Showing entry for Histone-lysine N-methyltransferase SETDB2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT019746
Protein NameHistone-lysine N-methyltransferase SETDB2
Uniport IdQ96T68
GeneSETDB2
Gene Id83852
DomainMBD; Pre-SET; SET
Pfam PF01429   PF05033   PF00856  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.5 Amino acid metabolism hsa00310 Lysine degradation
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0051301 cell division
Biological Process GO:0007059 chromosome segregation
Biological Process GO:0001947 heart looping
Biological Process GO:0070828 heterochromatin organization
Biological Process GO:0051567 histone H3-K9 methylation
Biological Process GO:0070986 left/right axis specification
Biological Process GO:0000278 mitotic cell cycle
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0045892 negative regulation of transcription, DNA-templated
Biological Process GO:0090309 positive regulation of DNA methylation-dependent heterochromatin assembly
molecular function GO:0003677 DNA binding
molecular function GO:0046974 histone methyltransferase activity (H3-K9 specific)
molecular function GO:0008270 zinc ion binding
cellular component GO:0005694 chromosome
cellular component GO:0005829 cytosol
cellular component GO:0042025 host cell nucleus
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-3214841 PKMTs methylate histone lysines
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-4839726 Chromatin organization
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0085584 BXGD003195 Encephalopathies Nervous System Diseases
C0085669 BXGD003233 Acute leukemia Pathological Conditions, Signs and Symptoms; Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598766 BXGD009669 Leukemogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0751606 BXGD010523 Adult Acute Lymphocytic Leukemia
C0949541 BXGD011578 Hurthle Cell Tumor Neoplasms
C1276071 BXGD012103 Childhood atopic dermatitis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C1306837 BXGD012377 Papillary Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1868683 BXGD016526 B-CELL MALIGNANCY, LOW-GRADE
C4728046 BXGD023884 Diabetic wound
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0000696 Tartaric acid 150.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein