Showing entry for Roquin-1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT015851
Protein NameRoquin-1
Uniport IdQ5TC82
GeneRC3H1
Gene Id149041
DomainROQ_II; zf-CCCH; zf-RING_UBOX
Pfam PF18386   PF00642   PF13445  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0061158 3'-UTR-mediated mRNA destabilization
Biological Process GO:0001782 B cell homeostasis
Biological Process GO:0071347 cellular response to interleukin-1
Biological Process GO:0033962 cytoplasmic mRNA processing body assembly
Biological Process GO:0048535 lymph node development
Biological Process GO:0046007 negative regulation of activated T cell proliferation
Biological Process GO:0030889 negative regulation of B cell proliferation
Biological Process GO:0002635 negative regulation of germinal center formation
Biological Process GO:2000320 negative regulation of T-helper 17 cell differentiation
Biological Process GO:0045623 negative regulation of T-helper cell differentiation
Biological Process GO:0000956 nuclear-transcribed mRNA catabolic process
Biological Process GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
Biological Process GO:0061014 positive regulation of mRNA catabolic process
Biological Process GO:1901224 positive regulation of NIK/NF-kappaB signaling
Biological Process GO:0010608 posttranscriptional regulation of gene expression
Biological Process GO:0000209 protein polyubiquitination
Biological Process GO:0002634 regulation of germinal center formation
Biological Process GO:2000628 regulation of miRNA metabolic process
Biological Process GO:0043488 regulation of mRNA stability
Biological Process GO:0050856 regulation of T cell receptor signaling pathway
Biological Process GO:0048536 spleen development
Biological Process GO:0043029 T cell homeostasis
Biological Process GO:0042098 T cell proliferation
Biological Process GO:0050852 T cell receptor signaling pathway
Biological Process GO:0061470 T follicular helper cell differentiation
molecular function GO:0003725 double-stranded RNA binding
molecular function GO:0035198 miRNA binding
molecular function GO:0003730 mRNA 3'-UTR binding
molecular function GO:0003723 RNA binding
molecular function GO:0035613 RNA stem-loop binding
molecular function GO:0061630 ubiquitin protein ligase activity
molecular function GO:0004842 ubiquitin-protein transferase activity
molecular function GO:0008270 zinc ion binding
cellular component GO:0010494 cytoplasmic stress granule
cellular component GO:0000932 P-body
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0005890 BXGD000345 Body Height
C0020981 BXGD001474 Angioimmunoblastic Lymphadenopathy Immune System Diseases; Hemic and Lymphatic Diseases
C0021831 BXGD001516 Intestinal Diseases Digestive System Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024291 BXGD001757 Lymphohistiocytosis, Hemophagocytic Hemic and Lymphatic Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0079774 BXGD003101 Peripheral T-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002586 Calcium 40.08
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein