Showing entry for DNA polymerase theta


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005124
Protein NameDNA polymerase theta
Uniport IdO75417
GenePOLQ
Gene Id10721
DomainDEAD; DNA_pol_A; Helicase_C
Pfam PF00270   PF00476   PF00271  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006284 base-excision repair
Biological Process GO:0006974 cellular response to DNA damage stimulus
Biological Process GO:0006261 DNA-dependent DNA replication
Biological Process GO:0006281 DNA repair
Biological Process GO:0006302 double-strand break repair
Biological Process GO:0097681 double-strand break repair via alternative nonhomologous end joining
Biological Process GO:0000724 double-strand break repair via homologous recombination
Biological Process GO:2000042 negative regulation of double-strand break repair via homologous recombination
Biological Process GO:0051260 protein homooligomerization
Biological Process GO:0016446 somatic hypermutation of immunoglobulin genes
molecular function GO:0008409 5'-3' exonuclease activity
molecular function GO:0051575 5'-deoxyribose-5-phosphate lyase activity
molecular function GO:0005524 ATP binding
molecular function GO:0003682 chromatin binding
molecular function GO:0003684 damaged DNA binding
molecular function GO:0003887 DNA-directed DNA polymerase activity
molecular function GO:0042802 identical protein binding
molecular function GO:0017116 single-stranded DNA helicase activity
cellular component GO:0005694 chromosome
cellular component GO:0005737 cytoplasm
cellular component GO:0005654 nucleoplasm
Reactome
Pathway Id Pathway Name
R-HSA-5685939 HDR through MMEJ (alt-NHEJ)
R-HSA-5693532 DNA Double-Strand Break Repair
R-HSA-5693538 Homology Directed Repair
R-HSA-73894 DNA Repair
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007095 BXGD000423 Carcinoid Tumor Neoplasms
C0007114 BXGD000431 Malignant neoplasm of skin Neoplasms; Skin and Connective Tissue Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0019348 BXGD001325 Herpes Simplex Infections Infections; Skin and Connective Tissue Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0037286 BXGD002681 Skin Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C0043346 BXGD003043 Xeroderma Pigmentosum Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0085090 BXGD003122 Lymphoma, AIDS-Related Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085281 BXGD003152 Addictive Behavior Behavior and Behavior Mechanisms
C0085636 BXGD003218 Photophobia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0334108 BXGD006994 Multiple polyps Pathological Conditions, Signs and Symptoms
C0334299 BXGD007027 Carcinoid tumor no ICD-O subtype Neoplasms
C0346153 BXGD007781 Breast Cancer, Familial Neoplasms; Skin and Connective Tissue Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0398791 BXGD008233 Nijmegen Breakage Syndrome Nutritional and Metabolic Diseases
C0553723 BXGD009416 Squamous cell carcinoma of skin Neoplasms; Skin and Connective Tissue Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0751039 BXGD010302 Cockayne Syndrome, Type I Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1848410 BXGD014922 Xeroderma pigmentosum, variant type Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002586 Calcium 40.08
BXGC0002588 Magnesium 24.31
BXGC0002591 Potassium 39.1
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein