adisease

Showing entry for Classical phenylketonuria

General Disease Information
BXGD Id	BXGD010439
Disease Name	Classical phenylketonuria
Disease CUI Id	C0751434
MeSH Codes	C16 C18 C10
Disease Class Name	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id	HP:0001939
Human Phenotype Ontology Term	Abnormality of metabolism/homeostasis
Disease Ontology Id	DOID:0014667 DOID:630
Disease Ontology Class Name	disease of metabolism; genetic disease
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00555	BXGT003936	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	773	reviewed	Ion channel
O76082	BXGT005175	Solute carrier family 22 member 5	6584	reviewed	Transporter
P00439	BXGT005539	Phenylalanine-4-hydroxylase	5053	reviewed
P00441	BXGT005540	Superoxide dismutase [Cu-Zn]	6647	reviewed	Enzyme
P00966	BXGT005707	Argininosuccinate synthase	445	reviewed	Enzyme
P02751	BXGT005943	Fibronectin	2335	reviewed	Signaling
P02766	BXGT005953	Transthyretin	7276	reviewed	Transporter
P02768	BXGT005955	Serum albumin	213	reviewed	Transporter
P04040	BXGT006132	Catalase	847	reviewed	Enzyme
P05067	BXGT006306	Amyloid-beta precursor protein	351	reviewed	Enzyme modulator
P07101	BXGT006547	Tyrosine 3-monooxygenase	7054	reviewed
P09417	BXGT006888	Dihydropteridine reductase	5860	reviewed	Enzyme
P15559	BXGT008139	NAD(P)H dehydrogenase [quinone] 1	1728	reviewed
P19021	BXGT008449	Peptidyl-glycine alpha-amidating monooxygenase	5066	reviewed	Enzyme
P22352	BXGT008758	Glutathione peroxidase 3	2878	reviewed	Enzyme
P27338	BXGT009172	Amine oxidase [flavin-containing] B	4129	reviewed
P28482	BXGT009263	Mitogen-activated protein kinase 1	5594	reviewed	Kinase
P35270	BXGT009807	Sepiapterin reductase	6697	reviewed
P41594	BXGT010266	Metabotropic glutamate receptor 5	2915	reviewed	G-protein coupled receptor
P46108	BXGT010509	Adapter molecule crk	1398	reviewed
P54098	BXGT011030	DNA polymerase subunit gamma-1	5428	reviewed	Enzyme
P55809	BXGT011127	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	5019	reviewed	Enzyme
P68871	BXGT011615	Hemoglobin subunit beta	3043	reviewed
Q01650	BXGT012603	Large neutral amino acids transporter small subunit 1	8140	reviewed	Transporter
Q03393	BXGT012711	6-pyruvoyl tetrahydrobiopterin synthase	5805	reviewed
Q13155	BXGT013320	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2	7965	reviewed
Q13535	BXGT013370	Serine/threonine-protein kinase ATR	545	reviewed	Kinase
Q16539	BXGT013634	Mitogen-activated protein kinase 14	1432	reviewed	Kinase
Q5T6L4	BXGT015848	Argininosuccinate synthase 1 isoform 1	445	unreviewed
Q9Y4U1	BXGT022285	Methylmalonic aciduria and homocystinuria type C protein	25974	reviewed

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}