adisease

Showing entry for Down Syndrome

General Disease Information
BXGD Id	BXGD000797
Disease Name	Down Syndrome
Disease CUI Id	C0013080
MeSH Codes	C16 C10
Disease Class Name	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id
Human Phenotype Ontology Term
Disease Ontology Id	DOID:630
Disease Ontology Class Name	genetic disease
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
F7VJQ1	BXGT003310	Alternative prion protein	5621	reviewed
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O00329	BXGT003909	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	5293	reviewed	Kinase
O00429	BXGT003919	Dynamin-1-like protein	10059	reviewed	Enzyme modulator
O00764	BXGT003948	Pyridoxal kinase	8566	reviewed	Kinase
O15151	BXGT004132	Protein Mdm4	4194	reviewed	Nucleic acid binding
O15350	BXGT004154	Tumor protein p73	7161	reviewed	Transcription factor
O15394	BXGT004163	Neural cell adhesion molecule 2	4685	reviewed
O15540	BXGT004178	Fatty acid-binding protein, brain	2173	reviewed
O43678	BXGT004613	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2	4695	reviewed	Enzyme
O60603	BXGT004887	Toll-like receptor 2	7097	reviewed
O60674	BXGT004892	Tyrosine-protein kinase JAK2	3717	reviewed	Kinase
O60760	BXGT004899	Hematopoietic prostaglandin D synthase	27306	reviewed
O75015	BXGT005095	Low affinity immunoglobulin gamma Fc region receptor III-B	2215	reviewed	Cell adhesion
O75368	BXGT005118	SH3 domain-binding glutamic acid-rich-like protein	6451	reviewed
O75489	BXGT005131	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	4722	reviewed
O75496	BXGT005132	Geminin	51053	reviewed
O75628	BXGT005140	GTP-binding protein REM 1	28954	reviewed
O75914	BXGT005165	Serine/threonine-protein kinase PAK 3	5063	reviewed	Kinase
O76039	BXGT005171	Cyclin-dependent kinase-like 5	6792	reviewed	Kinase
O76083	BXGT005176	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	5152	reviewed
O94759	BXGT005327	Transient receptor potential cation channel subfamily M member 2	7226	reviewed	Ion channel
O95551	BXGT005384	Tyrosyl-DNA phosphodiesterase 2	51567	reviewed
O95631	BXGT005387	Netrin-1	9423	reviewed	Enzyme modulator
O95644	BXGT005389	Nuclear factor of activated T-cells, cytoplasmic 1	4772	reviewed	Transcription factor
P00374	BXGT005520	Dihydrofolate reductase	1719	reviewed	Enzyme
P00439	BXGT005539	Phenylalanine-4-hydroxylase	5053	reviewed
P00441	BXGT005540	Superoxide dismutase [Cu-Zn]	6647	reviewed	Enzyme
P00450	BXGT005544	Ceruloplasmin	1356	reviewed	Enzyme
P00519	BXGT005570	Tyrosine-protein kinase ABL1	25	reviewed	Kinase
P00533	BXGT005575	Epidermal growth factor receptor	1956	reviewed	Kinase
P00747	BXGT005639	Plasminogen	5340	reviewed	Enzyme
P00846	BXGT005674	ATP synthase subunit a	4508	reviewed	Transporter
P00918	BXGT005690	Carbonic anhydrase 2	760	reviewed
P01008	BXGT005713	Antithrombin-III	462	reviewed	Enzyme modulator
P01009	BXGT005714	Alpha-1-antitrypsin	5265	reviewed	Enzyme modulator
P01011	BXGT005715	Alpha-1-antichymotrypsin	12	reviewed	Enzyme modulator
P01023	BXGT005718	Alpha-2-macroglobulin	2	reviewed	Enzyme modulator
P01034	BXGT005721	Cystatin-C	1471	reviewed
P01042	BXGT005722	Kininogen-1	3827	reviewed	Enzyme modulator
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01138	BXGT005738	Beta-nerve growth factor	4803	reviewed	Signaling
P01215	BXGT005743	Glycoprotein hormones alpha chain	1081	reviewed
P01236	BXGT005744	Prolactin	5617	reviewed	Signaling
P01270	BXGT005746	Parathyroid hormone	5741	reviewed
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01579	BXGT005770	Interferon gamma	3458	reviewed
P01583	BXGT005771	Interleukin-1 alpha	3552	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P01589	BXGT005773	Interleukin-2 receptor subunit alpha	3559	reviewed	Receptor
P01889	BXGT005809	HLA class I histocompatibility antigen, B-7 alpha chain	3106	reviewed
P01909	BXGT005815	HLA class II histocompatibility antigen, DQ alpha 1 chain	3117	reviewed	Immune response
P02647	BXGT005908	Apolipoprotein A-I	335	reviewed
P02649	BXGT005909	Apolipoprotein E	348	reviewed
P02652	BXGT005910	Apolipoprotein A-II	336	reviewed	Transporter
P02655	BXGT005912	Apolipoprotein C-II	344	reviewed
P02724	BXGT005934	Glycophorin-A	2993	reviewed
P02741	BXGT005936	C-reactive protein	1401	reviewed
P02748	BXGT005940	Complement component C9	735	reviewed
P02751	BXGT005943	Fibronectin	2335	reviewed	Signaling
P02753	BXGT005945	Retinol-binding protein 4	5950	reviewed	Transporter
P02765	BXGT005952	Alpha-2-HS-glycoprotein	197	reviewed	Enzyme modulator
P02766	BXGT005953	Transthyretin	7276	reviewed	Transporter
P02768	BXGT005955	Serum albumin	213	reviewed	Transporter
P02795	BXGT005968	Metallothionein-2	4502	reviewed
P03372	BXGT006059	Estrogen receptor	2099	reviewed	Nuclear receptor
P03897	BXGT006111	NADH-ubiquinone oxidoreductase chain 3	4537	reviewed
P04040	BXGT006132	Catalase	847	reviewed	Enzyme
P04155	BXGT006155	Trefoil factor 1	7031	reviewed	Signaling
P04156	BXGT006156	Major prion protein	5621	reviewed
P04179	BXGT006163	Superoxide dismutase [Mn], mitochondrial	6648	reviewed	Enzyme
P04217	BXGT006171	Alpha-1B-glycoprotein	1	reviewed	Receptor
P04271	BXGT006177	Protein S100-B	6285	reviewed	Calcium-binding protein
P04278	BXGT006182	Sex hormone-binding globulin	6462	reviewed
P04406	BXGT006207	Glyceraldehyde-3-phosphate dehydrogenase	2597	reviewed	Enzyme
P04626	BXGT006238	Receptor tyrosine-protein kinase erbB-2	2064	reviewed	Kinase
P04629	BXGT006239	High affinity nerve growth factor receptor	4914	reviewed	Kinase
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P04818	BXGT006269	Thymidylate synthase	7298	reviewed	Enzyme
P05067	BXGT006306	Amyloid-beta precursor protein	351	reviewed	Enzyme modulator
P05093	BXGT006313	Steroid 17-alpha-hydroxylase/17,20 lyase	1586	reviewed
P05107	BXGT006316	Integrin beta-2	3689	reviewed	Receptor
P05164	BXGT006333	Myeloperoxidase	4353	reviewed	Enzyme
P05231	BXGT006345	Interleukin-6	3569	reviewed
P05362	BXGT006350	Intercellular adhesion molecule 1	3383	reviewed
P05413	BXGT006355	Fatty acid-binding protein, heart	2170	reviewed
P05787	BXGT006385	Keratin, type II cytoskeletal 8	3856	reviewed
P06241	BXGT006429	Tyrosine-protein kinase Fyn	2534	reviewed	Kinase
P06276	BXGT006430	Cholinesterase	590	reviewed
P06396	BXGT006435	Gelsolin	2934	reviewed	Cellular structure
P06493	BXGT006445	Cyclin-dependent kinase 1	983	reviewed	Kinase
P06744	BXGT006494	Glucose-6-phosphate isomerase	2821	reviewed	Enzyme
P06746	BXGT006496	DNA polymerase beta	5423	reviewed	Enzyme
P06748	BXGT006497	Nucleophosmin	4869	reviewed	Chaperone
P07202	BXGT006565	Thyroid peroxidase	7173	reviewed	Enzyme
P07203	BXGT006566	Glutathione peroxidase 1	2876	reviewed	Enzyme
P07550	BXGT006636	Beta-2 adrenergic receptor	154	reviewed	G-protein coupled receptor
P07949	BXGT006703	Proto-oncogene tyrosine-protein kinase receptor Ret	5979	reviewed	Kinase
P07996	BXGT006710	Thrombospondin-1	7057	reviewed
P08183	BXGT006741	ATP-dependent translocase ABCB1	5243	reviewed	Transporter
P08246	BXGT006756	Neutrophil elastase	1991	reviewed	Enzyme
P08473	BXGT006773	Neprilysin	4311	reviewed	Enzyme
P08514	BXGT006781	Integrin alpha-IIb	3674	reviewed
P08603	BXGT006798	Complement factor H	3075	reviewed
P08637	BXGT006802	Low affinity immunoglobulin gamma Fc region receptor III-A	2214	reviewed	Cell adhesion
P08842	BXGT006830	Steryl-sulfatase	412	reviewed	Enzyme
P09104	BXGT006856	Gamma-enolase	2026	reviewed	Enzyme
P09172	BXGT006865	Dopamine beta-hydroxylase	1621	reviewed
P09429	BXGT006889	High mobility group protein B1	3146	reviewed	Nucleic acid binding
P09601	BXGT006909	Heme oxygenase 1	3162	reviewed
P09874	BXGT006934	Poly [ADP-ribose] polymerase 1	142	reviewed
P09960	BXGT006952	Leukotriene A-4 hydrolase	4048	reviewed
P0CG47	BXGT007467	Polyubiquitin-B	7314	reviewed	Nucleic acid binding
P0DN79	BXGT007511	Cystathionine beta-synthase-like protein	875	reviewed
P10145	BXGT007542	Interleukin-8	3576	reviewed	Signaling
P10276	BXGT007553	Retinoic acid receptor alpha	5914	reviewed	Nuclear receptor
P10415	BXGT007567	Apoptosis regulator Bcl-2	596	reviewed	Signaling
P10586	BXGT007581	Receptor-type tyrosine-protein phosphatase F	5792	reviewed	Enzyme
P10599	BXGT007583	Thioredoxin	7295	reviewed
P10636	BXGT007596	Microtubule-associated protein tau	4137	reviewed
P10721	BXGT007605	Mast/stem cell growth factor receptor Kit	3815	reviewed	Kinase
P10809	BXGT007617	60 kDa heat shock protein, mitochondrial	3329	reviewed
P10909	BXGT007630	Clusterin	1191	reviewed
P11215	BXGT007672	Integrin alpha-M	3684	reviewed
P11274	BXGT007681	Breakpoint cluster region protein	613	reviewed	Enzyme modulator
P11308	BXGT007684	Transcriptional regulator ERG	2078	reviewed	Transcription factor
P11362	BXGT007693	Fibroblast growth factor receptor 1	2260	reviewed	Kinase
P11511	BXGT007717	Aromatase	1588	reviewed	Enzyme
P11586	BXGT007723	C-1-tetrahydrofolate synthase, cytoplasmic	4522	reviewed	Enzyme
P13236	BXGT007891	C-C motif chemokine 4	6351	reviewed
P13500	BXGT007916	C-C motif chemokine 2	6347	reviewed	Signaling
P14625	BXGT008029	Endoplasmin	7184	reviewed	Chaperone
P14735	BXGT008042	Insulin-degrading enzyme	3416	reviewed	Enzyme
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P14902	BXGT008065	Indoleamine 2,3-dioxygenase 1	3620	reviewed
P15036	BXGT008073	Protein C-ets-2	2114	reviewed	Transcription factor
P15289	BXGT008102	Arylsulfatase A	410	reviewed	Enzyme
P15382	BXGT008116	Potassium voltage-gated channel subfamily E member 1	3753	reviewed	Ion channel
P15529	BXGT008134	Membrane cofactor protein	4179	reviewed
P15531	BXGT008136	Nucleoside diphosphate kinase A	4830	reviewed	Kinase
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P16152	BXGT008201	Carbonyl reductase [NADPH] 1	873	reviewed
P16157	BXGT008203	Ankyrin-1	286	reviewed
P16220	BXGT008206	Cyclic AMP-responsive element-binding protein 1	1385	reviewed
P16473	BXGT008234	Thyrotropin receptor	7253	reviewed	G-protein coupled receptor
P17643	BXGT008323	5,6-dihydroxyindole-2-carboxylic acid oxidase	7306	reviewed	Enzyme
P17787	BXGT008341	Neuronal acetylcholine receptor subunit beta-2	1141	reviewed	Ion channel
P17948	BXGT008358	Vascular endothelial growth factor receptor 1	2321	reviewed	Kinase
P18074	BXGT008374	General transcription and DNA repair factor IIH helicase subunit XPD	2068	reviewed	Enzyme
P18089	BXGT008379	Alpha-2B adrenergic receptor	151	reviewed	G-protein coupled receptor
P18887	BXGT008437	DNA repair protein XRCC1	7515	reviewed
P19438	BXGT008480	Tumor necrosis factor receptor superfamily member 1A	7132	reviewed
P19544	BXGT008494	Wilms tumor protein	7490	reviewed	Nucleic acid binding
P19838	BXGT008526	Nuclear factor NF-kappa-B p105 subunit	4790	reviewed	Transcription factor
P20062	BXGT008543	Transcobalamin-2	6948	reviewed
P20132	BXGT008546	L-serine dehydratase/L-threonine deaminase	10993	reviewed	Enzyme
P20338	BXGT008564	Ras-related protein Rab-4A	5867	reviewed
P20339	BXGT008565	Ras-related protein Rab-5A	5868	reviewed
P20591	BXGT008586	Interferon-induced GTP-binding protein Mx1	4599	reviewed	Enzyme modulator
P20701	BXGT008591	Integrin alpha-L	3683	reviewed
P20813	BXGT008603	Cytochrome P450 2B6	1555	reviewed
P20933	BXGT008618	N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	175	reviewed	Enzyme
P21333	BXGT008638	Filamin-A	2316	reviewed
P21397	BXGT008644	Amine oxidase [flavin-containing] A	4128	reviewed
P21399	BXGT008646	Cytoplasmic aconitate hydratase	48	reviewed	Enzyme
P21554	BXGT008662	Cannabinoid receptor 1	1268	reviewed	G-protein coupled receptor
P21579	BXGT008665	Synaptotagmin-1	6857	reviewed	Transporter
P21589	BXGT008669	5'-nucleotidase	4907	reviewed	Enzyme
P21917	BXGT008707	D(4) dopamine receptor	1815	reviewed	G-protein coupled receptor
P21964	BXGT008714	Catechol O-methyltransferase	1312	reviewed	Enzyme
P21980	BXGT008715	Protein-glutamine gamma-glutamyltransferase 2	7052	reviewed	Enzyme
P22001	BXGT008716	Potassium voltage-gated channel subfamily A member 3	3738	reviewed	Ion channel
P22102	BXGT008731	Trifunctional purine biosynthetic protein adenosine-3	2618	reviewed	Enzyme
P22352	BXGT008758	Glutathione peroxidase 3	2878	reviewed	Enzyme
P22607	BXGT008784	Fibroblast growth factor receptor 3	2261	reviewed	Kinase
P22626	BXGT008787	Heterogeneous nuclear ribonucleoproteins A2/B1	3181	reviewed
P22749	BXGT008803	Granulysin	10578	reviewed
P22897	BXGT008816	Macrophage mannose receptor 1	4360	reviewed
P23246	BXGT008840	Splicing factor, proline- and glutamine-rich	6421	reviewed	Nucleic acid binding
P23297	BXGT008848	Protein S100-A1	6271	reviewed	Calcium-binding protein
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P24298	BXGT008960	Alanine aminotransferase 1	2875	reviewed	Enzyme
P24385	BXGT008965	G1/S-specific cyclin-D1	595	reviewed	Enzyme modulator
P24530	BXGT008975	Endothelin receptor type B	1910	reviewed	G-protein coupled receptor
P24855	BXGT008998	Deoxyribonuclease-1	1773	reviewed
P25101	BXGT009018	Endothelin-1 receptor	1909	reviewed	G-protein coupled receptor
P25311	BXGT009036	Zinc-alpha-2-glycoprotein	563	reviewed
P25440	BXGT009044	Bromodomain-containing protein 2	6046	reviewed	Epigenetic regulator
P26358	BXGT009104	DNA (cytosine-5)-methyltransferase 1	1786	reviewed	Epigenetic regulator
P27169	BXGT009161	Serum paraoxonase/arylesterase 1	5444	reviewed
P27540	BXGT009190	Aryl hydrocarbon receptor nuclear translocator	405	reviewed	Transcription factor
P27695	BXGT009199	DNA-(apurinic or apyrimidinic site) lyase	328	reviewed
P27707	BXGT009201	Deoxycytidine kinase	1633	reviewed	Kinase
P28066	BXGT009227	Proteasome subunit alpha type-5	5686	reviewed
P28161	BXGT009234	Glutathione S-transferase Mu 2	2946	reviewed
P28329	BXGT009251	Choline O-acetyltransferase	1103	reviewed	Enzyme
P28907	BXGT009301	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	952	reviewed	Enzyme
P29033	BXGT009308	Gap junction beta-2 protein	2706	reviewed	Cell-cell junction
P29074	BXGT009313	Tyrosine-protein phosphatase non-receptor type 4	5775	reviewed
P29466	BXGT009349	Caspase-1	834	reviewed	Enzyme
P29474	BXGT009352	Nitric oxide synthase, endothelial	4846	reviewed
P30041	BXGT009393	Peroxiredoxin-6	9588	reviewed	Enzyme
P30556	BXGT009441	Type-1 angiotensin II receptor	185	reviewed	G-protein coupled receptor
P31327	BXGT009523	Carbamoyl-phosphate synthase [ammonia], mitochondrial	1373	reviewed	Enzyme
P31391	BXGT009535	Somatostatin receptor type 4	6754	reviewed	G-protein coupled receptor
P31645	BXGT009558	Sodium-dependent serotonin transporter	6532	reviewed	Transporter
P31749	BXGT009574	RAC-alpha serine/threonine-protein kinase	207	reviewed	Kinase
P31948	BXGT009590	Stress-induced-phosphoprotein 1	10963	reviewed
P32119	BXGT009600	Peroxiredoxin-2	7001	reviewed	Enzyme
P32241	BXGT009613	Vasoactive intestinal polypeptide receptor 1	7433	reviewed	G-protein coupled receptor
P32297	BXGT009616	Neuronal acetylcholine receptor subunit alpha-3	1136	reviewed	Ion channel
P32320	BXGT009622	Cytidine deaminase	978	reviewed	Enzyme
P34896	BXGT009767	Serine hydroxymethyltransferase, cytosolic	6470	reviewed	Enzyme
P34897	BXGT009768	Serine hydroxymethyltransferase, mitochondrial	6472	reviewed	Enzyme
P34932	BXGT009772	Heat shock 70 kDa protein 4	3308	reviewed
P35222	BXGT009799	Catenin beta-1	1499	reviewed
P35228	BXGT009800	Nitric oxide synthase, inducible	4843	reviewed
P35348	BXGT009814	Alpha-1A adrenergic receptor	148	reviewed	G-protein coupled receptor
P35354	BXGT009816	Prostaglandin G/H synthase 2	5743	reviewed	Enzyme
P35520	BXGT009842	Cystathionine beta-synthase	875	reviewed
P35610	BXGT009855	Sterol O-acyltransferase 1	6646	reviewed	Enzyme
P36551	BXGT009927	Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial	1371	reviewed	Enzyme
P36888	BXGT009938	Receptor-type tyrosine-protein kinase FLT3	2322	reviewed	Kinase
P37840	BXGT010015	Alpha-synuclein	6622	reviewed	Transporter
P38936	BXGT010074	Cyclin-dependent kinase inhibitor 1	1026	reviewed
P39019	BXGT010082	40S ribosomal protein S19	6223	reviewed	Nucleic acid binding
P39060	BXGT010088	Collagen alpha-1(XVIII) chain	80781	reviewed
P39086	BXGT010093	Glutamate receptor ionotropic, kainate 1	2897	reviewed	Ion channel
P40763	BXGT010202	Signal transducer and activator of transcription 3	6774	reviewed	Nucleic acid binding
P40933	BXGT010209	Interleukin-15	3600	reviewed
P41182	BXGT010231	B-cell lymphoma 6 protein	604	reviewed
P41212	BXGT010235	Transcription factor ETV6	2120	reviewed	Transcription factor
P41440	BXGT010261	Folate transporter 1	6573	reviewed	Transporter
P41597	BXGT010268	C-C chemokine receptor type 2	729230	reviewed
P42224	BXGT010286	Signal transducer and activator of transcription 1-alpha/beta	6772	reviewed	Nucleic acid binding
P42345	BXGT010304	Serine/threonine-protein kinase mTOR	2475	reviewed	Kinase
P42574	BXGT010317	Caspase-3	836	reviewed	Enzyme
P42898	BXGT010344	Methylenetetrahydrofolate reductase	4524	reviewed
P43354	BXGT010381	Nuclear receptor subfamily 4 group A member 2	4929	reviewed	Nuclear receptor
P43681	BXGT010407	Neuronal acetylcholine receptor subunit alpha-4	1137	reviewed	Ion channel
P45379	BXGT010459	Troponin T, cardiac muscle	7139	reviewed	Cellular structure
P45381	BXGT010460	Aspartoacylase	443	reviewed
P45974	BXGT010493	Ubiquitin carboxyl-terminal hydrolase 5	8078	reviewed	Enzyme
P46527	BXGT010525	Cyclin-dependent kinase inhibitor 1B	1027	reviewed
P46663	BXGT010531	B1 bradykinin receptor	623	reviewed	G-protein coupled receptor
P46939	BXGT010555	Utrophin	7402	reviewed
P48051	BXGT010611	G protein-activated inward rectifier potassium channel 2	3763	reviewed	Ion channel
P48426	BXGT010630	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	5305	reviewed	Kinase
P48551	BXGT010645	Interferon alpha/beta receptor 2	3455	reviewed	Receptor
P48723	BXGT010653	Heat shock 70 kDa protein 13	6782	reviewed
P49286	BXGT010691	Melatonin receptor type 1B	4544	reviewed	G-protein coupled receptor
P49418	BXGT010704	Amphiphysin	273	reviewed
P49585	BXGT010712	Choline-phosphate cytidylyltransferase A	5130	reviewed
P49763	BXGT010737	Placenta growth factor	5228	reviewed	Signaling
P49768	BXGT010740	Presenilin-1	5663	reviewed	Enzyme
P49773	BXGT010741	Histidine triad nucleotide-binding protein 1	3094	reviewed	Enzyme
P49810	BXGT010747	Presenilin-2	5664	reviewed	Enzyme
P49913	BXGT010761	Cathelicidin antimicrobial peptide	820	reviewed
P50135	BXGT010776	Histamine N-methyltransferase	3176	reviewed
P50591	BXGT010814	Tumor necrosis factor ligand superfamily member 10	8743	reviewed	Signaling
P50747	BXGT010817	Biotin--protein ligase	3141	reviewed	Enzyme
P51681	BXGT010878	C-C chemokine receptor type 5	1234	reviewed	G-protein coupled receptor
P52209	BXGT010923	6-phosphogluconate dehydrogenase, decarboxylating	5226	reviewed	Enzyme
P52333	BXGT010928	Tyrosine-protein kinase JAK3	3718	reviewed	Kinase
P52952	BXGT010966	Homeobox protein Nkx-2.5	1482	reviewed	Transcription factor
P53779	BXGT011014	Mitogen-activated protein kinase 10	5602	reviewed	Kinase
P55087	BXGT011105	Aquaporin-4	361	reviewed	Ion channel
P55265	BXGT011117	Double-stranded RNA-specific adenosine deaminase	103	reviewed	Enzyme
P56181	BXGT011148	NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial	4731	reviewed
P56817	BXGT011200	Beta-secretase 1	23621	reviewed	Enzyme
P56945	BXGT011206	Breast cancer anti-estrogen resistance protein 1	9564	reviewed
P60568	BXGT011315	Interleukin-2	3558	reviewed
P60709	BXGT011322	Actin, cytoplasmic 1	60	reviewed	Cellular structure
P60880	BXGT011335	Synaptosomal-associated protein 25	6616	reviewed	Transporter
P61160	BXGT011365	Actin-related protein 2	10097	reviewed	Cellular structure
P61981	BXGT011400	14-3-3 protein gamma	7532	reviewed	Chaperone
P63244	BXGT011510	Receptor of activated protein C kinase 1	10399	reviewed
P67775	BXGT011563	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	5515	reviewed
P68104	BXGT011575	Elongation factor 1-alpha 1	1915	reviewed	Enzyme
P98164	BXGT012230	Low-density lipoprotein receptor-related protein 2	4036	reviewed
Q00059	BXGT012512	Transcription factor A, mitochondrial	7019	reviewed
Q00534	BXGT012533	Cyclin-dependent kinase 6	1021	reviewed	Kinase
Q00987	BXGT012559	E3 ubiquitin-protein ligase Mdm2	4193	reviewed	Nucleic acid binding
Q01081	BXGT012566	Splicing factor U2AF 35 kDa subunit	7307	reviewed
Q01094	BXGT012568	Transcription factor E2F1	1869	reviewed	Nucleic acid binding
Q01105	BXGT012569	Protein SET	6418	reviewed	Enzyme modulator
Q01196	BXGT012575	Runt-related transcription factor 1	861	reviewed	Transcription factor
Q01469	BXGT012590	Fatty acid-binding protein 5	2171	reviewed
Q03164	BXGT012700	Histone-lysine N-methyltransferase 2A	4297	reviewed
Q04206	BXGT012754	Transcription factor p65	5970	reviewed	Transcription factor
Q04771	BXGT012783	Activin receptor type-1	90	reviewed	Kinase
Q06124	BXGT012856	Tyrosine-protein phosphatase non-receptor type 11	5781	reviewed
Q06710	BXGT012887	Paired box protein Pax-8	7849	reviewed
Q06787	BXGT012890	Synaptic functional regulator FMR1	2332	reviewed	Nucleic acid binding
Q06830	BXGT012894	Peroxiredoxin-1	5052	reviewed	Enzyme
Q07343	BXGT012926	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	5142	reviewed
Q07812	BXGT012940	Apoptosis regulator BAX	581	reviewed	Signaling
Q07817	BXGT012941	Bcl-2-like protein 1	598	reviewed	Signaling
Q08334	BXGT012981	Interleukin-10 receptor subunit beta	3588	reviewed	Receptor
Q08493	BXGT012987	cAMP-specific 3',5'-cyclic phosphodiesterase 4C	5143	reviewed
Q10589	BXGT013203	Bone marrow stromal antigen 2	684	reviewed
Q13009	BXGT013305	T-lymphoma invasion and metastasis-inducing protein 1	7074	reviewed
Q13075	BXGT013308	Baculoviral IAP repeat-containing protein 1	4671	reviewed
Q13148	BXGT013318	TAR DNA-binding protein 43	23435	reviewed
Q13153	BXGT013319	Serine/threonine-protein kinase PAK 1	5058	reviewed	Kinase
Q13219	BXGT013327	Pappalysin-1	5069	reviewed
Q13501	BXGT013365	Sequestosome-1	8878	reviewed
Q13509	BXGT013366	Tubulin beta-3 chain	10381	reviewed	Cellular structure
Q13627	BXGT013385	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	1859	reviewed	Kinase
Q14149	BXGT013449	MORC family CW-type zinc finger protein 3	23515	reviewed
Q14195	BXGT013453	Dihydropyrimidinase-related protein 3	1809	reviewed	Enzyme
Q14232	BXGT013457	Translation initiation factor eIF-2B subunit alpha	1967	reviewed
Q15561	BXGT013578	Transcriptional enhancer factor TEF-3	7004	reviewed	Transcription factor
Q15811	BXGT013600	Intersectin-1	6453	reviewed	Enzyme modulator
Q15848	BXGT013609	Adiponectin	9370	reviewed
Q15910	BXGT013612	Histone-lysine N-methyltransferase EZH2	2146	reviewed	Epigenetic regulator
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	4780	reviewed	Enzyme
Q16555	BXGT013638	Dihydropyrimidinase-related protein 2	1808	reviewed	Enzyme
Q16658	BXGT013651	Fascin	6624	reviewed	Cellular structure
Q53H47	BXGT015014	Histone-lysine N-methyltransferase SETMAR	6419	reviewed	Epigenetic regulator
Q6N021	BXGT016378	Methylcytosine dioxygenase TET2	54790	reviewed
Q7L5Y1	BXGT016996	Mitochondrial enolase superfamily member 1	55556	reviewed	Enzyme
Q7Z7C8	BXGT017261	Transcription initiation factor TFIID subunit 8	129685	reviewed
Q86XF0	BXGT017629	Dihydrofolate reductase 2, mitochondrial	200895	reviewed	Enzyme
Q8IVA8	BXGT018342	Glutamate decarboxylase 1 (Brain, 67kDa)	2571	unreviewed
Q8TBC4	BXGT018789	NEDD8-activating enzyme E1 catalytic subunit	9039	reviewed	Enzyme
Q8WZ42	BXGT019023	Titin	7273	reviewed	Kinase
Q92731	BXGT019366	Estrogen receptor beta	2100	reviewed	Nuclear receptor
Q92736	BXGT019367	Ryanodine receptor 2	6262	reviewed	Ion channel
Q92835	BXGT019382	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1	3635	reviewed
Q93009	BXGT019455	Ubiquitin carboxyl-terminal hydrolase 7	7874	reviewed	Enzyme
Q93088	BXGT019458	Betaine--homocysteine S-methyltransferase 1	635	reviewed
Q96AZ6	BXGT019621	Interferon-stimulated gene 20 kDa protein	3669	reviewed
Q96BI3	BXGT019623	Gamma-secretase subunit APH-1A	51107	reviewed	Enzyme modulator
Q96L92	BXGT019690	Sorting nexin-27	81609	reviewed
Q99259	BXGT019915	Glutamate decarboxylase 1	2571	reviewed	Enzyme
Q99558	BXGT019934	Mitogen-activated protein kinase kinase kinase 14	9020	reviewed	Kinase
Q99707	BXGT019952	Methionine synthase	4548	reviewed
Q99712	BXGT019953	ATP-sensitive inward rectifier potassium channel 15	3772	reviewed	Ion channel
Q99714	BXGT019954	3-hydroxyacyl-CoA dehydrogenase type-2	3028	reviewed	Enzyme
Q99784	BXGT019961	Noelin	10439	reviewed	Cellular structure
Q99814	BXGT019965	Endothelial PAS domain-containing protein 1	2034	reviewed	Transcription factor
Q99828	BXGT019967	Calcium and integrin-binding protein 1	10519	reviewed
Q99836	BXGT019970	Myeloid differentiation primary response protein MyD88	4615	reviewed	Enzyme modulator
Q9BT78	BXGT020125	COP9 signalosome complex subunit 4	51138	reviewed
Q9GZX6	BXGT020428	Interleukin-22	50616	reviewed
Q9H0P0	BXGT020439	Cytosolic 5'-nucleotidase 3A	51251	reviewed	Enzyme
Q9H2X9	BXGT020459	Solute carrier family 12 member 5	57468	reviewed	Transporter
Q9H4A3	BXGT020473	Serine/threonine-protein kinase WNK1	65125	reviewed	Kinase
Q9HC29	BXGT020526	Nucleotide-binding oligomerization domain-containing protein 2	64127	reviewed	Enzyme
Q9NQW7	BXGT021171	Xaa-Pro aminopeptidase 1	7511	reviewed
Q9NSI6	BXGT021208	Bromodomain and WD repeat-containing protein 1	54014	reviewed
Q9NWB1	BXGT021231	RNA binding protein fox-1 homolog 1	54715	reviewed	Nucleic acid binding
Q9NZJ5	BXGT021275	Eukaryotic translation initiation factor 2-alpha kinase 3	9451	reviewed	Kinase
Q9P0L2	BXGT021289	Serine/threonine-protein kinase MARK1	4139	reviewed	Kinase
Q9P2R7	BXGT021304	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	8803	reviewed	Enzyme
Q9P2W7	BXGT021306	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1	27087	reviewed	Enzyme
Q9UBC3	BXGT021650	DNA (cytosine-5)-methyltransferase 3B	1789	reviewed
Q9UBK8	BXGT021655	Methionine synthase reductase	4552	reviewed
Q9UH17	BXGT021691	DNA dC->dU-editing enzyme APOBEC-3B	9582	reviewed	Enzyme
Q9UHI8	BXGT021701	A disintegrin and metalloproteinase with thrombospondin motifs 1	9510	reviewed	Enzyme
Q9UHV8	BXGT021706	Galactoside-binding soluble lectin 13	29124	reviewed	Signaling
Q9UI95	BXGT021714	Mitotic spindle assembly checkpoint protein MAD2B	10459	reviewed
Q9UIK4	BXGT021720	Death-associated protein kinase 2	23604	reviewed	Kinase
Q9UIV1	BXGT021722	CCR4-NOT transcription complex subunit 7	29883	reviewed	Transcription factor
Q9UJW3	BXGT021732	DNA (cytosine-5)-methyltransferase 3-like	29947	reviewed
Q9UNK4	BXGT021789	Group IID secretory phospholipase A2	26279	reviewed	Enzyme
Q9UNQ0	BXGT021792	ATP-binding cassette sub-family G member 2	9429	reviewed	Transporter
Q9UPY3	BXGT021802	Endoribonuclease Dicer	23405	reviewed	Enzyme
Q9Y5Z0	BXGT022310	Beta-secretase 2	25825	reviewed	Enzyme
Q9Y6K1	BXGT022331	DNA (cytosine-5)-methyltransferase 3A	1788	reviewed
P04439	BXGT022649	HLA class I histocompatibility antigen, A-3 alpha chain	3105	reviewed
P00738	BXGT022874	Haptoglobin	3240	reviewed	Enzyme
Q9UKG1	BXGT022975	DCC-interacting protein 13-alpha	26060	reviewed
Q7Z4S6	BXGT023001	Kinesin-like protein KIF21A	55605	reviewed	Cellular structure
Q01955	BXGT023255	Collagen alpha-3(IV) chain	1285	reviewed
Q16552	BXGT023419	Interleukin-17A	3605	reviewed
Q9BQQ3	BXGT024065	Golgi reassembly-stacking protein 1	64689	reviewed
Q9UHP3	BXGT024139	Ubiquitin carboxyl-terminal hydrolase 25	29761	reviewed	Enzyme
P29590	BXGT024350	Protein PML	5371	reviewed
O43583	BXGT024866	Density-regulated protein	8562	reviewed	Enzyme
Q13635	BXGT024910	Protein patched homolog 1	5727	reviewed
P51608	BXGT025073	Methyl-CpG-binding protein 2	4204	reviewed	Epigenetic regulator
Q05086	BXGT025648	Ubiquitin-protein ligase E3A	7337	reviewed
Q9NVA2	BXGT025757	Septin-11	55752	reviewed	Enzyme modulator
P35251	BXGT025853	Replication factor C subunit 1	5981	reviewed
Q9UKU9	BXGT025985	Angiopoietin-related protein 2	23452	reviewed	Signaling
Q13564	BXGT026096	NEDD8-activating enzyme E1 regulatory subunit	8883	reviewed	Enzyme

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}