Showing entry for COP9 signalosome complex subunit 4


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT020125
Protein NameCOP9 signalosome complex subunit 4
Uniport IdQ9BT78
GeneCOPS4
Gene Id51138
DomainCSN4_RPN5_eIF3a; PCI
Pfam PF18420   PF01399  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0000715 nucleotide-excision repair, DNA damage recognition
Biological Process GO:0043687 post-translational protein modification
Biological Process GO:0000338 protein deneddylation
Biological Process GO:0006283 transcription-coupled nucleotide-excision repair
molecular function GO:0019784 NEDD8-specific protease activity
cellular component GO:0030054 cell junction
cellular component GO:0008180 COP9 signalosome
cellular component GO:0005829 cytosol
cellular component GO:0016607 nuclear speck
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0008021 synaptic vesicle
Reactome
Pathway Id Pathway Name
R-HSA-199991 Membrane Trafficking
R-HSA-392499 Metabolism of proteins
R-HSA-5653656 Vesicle-mediated transport
R-HSA-5696394 DNA Damage Recognition in GG-NER
R-HSA-5696398 Nucleotide Excision Repair
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER)
R-HSA-597592 Post-translational protein modification
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
R-HSA-73894 DNA Repair
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
R-HSA-8951664 Neddylation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003504 BXGD000202 Aortic Valve Insufficiency Cardiovascular Diseases
C0013080 BXGD000797 Down Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein