kinase STK11 6794 reviewed Kinase
Q15910 BXGT013612 Histone-lysine N-methyltransferase EZH2 2146 reviewed Epigenetic regulator
Q16584 BXGT013642 Mitogen-activated protein kinase kinase kinase 11 4296 reviewed Kinase
Q16611 BXGT013644 Bcl-2 homologous antagonist/killer 578 reviewed Signaling
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha 3091 reviewed Transcription factor
Q16698 BXGT013659 2,4-dienoyl-CoA reductase, mitochondrial 1666 reviewed Enzyme
Q16878 BXGT013687 Cysteine dioxygenase type 1 1036 reviewed
Q53EL6 BXGT015008 Programmed cell death protein 4 27250 reviewed Nucleic acid binding
Q8IXJ6 BXGT018362 NAD-dependent protein deacetylase sirtuin-2 22933 reviewed Epigenetic regulator
Q8TDQ0 BXGT018810 Hepatitis A virus cellular receptor 2 84868 reviewed
Q92887 BXGT019389 Canalicular multispecific organic anion transporter 1 1244 reviewed Transporter
Q92945 BXGT019397 Far upstream element-binding protein 2 8570 reviewed Enzyme
Q92956 BXGT019399 Tumor necrosis factor receptor superfamily member 14 8764 reviewed
Q96EB6 BXGT019646 NAD-dependent protein deacetylase sirtuin-1 23411 reviewed Epigenetic regulator
Q96GD4 BXGT019667 Aurora kinase B 9212 reviewed Kinase
Q96QV1 BXGT019722 Hedgehog-interacting protein 64399 reviewed
Q99523 BXGT019929 Sortilin 6272 reviewed Transporter
Q99808 BXGT019964 Equilibrative nucleoside transporter 1 2030 reviewed Transporter
Q99816 BXGT019966 Tumor susceptibility gene 101 protein 7251 reviewed Enzyme
Q9BW19 BXGT020148 Kinesin-like protein KIFC1 3833 reviewed Cellular structure
Q9BZS1 BXGT020203 Forkhead box protein P3 50943 reviewed
Q9H3M7 BXGT020462 Thioredoxin-interacting protein 10628 reviewed
Q9HAW7 BXGT020508 UDP-glucuronosyltransferase 1-7 54577 reviewed
Q9HC29 BXGT020526 Nucleotide-binding oligomerization domain-containing protein 2 64127 reviewed Enzyme
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 28234 reviewed Transporter
Q9NR96 BXGT021181 Toll-like receptor 9 54106 reviewed
Q9NS87 BXGT021201 Kinesin-like protein KIF15 56992 reviewed Cellular structure
Q9NZQ7 BXGT021281 Programmed cell death 1 ligand 1 29126 reviewed Receptor
Q9P212 BXGT021297 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 51196 reviewed Enzyme
Q9UIF7 BXGT021717 Adenine DNA glycosylase 4595 reviewed Enzyme
Q9UKU7 BXGT021749 Isobutyryl-CoA dehydrogenase, mitochondrial 27034 reviewed Enzyme
Q9UKV0 BXGT021750 Histone deacetylase 9 9734 reviewed Epigenetic regulator
Q9UN36 BXGT021780 Protein NDRG2 57447 reviewed Enzyme
Q9UNQ0 BXGT021792 ATP-binding cassette sub-family G member 2 9429 reviewed Transporter
Q9Y251 BXGT022215 Heparanase 10855 reviewed Enzyme
Q9Y286 BXGT022225 Sialic acid-binding Ig-like lectin 7 27036 reviewed Receptor
Q9Y5S8 BXGT022302 NADPH oxidase 1 27035 reviewed
Q9Y5W5 BXGT022303 Wnt inhibitory factor 1 11197 reviewed Calcium-binding protein
P43146 BXGT022852 Netrin receptor DCC 1630 reviewed
P25054 BXGT022961 Adenomatous polyposis coli protein 324 reviewed
Q16552 BXGT023419 Interleukin-17A 3605 reviewed
P00395 BXGT023596 Cytochrome c oxidase subunit 1 4512 reviewed Enzyme
P40198 BXGT023750 Carcinoembryonic antigen-related cell adhesion molecule 3 1084 reviewed
Q9Y294 BXGT023981 Histone chaperone ASF1A 25842 reviewed Nucleic acid binding
P20809 BXGT025043 Interleukin-11 3589 reviewed
Q99435 BXGT025240 Protein kinase C-binding protein NELL2 4753 reviewed Calcium-binding protein
Q9UGM3 BXGT025543 Deleted in malignant brain tumors 1 protein 1755 reviewed Enzyme
Q7Z628 BXGT026116 Neuroepithelial cell-transforming gene 1 protein 10276 reviewed
P00403 BXGT026137 Cytochrome c oxidase subunit 2 4513 reviewed Enzyme
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease