protein

Showing entry for G protein-activated inward rectifier potassium channel 3

　　　　　　　　　　　　

General Target Information
BXGT Id	BXGT019378
Protein Name	G protein-activated inward rectifier potassium channel 3
Uniport Id	Q92806
Gene	KCNJ9
Gene Id	3765
Domain	IRK; IRK_C
Pfam	PF01007 PF17655
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name
5. Organismal Systems	5.10 Environmental adaptation	hsa04713	Circadian entrainment
5. Organismal Systems	5.6 Nervous system	hsa04723	Retrograde endocannabinoid signaling
5. Organismal Systems	5.6 Nervous system	hsa04726	Serotonergic synapse
5. Organismal Systems	5.6 Nervous system	hsa04728	Dopaminergic synapse
5. Organismal Systems	5.2 Endocrine system	hsa04915	Estrogen signaling pathway
5. Organismal Systems	5.2 Endocrine system	hsa04921	Oxytocin signaling pathway
6. Human Diseases	6.5 Substance dependence	hsa05032	Morphine addiction

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:1990573	potassium ion import across plasma membrane
Biological Process	GO:0034765	regulation of ion transmembrane transport
molecular function	GO:0015467	G-protein activated inward rectifier potassium channel activity
molecular function	GO:0005242	inward rectifier potassium channel activity
cellular component	GO:0099056	integral component of presynaptic membrane
cellular component	GO:0098688	parallel fiber to Purkinje cell synapse
cellular component	GO:0005886	plasma membrane

Reactome

Pathway Id	Pathway Name
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112315	Transmission across Chemical Synapses
R-HSA-112316	Neuronal System
R-HSA-1296041	Activation of G protein gated Potassium channels
R-HSA-1296059	G protein gated Potassium channels
R-HSA-1296065	Inwardly rectifying K+ channels
R-HSA-1296071	Potassium Channels
R-HSA-977443	GABA receptor activation
R-HSA-977444	GABA B receptor activation
R-HSA-991365	Activation of GABAB receptors
R-HSA-997272	Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0011847	BXGD000749	Diabetes	Endocrine System Diseases
C0011849	BXGD000751	Diabetes Mellitus	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860	BXGD000755	Diabetes Mellitus, Non-Insulin-Dependent	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0014556	BXGD000932	Epilepsy, Temporal Lobe	Nervous System Diseases
C0023976	BXGD001724	Long QT Syndrome	Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0024121	BXGD001735	Lung Neoplasms	Neoplasms; Respiratory Tract Diseases
C0085281	BXGD003152	Addictive Behavior	Behavior and Behavior Mechanisms
C1827973	BXGD013783	Barbiturate withdrawal
C4511324	BXGD023001	Hypnotic withdrawal

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0000434	Ethanol		46.07

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}