Showing entry for E3 ubiquitin-protein ligase DTX3L


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT018807
Protein NameE3 ubiquitin-protein ligase DTX3L
Uniport IdQ8TDB6
GeneDTX3L
Gene Id151636
DomainDTC; zf-C3HC4_2
Pfam PF18102  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04330 Notch signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006974 cellular response to DNA damage stimulus
Biological Process GO:0051607 defense response to virus
Biological Process GO:0006302 double-strand break repair
Biological Process GO:0008333 endosome to lysosome transport
Biological Process GO:0033522 histone H2A ubiquitination
Biological Process GO:0033523 histone H2B ubiquitination
Biological Process GO:0010390 histone monoubiquitination
Biological Process GO:0045087 innate immune response
Biological Process GO:0051444 negative regulation of ubiquitin-protein transferase activity
Biological Process GO:0007219 Notch signaling pathway
Biological Process GO:0035563 positive regulation of chromatin binding
Biological Process GO:0002230 positive regulation of defense response to virus by host
Biological Process GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining
Biological Process GO:1901666 positive regulation of NAD+ ADP-ribosyltransferase activity
Biological Process GO:0032092 positive regulation of protein binding
Biological Process GO:1902966 positive regulation of protein localization to early endosome
Biological Process GO:1900182 positive regulation of protein localization to nucleus
Biological Process GO:2000646 positive regulation of receptor catabolic process
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0051865 protein autoubiquitination
Biological Process GO:0070936 protein K48-linked ubiquitination
Biological Process GO:0000209 protein polyubiquitination
Biological Process GO:0015031 protein transport
Biological Process GO:0016567 protein ubiquitination
Biological Process GO:0006511 ubiquitin-dependent protein catabolic process
Biological Process GO:0016032 viral process
molecular function GO:0008047 enzyme activator activity
molecular function GO:0019899 enzyme binding
molecular function GO:0004857 enzyme inhibitor activity
molecular function GO:0042393 histone binding
molecular function GO:0046872 metal ion binding
molecular function GO:0097677 STAT family protein binding
molecular function GO:0044389 ubiquitin-like protein ligase binding
molecular function GO:0061630 ubiquitin protein ligase activity
molecular function GO:0004842 ubiquitin-protein transferase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0031901 early endosome membrane
cellular component GO:0005765 lysosomal membrane
cellular component GO:0005764 lysosome
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0032991 protein-containing complex
Reactome
Pathway Id Pathway Name
R-HSA-1280218 Adaptive Immune System
R-HSA-168256 Immune System
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
R-HSA-983169 Class I MHC mediated antigen processing & presentation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0278883 BXGD006614 Metastatic melanoma Neoplasms
C0936223 BXGD011477 Metastatic Prostate Carcinoma Neoplasms; Male Urogenital Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1282496 BXGD012147 Metastasis from malignant tumor of prostate
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332201 BXGD012502 Adult Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0006198 Citric acid 192.12
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein