Showing entry for Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT023781
Protein NamePhosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein
Uniport IdQ70Z35
GenePREX2
Gene Id80243
DomainDEP; PH; RhoGEF
Pfam PF00610   PF00169   PF00621  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0008344 adult locomotory behavior
Biological Process GO:0048813 dendrite morphogenesis
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0014065 phosphatidylinositol 3-kinase signaling
molecular function GO:0005096 GTPase activator activity
molecular function GO:0030676 Rac guanyl-nucleotide exchange factor activity
cellular component GO:0005829 cytosol
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-162582 Signal Transduction
R-HSA-6807070 PTEN Regulation
R-HSA-8948751 Regulation of PTEN stability and activity
R-HSA-9006925 Intracellular signaling by second messengers
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0005689 BXGD000321 Bladder Exstrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009952 BXGD000639 Febrile Convulsions Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0151779 BXGD003473 Cutaneous Melanoma Neoplasms; Skin and Connective Tissue Diseases
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0220641 BXGD004305 Lip and Oral Cavity Carcinoma Neoplasms; Stomatognathic Diseases
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0871470 BXGD011316 Systolic Pressure
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1335302 BXGD012775 Pancreatic Ductal Adenocarcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein