Showing entry for Arachidonate 12-lipoxygenase, 12S-type


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008370
Protein NameArachidonate 12-lipoxygenase, 12S-type
Uniport IdP18054
GeneALOX12
Gene Id239
DomainLipoxygenase; PLAT
Pfam PF00305   PF01477  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00590 Arachidonic acid metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
6. Human Diseases 6.12 Drug resistance: Antineoplastic hsa01523 Antifolate resistance
5. Organismal Systems 5.6 Nervous system hsa04726 Serotonergic synapse
5. Organismal Systems 5.7 Sensory system hsa04750 Inflammatory mediator regulation of TRP channels
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007568 aging
Biological Process GO:0019369 arachidonic acid metabolic process
Biological Process GO:0071396 cellular response to lipid
Biological Process GO:0061436 establishment of skin barrier
Biological Process GO:0019395 fatty acid oxidation
Biological Process GO:0051122 hepoxilin biosynthetic process
Biological Process GO:0051121 hepoxilin metabolic process
Biological Process GO:1901751 leukotriene A4 metabolic process
Biological Process GO:0043651 linoleic acid metabolic process
Biological Process GO:0006629 lipid metabolic process
Biological Process GO:0034440 lipid oxidation
Biological Process GO:2001303 lipoxin A4 biosynthetic process
Biological Process GO:2001306 lipoxin B4 biosynthetic process
Biological Process GO:2001301 lipoxin biosynthetic process
Biological Process GO:0019372 lipoxygenase pathway
Biological Process GO:0042759 long-chain fatty acid biosynthetic process
Biological Process GO:0010656 negative regulation of muscle cell apoptotic process
Biological Process GO:0090331 negative regulation of platelet aggregation
Biological Process GO:0097755 positive regulation of blood vessel diameter
Biological Process GO:0043536 positive regulation of blood vessel endothelial cell migration
Biological Process GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
Biological Process GO:1905956 positive regulation of endothelial tube morphogenesis
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0051901 positive regulation of mitochondrial depolarization
Biological Process GO:0048661 positive regulation of smooth muscle cell proliferation
Biological Process GO:0042554 superoxide anion generation
Biological Process GO:0033559 unsaturated fatty acid metabolic process
molecular function GO:0004052 arachidonate 12(S)-lipoxygenase activity
molecular function GO:0050473 arachidonate 15-lipoxygenase activity
molecular function GO:0047977 hepoxilin-epoxide hydrolase activity
molecular function GO:0005506 iron ion binding
molecular function GO:0016165 linoleate 13S-lipoxygenase activity
molecular function GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0016020 membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0042383 sarcolemma
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-2142696 Synthesis of Hepoxilins (HX) and Trioxilins (TrX)
R-HSA-2142700 Synthesis of Lipoxins (LX)
R-HSA-2142712 Synthesis of 12-eicosatetraenoic acid derivatives
R-HSA-2142753 Arachidonic acid metabolism
R-HSA-556833 Metabolism of lipids
R-HSA-8978868 Fatty acid metabolism
R-HSA-9018677 Biosynthesis of DHA-derived SPMs
R-HSA-9018678 Biosynthesis of specialized proresolving mediators (SPMs)
R-HSA-9018683 Biosynthesis of DPA-derived SPMs
R-HSA-9025094 Biosynthesis of DPAn-3 SPMs
R-HSA-9025106 Biosynthesis of DPAn-6 SPMs
R-HSA-9026290 Biosynthesis of DPAn-3-derived maresins
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0001430 BXGD000054 Adenoma Neoplasms
C0001883 BXGD000086 Airway Obstruction Respiratory Tract Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002726 BXGD000125 Amyloidosis Nutritional and Metabolic Diseases
C0002793 BXGD000130 Anaplasia Pathological Conditions, Signs and Symptoms; Neoplasms
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007113 BXGD000430 Rectal Carcinoma Digestive System Diseases; Neoplasms
C0007115 BXGD000432 Malignant neoplasm of thyroid Neoplasms; Endocrine System Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0010200 BXGD000653 Coughing Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0020429 BXGD001378 Hyperalgesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023440 BXGD001646 Acute Erythroblastic Leukemia Neoplasms; Hemic and Lymphatic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0025500 BXGD001874 Mesothelioma Neoplasms
C0027022 BXGD001962 Myeloproliferative disease Hemic and Lymphatic Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029925 BXGD002181 Ovarian Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0035126 BXGD002509 Reperfusion Injury Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0037274 BXGD002676 Dermatologic disorders Skin and Connective Tissue Diseases
C0037286 BXGD002681 Skin Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C0038436 BXGD002755 Post-Traumatic Stress Disorder Mental Disorders
C0039590 BXGD002822 Testicular Neoplasms Neoplasms; Male Urogenital Diseases; Endocrine System Diseases
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0040558 BXGD002873 Toxoplasmosis Infections
C0040560 BXGD002875 Toxoplasmosis, Congenital Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Infections; Nervous System Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0042900 BXGD003012 Vitiligo Skin and Connective Tissue Diseases
C0043144 BXGD003032 Wheezing Pathological Conditions, Signs and Symptoms
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0087031 BXGD003319 Juvenile-Onset Still Disease Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0156259 BXGD003845 Hypertrophy of kidney Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0280100 BXGD006713 Solid Neoplasm Neoplasms
C0282612 BXGD006820 Prostatic Intraepithelial Neoplasias Neoplasms
C0339510 BXGD007257 Vitelliform Macular Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0458247 BXGD008904 Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677886 BXGD009734 Epithelial ovarian cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0751211 BXGD010350 Hyperalgesia, Primary Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751212 BXGD010351 Hyperalgesia, Secondary Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751213 BXGD010352 Tactile Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751214 BXGD010353 Hyperalgesia, Thermal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0854889 BXGD011044 Pleural mesothelioma malignant advanced
C0917713 BXGD011404 Becker Muscular Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1302401 BXGD012303 Adenoma of large intestine Digestive System Diseases; Neoplasms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1519670 BXGD013241 Tumor Angiogenesis Pathological Conditions, Signs and Symptoms
C1704272 BXGD013537 Benign Prostatic Hyperplasia Male Urogenital Diseases
C1847835 BXGD014892 VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) Skin and Connective Tissue Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2347748 BXGD017041 Adult Erythroleukemia
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2825139 BXGD017770 Acute Myeloid Leukemia with Myelodysplasia-Related Changes Neoplasms
C2936719 BXGD018130 Mechanical Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3489532 BXGD018934 Cone-Rod Dystrophy 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C3495559 BXGD018994 Juvenile arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C3714636 BXGD019421 Pneumonitis Infections; Respiratory Tract Diseases
C3714758 BXGD019431 Juvenile psoriatic arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4520840 BXGD023041 Erythroleukemia (Erythroid/Myeloid) Neoplasms; Hemic and Lymphatic Diseases
C4529962 BXGD023178 Fatty Liver Disease
C4552091 BXGD023485 Polyarthritis, Juvenile, Rheumatoid Factor Negative Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C4704862 BXGD023681 Polyarthritis, Juvenile, Rheumatoid Factor Positive Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000194 Sanguinarine 332.33
BXGC0000202 Papaverine 339.39
BXGC0000332 Fisetin 286.24
BXGC0000430 Gossypol 518.55
BXGC0000572 Naphthalene 128.17
BXGC0000764 L-Ascorbic acid 176.12
BXGC0001899 Daidzein 254.24
BXGC0001911 5,7-Dihydroxyisoflavone 254.24
BXGC0001958 (E,E)-Boviquinone 3 344.44
BXGC0002906 Caffeic acid ester 284.31
BXGC0003066 Phenols 199.27
BXGC0003218 Foluene 92.14
BXGC0003328 Tetrahydrocurcumin 372.41
BXGC0003397 Lipoxygenase 229.2
BXGC0004335 6-Hydroxydaidzein 270.24
BXGC0004378 3-Hydroxyflavone 238.24
BXGC0004575 2-Bromophenol 173.01
BXGC0004595 2,4-Dibromophenol 251.9
BXGC0004596 2,6-Dibromophenol 251.9
BXGC0004965 Rhein 284.22
BXGC0005313 Moracin C 310.34
BXGC0005682 3,3',4,4'-Tetrahydroxylignan 302.36
BXGC0005683 Quercetin 302.24
BXGC0005793 Baicalein 270.24
BXGC0005919 Biochanin A 284.27
BXGC0005982 Curcumin 368.38
BXGC0005985 Piceatannol 244.25
BXGC0006060 1-Methoxy-4-(2-propenyl)benzene 148.2
BXGC0006212 Hypericin 504.44
BXGC0006306 Myricetin 318.24
BXGC0006635 Luteolin 286.24
BXGC0007028 beta-Thujaplicin 164.2
BXGC0007560 alpha-Mangostin 410.46
BXGC0008181 Morusin 420.45
BXGC0008958 Naringenin fructoside 272.26
BXGC0012352 Chelerythrine 348.12
BXGC0012974 Formonetin 284.07
BXGC0013582 Curcumin 368.13
BXGC0015897 2-Hydroxy-5-Methoxy-3-Hexadecyl-1,4-Benzoquinone 378.28
BXGC0016247 3,5-Dihydroxy-2-Phenylchromen-4-One 254.06
BXGC0017519 Dysidenin 542.96
BXGC0017558 2,3,4,5-Tetrabromo-6-(3,5-Dibromo-2-Hydroxyphenoxy)Phenol 669.53
BXGC0018073 2-Phenylethyl (Z)-3-(3,4-Dihydroxyphenyl)Prop-2-Enoate 284.1
BXGC0018252 Embelin 294.18
BXGC0018504 Neodysidenin 542.96
BXGC0018772 Pseudoephedrine 165.12
BXGC0020344 Icosa-5,8,11,14-Tetraynoic Acid 296.18
BXGC0020590 2,3,4,5-Tetrabromo-6-(2,4-Dibromophenoxy)Phenol 653.53
BXGC0020654 Dopa 197.07
BXGC0022677 (9Z,11E)-13-Oxooctadeca-9,11-Dienoic Acid 294.22
BXGC0024915 Dehydroglaucine 353.16
BXGC0024988 Nifedipine 346.12
BXGC0025027 3,4-Dibromo-2-(5-Bromo-2-Hydroxyphenoxy)Phenol 435.79
BXGC0029810 1,5-Bis(4-Hydroxy-3-Methoxyphenyl)-1,4-Pentadien-3-One 326.12
BXGC0031384 Epinephrine 183.09
BXGC0031717 Purpurin 256.04
BXGC0032327 5-O-Methylembelin 308.2
BXGC0034968 Dienestrol 266.13
BXGC0035097 Sorgoleone-364 336.23
BXGC0037152 (Z)-1-[6-[(3-Acetyl-2,4,6-Trihydroxy-5-Methylphenyl)Methyl]-5,7-Dihydroxy-2,2-Dimethylchromen-8-Yl]-3-Phenylprop-2-En-1-One 516.18
BXGC0037599 Tanshinone Iia 294.13
BXGC0039306 Carnosic Acid 332.2
BXGC0039397 Athraquinones A 240.04
BXGC0039750 Resveratrol 4'-Methyl Ether 242.09
BXGC0040109 3,7-Dihydroxyflavone 254.06
BXGC0041560 Thiram 239.99
BXGC0042285 2,5-dihydroxy-3-butyl-2,5-cyclohexadiene-1,4-dione 196.07
BXGC0042870 Piceatannol 244.07
BXGC0043657 2,3,5-Tribromo-6-(3,5-Dibromo-2-Hydroxyphenoxy)Phenol 591.62
BXGC0047287 Rapanone 322.21
BXGC0047871 7-Hydroxyflavone 238.06
BXGC0049646 2,5-Dihydroxyl-3-Undecyl-1,4-Benzoquinone 350.25
BXGC0053568 (+)-Epitaxifolin 304.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein