acompound

Showing entry for Levomefolic Acid

General Compound Information
BXGC Id	BXGC0019003
Compound Name	Levomefolic Acid
Structure
Formula	C20H25N7O6
InchiKey	ZNOVTXRBGFNYRX-STQMWFEESA-N
SMILES	OC(=O)CC[C@@H](C(=O)O)NC(=O)c1ccc(cc1)NC[C@H]1CNc2c(N1C)c(O)nc(=N)[nH]2
Inchi	InChI=1S/C20H25N7O6/c1-27-12(9-23-16-15(27)18(31)26-20(21)25-16)8-22-11-4-2-10(3-5-11)17(30)24-13(19(32)33)6-7-14(28)29/h2-5,12-13,22H,6-9H2,1H3,(H,24,30)(H,28,29)(H,32,33)(H4,21,23,25,26,31)/t12-,13-/m0/s1
IUPAC	(2S)-2-[[4-[[(6S)-2-amino-5-methyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioic acid
Molecular Weight	459.19
Pubchem Id	135398561
Chembl Id	CHEMBL1231574

Targets of Information Source

DrugBank

n.a

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type

PDB

C2F

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
P0CI79	BXGT007475	Thymidylate synthase 1	reviewed	thyA1	-	-	-	-	-
Q9WYA5	BXGT021984	5-methyltetrahydrofolate S-homocysteine methyltransferase	unreviewed	TM_0268	-	-	-	-	-
P0A884	BXGT007141	Thymidylate synthase	reviewed	thyA	-	-	-	-	-
O50008	BXGT004658	5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1	reviewed	MS1	-	-	-	-	-
P48728	BXGT010654	Aminomethyltransferase, mitochondrial	reviewed	AMT	-	-	-	-	-
Q9X112	BXGT022084	5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase	reviewed	metE	-	-	-	-	-
P0AEZ1	BXGT007337	5,10-methylenetetrahydrofolate reductase	reviewed	metF	-	-	-	-	-
Q46389	BXGT014640	5-methyltetrahydrofolate:corrinoid/iron-sulfur protein co-methyltransferase	reviewed	acsE	-	-	-	790	-
P13255	BXGT007894	Glycine N-methyltransferase	reviewed	Gnmt	-	-	-	-	-
Q46389	BXGT014640	5-methyltetrahydrofolate:corrinoid/iron-sulfur protein co-methyltransferase	reviewed	acsE	-	-	-	33200	-
Q3ACR9	BXGT014397	5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase	unreviewed	acsE	-	-	-	-	-
P27248	BXGT009167	Aminomethyltransferase	reviewed	gcvT	-	-	-	-	-
P9WHM5	BXGT012301	Phosphoribosylglycinamide formyltransferase	reviewed	purN	-	-	-	-	-
A3DHS7	BXGT001140	Methylenetetrahydrofolate reductase	unreviewed	Cthe_2304	-	-	-	-	-
Q8ABD0	BXGT017889	Methionine synthase	unreviewed	BT_0180	-	-	-	-	-
Q46389	BXGT014640	5-methyltetrahydrofolate:corrinoid/iron-sulfur protein co-methyltransferase	reviewed	acsE	-	-	-	-	-
P9WFR9	BXGT012248	Thymidylate synthase ThyA	reviewed	thyA	-	-	-	-	-
P82610	BXGT011983	5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase	reviewed	MET6	-	-	-	-	-
B8FW00	BXGT002295	Dihydropteroate synthase DHPS	unreviewed	Dhaf_0722	-	-	-	-	-
P07607	BXGT006648	Thymidylate synthase	reviewed	Tyms	-	-	-	-	-
Q5SKM5	BXGT015773	Methionine synthase	unreviewed	TTHA0618	-	-	-	-	-
B8FUR2	BXGT025569	Tetrahydromethanopterin S-methyltransferase	unreviewed	Dhaf_4327	-	-	-	-	-
Q24SP6	BXGT025576	Methylcorrinoid:tetrahydrofolate methyltransferase	reviewed	mtgA	-	-	-	-	-

Binding DB

50391007

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
reviewed	BXGT016061	Canalicular multispecific organic anion transporter 1	reviewed		Abcc2	121000	-	-	-
reviewed	BXGT011672	Solute carrier organic anion transporter family member 1A3	reviewed		Slco1a3	1200	-	-	-

CHEMBL

CHEMBL1231574

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	width="10%">Type	Relation	value	Units
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Type	Relation	value	Units
Q63120	BXGT016061	Canalicular multispecific organic anion transporter 1	reviewed	-	Abcc2	Ki	'='	121000	nM
Q63120	BXGT016061	Canalicular multispecific organic anion transporter 1	reviewed	-	Abcc2	Km	'='	126000	nM
P70502	BXGT011672	Solute carrier organic anion transporter family member 1A3	reviewed	-	Slco1a3	Ki	'='	1200	nM

Foods containing the compound

Foods

BXGF Id	Food Name	Scientific Name	Food Group
BXGF Id	Food Name	Scientific Name	Food Group
BXGF00040	Pepper (C. annuum)	Capsicum annuum	Vegetables

The compound-realted diseases

Diseases

BXGD Id	Disease Name	CUI Disease Id	Disease Class Name	Number of targets^{?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease}