acompound

Showing entry for Deoxyuridine

General Compound Information
BXGC Id	BXGC0013263
Compound Name	Deoxyuridine
Structure
Formula	C9H12N2O5
InchiKey	MXHRCPNRJAMMIM-SHYZEUOFSA-N
SMILES	OC[C@H]1O[C@H](C[C@@H]1O)n1ccc(nc1=O)O
Inchi	InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1
IUPAC	1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
Molecular Weight	228.07
Pubchem Id	13712
Chembl Id	CHEMBL353955

Targets of Information Source

DrugBank

DB02256

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
P12758	BXGT007845	Uridine phosphorylase	reviewed	-	udp	experimental	-
P0A884	BXGT007141	Thymidylate synthase	reviewed	-	thyA	experimental	-

PDB

DUR

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
P0A884	BXGT007141	Thymidylate synthase	reviewed	thyA	-	-	-	-	-
P12758	BXGT007845	Uridine phosphorylase	reviewed	udp	-	-	-	-	-
P10186	BXGT007545	Uracil-DNA glycosylase	reviewed	UL2	-	-	-	-	-
Q8TCD5	BXGT018796	5'(3')-deoxyribonucleotidase, cytosolic type	reviewed	NT5C	-	-	-	-	-
O15826	BXGT004189	Putative deoxyuridine triphosphatase	unreviewed	dut	-	-	-	140000	-
A5PJH9	BXGT001350	Uridine phosphorylase	unreviewed	UPP1	-	-	-	-	-
O31801	BXGT004415	Probable deoxyuridine 5'-triphosphate nucleotidohydrolase YncF	reviewed	yncF	-	-	-	-	-
A4TVL0	BXGT001255	Cereblon isoform 4	unreviewed	MGR_0879	-	-	-	-	-
Q9WYT0	BXGT022003	Flavin-dependent thymidylate synthase	reviewed	thyX	-	-	-	78000	-
Q77J78	BXGT016884	Wsv112	unreviewed		-	-	-	-	-
A0A410UCT3	BXGT024581	Uridine phosphorylase	unreviewed	up	-	-	-	-	-
A0A1Z0YU86	BXGT000770	dUTP pyrophosphatase	unreviewed	FDP41_011884	-	-	-	-	-

Binding DB

n.a

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM

CHEMBL

CHEMBL353955

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	width="10%">Type	Relation	value	Units
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Type	Relation	value	Units
P04183	BXGT006166	Thymidine kinase, cytosolic	reviewed	Kinase	TK1	ID50	'='	400	uM
P07650	BXGT006654	Thymidine phosphorylase	reviewed	-	deoA	Activity	'='	88	%
P04183	BXGT006166	Thymidine kinase, cytosolic	reviewed	Kinase	TK1	Activity	-	-	-
P27158	BXGT009160	Thymidine kinase, cytosolic	reviewed	-	Tk1	Inhibition	'='	90	%
Q8BW75	BXGT017924	Amine oxidase [flavin-containing] B	reviewed	-	Maob	Activity	-	-	-
P30305	BXGT009419	M-phase inducer phosphatase 2	reviewed	Enzyme	CDC25B	Activity	-	-	-
P43346	BXGT010379	Deoxycytidine kinase	reviewed	-	Dck	Activity	'='	92	%
P04183	BXGT006166	Thymidine kinase, cytosolic	reviewed	Kinase	TK1	Relative phosphorylation	'='	1	-
Q64133	BXGT016109	Amine oxidase [flavin-containing] A	reviewed	-	Maoa	Activity	-	-	-
P06746	BXGT006496	DNA polymerase beta	reviewed	Enzyme	POLB	Activity	-	-	-
P09768	BXGT006916	Thymidine kinase, cytosolic	reviewed	-	TK1	Inhibition	'='	38	%
P04184	BXGT006167	Thymidine kinase, cytosolic	reviewed	-	Tk1	Activity	'='	93	%
P04184	BXGT006167	Thymidine kinase, cytosolic	reviewed	-	Tk1	Activity	'='	65	%
D3ZGQ2	BXGT002918	Thymidine kinase 2	unreviewed	-	Tk2	Inhibition	'='	74	%
P19971	BXGT008537	Thymidine phosphorylase	reviewed	Enzyme	TYMP	Km	'='	559000	nM
P43346	BXGT010379	Deoxycytidine kinase	reviewed	-	Dck	Activity	'='	88	%
P04184	BXGT006167	Thymidine kinase, cytosolic	reviewed	-	Tk1	Relative phosphorylation	'='	0	-
P09768	BXGT006916	Thymidine kinase, cytosolic	reviewed	-	TK1	Inhibition	'='	59	%
P07650	BXGT006654	Thymidine phosphorylase	reviewed	-	deoA	Activity	'='	83	%

Foods containing the compound

Foods

BXGF Id	Food Name	Scientific Name	Food Group
BXGF Id	Food Name	Scientific Name	Food Group
BXGF00337	Ginkgo nuts	Ginkgo biloba	Herbs and Spices
BXGF03811	Euryale ferox	Euryale ferox	Medicinal Plant
BXGF05330	Arum ternatum thunb	Arum ternatum thunb	Others

The compound-realted diseases

Diseases

BXGD Id	Disease Name	CUI Disease Id	Disease Class Name	Number of targets^{?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease}