adisease

Showing entry for Systolic Pressure

General Disease Information
BXGD Id	BXGD011316
Disease Name	Systolic Pressure
Disease CUI Id	C0871470
MeSH Codes
Disease Class Name
Semantic Type	Clinical Attribute
Human Phenotype Ontology Id
Human Phenotype Ontology Term
Disease Ontology Id
Disease Ontology Class Name
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00238	BXGT003900	Bone morphogenetic protein receptor type-1B	658	reviewed	Kinase
O00337	BXGT003911	Sodium/nucleoside cotransporter 1	9154	reviewed	Transporter
O00443	BXGT003920	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	5286	reviewed	Kinase
O14980	BXGT004119	Exportin-1	7514	reviewed	Receptor
O15123	BXGT004130	Angiopoietin-2	285	reviewed	Signaling
O15151	BXGT004132	Protein Mdm4	4194	reviewed	Nucleic acid binding
O15409	BXGT004166	Forkhead box protein P2	93986	reviewed
O43169	BXGT004573	Cytochrome b5 type B	80777	reviewed	Enzyme
O43678	BXGT004613	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2	4695	reviewed	Enzyme
O60218	BXGT004858	Aldo-keto reductase family 1 member B10	57016	reviewed	Enzyme
O60427	BXGT004875	Acyl-CoA (8-3)-desaturase	3992	reviewed
O60658	BXGT004890	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	5151	reviewed
O60885	BXGT004906	Bromodomain-containing protein 4	23476	reviewed	Epigenetic regulator
O75129	BXGT005101	Astrotactin-2	23245	reviewed
O76074	BXGT005174	cGMP-specific 3',5'-cyclic phosphodiesterase	8654	reviewed
O94788	BXGT005333	Retinal dehydrogenase 2	8854	reviewed	Enzyme
O94806	BXGT005335	Serine/threonine-protein kinase D3	23683	reviewed	Kinase
O94921	BXGT005341	Cyclin-dependent kinase 14	5218	reviewed	Kinase
O95271	BXGT005369	Poly [ADP-ribose] polymerase tankyrase-1	8658	reviewed
O95696	BXGT005390	Bromodomain-containing protein 1	23774	reviewed
O95864	BXGT005403	Acyl-CoA 6-desaturase	9415	reviewed
P00325	BXGT005498	Alcohol dehydrogenase 1B	125	reviewed	Enzyme
P00797	BXGT005658	Renin	5972	reviewed	Enzyme
P01009	BXGT005714	Alpha-1-antitrypsin	5265	reviewed	Enzyme modulator
P01019	BXGT005717	Angiotensinogen	183	reviewed	Enzyme modulator
P01138	BXGT005738	Beta-nerve growth factor	4803	reviewed	Signaling
P02647	BXGT005908	Apolipoprotein A-I	335	reviewed
P02649	BXGT005909	Apolipoprotein E	348	reviewed
P02749	BXGT005941	Beta-2-glycoprotein 1	350	reviewed
P02751	BXGT005943	Fibronectin	2335	reviewed	Signaling
P03372	BXGT006059	Estrogen receptor	2099	reviewed	Nuclear receptor
P05026	BXGT006296	Sodium/potassium-transporting ATPase subunit beta-1	481	reviewed	Transporter
P05093	BXGT006313	Steroid 17-alpha-hydroxylase/17,20 lyase	1586	reviewed
P06213	BXGT006425	Insulin receptor	3643	reviewed	Kinase
P06241	BXGT006429	Tyrosine-protein kinase Fyn	2534	reviewed	Kinase
P07332	BXGT006601	Tyrosine-protein kinase Fes/Fps	2242	reviewed	Kinase
P07947	BXGT006701	Tyrosine-protein kinase Yes	7525	reviewed	Kinase
P07948	BXGT006702	Tyrosine-protein kinase Lyn	4067	reviewed	Kinase
P08588	BXGT006795	Beta-1 adrenergic receptor	153	reviewed	G-protein coupled receptor
P08686	BXGT006813	Steroid 21-hydroxylase	1589	reviewed
P09172	BXGT006865	Dopamine beta-hydroxylase	1621	reviewed
P09769	BXGT006917	Tyrosine-protein kinase Fgr	2268	reviewed	Kinase
P09958	BXGT006950	Furin	5045	reviewed	Enzyme
P10301	BXGT007556	Ras-related protein R-Ras	6237	reviewed	Enzyme modulator
P10415	BXGT007567	Apoptosis regulator Bcl-2	596	reviewed	Signaling
P10636	BXGT007596	Microtubule-associated protein tau	4137	reviewed
P12821	BXGT007849	Angiotensin-converting enzyme	1636	reviewed	Enzyme
P12955	BXGT007865	Xaa-Pro dipeptidase	5184	reviewed	Enzyme
P14672	BXGT008037	Solute carrier family 2, facilitated glucose transporter member 4	6517	reviewed	Transporter
P15884	BXGT008166	Transcription factor 4	6925	reviewed	Transcription factor
P16066	BXGT008185	Atrial natriuretic peptide receptor 1	4881	reviewed	Kinase
P16220	BXGT008206	Cyclic AMP-responsive element-binding protein 1	1385	reviewed
P16591	BXGT008246	Tyrosine-protein kinase Fer	2241	reviewed	Kinase
P16662	BXGT008253	UDP-glucuronosyltransferase 2B7	7364	reviewed
P17252	BXGT008294	Protein kinase C alpha type	5578	reviewed	Kinase
P17342	BXGT008302	Atrial natriuretic peptide receptor 3	4883	reviewed
P17844	BXGT008346	Probable ATP-dependent RNA helicase DDX5	1655	reviewed
P18206	BXGT008389	Vinculin	7414	reviewed
P18754	BXGT008423	Regulator of chromosome condensation	1104	reviewed
P18846	BXGT008430	Cyclic AMP-dependent transcription factor ATF-1	466	reviewed
P19099	BXGT008456	Cytochrome P450 11B2, mitochondrial	1585	reviewed
P19174	BXGT008467	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	5335	reviewed	Enzyme
P19544	BXGT008494	Wilms tumor protein	7490	reviewed	Nucleic acid binding
P21579	BXGT008665	Synaptotagmin-1	6857	reviewed	Transporter
P21964	BXGT008714	Catechol O-methyltransferase	1312	reviewed	Enzyme
P23468	BXGT008870	Receptor-type tyrosine-protein phosphatase delta	5789	reviewed	Enzyme
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P24557	BXGT008976	Thromboxane-A synthase	6916	reviewed
P25101	BXGT009018	Endothelin-1 receptor	1909	reviewed	G-protein coupled receptor
P25786	BXGT009068	Proteasome subunit alpha type-1	5682	reviewed
P25963	BXGT009080	NF-kappa-B inhibitor alpha	4792	reviewed
P26358	BXGT009104	DNA (cytosine-5)-methyltransferase 1	1786	reviewed	Epigenetic regulator
P27037	BXGT009153	Activin receptor type-2A	92	reviewed	Kinase
P27448	BXGT009183	MAP/microtubule affinity-regulating kinase 3	4140	reviewed	Kinase
P27816	BXGT009209	Microtubule-associated protein 4	4134	reviewed
P29375	BXGT009338	Lysine-specific demethylase 5A	5927	reviewed
P29474	BXGT009352	Nitric oxide synthase, endothelial	4846	reviewed
P30279	BXGT009415	G1/S-specific cyclin-D2	894	reviewed	Enzyme modulator
P30419	BXGT009426	Glycylpeptide N-tetradecanoyltransferase 1	4836	reviewed	Enzyme
P30542	BXGT009436	Adenosine receptor A1	134	reviewed	G-protein coupled receptor
P30825	BXGT009469	High affinity cationic amino acid transporter 1	6541	reviewed	Transporter
P31152	BXGT009511	Mitogen-activated protein kinase 4	5596	reviewed	Kinase
P31327	BXGT009523	Carbamoyl-phosphate synthase [ammonia], mitochondrial	1373	reviewed	Enzyme
P32418	BXGT009635	Sodium/calcium exchanger 1	6546	reviewed	Transporter
P33261	BXGT009707	Cytochrome P450 2C19	1557	reviewed
P35367	BXGT009821	Histamine H1 receptor	3269	reviewed	G-protein coupled receptor
P35555	BXGT009845	Fibrillin-1	2200	reviewed	Calcium-binding protein
P35557	BXGT009846	Glucokinase	2645	reviewed	Kinase
P41146	BXGT010226	Nociceptin receptor	4987	reviewed	G-protein coupled receptor
P41240	BXGT010242	Tyrosine-protein kinase CSK	1445	reviewed	Kinase
P42898	BXGT010344	Methylenetetrahydrofolate reductase	4524	reviewed
P43351	BXGT010380	DNA repair protein RAD52 homolog	5893	reviewed	Nucleic acid binding
P46108	BXGT010509	Adapter molecule crk	1398	reviewed
P46527	BXGT010525	Cyclin-dependent kinase inhibitor 1B	1027	reviewed
P48546	BXGT010642	Gastric inhibitory polypeptide receptor	2696	reviewed	G-protein coupled receptor
P49789	BXGT010742	Bis(5'-adenosyl)-triphosphatase	2272	reviewed
P49795	BXGT010744	Regulator of G-protein signaling 19	10287	reviewed	Enzyme modulator
P49902	BXGT010758	Cytosolic purine 5'-nucleotidase	22978	reviewed	Enzyme
P51787	BXGT010889	Potassium voltage-gated channel subfamily KQT member 1	3784	reviewed	Ion channel
P54619	BXGT011060	5'-AMP-activated protein kinase subunit gamma-1	5571	reviewed	Kinase
P54707	BXGT011068	Potassium-transporting ATPase alpha chain 2	479	reviewed	Transporter
P55040	BXGT011099	GTP-binding protein GEM	2669	reviewed
P55263	BXGT011115	Adenosine kinase	132	reviewed	Kinase
P58400	BXGT011235	Neurexin-1-beta	9378	reviewed
P60484	BXGT011307	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	5728	reviewed	Enzyme
P63000	BXGT011481	Ras-related C3 botulinum toxin substrate 1	5879	reviewed	Enzyme modulator
P63279	BXGT011514	SUMO-conjugating enzyme UBC9	7329	reviewed
P82279	BXGT011972	Protein crumbs homolog 1	23418	reviewed
P98164	BXGT012230	Low-density lipoprotein receptor-related protein 2	4036	reviewed
Q00532	BXGT012532	Cyclin-dependent kinase-like 1	8814	reviewed	Kinase
Q00534	BXGT012533	Cyclin-dependent kinase 6	1021	reviewed	Kinase
Q01668	BXGT012605	Voltage-dependent L-type calcium channel subunit alpha-1D	776	reviewed	Ion channel
Q01970	BXGT012627	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	5331	reviewed	Enzyme
Q02108	BXGT012634	Guanylate cyclase soluble subunit alpha-1	2982	reviewed
Q02156	BXGT012639	Protein kinase C epsilon type	5581	reviewed	Kinase
Q03181	BXGT012701	Peroxisome proliferator-activated receptor delta	5467	reviewed	Nuclear receptor
Q04756	BXGT012780	Hepatocyte growth factor activator	3083	reviewed	Enzyme
Q05397	BXGT012815	Focal adhesion kinase 1	5747	reviewed	Kinase
Q06124	BXGT012856	Tyrosine-protein phosphatase non-receptor type 11	5781	reviewed
Q07075	BXGT012917	Glutamyl aminopeptidase	2028	reviewed	Enzyme
Q07820	BXGT012942	Induced myeloid leukemia cell differentiation protein Mcl-1	4170	reviewed	Signaling
Q08289	BXGT012979	Voltage-dependent L-type calcium channel subunit beta-2	783	reviewed	Ion channel
Q12866	BXGT013273	Tyrosine-protein kinase Mer	10461	reviewed	Kinase
Q12874	BXGT013274	Splicing factor 3A subunit 3	10946	reviewed	Nucleic acid binding
Q13188	BXGT013324	Serine/threonine-protein kinase 3	6788	reviewed	Kinase
Q13224	BXGT013328	Glutamate receptor ionotropic, NMDA 2B	2904	reviewed	Ion channel
Q13237	BXGT013331	cGMP-dependent protein kinase 2	5593	reviewed	Kinase
Q13370	BXGT013345	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	5140	reviewed
Q13472	BXGT013360	DNA topoisomerase 3-alpha	7156	reviewed	Enzyme
Q13554	BXGT013374	Calcium/calmodulin-dependent protein kinase type II subunit beta	816	reviewed	Kinase
Q13639	BXGT013389	5-hydroxytryptamine receptor 4	3360	reviewed	G-protein coupled receptor
Q13976	BXGT013409	cGMP-dependent protein kinase 1	5592	reviewed	Kinase
Q14149	BXGT013449	MORC family CW-type zinc finger protein 3	23515	reviewed
Q14397	BXGT013467	Glucokinase regulatory protein	2646	reviewed
Q14432	BXGT013469	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	5139	reviewed
Q14654	BXGT013495	ATP-sensitive inward rectifier potassium channel 11	3767	reviewed	Ion channel
Q14831	BXGT013506	Metabotropic glutamate receptor 7	2917	reviewed	G-protein coupled receptor
Q14982	BXGT013518	Opioid-binding protein/cell adhesion molecule	4978	reviewed
Q15067	BXGT013532	Peroxisomal acyl-coenzyme A oxidase 1	51	reviewed	Enzyme
Q15139	BXGT013546	Serine/threonine-protein kinase D1	5587	reviewed	Kinase
Q15149	BXGT013547	Plectin	5339	reviewed	Cellular structure
Q15303	BXGT013557	Receptor tyrosine-protein kinase erbB-4	2066	reviewed	Kinase
Q15349	BXGT013558	Ribosomal protein S6 kinase alpha-2	6196	reviewed	Kinase
Q15438	BXGT013572	Cytohesin-1	9267	reviewed
Q15599	BXGT013583	Na(+)/H(+) exchange regulatory cofactor NHE-RF2	9351	reviewed
Q15811	BXGT013600	Intersectin-1	6453	reviewed	Enzyme modulator
Q15843	BXGT013608	NEDD8	4738	reviewed	Nucleic acid binding
Q16513	BXGT013632	Serine/threonine-protein kinase N2	5586	reviewed	Kinase
Q16874	BXGT013685	Cytochrome P450 21-hydroxylase	1589	unreviewed
Q30201	BXGT014297	Hereditary hemochromatosis protein	3077	reviewed
Q5TDH0	BXGT015854	Protein DDI1 homolog 2	84301	reviewed	Enzyme
Q63HR2	BXGT016085	Tensin-2	23371	reviewed
Q6IB77	BXGT016325	Glycine N-acyltransferase	10249	reviewed
Q6UX04	BXGT016571	Spliceosome-associated protein CWC27 homolog	10283	reviewed	Enzyme
Q6ZUM4	BXGT016638	Rho GTPase-activating protein 27	201176	reviewed	Enzyme modulator
Q7KZF4	BXGT016989	Staphylococcal nuclease domain-containing protein 1	27044	reviewed	Transcription factor
Q7Z3B3	BXGT017249	KAT8 regulatory NSL complex subunit 1	284058	reviewed
Q86YI8	BXGT017634	PHD finger protein 13	148479	reviewed	Epigenetic regulator
Q8IWB6	BXGT018354	Inactive serine/threonine-protein kinase TEX14	56155	reviewed	Kinase
Q8N807	BXGT018527	Protein disulfide-isomerase-like protein of the testis	204474	reviewed
Q8NEM0	BXGT018555	Microcephalin	79648	reviewed	Nucleic acid binding
Q8TEK3	BXGT018822	Histone-lysine N-methyltransferase, H3 lysine-79 specific	84444	reviewed	Epigenetic regulator
Q8WUI4	BXGT018992	Histone deacetylase 7	51564	reviewed	Epigenetic regulator
Q8WWQ0	BXGT019003	PH-interacting protein	55023	reviewed	Epigenetic regulator
Q8WXF7	BXGT019011	Atlastin-1	51062	reviewed	Enzyme modulator
Q8WZ42	BXGT019023	Titin	7273	reviewed	Kinase
Q92743	BXGT019368	Serine protease HTRA1	5654	reviewed	Enzyme
Q92831	BXGT019380	Histone acetyltransferase KAT2B	8850	reviewed
Q93062	BXGT019456	RNA-binding protein with multiple splicing	11030	reviewed	Nucleic acid binding
Q96AC1	BXGT019617	Fermitin family homolog 2	10979	reviewed
Q96JA1	BXGT019681	Leucine-rich repeats and immunoglobulin-like domains protein 1	26018	reviewed	Receptor
Q96KQ7	BXGT019687	Histone-lysine N-methyltransferase EHMT2	10919	reviewed	Epigenetic regulator
Q96L34	BXGT019689	MAP/microtubule affinity-regulating kinase 4	57787	reviewed	Kinase
Q96PU5	BXGT019711	E3 ubiquitin-protein ligase NEDD4-like	23327	reviewed	Enzyme
Q96QE3	BXGT019718	ATPase family AAA domain-containing protein 5	79915	reviewed
Q96T88	BXGT019747	E3 ubiquitin-protein ligase UHRF1	29128	reviewed
Q99593	BXGT019939	T-box transcription factor TBX5	6910	reviewed	Transcription factor
Q99700	BXGT019949	Ataxin-2	6311	reviewed	Nucleic acid binding
Q9BUL9	BXGT020136	Ribonuclease P protein subunit p25	54913	reviewed	Enzyme
Q9BX66	BXGT020158	Sorbin and SH3 domain-containing protein 1	10580	reviewed
Q9BY84	BXGT020184	Dual specificity protein phosphatase 16	80824	reviewed
Q9BZ95	BXGT020196	Histone-lysine N-methyltransferase NSD3	54904	reviewed	Epigenetic regulator
Q9C0B1	BXGT020209	Alpha-ketoglutarate-dependent dioxygenase FTO	79068	reviewed
Q9H2X6	BXGT020458	Homeodomain-interacting protein kinase 2	28996	reviewed	Kinase
Q9H4B7	BXGT020475	Tubulin beta-1 chain	81027	reviewed	Cellular structure
Q9H8M5	BXGT020496	Metal transporter CNNM2	54805	reviewed
Q9HB21	BXGT020513	Pleckstrin homology domain-containing family A member 1	59338	reviewed	Epigenetic regulator
Q9HCR9	BXGT020537	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	50940	reviewed
Q9NPH5	BXGT021159	NADPH oxidase 4	50507	reviewed	Enzyme
Q9NQV5	BXGT021170	PR domain-containing protein 11	56981	reviewed
Q9NRM7	BXGT021190	Serine/threonine-protein kinase LATS2	26524	reviewed	Kinase
Q9NTK5	BXGT021213	Obg-like ATPase 1	29789	reviewed	Enzyme modulator
Q9NWB1	BXGT021231	RNA binding protein fox-1 homolog 1	54715	reviewed	Nucleic acid binding
Q9NYY3	BXGT021264	Serine/threonine-protein kinase PLK2	10769	reviewed	Kinase
Q9NZ08	BXGT021266	Endoplasmic reticulum aminopeptidase 1	51752	reviewed	Enzyme
Q9NZ09	BXGT021267	Ubiquitin-associated protein 1	51271	reviewed
Q9P212	BXGT021297	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	51196	reviewed	Enzyme
Q9P2K8	BXGT021302	eIF-2-alpha kinase GCN2	440275	reviewed
Q9UBG0	BXGT021654	C-type mannose receptor 2	9902	reviewed
Q9UBT6	BXGT021664	DNA polymerase kappa	51426	reviewed
Q9UF33	BXGT021676	Ephrin type-A receptor 6	285220	reviewed	Kinase
Q9UGJ0	BXGT021683	5'-AMP-activated protein kinase subunit gamma-2	51422	reviewed	Enzyme modulator
Q9UHD8	BXGT021698	Septin-9	10801	reviewed	Enzyme modulator
Q9UJT1	BXGT021729	Tubulin delta chain	51174	reviewed	Cellular structure
Q9UJU2	BXGT021730	Lymphoid enhancer-binding factor 1	51176	reviewed
Q9UM73	BXGT021773	ALK tyrosine kinase receptor	238	reviewed	Kinase
Q9UMR2	BXGT021775	ATP-dependent RNA helicase DDX19B	11269	reviewed
Q9UMX1	BXGT021778	Suppressor of fused homolog	51684	reviewed
Q9Y233	BXGT022210	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	10846	reviewed
Q9Y266	BXGT022221	Nuclear migration protein nudC	10726	reviewed	Cellular structure
Q9Y2K2	BXGT022238	Serine/threonine-protein kinase SIK3	23387	reviewed	Kinase
Q9Y3P9	BXGT022262	Rab GTPase-activating protein 1	23637	reviewed	Enzyme
Q9Y5P4	BXGT022298	Collagen type IV alpha-3-binding protein	10087	reviewed	Transporter
Q9Y694	BXGT022321	Solute carrier family 22 member 7	10864	reviewed	Transporter
Q7Z3S7	BXGT022658	Voltage-dependent calcium channel subunit alpha-2/delta-4	93589	reviewed	Ion channel
P35232	BXGT022663	Prohibitin	5245	reviewed
Q86XP1	BXGT022668	Diacylglycerol kinase eta	160851	reviewed	Kinase
Q86US8	BXGT022850	Telomerase-binding protein EST1A	23293	reviewed
P16284	BXGT022972	Platelet endothelial cell adhesion molecule	5175	reviewed	Cell adhesion
Q9UK05	BXGT023094	Growth/differentiation factor 2	2658	reviewed	Signaling
Q5U651	BXGT023159	Ras-interacting protein 1	54922	reviewed
O00308	BXGT023349	NEDD4-like E3 ubiquitin-protein ligase WWP2	11060	reviewed	Enzyme
Q9ULM3	BXGT023501	YEATS domain-containing protein 2	55689	reviewed	Nucleic acid binding
A9YTQ3	BXGT023537	Aryl hydrocarbon receptor repressor	57491	reviewed	Transcription factor
Q63ZY3	BXGT023544	KN motif and ankyrin repeat domain-containing protein 2	25959	reviewed
P46379	BXGT023748	Large proline-rich protein BAG6	7917	reviewed	Enzyme modulator
Q70Z35	BXGT023781	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein	80243	reviewed	Enzyme modulator
Q9H694	BXGT024116	Protein bicaudal C homolog 1	80114	reviewed	Transporter
Q02153	BXGT024538	Guanylate cyclase soluble subunit beta-1	2983	reviewed
Q96DR7	BXGT024880	Rho guanine nucleotide exchange factor 26	26084	reviewed
O14649	BXGT025486	Potassium channel subfamily K member 3	3777	reviewed	Ion channel
Q9UK61	BXGT025658	Protein TASOR	23272	reviewed
Q96C45	BXGT025705	Serine/threonine-protein kinase ULK4	54986	reviewed	Kinase
Q8N122	BXGT026091	Regulatory-associated protein of mTOR	57521	reviewed
O14967	BXGT026127	Calmegin	1047	reviewed	Chaperone

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}