Showing entry for Rho GTPase-activating protein 35


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021199
Protein NameRho GTPase-activating protein 35
Uniport IdQ9NRY4
GeneARHGAP35
Gene Id2909
DomainFF; Ras; RhoGAP; RhoGAP-FF1
Pfam PF01846   PF00071   PF00620   PF16512  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04510 Focal adhesion
5. Organismal Systems 5.1 Immune system hsa04611 Platelet activation
5. Organismal Systems 5.1 Immune system hsa04670 Leukocyte transendothelial migration
4. Cellular Processes 4.5 Cell motility hsa04810 Regulation of actin cytoskeleton
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007413 axonal fasciculation
Biological Process GO:0007411 axon guidance
Biological Process GO:0043010 camera-type eye development
Biological Process GO:0016477 cell migration
Biological Process GO:0031668 cellular response to extracellular stimulus
Biological Process GO:0021955 central nervous system neuron axonogenesis
Biological Process GO:0030950 establishment or maintenance of actin cytoskeleton polarity
Biological Process GO:0030900 forebrain development
Biological Process GO:0030879 mammary gland development
Biological Process GO:0035024 negative regulation of Rho protein signal transduction
Biological Process GO:0043116 negative regulation of vascular permeability
Biological Process GO:0001843 neural tube closure
Biological Process GO:0097485 neuron projection guidance
Biological Process GO:0045724 positive regulation of cilium assembly
Biological Process GO:0010976 positive regulation of neuron projection development
Biological Process GO:0032956 regulation of actin cytoskeleton organization
Biological Process GO:0008064 regulation of actin polymerization or depolymerization
Biological Process GO:0050770 regulation of axonogenesis
Biological Process GO:0008360 regulation of cell shape
Biological Process GO:0051056 regulation of small GTPase mediated signal transduction
Biological Process GO:0007165 signal transduction
Biological Process GO:0044319 wound healing, spreading of cells
molecular function GO:0003677 DNA binding
molecular function GO:0005096 GTPase activator activity
molecular function GO:0003924 GTPase activity
molecular function GO:0005525 GTP binding
molecular function GO:0005543 phospholipid binding
cellular component GO:0015629 actin cytoskeleton
cellular component GO:0036064 ciliary basal body
cellular component GO:0005829 cytosol
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-162582 Signal Transduction
R-HSA-194315 Signaling by Rho GTPases
R-HSA-194840 Rho GTPase cycle
R-HSA-373755 Semaphorin interactions
R-HSA-400685 Sema4D in semaphorin signaling
R-HSA-416550 Sema4D mediated inhibition of cell attachment and migration
R-HSA-422475 Axon guidance
R-HSA-8848021 Signaling by PTK6
R-HSA-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases
R-HSA-9675108 Nervous system development
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0023508 BXGD001675 White Blood Cell Count procedure
C0025202 BXGD001832 melanoma Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028945 BXGD002099 oligodendroglioma Neoplasms
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0751396 BXGD010425 Well Differentiated Oligodendroglioma Neoplasms
C0751706 BXGD010559 Primary Progressive Nonfluent Aphasia Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1800706 BXGD013755 Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases
C3160909 BXGD018497 Autoimmune arthritis
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
BXGC0004275 Acetaldehyde 44.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein