adisease

General Disease Information
BXGD Id	BXGD002068
Disease Name	Niemann-Pick Diseases
Disease CUI Id	C0028064
MeSH Codes	C16 C18 C10 C15
Disease Class Name	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Hemic and Lymphatic Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id
Human Phenotype Ontology Term
Disease Ontology Id	DOID:0014667 DOID:630
Disease Ontology Class Name	disease of metabolism; genetic disease
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O15118	BXGT004127	NPC intracellular cholesterol transporter 1	4864	reviewed	Transporter
O43451	BXGT004594	Maltase-glucoamylase, intestinal	8972	reviewed	Enzyme
O60906	BXGT004908	Sphingomyelin phosphodiesterase 2	6610	reviewed
O95477	BXGT005383	Phospholipid-transporting ATPase ABCA1	19	reviewed	Transporter
P02649	BXGT005909	Apolipoprotein E	348	reviewed
P04062	BXGT006140	Lysosomal acid glucosylceramidase	2629	reviewed
P06280	BXGT006433	Alpha-galactosidase A	2717	reviewed
P07858	BXGT006689	Cathepsin B	1508	reviewed	Enzyme
P14410	BXGT008009	Sucrase-isomaltase, intestinal	6476	reviewed	Enzyme
P17405	BXGT008304	Sphingomyelin phosphodiesterase	6609	reviewed	Enzyme
P33981	BXGT009744	Dual specificity protein kinase TTK	7272	reviewed	Kinase
P34932	BXGT009772	Heat shock 70 kDa protein 4	3308	reviewed
P35475	BXGT009837	Alpha-L-iduronidase	3425	reviewed	Enzyme
P54803	BXGT011082	Galactocerebrosidase	2581	reviewed
Q12772	BXGT013262	Sterol regulatory element-binding protein 2	6721	reviewed
Q13231	BXGT013329	Chitotriosidase-1	1118	reviewed
Q2M385	BXGT014131	Macrophage-expressed gene 1 protein	219972	reviewed
Q92484	BXGT023018	Acid sphingomyelinase-like phosphodiesterase 3a	10924	reviewed	Enzyme
O60502	BXGT023392	Protein O-GlcNAcase	10724	reviewed
P61916	BXGT025881	NPC intracellular cholesterol transporter 2	10577	reviewed

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}