Showing entry for Sphingomyelin phosphodiesterase 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004908
Protein NameSphingomyelin phosphodiesterase 2
Uniport IdO60906
GeneSMPD2
Gene Id6610
DomainExo_endo_phos
Pfam PF03372  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00600 Sphingolipid metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
3. Environmental Information Processing 3.2 Signal transduction hsa04071 Sphingolipid signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0046513 ceramide biosynthetic process
Biological Process GO:0006687 glycosphingolipid metabolic process
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:2000304 positive regulation of ceramide biosynthetic process
Biological Process GO:0009612 response to mechanical stimulus
Biological Process GO:0030149 sphingolipid catabolic process
Biological Process GO:0006685 sphingomyelin catabolic process
Biological Process GO:0006684 sphingomyelin metabolic process
molecular function GO:0046872 metal ion binding
molecular function GO:0004767 sphingomyelin phosphodiesterase activity
cellular component GO:0005901 caveola
cellular component GO:0071944 cell periphery
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0016020 membrane
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-1660662 Glycosphingolipid metabolism
R-HSA-193681 Ceramide signalling
R-HSA-193704 p75 NTR receptor-mediated signalling
R-HSA-428157 Sphingolipid metabolism
R-HSA-556833 Metabolism of lipids
R-HSA-5626978 TNFR1-mediated ceramide production
R-HSA-73887 Death Receptor Signalling
R-HSA-73887 Death Receptor Signalling
R-HSA-75893 TNF signaling
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0011615 BXGD000738 Dermatitis, Atopic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C0013274 BXGD000809 Patent ductus arteriosus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0018378 BXGD001190 Guillain-Barre Syndrome Immune System Diseases; Nervous System Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0023290 BXGD001631 Leishmaniasis, Visceral Infections
C0023418 BXGD001642 leukemia Neoplasms
C0026918 BXGD001948 Mycobacterium Infections Infections
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0028064 BXGD002068 Niemann-Pick Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Hemic and Lymphatic Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0034067 BXGD002456 Pulmonary Emphysema Respiratory Tract Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C3714636 BXGD019421 Pneumonitis Infections; Respiratory Tract Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0004847 Dulxanthone D 342.34
BXGC0007560 alpha-Mangostin 410.46
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein