Showing entry for Cyclin-K



                       
General Target Information
BXGT IdBXGT005163
Protein NameCyclin-K
Uniport IdO75909
GeneCCNK
Gene Id8812
DomainCyclin_C; Cyclin_N
Pfam PF02984   PF00134  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007049 cell cycle
Biological Process GO:0051301 cell division
Biological Process GO:0006974 cellular response to DNA damage stimulus
Biological Process GO:0044828 negative regulation by host of viral genome replication
Biological Process GO:0032786 positive regulation of DNA-templated transcription, elongation
Biological Process GO:2001165 positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0042795 snRNA transcription by RNA polymerase II
Biological Process GO:0006366 transcription by RNA polymerase II
Biological Process GO:0006368 transcription elongation from RNA polymerase II promoter
molecular function GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity
molecular function GO:0004693 cyclin-dependent protein serine/threonine kinase activity
molecular function GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity
molecular function GO:0019901 protein kinase binding
molecular function GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity
cellular component GO:0008024 cyclin/CDK positive transcription elongation factor complex
cellular component GO:0002944 cyclin K-CDK12 complex
cellular component GO:0002945 cyclin K-CDK13 complex
cellular component GO:0042025 host cell nucleus
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-112382 Formation of RNA Pol II elongation complex
R-HSA-162582 Signal Transduction
R-HSA-162587 HIV Life Cycle
R-HSA-162599 Late Phase of HIV Life Cycle
R-HSA-162906 HIV Infection
R-HSA-1643685 Disease
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat
R-HSA-167172 Transcription of the HIV genome
R-HSA-167287 HIV elongation arrest and recovery
R-HSA-167290 Pausing and recovery of HIV elongation
R-HSA-170834 Signaling by TGF-beta Receptor Complex
R-HSA-212436 Generic Transcription Pathway
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-5663205 Infectious disease
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-HSA-6807505 RNA polymerase II transcribes snRNA genes
R-HSA-6807505 RNA polymerase II transcribes snRNA genes
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-74160 Gene expression (Transcription)
R-HSA-75955 RNA Polymerase II Transcription Elongation
R-HSA-9006936 Signaling by TGFB family members
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0016202 BXGD001050 Flatfoot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0020534 BXGD001421 Orbital separation excessive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0153594 BXGD003669 Malignant neoplasm of testis Neoplasms; Male Urogenital Diseases; Endocrine System Diseases
C0221355 BXGD004447 Macrocephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0239234 BXGD004974 Low set ears
C0266617 BXGD005700 Congenital anomaly of face Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Musculoskeletal Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0426429 BXGD008564 Broad nasal tip
C0426886 BXGD008594 Tapering fingers (finding)
C0431478 BXGD008692 Posteriorly rotated ear
C0557874 BXGD009444 Global developmental delay
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C1535926 BXGD013322 Neurodevelopmental Disorders Mental Disorders
C1844809 BXGD014677 Thick nasal alae
C1849340 BXGD015039 Long palpebral fissure
C1849367 BXGD015046 Nasal bridge wide
C1865014 BXGD016282 Long philtrum
C3276036 BXGD018682 High anterior hairline
C4021066 BXGD020539 Narrow jaw
C4281771 BXGD022414 Thin eyebrow
C4748381 BXGD024000 INTELLECTUAL DEVELOPMENTAL DISORDER WITH HYPERTELORISM AND DISTINCTIVE FACIES
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein