Showing entry for Tyrosine-protein kinase JAK2



                       
General Target Information
BXGT IdBXGT016039
Protein NameTyrosine-protein kinase JAK2
Uniport IdQ62689
GeneJak2
Gene Id24514
DomainFERM_F1; FERM_F2; Jak1_Phl; Pkinase_Tyr; SH2
Pfam PF18379   PF18377   PF17887   PF07714   PF00017  
OrganismRattus norvegicus (Rat)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
Biological Process GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Biological Process GO:0042976 activation of Janus kinase activity
Biological Process GO:0000186 activation of MAPKK activity
Biological Process GO:0002250 adaptive immune response
Biological Process GO:0031103 axon regeneration
Biological Process GO:0030154 cell differentiation
Biological Process GO:0071549 cellular response to dexamethasone stimulus
Biological Process GO:0036016 cellular response to interleukin-3
Biological Process GO:0071222 cellular response to lipopolysaccharide
Biological Process GO:0019221 cytokine-mediated signaling pathway
Biological Process GO:0007167 enzyme linked receptor protein signaling pathway
Biological Process GO:0030218 erythrocyte differentiation
Biological Process GO:0097191 extrinsic apoptotic signaling pathway
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0060396 growth hormone receptor signaling pathway
Biological Process GO:0060397 growth hormone receptor signaling pathway via JAK-STAT
Biological Process GO:0035409 histone H3-Y41 phosphorylation
Biological Process GO:0009755 hormone-mediated signaling pathway
Biological Process GO:0034050 host programmed cell death induced by symbiont
Biological Process GO:0060333 interferon-gamma-mediated signaling pathway
Biological Process GO:0035722 interleukin-12-mediated signaling pathway
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
Biological Process GO:0061180 mammary gland epithelium development
Biological Process GO:0001774 microglial cell activation
Biological Process GO:0031959 mineralocorticoid receptor signaling pathway
Biological Process GO:0050804 modulation of chemical synaptic transmission
Biological Process GO:0030099 myeloid cell differentiation
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0010667 negative regulation of cardiac muscle cell apoptotic process
Biological Process GO:0022408 negative regulation of cell-cell adhesion
Biological Process GO:0060548 negative regulation of cell death
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0043392 negative regulation of DNA binding
Biological Process GO:0045822 negative regulation of heart contraction
Biological Process GO:0043524 negative regulation of neuron apoptotic process
Biological Process GO:0018108 peptidyl-tyrosine phosphorylation
Biological Process GO:0048008 platelet-derived growth factor receptor signaling pathway
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:2001235 positive regulation of apoptotic signaling pathway
Biological Process GO:0050867 positive regulation of cell activation
Biological Process GO:0045597 positive regulation of cell differentiation
Biological Process GO:0030335 positive regulation of cell migration
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0010811 positive regulation of cell-substrate adhesion
Biological Process GO:0120162 positive regulation of cold-induced thermogenesis
Biological Process GO:0007204 positive regulation of cytosolic calcium ion concentration
Biological Process GO:0043388 positive regulation of DNA binding
Biological Process GO:0051091 positive regulation of DNA-binding transcription factor activity
Biological Process GO:1904037 positive regulation of epithelial cell apoptotic process
Biological Process GO:1902728 positive regulation of growth factor dependent skeletal muscle satellite cell proliferation
Biological Process GO:0060399 positive regulation of growth hormone receptor signaling pathway
Biological Process GO:0050729 positive regulation of inflammatory response
Biological Process GO:0032024 positive regulation of insulin secretion
Biological Process GO:0032731 positive regulation of interleukin-1 beta production
Biological Process GO:0045348 positive regulation of MHC class II biosynthetic process
Biological Process GO:0045429 positive regulation of nitric oxide biosynthetic process
Biological Process GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
Biological Process GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
Biological Process GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
Biological Process GO:0032516 positive regulation of phosphoprotein phosphatase activity
Biological Process GO:0042307 positive regulation of protein import into nucleus
Biological Process GO:0010870 positive regulation of receptor biosynthetic process
Biological Process GO:0060391 positive regulation of SMAD protein signal transduction
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0042535 positive regulation of tumor necrosis factor biosynthetic process
Biological Process GO:0032760 positive regulation of tumor necrosis factor production
Biological Process GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
Biological Process GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
Biological Process GO:0035166 post-embryonic hemopoiesis
Biological Process GO:0099527 postsynapse to nucleus signaling pathway
Biological Process GO:0046777 protein autophosphorylation
Biological Process GO:0007259 receptor signaling pathway via JAK-STAT
Biological Process GO:0042981 regulation of apoptotic process
Biological Process GO:0050727 regulation of inflammatory response
Biological Process GO:0045428 regulation of nitric oxide biosynthetic process
Biological Process GO:0046677 response to antibiotic
Biological Process GO:0033194 response to hydroperoxide
Biological Process GO:0070671 response to interleukin-12
Biological Process GO:0032496 response to lipopolysaccharide
Biological Process GO:0006979 response to oxidative stress
Biological Process GO:0034612 response to tumor necrosis factor
Biological Process GO:0007165 signal transduction
Biological Process GO:0033209 tumor necrosis factor-mediated signaling pathway
Biological Process GO:0007260 tyrosine phosphorylation of STAT protein
molecular function GO:0033130 acetylcholine receptor binding
molecular function GO:0005524 ATP binding
molecular function GO:0005131 growth hormone receptor binding
molecular function GO:0020037 heme binding
molecular function GO:0042393 histone binding
molecular function GO:0035401 histone kinase activity (H3-Y41 specific)
molecular function GO:0042802 identical protein binding
molecular function GO:0043560 insulin receptor substrate binding
molecular function GO:0005143 interleukin-12 receptor binding
molecular function GO:0046872 metal ion binding
molecular function GO:0004715 non-membrane spanning protein tyrosine kinase activity
molecular function GO:0051428 peptide hormone receptor binding
molecular function GO:0043548 phosphatidylinositol 3-kinase binding
molecular function GO:0008022 protein C-terminus binding
molecular function GO:0019901 protein kinase binding
molecular function GO:0004713 protein tyrosine kinase activity
molecular function GO:0042169 SH2 domain binding
molecular function GO:0005102 signaling receptor binding
molecular function GO:0031702 type 1 angiotensin receptor binding
cellular component GO:0005901 caveola
cellular component GO:0005737 cytoplasm
cellular component GO:0005856 cytoskeleton
cellular component GO:0005829 cytosol
cellular component GO:0012505 endomembrane system
cellular component GO:0000791 euchromatin
cellular component GO:0005925 focal adhesion
cellular component GO:0098978 glutamatergic synapse
cellular component GO:0045121 membrane raft
cellular component GO:0005730 nucleolus
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0098794 postsynapse
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0006389 Rotenone 394.42
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein