Showing entry for Rho guanine nucleotide exchange factor 26


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT024880
Protein NameRho guanine nucleotide exchange factor 26
Uniport IdQ96DR7
GeneARHGEF26
Gene Id26084
DomainRhoGEF; SH3_9
Pfam PF00621   PF14604  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05100 Bacterial invasion of epithelial cells
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0090630 activation of GTPase activity
Biological Process GO:0001886 endothelial cell morphogenesis
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0051056 regulation of small GTPase mediated signal transduction
Biological Process GO:0097178 ruffle assembly
molecular function GO:0005089 Rho guanyl-nucleotide exchange factor activity
cellular component GO:0005829 cytosol
cellular component GO:0001726 ruffle
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-193648 NRAGE signals death through JNK
R-HSA-193704 p75 NTR receptor-mediated signalling
R-HSA-194315 Signaling by Rho GTPases
R-HSA-194840 Rho GTPase cycle
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE
R-HSA-372790 Signaling by GPCR
R-HSA-388396 GPCR downstream signalling
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-73887 Death Receptor Signalling
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0205682 BXGD004105 Waist-Hip Ratio
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0871470 BXGD011316 Systolic Pressure
C1269955 BXGD012005 Tumor Cell Invasion
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0004275 Acetaldehyde 44.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein