Showing entry for 3,7-Dihydroxyflavone


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0040109
Compound Name3,7-Dihydroxyflavone
Structure
FormulaC15H10O4
InchiKeyUWQJWDYDYIJWKY-UHFFFAOYSA-N
SMILESOc1ccc2c(c1)oc(c(c2=O)O)c1ccccc1
InchiInChI=1S/C15H10O4/c16-10-6-7-11-12(8-10)19-15(14(18)13(11)17)9-4-2-1-3-5-9/h1-8,16,18H
IUPAC3,7-dihydroxy-2-phenylchromen-4-one
Molecular Weight254.06
Pubchem Id5393152
Chembl IdCHEMBL210276
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB HHF
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
O93874 BXGT005316 17beta-hydroxysteroid dehydrogenase unreviewed 17HSDcl - - - - -
Binding DB 26660
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT007685 Serine/threonine-protein kinase pim-1 reviewed Kinase PIM1 - 4600 - -
reviewed BXGT021247 Dipeptidyl peptidase 3 reviewed Enzyme DPP3 - 98000 - -
reviewed BXGT007685 Serine/threonine-protein kinase pim-1 reviewed Kinase PIM1 - 4571 - -
reviewed BXGT004148 Arachidonate 15-lipoxygenase B reviewed Enzyme ALOX15B - >100000 - -
reviewed BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 - >100000 - -
reviewed BXGT008370 Arachidonate 12-lipoxygenase, 12S-type reviewed Enzyme ALOX12 - >100000 - -
reviewed BXGT010620 Prolyl endopeptidase reviewed Enzyme PREP - >200000 - -
reviewed BXGT009187 Dipeptidyl peptidase 4 reviewed Enzyme DPP4 - >200000 - -
CHEMBL CHEMBL210276
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 Potency '=' 25118 nM
P48147 BXGT010620 Prolyl endopeptidase reviewed Enzyme PREP IC50 '>' 200000 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 39810 nM
Q965D5 BXGT019600 Enoyl-acyl-carrier protein reductase unreviewed - fabI IC50 '=' 10000 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 3162 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 3162 nM
P18054 BXGT008370 Arachidonate 12-lipoxygenase, 12S-type reviewed Enzyme ALOX12 IC50 '>' 100000 nM
O15296 BXGT004148 Arachidonate 15-lipoxygenase B reviewed Enzyme ALOX15B IC50 '>' 100000 nM
P11309 BXGT007685 Serine/threonine-protein kinase pim-1 reviewed Kinase PIM1 #NAME? '=' 0 uM
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 IC50 '>' 100000 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 31622 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 18356 nM
Q92830 BXGT019379 Histone acetyltransferase KAT2A reviewed - KAT2A Potency - 31622 nM
P27487 BXGT009187 Dipeptidyl peptidase 4 reviewed Enzyme DPP4 IC50 '>' 200000 nM
Q965D6 BXGT019601 3-oxoacyl-acyl-carrier protein reductase unreviewed - fabG Activity - - -
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 44668 nM
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 39810 nM
P03126 BXGT006024 Protein E6 reviewed - E6 Inhibition - - -
Q965D7 BXGT019602 Beta-hydroxyacyl-ACP dehydratase unreviewed - fabZ Activity - - -
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 120 %
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 16360 nM
P02791 BXGT005965 Ferritin light chain reviewed - FTL Potency '=' 25118 nM
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 Potency '=' 19952 nM
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 151 %
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 31622 nM
P55210 BXGT011110 Caspase-7 reviewed Enzyme CASP7 Potency '=' 15848 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF03988 Rheum coreanum Rheum coreanum Others
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease