Showing entry for Addictive Behavior


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD003152
Disease NameAddictive Behavior
Disease CUI IdC0085281
MeSH Codes F01  
Disease Class NameBehavior and Behavior Mechanisms
Semantic TypeMental or Behavioral Dysfunction
Human Phenotype Ontology Id HP:0000707  
Human Phenotype Ontology TermAbnormality of the nervous system
Disease Ontology Id   
Disease Ontology Class Name
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
A0A024RAV5 BXGT000013 V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b 3845 unreviewed
O00206 BXGT003894 Toll-like receptor 4 7099 reviewed
O00329 BXGT003909 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 5293 reviewed Kinase
O00519 BXGT003934 Fatty-acid amide hydrolase 1 2166 reviewed
O00522 BXGT003935 Krev interaction trapped protein 1 889 reviewed
O00767 BXGT003949 Acyl-CoA desaturase 6319 reviewed
O14733 BXGT004087 Dual specificity mitogen-activated protein kinase kinase 7 5609 reviewed Kinase
O15374 BXGT004157 Monocarboxylate transporter 5 9122 reviewed Transporter
O15427 BXGT004167 Monocarboxylate transporter 4 9123 reviewed Transporter
O43612 BXGT004605 Orexin 3060 reviewed
O43614 BXGT004606 Orexin receptor type 2 3062 reviewed G-protein coupled receptor
O43639 BXGT004608 Cytoplasmic protein NCK2 8440 reviewed
O75030 BXGT005096 Microphthalmia-associated transcription factor 4286 reviewed
O75365 BXGT005115 Protein tyrosine phosphatase type IVA 3 11156 reviewed
O75417 BXGT005124 DNA polymerase theta 10721 reviewed Enzyme
O75899 BXGT005161 Gamma-aminobutyric acid type B receptor subunit 2 9568 reviewed G-protein coupled receptor
O94925 BXGT005342 Glutaminase kidney isoform, mitochondrial 2744 reviewed Enzyme
P00325 BXGT005498 Alcohol dehydrogenase 1B 125 reviewed Enzyme
P00519 BXGT005570 Tyrosine-protein kinase ABL1 25 reviewed Kinase
P00533 BXGT005575 Epidermal growth factor receptor 1956 reviewed Kinase
P01106 BXGT005730 Myc proto-oncogene protein 4609 reviewed Transcription factor
P01111 BXGT005731 GTPase NRas 4893 reviewed Enzyme modulator
P01116 BXGT005733 GTPase KRas 3845 reviewed Enzyme modulator
P01189 BXGT005742 Pro-opiomelanocortin 5443 reviewed
P01275 BXGT005747 Glucagon 2641 reviewed
P01303 BXGT005748 Pro-neuropeptide Y 4852 reviewed Signaling
P01584 BXGT005772 Interleukin-1 beta 3553 reviewed
P01732 BXGT005782 T-cell surface glycoprotein CD8 alpha chain 925 reviewed
P02751 BXGT005943 Fibronectin 2335 reviewed Signaling
P02753 BXGT005945 Retinol-binding protein 4 5950 reviewed Transporter
P03372 BXGT006059 Estrogen receptor 2099 reviewed Nuclear receptor
P03956 BXGT006120 Interstitial collagenase 4312 reviewed Enzyme
P04049 BXGT006133 RAF proto-oncogene serine/threonine-protein kinase 5894 reviewed Kinase
P04150 BXGT006154 Glucocorticoid receptor 2908 reviewed Nuclear receptor
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 2064 reviewed Kinase
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P05091 BXGT006312 Aldehyde dehydrogenase, mitochondrial 217 reviewed Enzyme
P06213 BXGT006425 Insulin receptor 3643 reviewed Kinase
P06276 BXGT006430 Cholinesterase 590 reviewed
P06396 BXGT006435 Gelsolin 2934 reviewed Cellular structure
P06730 BXGT006487 Eukaryotic translation initiation factor 4E 1977 reviewed Nucleic acid binding
P06850 BXGT006511 Corticoliberin 1392 reviewed Signaling
P07101 BXGT006547 Tyrosine 3-monooxygenase 7054 reviewed
P07900 BXGT006696 Heat shock protein HSP 90-alpha 3320 reviewed Chaperone
P08069 BXGT006723 Insulin-like growth factor 1 receptor 3480 reviewed Kinase
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 1129 reviewed G-protein coupled receptor
P08183 BXGT006741 ATP-dependent translocase ABCB1 5243 reviewed Transporter
P08235 BXGT006751 Mineralocorticoid receptor 4306 reviewed Nuclear receptor
P08581 BXGT006794 Hepatocyte growth factor receptor 4233 reviewed Kinase
P08603 BXGT006798 Complement factor H 3075 reviewed
P08684 BXGT006812 Cytochrome P450 3A4 1576 reviewed Enzyme
P08697 BXGT006815 Alpha-2-antiplasmin 5345 reviewed Enzyme modulator
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 1133 reviewed G-protein coupled receptor
P08913 BXGT006841 Alpha-2A adrenergic receptor 150 reviewed G-protein coupled receptor
P09038 BXGT006851 Fibroblast growth factor 2 2247 reviewed Signaling
P09172 BXGT006865 Dopamine beta-hydroxylase 1621 reviewed
P09429 BXGT006889 High mobility group protein B1 3146 reviewed Nucleic acid binding
P09917 BXGT006941 Arachidonate 5-lipoxygenase 240 reviewed Enzyme
P0CG29 BXGT007465 Glutathione S-transferase theta-2 2953 reviewed
P0CG30 BXGT007466 Glutathione S-transferase theta-2B 653689 reviewed
P0DP23 BXGT007520 Calmodulin-1 808 reviewed
P0DP24 BXGT007521 Calmodulin-2 808 reviewed
P10275 BXGT007552 Androgen receptor 367 reviewed Nuclear receptor
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P10599 BXGT007583 Thioredoxin 7295 reviewed
P10635 BXGT007595 Cytochrome P450 2D6 1565 reviewed
P10721 BXGT007605 Mast/stem cell growth factor receptor Kit 3815 reviewed Kinase
P11166 BXGT007661 Solute carrier family 2, facilitated glucose transporter member 1 6513 reviewed Transporter
P11169 BXGT007664 Solute carrier family 2, facilitated glucose transporter member 3 6515 reviewed Transporter
P11413 BXGT007701 Glucose-6-phosphate 1-dehydrogenase 2539 reviewed Enzyme
P11509 BXGT007716 Cytochrome P450 2A6 1548 reviewed
P11511 BXGT007717 Aromatase 1588 reviewed Enzyme
P12821 BXGT007849 Angiotensin-converting enzyme 1636 reviewed Enzyme
P14416 BXGT008011 D(2) dopamine receptor 1813 reviewed G-protein coupled receptor
P14780 BXGT008053 Matrix metalloproteinase-9 4318 reviewed Enzyme
P15056 BXGT008075 Serine/threonine-protein kinase B-raf 673 reviewed Kinase
P15529 BXGT008134 Membrane cofactor protein 4179 reviewed
P16220 BXGT008206 Cyclic AMP-responsive element-binding protein 1 1385 reviewed
P19174 BXGT008467 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 5335 reviewed Enzyme
P19440 BXGT008481 Glutathione hydrolase 1 proenzyme 2678 reviewed Enzyme
P19793 BXGT008515 Retinoic acid receptor RXR-alpha 6256 reviewed Nuclear receptor
P21397 BXGT008644 Amine oxidase [flavin-containing] A 4128 reviewed
P21554 BXGT008662 Cannabinoid receptor 1 1268 reviewed G-protein coupled receptor
P21579 BXGT008665 Synaptotagmin-1 6857 reviewed Transporter
P21673 BXGT008676 Diamine acetyltransferase 1 6303 reviewed
P21728 BXGT008686 D(1A) dopamine receptor 1812 reviewed G-protein coupled receptor
P21802 BXGT008691 Fibroblast growth factor receptor 2 2263 reviewed Kinase
P21860 BXGT008698 Receptor tyrosine-protein kinase erbB-3 2065 reviewed Kinase
P21917 BXGT008707 D(4) dopamine receptor 1815 reviewed G-protein coupled receptor
P21964 BXGT008714 Catechol O-methyltransferase 1312 reviewed Enzyme
P22303 BXGT008751 Acetylcholinesterase 43 reviewed Enzyme
P23560 BXGT008883 Brain-derived neurotrophic factor 627 reviewed Signaling
P23975 BXGT008935 Sodium-dependent noradrenaline transporter 6530 reviewed Transporter
P24387 BXGT008966 Corticotropin-releasing factor-binding protein 1393 reviewed Signaling
P25103 BXGT009020 Substance-P receptor 6869 reviewed G-protein coupled receptor
P27338 BXGT009172 Amine oxidase [flavin-containing] B 4129 reviewed
P27361 BXGT009176 Mitogen-activated protein kinase 3 5595 reviewed Kinase
P27815 BXGT009208 cAMP-specific 3',5'-cyclic phosphodiesterase 4A 5141 reviewed
P28223 BXGT009239 5-hydroxytryptamine receptor 2A 3356 reviewed G-protein coupled receptor
P28335 BXGT009255 5-hydroxytryptamine receptor 2C 3358 reviewed G-protein coupled receptor
P28482 BXGT009263 Mitogen-activated protein kinase 1 5594 reviewed Kinase
P28562 BXGT009270 Dual specificity protein phosphatase 1 1843 reviewed
P29320 BXGT009332 Ephrin type-A receptor 3 2042 reviewed Kinase
P29323 BXGT009334 Ephrin type-B receptor 2 2048 reviewed Kinase
P29401 BXGT009344 Transketolase 7086 reviewed Enzyme
P30086 BXGT009400 Phosphatidylethanolamine-binding protein 1 5037 reviewed Enzyme modulator
P30531 BXGT009432 Sodium- and chloride-dependent GABA transporter 1 6529 reviewed Transporter
P30532 BXGT009433 Neuronal acetylcholine receptor subunit alpha-5 1138 reviewed Ion channel
P30536 BXGT009435 Translocator protein 706 reviewed
P30926 BXGT009482 Neuronal acetylcholine receptor subunit beta-4 1143 reviewed Ion channel
P31645 BXGT009558 Sodium-dependent serotonin transporter 6532 reviewed Transporter
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase 207 reviewed Kinase
P32297 BXGT009616 Neuronal acetylcholine receptor subunit alpha-3 1136 reviewed Ion channel
P34998 BXGT009781 Corticotropin-releasing factor receptor 1 1394 reviewed
P35354 BXGT009816 Prostaglandin G/H synthase 2 5743 reviewed Enzyme
P35372 BXGT009823 Mu-type opioid receptor 4988 reviewed G-protein coupled receptor
P35462 BXGT009835 D(3) dopamine receptor 1814 reviewed G-protein coupled receptor
P40692 BXGT010195 DNA mismatch repair protein Mlh1 4292 reviewed Nucleic acid binding
P40763 BXGT010202 Signal transducer and activator of transcription 3 6774 reviewed Nucleic acid binding
P40933 BXGT010209 Interleukin-15 3600 reviewed
P41143 BXGT010223 Delta-type opioid receptor 4985 reviewed G-protein coupled receptor
P41145 BXGT010225 Kappa-type opioid receptor 4986 reviewed G-protein coupled receptor
P41146 BXGT010226 Nociceptin receptor 4987 reviewed G-protein coupled receptor
P41594 BXGT010266 Metabotropic glutamate receptor 5 2915 reviewed G-protein coupled receptor
P42224 BXGT010286 Signal transducer and activator of transcription 1-alpha/beta 6772 reviewed Nucleic acid binding
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5290 reviewed Kinase
P42338 BXGT010303 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 5291 reviewed Kinase
P42345 BXGT010304 Serine/threonine-protein kinase mTOR 2475 reviewed Kinase
P42898 BXGT010344 Methylenetetrahydrofolate reductase 4524 reviewed
P43004 BXGT010348 Excitatory amino acid transporter 2 6506 reviewed Transporter
P43220 BXGT010367 Glucagon-like peptide 1 receptor 2740 reviewed G-protein coupled receptor
P43354 BXGT010381 Nuclear receptor subfamily 4 group A member 2 4929 reviewed Nuclear receptor
P43681 BXGT010407 Neuronal acetylcholine receptor subunit alpha-4 1137 reviewed Ion channel
P46937 BXGT010554 Transcriptional coactivator YAP1 10413 reviewed Enzyme modulator
P47869 BXGT010590 Gamma-aminobutyric acid receptor subunit alpha-2 2555 reviewed Ion channel
P48051 BXGT010611 G protein-activated inward rectifier potassium channel 2 3763 reviewed Ion channel
P48736 BXGT010658 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 5294 reviewed Kinase
P49585 BXGT010712 Choline-phosphate cytidylyltransferase A 5130 reviewed
P49789 BXGT010742 Bis(5'-adenosyl)-triphosphatase 2272 reviewed
P49916 BXGT010764 DNA ligase 3 3980 reviewed Enzyme
P50613 BXGT010815 Cyclin-dependent kinase 7 1022 reviewed Kinase
P50750 BXGT010818 Cyclin-dependent kinase 9 1025 reviewed Kinase
P53350 BXGT010984 Serine/threonine-protein kinase PLK1 5347 reviewed Kinase
P53667 BXGT011008 LIM domain kinase 1 3984 reviewed Kinase
P60484 BXGT011307 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 5728 reviewed Enzyme
P60709 BXGT011322 Actin, cytoplasmic 1 60 reviewed Cellular structure
P60880 BXGT011335 Synaptosomal-associated protein 25 6616 reviewed Transporter
P60981 BXGT011344 Destrin 11034 reviewed
P78504 BXGT011844 Protein jagged-1 182 reviewed
Q00535 BXGT012534 Cyclin-dependent-like kinase 5 1020 reviewed Kinase
Q00613 BXGT012540 Heat shock factor protein 1 3297 reviewed Transcription factor
Q01094 BXGT012568 Transcription factor E2F1 1869 reviewed Nucleic acid binding
Q01196 BXGT012575 Runt-related transcription factor 1 861 reviewed Transcription factor
Q01959 BXGT012624 Sodium-dependent dopamine transporter 6531 reviewed Transporter
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A 4297 reviewed
Q04912 BXGT012790 Macrophage-stimulating protein receptor 4486 reviewed Kinase
Q05940 BXGT012846 Synaptic vesicular amine transporter 6571 reviewed Transporter
Q07021 BXGT012915 Complement component 1 Q subcomponent-binding protein, mitochondrial 708 reviewed
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform 5530 reviewed
Q12879 BXGT013275 Glutamate receptor ionotropic, NMDA 2A 2903 reviewed Ion channel
Q13164 BXGT013322 Mitogen-activated protein kinase 7 5598 reviewed Kinase
Q13224 BXGT013328 Glutamate receptor ionotropic, NMDA 2B 2904 reviewed Ion channel
Q13255 BXGT013332 Metabotropic glutamate receptor 1 2911 reviewed G-protein coupled receptor
Q14145 BXGT013448 Kelch-like ECH-associated protein 1 9817 reviewed
Q14416 BXGT013468 Metabotropic glutamate receptor 2 2912 reviewed G-protein coupled receptor
Q14832 BXGT013507 Metabotropic glutamate receptor 3 2913 reviewed G-protein coupled receptor
Q15389 BXGT013564 Angiopoietin-1 284 reviewed Signaling
Q15758 BXGT013594 Neutral amino acid transporter B(0) 6510 reviewed Transporter
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 4780 reviewed Enzyme
Q16566 BXGT013639 Calcium/calmodulin-dependent protein kinase type IV 814 reviewed Kinase
Q16568 BXGT013640 Cocaine- and amphetamine-regulated transcript protein 9607 reviewed
Q16620 BXGT013645 BDNF/NT-3 growth factors receptor 4915 reviewed Kinase
Q59FK2 BXGT015276 Selenocysteine lyase variant 51540 unreviewed
Q6PHR2 BXGT016467 Serine/threonine-protein kinase ULK3 25989 reviewed Kinase
Q86X55 BXGT017627 Histone-arginine methyltransferase CARM1 10498 reviewed Epigenetic regulator
Q8NCD3 BXGT018547 Holliday junction recognition protein 55355 reviewed
Q8NER1 BXGT018556 Transient receptor potential cation channel subfamily V member 1 7442 reviewed Ion channel
Q8NFD2 BXGT018559 Ankyrin repeat and protein kinase domain-containing protein 1 255239 reviewed Kinase
Q8TCU5 BXGT018802 Glutamate receptor ionotropic, NMDA 3A 116443 reviewed Ion channel
Q92793 BXGT019374 CREB-binding protein 1387 reviewed
Q92806 BXGT019378 G protein-activated inward rectifier potassium channel 3 3765 reviewed Ion channel
Q96I15 BXGT019674 Selenocysteine lyase 51540 reviewed Enzyme
Q96RJ0 BXGT019728 Trace amine-associated receptor 1 134864 reviewed G-protein coupled receptor
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 10280 reviewed
Q99836 BXGT019970 Myeloid differentiation primary response protein MyD88 4615 reviewed Enzyme modulator
Q9BW19 BXGT020148 Kinesin-like protein KIFC1 3833 reviewed Cellular structure
Q9C0B1 BXGT020209 Alpha-ketoglutarate-dependent dioxygenase FTO 79068 reviewed
Q9H9B1 BXGT020501 Histone-lysine N-methyltransferase EHMT1 79813 reviewed Epigenetic regulator
Q9NR12 BXGT021174 PDZ and LIM domain protein 7 9260 reviewed Cellular structure
Q9NWB1 BXGT021231 RNA binding protein fox-1 homolog 1 54715 reviewed Nucleic acid binding
Q9UBN7 BXGT021658 Histone deacetylase 6 10013 reviewed Epigenetic regulator
Q9UBS5 BXGT021662 Gamma-aminobutyric acid type B receptor subunit 1 2550 reviewed G-protein coupled receptor
Q9UHD2 BXGT021697 Serine/threonine-protein kinase TBK1 29110 reviewed Kinase
Q9UM73 BXGT021773 ALK tyrosine kinase receptor 238 reviewed Kinase
Q9UQF0 BXGT021812 Syncytin-1 30816 reviewed
Q9Y2Q3 BXGT022242 Glutathione S-transferase kappa 1 373156 reviewed
Q92847 BXGT022673 Growth hormone secretagogue receptor type 1 2693 reviewed G-protein coupled receptor
Q7Z624 BXGT022792 Calmodulin-lysine N-methyltransferase 79823 reviewed
P53539 BXGT023438 Protein fosB 2354 reviewed Transcription factor
P16104 BXGT024571 Histone H2AX 3014 reviewed Nucleic acid binding
P0DP25 BXGT024595 Calmodulin-3 808 reviewed
P20809 BXGT025043 Interleukin-11 3589 reviewed
O43613 BXGT025666 Orexin receptor type 1 3061 reviewed G-protein coupled receptor
Q92888 BXGT026130 Rho guanine nucleotide exchange factor 1 9138 reviewed
P00403 BXGT026137 Cytochrome c oxidase subunit 2 4513 reviewed Enzyme
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease