Showing entry for Breast Cancer, Familial


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD007781
Disease NameBreast Cancer, Familial
Disease CUI IdC0346153
MeSH Codes C04   C17  
Disease Class NameNeoplasms; Skin and Connective Tissue Diseases
Semantic TypeNeoplastic Process
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id DOID:7   DOID:14566  
Disease Ontology Class Namedisease of anatomical entity; disease of cellular proliferation
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
A0A024RAV5 BXGT000013 V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b 3845 unreviewed
O14745 BXGT004090 Na(+)/H(+) exchange regulatory cofactor NHE-RF1 9368 reviewed
O14757 BXGT004092 Serine/threonine-protein kinase Chk1 1111 reviewed Kinase
O15123 BXGT004130 Angiopoietin-2 285 reviewed Signaling
O15151 BXGT004132 Protein Mdm4 4194 reviewed Nucleic acid binding
O15297 BXGT004149 Protein phosphatase 1D 8493 reviewed Enzyme
O60566 BXGT004884 Mitotic checkpoint serine/threonine-protein kinase BUB1 beta 701 reviewed Kinase
O60674 BXGT004892 Tyrosine-protein kinase JAK2 3717 reviewed Kinase
O60760 BXGT004899 Hematopoietic prostaglandin D synthase 27306 reviewed
O75417 BXGT005124 DNA polymerase theta 10721 reviewed Enzyme
O94762 BXGT005329 ATP-dependent DNA helicase Q5 9400 reviewed Enzyme
O96017 BXGT005415 Serine/threonine-protein kinase Chk2 11200 reviewed Kinase
P00533 BXGT005575 Epidermal growth factor receptor 1956 reviewed Kinase
P01106 BXGT005730 Myc proto-oncogene protein 4609 reviewed Transcription factor
P01112 BXGT005732 GTPase HRas 3265 reviewed Enzyme modulator
P01116 BXGT005733 GTPase KRas 3845 reviewed Enzyme modulator
P01236 BXGT005744 Prolactin 5617 reviewed Signaling
P03372 BXGT006059 Estrogen receptor 2099 reviewed Nuclear receptor
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 2064 reviewed Kinase
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P04798 BXGT006265 Cytochrome P450 1A1 1543 reviewed Enzyme
P05093 BXGT006313 Steroid 17-alpha-hydroxylase/17,20 lyase 1586 reviewed
P07949 BXGT006703 Proto-oncogene tyrosine-protein kinase receptor Ret 5979 reviewed Kinase
P08183 BXGT006741 ATP-dependent translocase ABCB1 5243 reviewed Transporter
P09211 BXGT006869 Glutathione S-transferase P 2950 reviewed
P09488 BXGT006899 Glutathione S-transferase Mu 1 2944 reviewed
P09874 BXGT006934 Poly [ADP-ribose] polymerase 1 142 reviewed
P09936 BXGT006943 Ubiquitin carboxyl-terminal hydrolase isozyme L1 7345 reviewed Enzyme
P10275 BXGT007552 Androgen receptor 367 reviewed Nuclear receptor
P10635 BXGT007595 Cytochrome P450 2D6 1565 reviewed
P11511 BXGT007717 Aromatase 1588 reviewed Enzyme
P12830 BXGT007852 Cadherin-1 999 reviewed
P14061 BXGT007979 Estradiol 17-beta-dehydrogenase 1 3292 reviewed Enzyme
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P16070 BXGT008186 CD44 antigen 960 reviewed
P16455 BXGT008229 Methylated-DNA--protein-cysteine methyltransferase 4255 reviewed
P17936 BXGT008357 Insulin-like growth factor-binding protein 3 3486 reviewed Enzyme modulator
P18754 BXGT008423 Regulator of chromosome condensation 1104 reviewed
P18887 BXGT008437 DNA repair protein XRCC1 7515 reviewed
P19838 BXGT008526 Nuclear factor NF-kappa-B p105 subunit 4790 reviewed Transcription factor
P21802 BXGT008691 Fibroblast growth factor receptor 2 2263 reviewed Kinase
P21964 BXGT008714 Catechol O-methyltransferase 1312 reviewed Enzyme
P23470 BXGT008872 Receptor-type tyrosine-protein phosphatase gamma 5793 reviewed Enzyme
P24385 BXGT008965 G1/S-specific cyclin-D1 595 reviewed Enzyme modulator
P30279 BXGT009415 G1/S-specific cyclin-D2 894 reviewed Enzyme modulator
P30711 BXGT009460 Glutathione S-transferase theta-1 2952 reviewed
P31947 BXGT009589 14-3-3 protein sigma 2810 reviewed Chaperone
P33981 BXGT009744 Dual specificity protein kinase TTK 7272 reviewed Kinase
P35222 BXGT009799 Catenin beta-1 1499 reviewed
P35610 BXGT009855 Sterol O-acyltransferase 1 6646 reviewed Enzyme
P36897 BXGT009941 TGF-beta receptor type-1 7046 reviewed Kinase
P37059 BXGT009957 Estradiol 17-beta-dehydrogenase 2 3294 reviewed Enzyme
P38398 BXGT010037 Breast cancer type 1 susceptibility protein 672 reviewed Enzyme
P40692 BXGT010195 DNA mismatch repair protein Mlh1 4292 reviewed Nucleic acid binding
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5290 reviewed Kinase
P42898 BXGT010344 Methylenetetrahydrofolate reductase 4524 reviewed
P43246 BXGT010371 DNA mismatch repair protein Msh2 4436 reviewed Nucleic acid binding
P46063 BXGT010501 ATP-dependent DNA helicase Q1 5965 reviewed Enzyme
P48449 BXGT010632 Lanosterol synthase 4047 reviewed
P49789 BXGT010742 Bis(5'-adenosyl)-triphosphatase 2272 reviewed
P49959 BXGT010766 Double-strand break repair protein MRE11 4361 reviewed
P50225 BXGT010781 Sulfotransferase 1A1 6817 reviewed
P52701 BXGT010943 DNA mismatch repair protein Msh6 2956 reviewed Nucleic acid binding
P54132 BXGT011032 Bloom syndrome protein 641 reviewed
P54278 BXGT011038 Mismatch repair endonuclease PMS2 5395 reviewed Nucleic acid binding
P60484 BXGT011307 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 5728 reviewed Enzyme
Q00987 BXGT012559 E3 ubiquitin-protein ligase Mdm2 4193 reviewed Nucleic acid binding
Q02224 BXGT012643 Centromere-associated protein E 1062 reviewed Cellular structure
Q02763 BXGT012667 Angiopoietin-1 receptor 7010 reviewed Kinase
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A 4297 reviewed
Q06609 BXGT012884 DNA repair protein RAD51 homolog 1 5888 reviewed
Q09472 BXGT013038 Histone acetyltransferase p300 2033 reviewed
Q13315 BXGT013339 Serine-protein kinase ATM 472 reviewed Kinase
Q13535 BXGT013370 Serine/threonine-protein kinase ATR 545 reviewed Kinase
Q14191 BXGT013452 Werner syndrome ATP-dependent helicase 7486 reviewed Enzyme
Q14790 BXGT013505 Caspase-8 841 reviewed Enzyme
Q15389 BXGT013564 Angiopoietin-1 284 reviewed Signaling
Q15831 BXGT013604 Serine/threonine-protein kinase STK11 6794 reviewed Kinase
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha 3091 reviewed Transcription factor
Q17RS7 BXGT013697 Flap endonuclease GEN homolog 1 348654 reviewed
Q86YC2 BXGT017633 Partner and localizer of BRCA2 79728 reviewed
Q8IYD8 BXGT018367 Fanconi anemia group M protein 57697 reviewed Enzyme
Q8NEM0 BXGT018555 Microcephalin 79648 reviewed Nucleic acid binding
Q8WY64 BXGT019017 E3 ubiquitin-protein ligase MYLIP 29116 reviewed
Q92547 BXGT019355 DNA topoisomerase 2-binding protein 1 11073 reviewed
Q92698 BXGT019362 DNA repair and recombination protein RAD54-like 8438 reviewed
Q96RL1 BXGT019730 BRCA1-A complex subunit RAP80 51720 reviewed
Q99728 BXGT019956 BRCA1-associated RING domain protein 1 580 reviewed
Q99816 BXGT019966 Tumor susceptibility gene 101 protein 7251 reviewed Enzyme
Q9NPI1 BXGT021160 Bromodomain-containing protein 7 29117 reviewed Epigenetic regulator
Q9NR12 BXGT021174 PDZ and LIM domain protein 7 9260 reviewed Cellular structure
Q9NW38 BXGT021230 E3 ubiquitin-protein ligase FANCL 55120 reviewed Enzyme
Q9UIF7 BXGT021717 Adenine DNA glycosylase 4595 reviewed Enzyme
Q9UPY3 BXGT021802 Endoribonuclease Dicer 23405 reviewed Enzyme
Q9UQ84 BXGT021807 Exonuclease 1 9156 reviewed Enzyme
Q9Y253 BXGT022216 DNA polymerase eta 5429 reviewed
Q9Y2H9 BXGT022234 Microtubule-associated serine/threonine-protein kinase 1 22983 reviewed Kinase
Q9Y5W5 BXGT022303 Wnt inhibitory factor 1 11197 reviewed Calcium-binding protein
P35232 BXGT022663 Prohibitin 5245 reviewed
P25054 BXGT022961 Adenomatous polyposis coli protein 324 reviewed
Q92878 BXGT023071 DNA repair protein RAD50 10111 reviewed
Q9H611 BXGT024211 ATP-dependent DNA helicase PIF1 80119 reviewed
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease