Showing entry for cGMP-dependent 3',5'-cyclic phosphodiesterase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT019339
Protein NamecGMP-dependent 3',5'-cyclic phosphodiesterase
Uniport IdQ922S4
GenePde2a
Gene Id207728
DomainGAF; GAF_2; PDEase_I
Pfam PF01590   PF13185   PF00233  
OrganismMus musculus (Mouse)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Biological Process GO:0035904 aorta development
Biological Process GO:0019933 cAMP-mediated signaling
Biological Process GO:0003279 cardiac septum development
Biological Process GO:1904613 cellular response to 2,3,7,8-tetrachlorodibenzodioxine
Biological Process GO:0071320 cellular response to cAMP
Biological Process GO:0071321 cellular response to cGMP
Biological Process GO:0035690 cellular response to drug
Biological Process GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus
Biological Process GO:0071222 cellular response to lipopolysaccharide
Biological Process GO:0036006 cellular response to macrophage colony-stimulating factor stimulus
Biological Process GO:0071260 cellular response to mechanical stimulus
Biological Process GO:0046069 cGMP catabolic process
Biological Process GO:0019934 cGMP-mediated signaling
Biological Process GO:0060976 coronary vasculature development
Biological Process GO:0061028 establishment of endothelial barrier
Biological Process GO:0007507 heart development
Biological Process GO:0003170 heart valve development
Biological Process GO:0043951 negative regulation of cAMP-mediated signaling
Biological Process GO:0060548 negative regulation of cell death
Biological Process GO:0010754 negative regulation of cGMP-mediated signaling
Biological Process GO:0090324 negative regulation of oxidative phosphorylation
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0043116 negative regulation of vascular permeability
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0050729 positive regulation of inflammatory response
Biological Process GO:0043117 positive regulation of vascular permeability
Biological Process GO:0010821 regulation of mitochondrion organization
Biological Process GO:0010749 regulation of nitric oxide mediated signal transduction
Biological Process GO:0003281 ventricular septum development
molecular function GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
molecular function GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity
molecular function GO:0030552 cAMP binding
molecular function GO:0030553 cGMP binding
molecular function GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
molecular function GO:0008144 drug binding
molecular function GO:0036004 GAF domain binding
molecular function GO:0042802 identical protein binding
molecular function GO:0000287 magnesium ion binding
molecular function GO:0042301 phosphate ion binding
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0030911 TPR domain binding
molecular function GO:0008270 zinc ion binding
cellular component GO:0030424 axon
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0030425 dendrite
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005794 Golgi apparatus
cellular component GO:0097457 hippocampal mossy fiber
cellular component GO:0045121 membrane raft
cellular component GO:0005743 mitochondrial inner membrane
cellular component GO:0005759 mitochondrial matrix
cellular component GO:0005741 mitochondrial outer membrane
cellular component GO:0005739 mitochondrion
cellular component GO:0005634 nucleus
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0005886 plasma membrane
cellular component GO:0042734 presynaptic membrane
cellular component GO:0097060 synaptic membrane
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0036634 Cgmp 345.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein