Showing entry for Dihydropteridine reductase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT006888
Protein NameDihydropteridine reductase
Uniport IdP09417
GeneQDPR
Gene Id5860
Domainadh_short
Pfam PF00106  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.8 Metabolism of cofactors and vitamins hsa00790 Folate biosynthesis
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006520 cellular amino acid metabolic process
Biological Process GO:0035690 cellular response to drug
Biological Process GO:0051066 dihydrobiopterin metabolic process
Biological Process GO:0001889 liver development
Biological Process GO:0006559 L-phenylalanine catabolic process
Biological Process GO:0010044 response to aluminum ion
Biological Process GO:0033762 response to glucagon
Biological Process GO:0010288 response to lead ion
Biological Process GO:0006729 tetrahydrobiopterin biosynthetic process
molecular function GO:0004155 6,7-dihydropteridine reductase activity
molecular function GO:0009055 electron transfer activity
molecular function GO:0042802 identical protein binding
molecular function GO:0070404 NADH binding
molecular function GO:0070402 NADPH binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0043005 neuron projection
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-71291 Metabolism of amino acids and derivatives
R-HSA-8963691 Phenylalanine and tyrosine metabolism
R-HSA-8964208 Phenylalanine metabolism
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004782 BXGD000292 Basal Ganglia Diseases Nervous System Diseases
C0011168 BXGD000700 Deglutition Disorders Digestive System Diseases; Otorhinolaryngologic Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013132 BXGD000799 Drooling Stomatognathic Diseases
C0013421 BXGD000837 Dystonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0016412 BXGD001058 Folic Acid Deficiency Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0022107 BXGD001530 Irritable Mood Behavior and Behavior Mechanisms
C0023176 BXGD001612 Lead Poisoning Chemically-Induced Disorders
C0024591 BXGD001789 Malignant hyperpyrexia due to anesthesia Pathological Conditions, Signs and Symptoms
C0025362 BXGD001866 Mental Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026826 BXGD001935 Muscle Hypertonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0027066 BXGD001966 Myoclonus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0031485 BXGD002303 Phenylketonurias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0035021 BXGD002501 Relapsing Fever Infections
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037036 BXGD002661 Sialorrhea Stomatognathic Diseases
C0038220 BXGD002740 Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0042900 BXGD003012 Vitiligo Skin and Connective Tissue Diseases
C0085583 BXGD003194 Choreoathetosis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0152455 BXGD003598 Keratomalacia Nutritional and Metabolic Diseases
C0235031 BXGD004714 Neurologic Symptoms Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0238111 BXGD004877 Lennox-Gastaut syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0242387 BXGD005161 Mandibulofacial Dysostosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Musculoskeletal Diseases
C0268465 BXGD005955 Phenylketonuria II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0270685 BXGD006084 Cerebral calcification Nutritional and Metabolic Diseases; Nervous System Diseases
C0424230 BXGD008522 Motor retardation Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0557874 BXGD009444 Global developmental delay
C0751434 BXGD010439 Classical phenylketonuria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0751435 BXGD010440 Hyperphenylalaninaemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0751436 BXGD010441 Hyperphenylalaninemia, Non-Phenylketonuric Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C1847835 BXGD014892 VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) Skin and Connective Tissue Diseases
C1854838 BXGD015438 Progressive neurologic deterioration Mental Disorders
C1861403 BXGD016045 Variable expressivity
C2700617 BXGD017474 Irritation - emotion Behavior and Behavior Mechanisms
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3714772 BXGD019433 Recurrent fevers
C4552810 BXGD023525 Irritability, CTCAE
C4732730 BXGD023895 Blood spots
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0005169 4-Phenylpyridine 155.2
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein