Showing entry for Rotenone


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0006389
Compound NameRotenone
Structure
FormulaC23H22O6
InchiKeyJUVIOZPCNVVQFO-HBGVWJBISA-N
SMILES[H][C@@]12COC3=C(C=C(OC)C(OC)=C3)[C@]1([H])C(=O)C1=CC=C3O[C@H](CC3=C1O2)C(C)=C
InchiInChI=1S/C23H22O6/c1-11(2)16-8-14-15(28-16)6-5-12-22(24)21-13-7-18(25-3)19(26-4)9-17(13)27-10-20(21)29-23(12)14/h5-7,9,16,20-21H,1,8,10H2,2-4H3/t16-,20-,21+/m1/s1
IUPAC(1S,6R,13S)-16,17-dimethoxy-6-(prop-1-en-2-yl)-2,7,20-trioxapentacyclo[11.8.0.03,11.0?,?.01?,1?]henicosa-3,8,10,14(19),15,17-hexaen-12-one
Molecular Weight394.42
Pubchem Id6758
Chembl IdCHEMBL429023
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 50135527
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT009061 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial reviewed NDUFV1 - 5.1 - -
reviewed BXGT006113 NADH-ubiquinone oxidoreductase chain 4 reviewed Enzyme MT-ND4 - 3.5 - -
reviewed BXGT009242 Dihydroorotate dehydrogenase (fumarate) reviewed URA1 - >10000 - -
reviewed BXGT005592 Pancreatic triacylglycerol lipase reviewed PNLIP - >500000 - -
CHEMBL CHEMBL429023
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P03905 BXGT006113 NADH-ubiquinone oxidoreductase chain 4 reviewed Enzyme MT-ND4 IC50 '=' 3 nM
P54132 BXGT011032 Bloom syndrome protein reviewed - BLM Potency '=' 22387 nM
P12530 BXGT007827 Arachidonate 15-lipoxygenase reviewed - ALOX15 Ki - - -
P52505 BXGT010931 Acyl carrier protein, mitochondrial reviewed - NDUFAB1 IC50 '=' 5 nM
P25708 BXGT009061 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial reviewed - NDUFV1 IC50 '=' 5 nM
P19793 BXGT008515 Retinoic acid receptor RXR-alpha reviewed Nuclear receptor RXRA Potency - 19952 nM
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma reviewed Nuclear receptor PPARG Potency - 31622 nM
P25162 BXGT009029 Acetylcholine receptor subunit beta-like 2 reviewed - nAChRbeta2 Inhibition - - -
P25929 BXGT009078 Neuropeptide Y receptor type 1 reviewed G-protein coupled receptor NPY1R IC50 - - -
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 IC50 - - -
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 Ki - - -
P08311 BXGT006762 Cathepsin G reviewed Enzyme CTSG Ki - - -
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR Ki - - -
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK Ki - - -
Q9WKE8 BXGT021921 Reverse transcriptase unreviewed - reverse IC50 '>' 200 ug.mL-1
P81908 BXGT011959 Cholinesterase reviewed - BCHE Inhibition '=' 6 %
Q9UNA4 BXGT021785 DNA polymerase iota reviewed - POLI Potency - 22387 nM
P10275 BXGT007552 Androgen receptor reviewed Nuclear receptor AR Potency - 446 nM
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 Ki - - -
P25103 BXGT009020 Substance-P receptor reviewed G-protein coupled receptor TACR1 Ki - - -
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 1258 nM
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 IC50 - - -
P51681 BXGT010878 C-C chemokine receptor type 5 reviewed G-protein coupled receptor CCR5 IC50 - - -
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 IC50 - - -
Q01959 BXGT012624 Sodium-dependent dopamine transporter reviewed Transporter SLC6A3 IC50 - - -
P49146 BXGT010681 Neuropeptide Y receptor type 2 reviewed G-protein coupled receptor NPY2R IC50 - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Potency '=' 31622 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 14963 nM
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 2818 nM
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 501 nM
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 Ki - - -
P08588 BXGT006795 Beta-1 adrenergic receptor reviewed G-protein coupled receptor ADRB1 IC50 - - -
A6XA80 BXGT001522 Leukotriene C4 synthase reviewed - LTC4S IC50 - - -
A6XA80 BXGT001522 Leukotriene C4 synthase reviewed - LTC4S Ki - - -
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 IC50 - - -
P51679 BXGT010877 C-C chemokine receptor type 4 reviewed G-protein coupled receptor CCR4 IC50 - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Ki - - -
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 Ki - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ki - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ki - - -
P32241 BXGT009613 Vasoactive intestinal polypeptide receptor 1 reviewed G-protein coupled receptor VIPR1 IC50 - - -
Q194T2 BXGT013743 Non-structural protein 1 unreviewed - NS1 Potency '=' 39810 nM
Q6W5P4 BXGT016588 Neuropeptide S receptor reviewed - NPSR1 Potency '=' 12589 nM
P15917 BXGT008169 Lethal factor reviewed - lef Potency '=' 6309 nM
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK IC50 - - -
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A Ki - - -
Q92887 BXGT019389 Canalicular multispecific organic anion transporter 1 reviewed Transporter ABCC2 Activity '=' 92 %
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B IC50 - - -
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 Ki - - -
P23975 BXGT008935 Sodium-dependent noradrenaline transporter reviewed Transporter SLC6A2 IC50 - - -
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 891 nM
P51151 BXGT010837 Ras-related protein Rab-9A reviewed - RAB9A Potency '=' 73078 nM
P25103 BXGT009020 Substance-P receptor reviewed G-protein coupled receptor TACR1 IC50 - - -
P15207 BXGT008096 Androgen receptor reviewed - Ar Ki - - -
P24557 BXGT008976 Thromboxane-A synthase reviewed - TBXAS1 Ki - - -
P13945 BXGT007972 Beta-3 adrenergic receptor reviewed G-protein coupled receptor ADRB3 Ki - - -
P25024 BXGT009005 C-X-C chemokine receptor type 1 reviewed G-protein coupled receptor CXCR1 IC50 - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Potency '=' 1000 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 35481 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 15848 nM
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA IC50 - - -
P25929 BXGT009078 Neuropeptide Y receptor type 1 reviewed G-protein coupled receptor NPY1R Ki - - -
Q690N0 BXGT016199 Progesterone receptor unreviewed - PGR Ki - - -
P42345 BXGT010304 Serine/threonine-protein kinase mTOR reviewed Kinase MTOR Activity - - -
P46063 BXGT010501 ATP-dependent DNA helicase Q1 reviewed Enzyme RECQL Potency '=' 3162 nM
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 IC50 - - -
P15127 BXGT008085 Insulin receptor reviewed - Insr IC50 - - -
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA Ki - - -
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 IC50 - - -
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 Ki - - -
P03956 BXGT006120 Interstitial collagenase reviewed Enzyme MMP1 IC50 - - -
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 Ki - - -
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 reviewed Kinase ERBB2 Ki - - -
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 Ki '=' 404 nM
P31645 BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 IC50 - - -
O15118 BXGT004127 NPC intracellular cholesterol transporter 1 reviewed Transporter NPC1 Potency '=' 290928 nM
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 43 %
Q01453 BXGT012588 Peripheral myelin protein 22 reviewed Cellular structure PMP22 Potency '=' 47 nM
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 23 %
P42345 BXGT010304 Serine/threonine-protein kinase mTOR reviewed Kinase MTOR Inhibition - - -
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 Ki - - -
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 IC50 '=' 870 nM
P00591 BXGT005592 Pancreatic triacylglycerol lipase reviewed - PNLIP IC50 '=' 31 ug.mL-1
P18265 BXGT008393 Glycogen synthase kinase-3 alpha reviewed - Gsk3a Activity - - -
O75496 BXGT005132 Geminin reviewed - GMNN Potency '=' 1412 nM
P42345 BXGT010304 Serine/threonine-protein kinase mTOR reviewed Kinase MTOR Potency '=' 46 nM
P06746 BXGT006496 DNA polymerase beta reviewed Enzyme POLB Potency '=' 39810 nM
P18266 BXGT008394 Glycogen synthase kinase-3 beta reviewed - Gsk3b Activity - - -
P25779 BXGT009067 Cruzipain reviewed - Potency '=' 39810 nM
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma reviewed Nuclear receptor PPARG Potency - 44668 nM
P05412 BXGT006354 Transcription factor AP-1 reviewed Transcription factor JUN Activity - - -
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 2310 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 754 nM
P52505 BXGT010931 Acyl carrier protein, mitochondrial reviewed - NDUFAB1 Relative potency '=' 7 -
P25708 BXGT009061 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial reviewed - NDUFV1 Relative potency '=' 7 -
O95342 BXGT005373 Bile salt export pump reviewed Transporter ABCB11 IC50 '=' 8000 nM
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Potency - 50 nM
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA IC50 - - -
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 IC50 - - -
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 Ki - - -
P08588 BXGT006795 Beta-1 adrenergic receptor reviewed G-protein coupled receptor ADRB1 Ki - - -
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b Ki - - -
P30411 BXGT009424 B2 bradykinin receptor reviewed G-protein coupled receptor BDKRB2 IC50 - - -
P30988 BXGT009491 Calcitonin receptor reviewed G-protein coupled receptor CALCR Ki - - -
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 Ki - - -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 188 nM
P00591 BXGT005592 Pancreatic triacylglycerol lipase reviewed - PNLIP IC50 '>' 500000 nM
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 IC50 - - -
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 IC50 - - -
P04035 BXGT006129 3-hydroxy-3-methylglutaryl-coenzyme A reductase reviewed - HMGCR Ki - - -
P08311 BXGT006762 Cathepsin G reviewed Enzyme CTSG IC50 - - -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 - - -
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 IC50 - - -
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a IC50 - - -
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b IC50 - - -
P25100 BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D IC50 - - -
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 IC50 - - -
P51681 BXGT010878 C-C chemokine receptor type 5 reviewed G-protein coupled receptor CCR5 Ki - - -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 IC50 - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Ki - - -
P32245 BXGT009614 Melanocortin receptor 4 reviewed G-protein coupled receptor MC4R Ki - - -
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 IC50 - - -
P29476 BXGT009354 Nitric oxide synthase, brain reviewed - Nos1 IC50 - - -
P12822 BXGT007850 Angiotensin-converting enzyme reviewed - ACE IC50 - - -
P03956 BXGT006120 Interstitial collagenase reviewed Enzyme MMP1 Ki - - -
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA Ki - - -
P06241 BXGT006429 Tyrosine-protein kinase Fyn reviewed Kinase FYN Ki - - -
O70528 BXGT005068 5-hydroxytryptamine receptor 4 reviewed - HTR4 IC50 - - -
P25100 BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D Ki - - -
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B IC50 - - -
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C IC50 - - -
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Ki - - -
P13945 BXGT007972 Beta-3 adrenergic receptor reviewed G-protein coupled receptor ADRB3 IC50 - - -
P23975 BXGT008935 Sodium-dependent noradrenaline transporter reviewed Transporter SLC6A2 Ki - - -
P32238 BXGT009611 Cholecystokinin receptor type A reviewed G-protein coupled receptor CCKAR Ki - - -
P25101 BXGT009018 Endothelin-1 receptor reviewed G-protein coupled receptor EDNRA Ki - - -
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 21192 nM
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 reviewed Kinase FLT1 Ki - - -
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 Ki - - -
P50052 BXGT010768 Type-2 angiotensin II receptor reviewed G-protein coupled receptor AGTR2 Ki - - -
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 IC50 - - -
P25101 BXGT009018 Endothelin-1 receptor reviewed G-protein coupled receptor EDNRA IC50 - - -
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 22387 nM
Q99700 BXGT019949 Ataxin-2 reviewed Nucleic acid binding ATXN2 Potency - 251 nM
P03887 BXGT006109 NADH-ubiquinone oxidoreductase chain 1 reviewed - MT-ND1 IC50 '=' 25 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 1412 nM
P33032 BXGT009689 Melanocortin receptor 5 reviewed G-protein coupled receptor MC5R Ki - - -
P12530 BXGT007827 Arachidonate 15-lipoxygenase reviewed - ALOX15 IC50 - - -
P49146 BXGT010681 Neuropeptide Y receptor type 2 reviewed G-protein coupled receptor NPY2R Ki - - -
P25094 BXGT009014 Peripheral myelin protein 22 reviewed - Pmp22 Potency - 57 nM
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 reviewed Kinase FLT1 IC50 - - -
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 56234 nM
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 Potency - 25118 nM
P20781 BXGT008598 Glycine receptor subunit beta reviewed - Glrb IC50 - - -
P07727 BXGT006662 Glycine receptor subunit alpha-1 reviewed - Glra1 IC50 - - -
P24524 BXGT008974 Glycine receptor subunit alpha-3 reviewed - Glra3 IC50 - - -
P22771 BXGT008806 Glycine receptor subunit alpha-2 reviewed - Glra2 IC50 - - -
P20781 BXGT008598 Glycine receptor subunit beta reviewed - Glrb Ki - - -
P07727 BXGT006662 Glycine receptor subunit alpha-1 reviewed - Glra1 Ki - - -
P24524 BXGT008974 Glycine receptor subunit alpha-3 reviewed - Glra3 Ki - - -
P22771 BXGT008806 Glycine receptor subunit alpha-2 reviewed - Glra2 Ki - - -
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 Ki - - -
P08246 BXGT006756 Neutrophil elastase reviewed Enzyme ELANE Ki - - -
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 IC50 - - -
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 IC50 - - -
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 10 nM
P21452 BXGT008653 Substance-K receptor reviewed G-protein coupled receptor TACR2 IC50 - - -
P30411 BXGT009424 B2 bradykinin receptor reviewed G-protein coupled receptor BDKRB2 Ki - - -
P25025 BXGT009006 C-X-C chemokine receptor type 2 reviewed G-protein coupled receptor CXCR2 IC50 - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 - - -
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 Ki - - -
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 Ki - - -
P41597 BXGT010268 C-C chemokine receptor type 2 reviewed - CCR2 Ki - - -
P05181 BXGT006337 Cytochrome P450 2E1 reviewed - CYP2E1 Ki - - -
P49798 BXGT010745 Regulator of G-protein signaling 4 reviewed Enzyme modulator RGS4 Potency - 21192 nM
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 Ki - - -
P08173 BXGT006738 Muscarinic acetylcholine receptor M4 reviewed G-protein coupled receptor CHRM4 IC50 - - -
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 reviewed G-protein coupled receptor CHRM5 IC50 - - -
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 reviewed G-protein coupled receptor CHRM5 Ki - - -
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 IC50 - - -
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 IC50 - - -
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Ki - - -
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C Ki - - -
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 Ki - - -
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a Ki - - -
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Activity - - -
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 316 nM
P97697 BXGT012214 Inositol monophosphatase 1 reviewed - Impa1 Potency '=' 25118 nM
P10828 BXGT007624 Thyroid hormone receptor beta reviewed Nuclear receptor THRB Potency - 12589 nM
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 Ki - - -
P11509 BXGT007716 Cytochrome P450 2A6 reviewed - CYP2A6 IC50 - - -
P05181 BXGT006337 Cytochrome P450 2E1 reviewed - CYP2E1 IC50 - - -
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 IC50 - - -
Q03181 BXGT012701 Peroxisome proliferator-activated receptor delta reviewed Nuclear receptor PPARD Potency - 14125 nM
P02791 BXGT005965 Ferritin light chain reviewed - FTL Potency '=' 11220 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 39810 nM
Q62689 BXGT016039 Tyrosine-protein kinase JAK2 reviewed - Jak2 Activity - - -
P04035 BXGT006129 3-hydroxy-3-methylglutaryl-coenzyme A reductase reviewed - HMGCR IC50 - - -
P29476 BXGT009354 Nitric oxide synthase, brain reviewed - Nos1 Ki - - -
P12822 BXGT007850 Angiotensin-converting enzyme reviewed - ACE Ki - - -
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 IC50 - - -
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C reviewed Enzyme PTPRC IC50 - - -
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 231 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 30637 nM
P42345 BXGT010304 Serine/threonine-protein kinase mTOR reviewed Kinase MTOR Potency '=' 58 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 1065 nM
Q99549 BXGT019932 M-phase phosphoprotein 8 reviewed Epigenetic regulator MPHOSPH8 Potency - 37685 nM
Q99549 BXGT019932 M-phase phosphoprotein 8 reviewed Epigenetic regulator MPHOSPH8 Potency - 891 nM
P41597 BXGT010268 C-C chemokine receptor type 2 reviewed - CCR2 IC50 - - -
P97697 BXGT012214 Inositol monophosphatase 1 reviewed - Impa1 Potency '=' 31622 nM
Q9Y271 BXGT022222 Cysteinyl leukotriene receptor 1 reviewed G-protein coupled receptor CYSLTR1 IC50 - - -
P32245 BXGT009614 Melanocortin receptor 4 reviewed G-protein coupled receptor MC4R IC50 - - -
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 IC50 - - -
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed - PDE5A IC50 - - -
P25105 BXGT009021 Platelet-activating factor receptor reviewed G-protein coupled receptor PTAFR Ki - - -
P08246 BXGT006756 Neutrophil elastase reviewed Enzyme ELANE IC50 - - -
P06241 BXGT006429 Tyrosine-protein kinase Fyn reviewed Kinase FYN IC50 - - -
P07943 BXGT006700 Aldo-keto reductase family 1 member B1 reviewed - Akr1b1 IC50 - - -
P07943 BXGT006700 Aldo-keto reductase family 1 member B1 reviewed - Akr1b1 Ki - - -
P51679 BXGT010877 C-C chemokine receptor type 4 reviewed G-protein coupled receptor CCR4 Ki - - -
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 IC50 - - -
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform reviewed - PPP3CA Ki - - -
P15207 BXGT008096 Androgen receptor reviewed - Ar IC50 - - -
P37288 BXGT009977 Vasopressin V1a receptor reviewed G-protein coupled receptor AVPR1A Ki - - -
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 3932 nM
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency - 125 nM
Q99700 BXGT019949 Ataxin-2 reviewed Nucleic acid binding ATXN2 Potency - 22387 nM
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a Ki - - -
P50052 BXGT010768 Type-2 angiotensin II receptor reviewed G-protein coupled receptor AGTR2 IC50 - - -
P25024 BXGT009005 C-X-C chemokine receptor type 1 reviewed G-protein coupled receptor CXCR1 Ki - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Ki - - -
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C IC50 - - -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 237 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 920 nM
P11509 BXGT007716 Cytochrome P450 2A6 reviewed - CYP2A6 Ki - - -
P16473 BXGT008234 Thyrotropin receptor reviewed G-protein coupled receptor TSHR Potency '=' 1258 nM
O46521 BXGT004646 Cytochrome b-245 light chain reviewed - CYBA IC50 '=' 0 nM
P32238 BXGT009611 Cholecystokinin receptor type A reviewed G-protein coupled receptor CCKAR IC50 - - -
Q01959 BXGT012624 Sodium-dependent dopamine transporter reviewed Transporter SLC6A3 Ki - - -
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Ki - - -
P53778 BXGT011013 Mitogen-activated protein kinase 12 reviewed Kinase MAPK12 Activity - - -
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 Activity - - -
Q15759 BXGT013595 Mitogen-activated protein kinase 11 reviewed Kinase MAPK11 Activity - - -
O15264 BXGT004144 Mitogen-activated protein kinase 13 reviewed Kinase MAPK13 Activity - - -
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Ki - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Potency - 17782 nM
Q16637 BXGT013646 Survival motor neuron protein reviewed Epigenetic regulator SMN1 Potency '=' 63 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 8912 nM
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 Ki - - -
P41968 BXGT010275 Melanocortin receptor 3 reviewed G-protein coupled receptor MC3R IC50 - - -
P08173 BXGT006738 Muscarinic acetylcholine receptor M4 reviewed G-protein coupled receptor CHRM4 Ki - - -
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 Ki - - -
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed - PDE5A Ki - - -
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 IC50 - - -
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C reviewed Enzyme PTPRC Ki - - -
P28564 BXGT009272 5-hydroxytryptamine receptor 1B reviewed - Htr1b IC50 - - -
P28564 BXGT009272 5-hydroxytryptamine receptor 1B reviewed - Htr1b Ki - - -
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 Ki - - -
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 IC50 - - -
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A IC50 - - -
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A IC50 - - -
P06493 BXGT006445 Cyclin-dependent kinase 1 reviewed Kinase CDK1 Activity - - -
P03887 BXGT006109 NADH-ubiquinone oxidoreductase chain 1 reviewed - MT-ND1 IC50 '=' 4 nM
P83916 BXGT012025 Chromobox protein homolog 1 reviewed Epigenetic regulator CBX1 Potency - 35481 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency '=' 5 nM
Q54A96 BXGT015050 Dihydroorotate dehydrogenase unreviewed - dhod IC50 '>' 10000 nM
P15127 BXGT008085 Insulin receptor reviewed - Insr Ki - - -
P33032 BXGT009689 Melanocortin receptor 5 reviewed G-protein coupled receptor MC5R IC50 - - -
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 Ki - - -
Q9Y271 BXGT022222 Cysteinyl leukotriene receptor 1 reviewed G-protein coupled receptor CYSLTR1 Ki - - -
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 reviewed Kinase ERBB2 IC50 - - -
P23528 BXGT008879 Cofilin-1 reviewed - CFL1 Activity - - -
P41968 BXGT010275 Melanocortin receptor 3 reviewed G-protein coupled receptor MC3R Ki - - -
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 Ki - - -
P29477 BXGT009355 Nitric oxide synthase, inducible reviewed - Nos2 IC50 - - -
P29477 BXGT009355 Nitric oxide synthase, inducible reviewed - Nos2 Ki - - -
P25105 BXGT009021 Platelet-activating factor receptor reviewed G-protein coupled receptor PTAFR IC50 - - -
Q690N0 BXGT016199 Progesterone receptor unreviewed - PGR IC50 - - -
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 IC50 - - -
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR IC50 - - -
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a IC50 - - -
P21452 BXGT008653 Substance-K receptor reviewed G-protein coupled receptor TACR2 Ki - - -
P37288 BXGT009977 Vasopressin V1a receptor reviewed G-protein coupled receptor AVPR1A IC50 - - -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 149 nM
P28272 BXGT009242 Dihydroorotate dehydrogenase (fumarate) reviewed - URA1 IC50 '>' 10000 nM
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Ki - - -
P25025 BXGT009006 C-X-C chemokine receptor type 2 reviewed G-protein coupled receptor CXCR2 Ki - - -
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Inhibition '=' 16 %
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Ki - - -
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 Ki - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 - - -
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A IC50 - - -
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform reviewed - PPP3CA IC50 - - -
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A Ki - - -
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B Ki - - -
O70528 BXGT005068 5-hydroxytryptamine receptor 4 reviewed - HTR4 Ki - - -
P31645 BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 Ki - - -
P24557 BXGT008976 Thromboxane-A synthase reviewed - TBXAS1 IC50 - - -
P32241 BXGT009613 Vasoactive intestinal polypeptide receptor 1 reviewed G-protein coupled receptor VIPR1 Ki - - -
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 39810 nM
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 IC50 - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 IC50 - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Ki - - -
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ki - - -
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 Ki - - -
P25094 BXGT009014 Peripheral myelin protein 22 reviewed - Pmp22 Potency - 79 nM
P19793 BXGT008515 Retinoic acid receptor RXR-alpha reviewed Nuclear receptor RXRA Potency - 354 nM
O15439 BXGT004169 Multidrug resistance-associated protein 4 reviewed Transporter ABCC4 IC50 '=' 133000 nM
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 IC50 - - -
P30988 BXGT009491 Calcitonin receptor reviewed G-protein coupled receptor CALCR IC50 - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 IC50 '=' 3648 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 IC50 - - -
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Ki - - -
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 IC50 - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 - - -
O15648 BXGT004185 ATP-dependent 6-phosphofructokinase reviewed - pfk Potency - 849 nM
Q9EPQ1 BXGT020291 Toll-like receptor 1 reviewed - Tlr1 Inhibition '=' 70 %
Q9QUN7 BXGT021377 Toll-like receptor 2 reviewed - Tlr2 Inhibition '=' 70 %
Q92887 BXGT019389 Canalicular multispecific organic anion transporter 1 reviewed Transporter ABCC2 IC50 '=' 133000 nM
O15438 BXGT004168 Canalicular multispecific organic anion transporter 2 reviewed Transporter ABCC3 IC50 '=' 133000 nM
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 23778 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00468 Jicama Pachyrhizus erosus Vegetables
BXGF00819 Pulses Pulses
BXGF00867 Crotalaria paniculata Crotalaria paniculata Medicinal Plant
BXGF01471 Cordia americana Cordia americana Others
BXGF01788 Patrinia scabra Patrinia scabra Medicinal Plant
BXGF03532 Indigofera spicata Indigofera spicata Medicinal Plant
BXGF03795 Neorautanenia mitis Neorautanenia mitis Medicinal Plant
BXGF04150 Erycibe expansa Erycibe expansa Medicinal Plant
BXGF04298 Pedicularis semitorta Pedicularis semitorta Others
BXGF04698 Isodon rubescens Isodon rubescens Others
BXGF05032 derris malaccensis plain derris malaccensis plain Others
BXGF05172 Scopolia japonica Scopolia japonica Medicinal Plant
BXGF05289 Allium macrostemon Allium macrostemon Medicinal Plant
BXGF05450 Achillea cretica Achillea cretica Others
BXGF05528 Glycosmis montana Glycosmis montana Medicinal Plant
BXGF05594 Eupatorium riparium Eupatorium riparium Medicinal Plant
BXGF05658 Spiraea japonica Spiraea japonica Medicinal Plant
BXGF05995 Geijera parviflora Geijera parviflora Others
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease