Showing entry for E3 ubiquitin-protein ligase CBL-C


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021765
Protein NameE3 ubiquitin-protein ligase CBL-C
Uniport IdQ9ULV8
GeneCBLC
Gene Id23624
DomainCbl_N; Cbl_N2; Cbl_N3; Prok-RING_4
Pfam PF02262   PF02761   PF02762  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.3 Folding, sorting and degradation hsa04120 Ubiquitin mediated proteolysis
4. Cellular Processes 4.1 Transport and catabolism hsa04144 Endocytosis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007166 cell surface receptor signaling pathway
Biological Process GO:0007175 negative regulation of epidermal growth factor-activated receptor activity
Biological Process GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
Biological Process GO:0043407 negative regulation of MAP kinase activity
Biological Process GO:0016567 protein ubiquitination
Biological Process GO:0007165 signal transduction
Biological Process GO:0006511 ubiquitin-dependent protein catabolic process
molecular function GO:0005509 calcium ion binding
molecular function GO:0005154 epidermal growth factor receptor binding
molecular function GO:0001784 phosphotyrosine residue binding
molecular function GO:0030971 receptor tyrosine kinase binding
molecular function GO:0017124 SH3 domain binding
molecular function GO:0061630 ubiquitin protein ligase activity
molecular function GO:0008270 zinc ion binding
cellular component GO:0045121 membrane raft
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0027022 BXGD001962 Myeloproliferative disease Hemic and Lymphatic Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0200638 BXGD004043 Eosinophil count procedure
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0392885 BXGD008071 High density lipoprotein measurement
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1445957 BXGD013081 Serum total cholesterol measurement
C2985280 BXGD018223 Blood Protein Measurement
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein