acompound

Showing entry for Deoxycytidine

General Compound Information
BXGC Id	BXGC0030428
Compound Name	Deoxycytidine
Structure
Formula	C9H13N3O4
InchiKey	CKTSBUTUHBMZGZ-SHYZEUOFSA-N
SMILES	OC[C@H]1O[C@H](C[C@@H]1O)n1ccc(=N)nc1O
Inchi	InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1
IUPAC	4-amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
Molecular Weight	227.09
Pubchem Id	13711
Chembl Id	CHEMBL66115

Targets of Information Source

DrugBank

DB02594

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
P0AE22	BXGT007299	Class B acid phosphatase	reviewed	-	aphA	experimental; investigational	-
O00142	BXGT003883	Thymidine kinase 2, mitochondrial	reviewed	Kinase	TK2	experimental; investigational	-
P27707	BXGT009201	Deoxycytidine kinase	reviewed	Kinase	DCK	experimental; investigational	-

PDB

DCZ

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
Q9XZT6	BXGT022202	Deoxynucleoside kinase	reviewed	dnk	-	-	-	-	-
P27707	BXGT009201	Deoxycytidine kinase	reviewed	DCK	Kinase	-	-	-	-
P0AE22	BXGT007299	Class B acid phosphatase	reviewed	aphA	-	-	-	-	-
P05102	BXGT006314	Modification methylase HhaI	reviewed	hhaIM	-	-	-	-	-
P24627	BXGT008981	Lactotransferrin	reviewed	LTF	-	-	-	-	-
P24021	BXGT008942	Nuclease S1	reviewed	nucS	-	-	-	-	-
P9WPQ5	BXGT012471	ATP-dependent dethiobiotin synthetase BioD	reviewed	bioD	-	-	-	-	-

Binding DB

n.a

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM

CHEMBL

CHEMBL66115

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	width="10%">Type	Relation	value	Units
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Type	Relation	value	Units
Q0H0H0	BXGT013085	Deoxyadenosine kinase	unreviewed	-	dak	Km	'='	34400	nM
P07650	BXGT006654	Thymidine phosphorylase	reviewed	-	deoA	Activity	'='	0	%
Q0H0H0	BXGT013085	Deoxyadenosine kinase	unreviewed	-	dak	Vmax	'='	1	U/mg
Q0H0H0	BXGT013085	Deoxyadenosine kinase	unreviewed	-	dak	Kcat/Km	'='	1	10'4/M/s
Q9WJQ2	BXGT026089	Reverse transcriptase protein	unreviewed	-	reverse	Kd	'='	3000	nM
P32320	BXGT009622	Cytidine deaminase	reviewed	Enzyme	CDA	Kcat/Km	'='	0	/uM/s
D3ZGQ2	BXGT002918	Thymidine kinase 2	unreviewed	-	Tk2	Relative affinity	'='	0	-
Q9XZT6	BXGT022202	Deoxynucleoside kinase	reviewed	-	dnk	Activity	'='	43734	microM/min/mg
P27707	BXGT009201	Deoxycytidine kinase	reviewed	Kinase	DCK	Km	'='	1100	nM
P32320	BXGT009622	Cytidine deaminase	reviewed	Enzyme	CDA	Kcat	'='	4	/s
P56389	BXGT011166	Cytidine deaminase	reviewed	-	Cda	Relative initial rate	'='	39	-
P27707	BXGT009201	Deoxycytidine kinase	reviewed	Kinase	DCK	Kcat	'='	0	/s
Q9QNF7	BXGT021370	Thymidine kinase	reviewed	-	TK	Relative velocity	'='	119	%
D3ZGQ2	BXGT002918	Thymidine kinase 2	unreviewed	-	Tk2	Ki	'='	320000	nM
Q03164	BXGT012700	Histone-lysine N-methyltransferase 2A	reviewed	-	KMT2A	Potency	'='	39810	nM
O00255	BXGT003903	Menin	reviewed	-	MEN1	Potency	'='	39810	nM
P27707	BXGT009201	Deoxycytidine kinase	reviewed	Kinase	DCK	Km	'='	400	nM
P09768	BXGT006916	Thymidine kinase, cytosolic	reviewed	-	TK1	Inhibition	'='	10	%
P30648	BXGT009453	Probable deoxycytidylate deaminase	reviewed	-	ZK643.2	Km	'='	38000	nM
P30648	BXGT009453	Probable deoxycytidylate deaminase	reviewed	-	ZK643.2	Relative velocity	'='	1	-
P27707	BXGT009201	Deoxycytidine kinase	reviewed	Kinase	DCK	Kcat/Km	'='	0	/uM/s
Q9WJQ2	BXGT026089	Reverse transcriptase protein	unreviewed	-	reverse	Ratio	'='	26	/uM/min
P04183	BXGT006166	Thymidine kinase, cytosolic	reviewed	Kinase	TK1	Relative velocity	'='	100	%
D3ZGQ2	BXGT002918	Thymidine kinase 2	unreviewed	-	Tk2	Inhibition	'='	58	%
Q9QNF7	BXGT021370	Thymidine kinase	reviewed	-	TK	Relative velocity	'='	97	%
Q9HA47	BXGT020503	Uridine-cytidine kinase 1	reviewed	Kinase	UCK1	Activity	-	-	-
P04183	BXGT006166	Thymidine kinase, cytosolic	reviewed	Kinase	TK1	Relative velocity	'='	5	%
Q0H0H0	BXGT013085	Deoxyadenosine kinase	unreviewed	-	dak	Kcat	'='	0	/s
P27707	BXGT009201	Deoxycytidine kinase	reviewed	Kinase	DCK	Km	'='	2800	nM
Q9WKE8	BXGT021921	Reverse transcriptase	unreviewed	-	reverse	Kd	'='	1100	nM
P09768	BXGT006916	Thymidine kinase, cytosolic	reviewed	-	TK1	Inhibition	'='	24	%
P27158	BXGT009160	Thymidine kinase, cytosolic	reviewed	-	Tk1	Inhibition	'='	7	%
P32320	BXGT009622	Cytidine deaminase	reviewed	Enzyme	CDA	Km	'='	41000	nM
Q9WKE8	BXGT021921	Reverse transcriptase	unreviewed	-	reverse	Ratio	'='	65	/uM/min

Foods containing the compound

Foods

BXGF Id	Food Name	Scientific Name	Food Group
BXGF Id	Food Name	Scientific Name	Food Group
BXGF00337	Ginkgo nuts	Ginkgo biloba	Herbs and Spices
BXGF03811	Euryale ferox	Euryale ferox	Medicinal Plant

The compound-realted diseases

Diseases

BXGD Id	Disease Name	CUI Disease Id	Disease Class Name	Number of targets^{?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease}