adisease

Showing entry for Smoking

General Disease Information
BXGD Id	BXGD002691
Disease Name	Smoking
Disease CUI Id	C0037369
MeSH Codes	F01
Disease Class Name	Behavior and Behavior Mechanisms
Semantic Type	Individual Behavior
Human Phenotype Ontology Id
Human Phenotype Ontology Term
Disease Ontology Id	DOID:150
Disease Ontology Class Name	disease of mental health
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00167	BXGT003887	Eyes absent homolog 2	2139	reviewed
O15118	BXGT004127	NPC intracellular cholesterol transporter 1	4864	reviewed	Transporter
O43524	BXGT004599	Forkhead box protein O3	2309	reviewed
O60260	BXGT004864	E3 ubiquitin-protein ligase parkin	5071	reviewed	Enzyme
O60678	BXGT004893	Protein arginine N-methyltransferase 3	10196	reviewed	Epigenetic regulator
O94804	BXGT005334	Serine/threonine-protein kinase 10	6793	reviewed	Kinase
O95631	BXGT005387	Netrin-1	9423	reviewed	Enzyme modulator
O95639	BXGT005388	Cleavage and polyadenylation specificity factor subunit 4	10898	reviewed	Enzyme
P01009	BXGT005714	Alpha-1-antitrypsin	5265	reviewed	Enzyme modulator
P05165	BXGT006334	Propionyl-CoA carboxylase alpha chain, mitochondrial	5095	reviewed	Enzyme
P06753	BXGT006498	Tropomyosin alpha-3 chain	7170	reviewed	Cellular structure
P08069	BXGT006723	Insulin-like growth factor 1 receptor	3480	reviewed	Kinase
P08686	BXGT006813	Steroid 21-hydroxylase	1589	reviewed
P11509	BXGT007716	Cytochrome P450 2A6	1548	reviewed
P12955	BXGT007865	Xaa-Pro dipeptidase	5184	reviewed	Enzyme
P13569	BXGT007923	Cystic fibrosis transmembrane conductance regulator	1080	reviewed	Ion channel
P16455	BXGT008229	Methylated-DNA--protein-cysteine methyltransferase	4255	reviewed
P16591	BXGT008246	Tyrosine-protein kinase Fer	2241	reviewed	Kinase
P20309	BXGT008562	Muscarinic acetylcholine receptor M3	1131	reviewed	G-protein coupled receptor
P23468	BXGT008870	Receptor-type tyrosine-protein phosphatase delta	5789	reviewed	Enzyme
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P26012	BXGT009083	Integrin beta-8	3696	reviewed	Receptor
P26368	BXGT009106	Splicing factor U2AF 65 kDa subunit	11338	reviewed
P27348	BXGT009173	14-3-3 protein theta	10971	reviewed	Chaperone
P30532	BXGT009433	Neuronal acetylcholine receptor subunit alpha-5	1138	reviewed	Ion channel
P30926	BXGT009482	Neuronal acetylcholine receptor subunit beta-4	1143	reviewed	Ion channel
P30988	BXGT009491	Calcitonin receptor	799	reviewed	G-protein coupled receptor
P32297	BXGT009616	Neuronal acetylcholine receptor subunit alpha-3	1136	reviewed	Ion channel
P37058	BXGT009956	Testosterone 17-beta-dehydrogenase 3	3293	reviewed
P41161	BXGT010229	ETS translocation variant 5	2119	reviewed	Transcription factor
P42338	BXGT010303	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	5291	reviewed	Kinase
P43681	BXGT010407	Neuronal acetylcholine receptor subunit alpha-4	1137	reviewed	Ion channel
P49789	BXGT010742	Bis(5'-adenosyl)-triphosphatase	2272	reviewed
P49902	BXGT010758	Cytosolic purine 5'-nucleotidase	22978	reviewed	Enzyme
P52803	BXGT010958	Ephrin-A5	1946	reviewed	Signaling
P58400	BXGT011235	Neurexin-1-beta	9378	reviewed
P62508	BXGT011431	Estrogen-related receptor gamma	2104	reviewed	Nuclear receptor
P62937	BXGT011471	Peptidyl-prolyl cis-trans isomerase A	5478	reviewed
Q00534	BXGT012533	Cyclin-dependent kinase 6	1021	reviewed	Kinase
Q01196	BXGT012575	Runt-related transcription factor 1	861	reviewed	Transcription factor
Q01668	BXGT012605	Voltage-dependent L-type calcium channel subunit alpha-1D	776	reviewed	Ion channel
Q05901	BXGT012842	Neuronal acetylcholine receptor subunit beta-3	1142	reviewed	Ion channel
Q07343	BXGT012926	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	5142	reviewed
Q07912	BXGT012947	Activated CDC42 kinase 1	10188	reviewed	Kinase
Q13163	BXGT013321	Dual specificity mitogen-activated protein kinase kinase 5	5607	reviewed	Kinase
Q13219	BXGT013327	Pappalysin-1	5069	reviewed
Q14108	BXGT013440	Lysosome membrane protein 2	950	reviewed	Receptor
Q14123	BXGT013445	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	5137	reviewed
Q14624	BXGT013491	Inter-alpha-trypsin inhibitor heavy chain H4	3700	reviewed	Enzyme modulator
Q14643	BXGT013493	Inositol 1,4,5-trisphosphate receptor type 1	3708	reviewed	Ion channel
Q14982	BXGT013518	Opioid-binding protein/cell adhesion molecule	4978	reviewed
Q15257	BXGT013554	Serine/threonine-protein phosphatase 2A activator	5524	reviewed	Enzyme modulator
Q16874	BXGT013685	Cytochrome P450 21-hydroxylase	1589	unreviewed
Q52WX2	BXGT014988	Serine/threonine-protein kinase SBK1	388228	reviewed
Q59H18	BXGT015278	Serine/threonine-protein kinase TNNI3K	51086	reviewed
Q6MZZ7	BXGT016377	Calpain-13	92291	reviewed	Enzyme
Q6VAB6	BXGT016576	Kinase suppressor of Ras 2	283455	reviewed	Kinase
Q6WRI0	BXGT016596	Immunoglobulin superfamily member 10	285313	reviewed
Q6ZN17	BXGT016631	Protein lin-28 homolog B	389421	reviewed
Q76N89	BXGT016872	E3 ubiquitin-protein ligase HECW1	23072	reviewed	Enzyme
Q7L266	BXGT016993	Isoaspartyl peptidase/L-asparaginase	80150	reviewed	Enzyme
Q86U86	BXGT017611	Protein polybromo-1	55193	reviewed	Epigenetic regulator
Q86X55	BXGT017627	Histone-arginine methyltransferase CARM1	10498	reviewed	Epigenetic regulator
Q8IU85	BXGT018333	Calcium/calmodulin-dependent protein kinase type 1D	57118	reviewed	Kinase
Q8IZS8	BXGT018372	Voltage-dependent calcium channel subunit alpha-2/delta-3	55799	reviewed	Ion channel
Q8N0X4	BXGT018493	Citramalyl-CoA lyase, mitochondrial	171425	reviewed
Q8N183	BXGT018497	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2	91942	reviewed
Q8N884	BXGT018528	Cyclic GMP-AMP synthase	115004	reviewed
Q8NFH8	BXGT018561	RalBP1-associated Eps domain-containing protein 2	9185	reviewed	Enzyme modulator
Q8TF65	BXGT018825	PDZ domain-containing protein GIPC2	54810	reviewed	Enzyme
Q96KQ7	BXGT019687	Histone-lysine N-methyltransferase EHMT2	10919	reviewed	Epigenetic regulator
Q96KS0	BXGT019688	Egl nine homolog 2	112398	reviewed
Q96NN9	BXGT019700	Apoptosis-inducing factor 3	150209	reviewed	Enzyme
Q96QU1	BXGT019721	Protocadherin-15	65217	reviewed
Q96QV1	BXGT019722	Hedgehog-interacting protein	64399	reviewed
Q99624	BXGT019942	Sodium-coupled neutral amino acid transporter 3	10991	reviewed	Transporter
Q99700	BXGT019949	Ataxin-2	6311	reviewed	Nucleic acid binding
Q99784	BXGT019961	Noelin	10439	reviewed	Cellular structure
Q9BWU1	BXGT020156	Cyclin-dependent kinase 19	23097	reviewed	Kinase
Q9C005	BXGT020207	Protein dpy-30 homolog	84661	reviewed
Q9C0B1	BXGT020209	Alpha-ketoglutarate-dependent dioxygenase FTO	79068	reviewed
Q9H015	BXGT020432	Solute carrier family 22 member 4	6583	reviewed	Transporter
Q9H492	BXGT020472	Microtubule-associated proteins 1A/1B light chain 3A	84557	reviewed	Cellular structure
Q9H7Z6	BXGT020493	Histone acetyltransferase KAT8	84148	reviewed
Q9H8M5	BXGT020496	Metal transporter CNNM2	54805	reviewed
Q9NSI6	BXGT021208	Bromodomain and WD repeat-containing protein 1	54014	reviewed
Q9NT68	BXGT021210	Teneurin-2	57451	reviewed
Q9NYL2	BXGT021259	Mitogen-activated protein kinase kinase kinase 20	51776	reviewed	Kinase
Q9NZU7	BXGT021282	Calcium-binding protein 1	9478	reviewed
Q9P286	BXGT021299	Serine/threonine-protein kinase PAK 5	57144	reviewed	Kinase
Q9UBC3	BXGT021650	DNA (cytosine-5)-methyltransferase 3B	1789	reviewed
Q9UGM6	BXGT021687	Tryptophan--tRNA ligase, mitochondrial	10352	reviewed
Q9UKE5	BXGT021741	TRAF2 and NCK-interacting protein kinase	23043	reviewed	Kinase
Q9UMX1	BXGT021778	Suppressor of fused homolog	51684	reviewed
Q9UPP1	BXGT021800	Histone lysine demethylase PHF8	23133	reviewed
Q9Y4D2	BXGT022274	Sn1-specific diacylglycerol lipase alpha	747	reviewed
Q9Y5X0	BXGT022305	Sorting nexin-10	29887	reviewed
Q9Y5X4	BXGT022306	Photoreceptor-specific nuclear receptor	10002	reviewed	Nuclear receptor
Q9Y6K1	BXGT022331	DNA (cytosine-5)-methyltransferase 3A	1788	reviewed
P49619	BXGT022669	Diacylglycerol kinase gamma	1608	reviewed	Enzyme
Q86US8	BXGT022850	Telomerase-binding protein EST1A	23293	reviewed
P43146	BXGT022852	Netrin receptor DCC	1630	reviewed
P40198	BXGT023750	Carcinoembryonic antigen-related cell adhesion molecule 3	1084	reviewed
Q8IYS0	BXGT024087	Protein Aster-C	54762	reviewed
O15016	BXGT024295	Tripartite motif-containing protein 66	9866	reviewed
Q9Y297	BXGT024812	F-box/WD repeat-containing protein 1A	8945	reviewed
Q13635	BXGT024910	Protein patched homolog 1	5727	reviewed
Q92832	BXGT025242	Protein kinase C-binding protein NELL1	4745	reviewed	Calcium-binding protein
Q9P121	BXGT025711	Neurotrimin	50863	reviewed
Q8N122	BXGT026091	Regulatory-associated protein of mTOR	57521	reviewed
Q9BQ69	BXGT026098	ADP-ribose glycohydrolase MACROD1	28992	reviewed

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}