Showing entry for E3 ubiquitin-protein ligase HECW1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT016872
Protein NameE3 ubiquitin-protein ligase HECW1
Uniport IdQ76N89
GeneHECW1
Gene Id23072
DomainC2; HECT; HECW1_helix; HECW_N; WW
Pfam PF00168   PF00632   PF18436   PF16562   PF00397  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0090090 negative regulation of canonical Wnt signaling pathway
Biological Process GO:2000650 negative regulation of sodium ion transmembrane transporter activity
Biological Process GO:0045732 positive regulation of protein catabolic process
Biological Process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process GO:0000209 protein polyubiquitination
Biological Process GO:0016567 protein ubiquitination
Biological Process GO:0048814 regulation of dendrite morphogenesis
Biological Process GO:0006511 ubiquitin-dependent protein catabolic process
molecular function GO:0061630 ubiquitin protein ligase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-195721 Signaling by WNT
R-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-4641258 Degradation of DVL
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0017661 BXGD001139 IGA Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Immune System Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0037369 BXGD002691 Smoking Behavior and Behavior Mechanisms
C0341858 BXGD007425 Endometriosis of uterus Female Urogenital Diseases and Pregnancy Complications
C0410189 BXGD008413 Muscular Dystrophy, Emery-Dreifuss Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C1519383 BXGD013237 Smoking Behaviors Behavior and Behavior Mechanisms
C4317009 BXGD022717 Diverticular Diseases Digestive System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0004277 Acetic acid 60.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein