Showing entry for DNA polymerase beta


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT006496
Protein NameDNA polymerase beta
Uniport IdP06746
GenePOLB
Gene Id5423
DomainDNA_pol_B_palm; DNA_pol_B_thumb; DNA_pol_lambd_f; HHH_8
Pfam PF14792   PF14791   PF10391   PF14716  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.4 Replication and repair hsa03410 Base excision repair
6. Human Diseases 6.9 Infectious diseases: Viral hsa05166 Human T-cell leukemia virus 1 infection
6. Human Diseases 6.1 Cancers: Overview hsa05203 Viral carcinogenesis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007568 aging
Biological Process GO:0006284 base-excision repair
Biological Process GO:0006286 base-excision repair, base-free sugar-phosphate removal
Biological Process GO:0006288 base-excision repair, DNA ligation
Biological Process GO:0006287 base-excision repair, gap-filling
Biological Process GO:0006974 cellular response to DNA damage stimulus
Biological Process GO:0006261 DNA-dependent DNA replication
Biological Process GO:0006281 DNA repair
Biological Process GO:0006303 double-strand break repair via nonhomologous end joining
Biological Process GO:0048872 homeostasis of number of cells
Biological Process GO:0071707 immunoglobulin heavy chain V-D-J recombination
Biological Process GO:0006954 inflammatory response
Biological Process GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
Biological Process GO:0048535 lymph node development
Biological Process GO:0051402 neuron apoptotic process
Biological Process GO:0016579 protein deubiquitination
Biological Process GO:0006290 pyrimidine dimer repair
Biological Process GO:0045471 response to ethanol
Biological Process GO:0010332 response to gamma radiation
Biological Process GO:0055093 response to hyperoxia
Biological Process GO:0007435 salivary gland morphogenesis
Biological Process GO:0016446 somatic hypermutation of immunoglobulin genes
Biological Process GO:0048536 spleen development
molecular function GO:0003684 damaged DNA binding
molecular function GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
molecular function GO:0003887 DNA-directed DNA polymerase activity
molecular function GO:0019899 enzyme binding
molecular function GO:0016829 lyase activity
molecular function GO:0046872 metal ion binding
molecular function GO:0008017 microtubule binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005874 microtubule
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0032991 protein-containing complex
cellular component GO:0005876 spindle microtubule
Reactome
Pathway Id Pathway Name
R-HSA-110362 POLB-Dependent Long Patch Base Excision Repair
R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway
R-HSA-110381 Resolution of AP sites via the single-nucleotide replacement pathway
R-HSA-392499 Metabolism of proteins
R-HSA-5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair
R-HSA-5688426 Deubiquitination
R-HSA-5689880 Ub-specific processing proteases
R-HSA-597592 Post-translational protein modification
R-HSA-73884 Base Excision Repair
R-HSA-73894 DNA Repair
R-HSA-73930 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway
R-HSA-73933 Resolution of Abasic Sites (AP sites)
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002726 BXGD000125 Amyloidosis Nutritional and Metabolic Diseases
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006118 BXGD000372 Brain Neoplasms Neoplasms; Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0008626 BXGD000559 Congenital chromosomal disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0013080 BXGD000797 Down Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0016034 BXGD001034 Breast Fibrocystic Disease Skin and Connective Tissue Diseases
C0017638 BXGD001132 Glioma Neoplasms
C0018213 BXGD001187 Graves Disease Eye Diseases; Immune System Diseases; Endocrine System Diseases
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0022665 BXGD001573 Kidney Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025149 BXGD001826 Medulloblastoma Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029925 BXGD002181 Ovarian Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0032580 BXGD002362 Adenomatous Polyposis Coli Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms
C0033036 BXGD002389 Atrial Premature Complexes Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0035126 BXGD002509 Reperfusion Injury Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0036631 BXGD002626 Seminoma Neoplasms
C0043119 BXGD003029 Werner Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0152018 BXGD003518 Esophageal carcinoma Digestive System Diseases; Neoplasms
C0206650 BXGD004214 Fibroadenoma Neoplasms
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0278510 BXGD006526 Childhood Medulloblastoma Neoplasms
C0278876 BXGD006607 Adult Medulloblastoma Neoplasms
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0546837 BXGD009343 Malignant neoplasm of esophagus Digestive System Diseases; Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0940937 BXGD011490 precancerous lesions
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1145670 BXGD011764 Respiratory Failure Respiratory Tract Diseases
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1302401 BXGD012303 Adenoma of large intestine Digestive System Diseases; Neoplasms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1335059 BXGD012755 testicular nonseminoma
C2363741 BXGD017100 HIV-1 infection
C3828416 BXGD019740 Radiation Damage Wounds and Injuries
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C4521042 BXGD023055 Complete Trisomy 21 Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000061 Gallic acid 3-O-gallate 322.23
BXGC0000099 3,4-Dihydroxyphenylacetic acid 168.15
BXGC0000164 Oxoglaucine 351.35
BXGC0000324 Isovitexin 432.38
BXGC0000369 Methyl gallate 184.15
BXGC0000370 5-Hydroxy-7-(4-hydroxy-3-methoxyphenyl)-1-phenyl-3-heptanone 328.4
BXGC0000392 Eriodictyol 288.26
BXGC0000430 Gossypol 518.55
BXGC0000436 Glycerol 92.09
BXGC0000505 Protocatechuic acid 154.12
BXGC0000651 Harmalan 184.24
BXGC0000759 Arabinan 243.22
BXGC0000964 6-Methylscutellarein 300.26
BXGC0001002 1,2-Benzenediol 110.11
BXGC0001024 Cirsimaritin 314.29
BXGC0001123 5-O-Methylgenistein 284.26
BXGC0001385 Stigmasterol 412.7
BXGC0001476 Girinimbine 263.33
BXGC0001495 (R)-Roemerine 279.33
BXGC0001502 Caffeine 194.19
BXGC0001544 Harmaline 214.26
BXGC0001644 Quercetin 3-glucosyl-(1->2)-galactosyl-(1->2)-glucoside 788.66
BXGC0001691 Questiomycin A 212.2
BXGC0001742 Eupafolin 316.26
BXGC0001747 Rosmarinic acid 360.31
BXGC0001765 (E)-Resveratrol 3-glucoside 390.39
BXGC0001767 (E)-Resveratrol 228.25
BXGC0001777 Schaftoside 564.49
BXGC0001825 (R)-Oxypeucedanin 286.28
BXGC0001837 Quercetin 3-rutinoside 610.52
BXGC0001857 Caffeic acid 180.16
BXGC0001868 Catechin 290.27
BXGC0001876 Chrysoeriol 300.26
BXGC0001937 Dillapiol 222.24
BXGC0001940 Daphnetin 178.14
BXGC0001965 Hesperidin 610.56
BXGC0001994 Hyperin 464.38
BXGC0002018 Morin 302.24
BXGC0002029 Taxifolin 304.25
BXGC0002586 Calcium 40.08
BXGC0002588 Magnesium 24.31
BXGC0002591 Potassium 39.1
BXGC0002929 Hydantoin 100.08
BXGC0002971 alpha-Lipoic acid 206.33
BXGC0003066 Phenols 199.27
BXGC0003221 Xanthyletin 228.24
BXGC0003255 Lochnocarpol A 408.49
BXGC0003273 3-O-Methylkaempferol 300.26
BXGC0003364 Cerebroside 299.49
BXGC0003452 Pectolinarigenin 314.29
BXGC0003456 1,4-Benzoquinone 108.09
BXGC0003631 Phytosterol 414.72
BXGC0003696 Quercetin 3-O-methyl-ether 316.26
BXGC0003705 Chloride 35.45
BXGC0003852 Nigrin B 506.47
BXGC0004322 xi-3-Hydroxy-5-phenylpentanoic acid O-beta-D-Glucopyranoside 356.37
BXGC0004824 3-(2-Methylpropanoyloxy)-8-(2-methylbutanoyloxy)-9,10-epoxy-p-mentha-1,3,5-triene 334.41
BXGC0004965 Rhein 284.22
BXGC0005319 Garcinone E 464.55
BXGC0005502 Coumestrol 268.22
BXGC0005624 Genistein 270.24
BXGC0005683 Quercetin 302.24
BXGC0005750 2,6-Di-tert-butyl-4-methylphenol 220.35
BXGC0005945 2'-Hydroxygenistein 286.24
BXGC0005982 Curcumin 368.38
BXGC0006062 Isoorientin 448.38
BXGC0006102 Methyl N-methylanthranilate 165.19
BXGC0006193 Ellagic acid 302.19
BXGC0006259 Isopimpinellin 246.22
BXGC0006306 Myricetin 318.24
BXGC0006308 Myricetin 3-rhamnoside 464.38
BXGC0006389 Rotenone 394.42
BXGC0006466 Oleanolic acid 456.71
BXGC0006635 Luteolin 286.24
BXGC0007029 Emodin 270.24
BXGC0007530 Folic acid 441.4
BXGC0008184 Phloretin 274.27
BXGC0008661 Iron 55.85
BXGC0008753 Isoquercitrin 464.38
BXGC0008877 Homoeriodictyol 302.28
BXGC0008912 Panasenoside 610.52
BXGC0008943 Kaempferol 3-robinobioside 594.52
BXGC0009194 Quercetin 3-glucuronide 478.36
BXGC0009332 Pelanin 356.5
BXGC0009649 Dihydrocapsaicin 307.43
BXGC0009993 (R)-Mahanine 347.45
BXGC0010010 3,8''-Biapigenin 538.46
BXGC0011207 (R)-Bitalin A 218.25
BXGC0011280 Isothymonin 360.31
BXGC0011390 Dihydroroseoside 388.45
BXGC0011421 3-Hydroxy-1-(4-hydroxyphenyl)-1-propanone 166.17
BXGC0011887 (3S,5R,6S,7E,9x)-7-Megastigmene-3,6,9-triol 9-glucoside 390.47
BXGC0012702 (4As,6As,6Br,10S,12Ar)-10-Hydroxy-2,2,6A,6B,9,9,12A-Heptamethyl-1,3,4,5,6,6A,7,8,8A,10,11,12,13,14B-Tetradecahydropicene-4A-Carboxylic Acid 456.36
BXGC0013263 Deoxyuridine 228.07
BXGC0014262 O-Acetylursolic Acid 498.37
BXGC0016421 punicalin 782.06
BXGC0016681 Hispidin 246.05
BXGC0017596 Jatrorrhizine 338.14
BXGC0017701 Altenusin 290.08
BXGC0018618 3-(1H-Indol-3-Yl)-2-(Trimethylazaniumyl)Propanoate 246.14
BXGC0018736 Benzamide 121.05
BXGC0020302 Hortiacine 317.12
BXGC0020344 Icosa-5,8,11,14-Tetraynoic Acid 296.18
BXGC0020995 6-[(3E,5E,7S)-5,7-Dimethyl-2-Oxonona-3,5-Dienyl]-2,4-Dihydroxy-3-Methylbenzaldehyde 316.17
BXGC0021495 Dl-Anabasine 162.12
BXGC0021666 dicentrine 339.15
BXGC0021836 Honokiol 266.13
BXGC0022546 3-(p-coumaroyl)ursolic acid 602.4
BXGC0023321 Quercetin Dihydrate 302.04
BXGC0024086 Gomisin M2 386.17
BXGC0024428 3-(1H-Benzimidazol-2-Yl)-7-(Diethylamino)Chromen-2-One 333.15
BXGC0025115 4,6-Dimethoxy-5-Prop-2-Enyl-1,3-Benzodioxole 222.09
BXGC0025560 Deoxycytidine Monophosphate 307.06
BXGC0025603 [(9R,10R)-10-Acetyloxy-8,8-Dimethyl-2-Oxo-9,10-Dihydropyrano[2,3-F]Chromen-9-Yl] (Z)-2-Methylbut-2-Enoate 386.14
BXGC0026031 Protolichesterinic Acid 324.23
BXGC0026480 Osajin 404.16
BXGC0026607 epiberberine 336.12
BXGC0026658 (E)-3-Phenyl-N-(2-Phenylethyl)Prop-2-Enamide 251.13
BXGC0027015 (+)-Calanolide A 370.18
BXGC0027536 Diosmin 608.17
BXGC0028278 Rutaecarpine 287.11
BXGC0028589 5,6,7,8-Tetrahydroxy-2-(4-Hydroxyphenyl)Chromen-4-One 302.04
BXGC0030197 Prostaglandin B1 336.23
BXGC0030248 2-(4-Hydroxyphenyl)Chromen-4-One 238.06
BXGC0030568 3-Beta-Acetoxy-2-Alpha-Hydroxyurs-12-En-28-Oic Acid 514.37
BXGC0030714 Daphnoretin 352.06
BXGC0031002 Diffractaic Acid 374.14
BXGC0032381 Daucosterol 576.44
BXGC0033310 Epigalocatechin Gallate 458.08
BXGC0033577 Interiotherin C 556.23
BXGC0033953 Armenin-B 372.16
BXGC0034256 Rottlerin 516.18
BXGC0034712 (2R,3S)-2-(3,4-Dihydroxyphenyl)-3,5,7-Trihydroxy-2,3-Dihydrochromen-4-One 304.06
BXGC0035226 Betulinic Acid 456.36
BXGC0036860 Helenalin 262.12
BXGC0036918 5-Hydroxy-2-(4-Hydroxy-3,5-Dimethoxyphenyl)-6,7-Dimethoxychromen-4-One 374.1
BXGC0037599 Tanshinone Iia 294.13
BXGC0037622 Edgeworin 322.05
BXGC0038197 2-Methoxyphenazine 210.08
BXGC0038486 (2S)-3-[(2S,3S)-5,7-Dihydroxy-2-(4-Methoxyphenyl)-4-Oxo-2,3-Dihydrochromen-3-Yl]-5,7-Dihydroxy-2-(4-Methoxyphenyl)-2,3-Dihydrochromen-4-One 570.15
BXGC0038546 [(3Ar,4S,6Z,9E,11S,11Ar)-11-Hydroxy-6,10-Dimethyl-3-Methylidene-2,8-Dioxo-4,5,11,11A-Tetrahydro-3Ah-Cyclodeca[B]Furan-4-Yl] 2-Methylprop-2-Enoate 346.14
BXGC0038660 Tenulin 306.15
BXGC0038895 Emodic Acid 300.03
BXGC0039019 Harmol 198.08
BXGC0039979 2-(3,4-Dimethoxyphenyl)-N-Methylethanamine 195.13
BXGC0040358 Lobaric Acid 456.18
BXGC0040936 Sid26657808 284.07
BXGC0042046 Actinodaphnine 311.12
BXGC0042256 1,4-Bis[[(E)-3-(3,4-Dihydroxyphenyl)Prop-2-Enoyl]Oxy]-3,5-Dihydroxycyclohexane-1-Carboxylic Acid 516.13
BXGC0042397 5,7-Dihydroxy-2-(4-Hydroxyphenyl)-6-Methyl-2,3-Dihydrochromen-4-One 286.08
BXGC0042412 Swertifrancheside 720.13
BXGC0042870 Piceatannol 244.07
BXGC0043125 Taxifolin 304.06
BXGC0043790 2-(2-Acetyl-3,5-Dihydroxyphenyl)Acetic Acid 210.05
BXGC0044857 Sp-600125 220.06
BXGC0047088 Ursolic Acid 456.36
BXGC0047302 Icariin 676.24
BXGC0048313 Rosmarinic Acid 360.08
BXGC0048845 Guanosine Triphosphate 522.99
BXGC0049137 3-Benzoyl-7-Methoxychromen-2-One 280.07
BXGC0049447 acetate 59.01
BXGC0049758 Corosolic Acid 472.36
BXGC0050184 Myricitrin 464.1
BXGC0050651 Cryptotanshinone 296.14
BXGC0050823 Chebulinic acid 956.11
BXGC0050877 (2R,3S)-2-(3,4-Dihydroxyphenyl)-3,4-Dihydro-2H-Chromene-3,5,7-Triol;Hydrate 290.08
BXGC0051184 Calycosin 284.07
BXGC0051660 Endo-Atropine 289.17
BXGC0052374 Reserpine 608.27
BXGC0052595 (5R,9R,10R,13S,14S,17S)-4,4,10,13,14-Pentamethyl-17-[(2S,4R,5S)-4,5,6-Trihydroxy-6-Methylheptan-2-Yl]-1,2,5,6,9,11,12,15,16,17-Decahydrocyclopenta[A]Phenanthren-3-One 474.37
BXGC0052948 Tanshinone I 276.08
BXGC0053274 4-(2,3-Dihydroxy-3-Methylbutoxy)Furo[3,2-G]Chromen-7-One 304.09
BXGC0053641 Nagilactone A 348.16
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein