Showing entry for Dual specificity protein phosphatase 16


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT020184
Protein NameDual specificity protein phosphatase 16
Uniport IdQ9BY84
GeneDUSP16
Gene Id80824
DomainDSPc; Rhodanese
Pfam PF00782   PF00581  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04010 MAPK signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0016311 dephosphorylation
Biological Process GO:0000188 inactivation of MAPK activity
Biological Process GO:0045204 MAPK export from nucleus
Biological Process GO:0045209 MAPK phosphatase export from nucleus, leptomycin B sensitive
Biological Process GO:0035970 peptidyl-threonine dephosphorylation
Biological Process GO:0035335 peptidyl-tyrosine dephosphorylation
Biological Process GO:0006470 protein dephosphorylation
molecular function GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity
molecular function GO:0051019 mitogen-activated protein kinase binding
molecular function GO:0016791 phosphatase activity
molecular function GO:0004721 phosphoprotein phosphatase activity
molecular function GO:0008138 protein tyrosine/serine/threonine phosphatase activity
molecular function GO:0008330 protein tyrosine/threonine phosphatase activity
molecular function GO:0004725 protein tyrosine phosphatase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0031410 cytoplasmic vesicle
cellular component GO:0005829 cytosol
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-112409 RAF-independent MAPK1/3 activation
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-168256 Immune System
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
R-HSA-5663205 Infectious disease
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-5675221 Negative regulation of MAPK pathway
R-HSA-5683057 MAPK family signaling cascades
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-6802957 Oncogenic MAPK signaling
R-HSA-9607240 FLT3 Signaling
R-HSA-9635486 Infection with Mycobacterium tuberculosis
R-HSA-9636569 Suppression of autophagy
R-HSA-9637690 Response of Mtb to phagocytosis
R-HSA-9652817 Signaling by MAPK mutants
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006413 BXGD000397 Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007787 BXGD000487 Transient Ischemic Attack Nervous System Diseases; Cardiovascular Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0278764 BXGD006581 Adult Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0278879 BXGD006610 Childhood Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0871470 BXGD011316 Systolic Pressure
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C4546092 BXGD023293 Congenital obstructive hydrocephalus Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein