Showing entry for Neurodevelopmental Disorders


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD013322
Disease NameNeurodevelopmental Disorders
Disease CUI IdC1535926
MeSH Codes F03  
Disease Class NameMental Disorders
Semantic TypeMental or Behavioral Dysfunction
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id   
Disease Ontology Class Name
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
A1Z1Q3 BXGT001069 ADP-ribose glycohydrolase MACROD2 140733 reviewed
O00189 BXGT003891 AP-4 complex subunit mu-1 9179 reviewed Extracellular structure
O00329 BXGT003909 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 5293 reviewed Kinase
O00555 BXGT003936 Voltage-dependent P/Q-type calcium channel subunit alpha-1A 773 reviewed Ion channel
O00571 BXGT003938 ATP-dependent RNA helicase DDX3X 1654 reviewed
O14672 BXGT004081 Disintegrin and metalloproteinase domain-containing protein 10 102 reviewed
O14936 BXGT004114 Peripheral plasma membrane protein CASK 8573 reviewed Kinase
O15054 BXGT004121 Lysine-specific demethylase 6B 23135 reviewed Epigenetic regulator
O15297 BXGT004149 Protein phosphatase 1D 8493 reviewed Enzyme
O15379 BXGT004159 Histone deacetylase 3 8841 reviewed Epigenetic regulator
O15394 BXGT004163 Neural cell adhesion molecule 2 4685 reviewed
O15409 BXGT004166 Forkhead box protein P2 93986 reviewed
O15455 BXGT004171 Toll-like receptor 3 7098 reviewed Receptor
O43157 BXGT004572 Plexin-B1 5364 reviewed
O43175 BXGT004575 D-3-phosphoglycerate dehydrogenase 26227 reviewed Enzyme
O60260 BXGT004864 E3 ubiquitin-protein ligase parkin 5071 reviewed Enzyme
O60264 BXGT004865 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 8467 reviewed Enzyme
O60760 BXGT004899 Hematopoietic prostaglandin D synthase 27306 reviewed
O75129 BXGT005101 Astrotactin-2 23245 reviewed
O75151 BXGT005103 Lysine-specific demethylase PHF2 5253 reviewed
O75899 BXGT005161 Gamma-aminobutyric acid type B receptor subunit 2 9568 reviewed G-protein coupled receptor
O75909 BXGT005163 Cyclin-K 8812 reviewed Enzyme modulator
O76039 BXGT005171 Cyclin-dependent kinase-like 5 6792 reviewed Kinase
O95622 BXGT005386 Adenylate cyclase type 5 111 reviewed
O95985 BXGT005410 DNA topoisomerase 3-beta-1 8940 reviewed Enzyme
P00492 BXGT005556 Hypoxanthine-guanine phosphoribosyltransferase 3251 reviewed Enzyme
P01189 BXGT005742 Pro-opiomelanocortin 5443 reviewed
P02649 BXGT005909 Apolipoprotein E 348 reviewed
P02741 BXGT005936 C-reactive protein 1401 reviewed
P04629 BXGT006239 High affinity nerve growth factor receptor 4914 reviewed Kinase
P04899 BXGT006281 Guanine nucleotide-binding protein G(i) subunit alpha-2 2771 reviewed Enzyme modulator
P05067 BXGT006306 Amyloid-beta precursor protein 351 reviewed Enzyme modulator
P05231 BXGT006345 Interleukin-6 3569 reviewed
P05362 BXGT006350 Intercellular adhesion molecule 1 3383 reviewed
P06213 BXGT006425 Insulin receptor 3643 reviewed Kinase
P06730 BXGT006487 Eukaryotic translation initiation factor 4E 1977 reviewed Nucleic acid binding
P07384 BXGT006619 Calpain-1 catalytic subunit 823 reviewed Enzyme
P08243 BXGT006755 Asparagine synthetase [glutamine-hydrolyzing] 440 reviewed Enzyme
P08581 BXGT006794 Hepatocyte growth factor receptor 4233 reviewed Kinase
P08842 BXGT006830 Steryl-sulfatase 412 reviewed Enzyme
P09038 BXGT006851 Fibroblast growth factor 2 2247 reviewed Signaling
P09211 BXGT006869 Glutathione S-transferase P 2950 reviewed
P0C0S5 BXGT007390 Histone H2A.Z 3015 reviewed
P10636 BXGT007596 Microtubule-associated protein tau 4137 reviewed
P11166 BXGT007661 Solute carrier family 2, facilitated glucose transporter member 1 6513 reviewed Transporter
P11473 BXGT007709 Vitamin D3 receptor 7421 reviewed Nuclear receptor
P11498 BXGT007714 Pyruvate carboxylase, mitochondrial 5091 reviewed Enzyme
P11712 BXGT007738 Cytochrome P450 2C9 1559 reviewed
P11926 BXGT007760 Ornithine decarboxylase 4953 reviewed Enzyme
P13637 BXGT007933 Sodium/potassium-transporting ATPase subunit alpha-3 478 reviewed Transporter
P14867 BXGT008061 Gamma-aminobutyric acid receptor subunit alpha-1 2554 reviewed Ion channel
P14868 BXGT008062 Aspartate--tRNA ligase, cytoplasmic 1615 reviewed Enzyme
P15056 BXGT008075 Serine/threonine-protein kinase B-raf 673 reviewed Kinase
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P15884 BXGT008166 Transcription factor 4 6925 reviewed Transcription factor
P16389 BXGT008221 Potassium voltage-gated channel subfamily A member 2 3737 reviewed Ion channel
P16410 BXGT008224 Cytotoxic T-lymphocyte protein 4 1493 reviewed
P18089 BXGT008379 Alpha-2B adrenergic receptor 151 reviewed G-protein coupled receptor
P18507 BXGT008411 Gamma-aminobutyric acid receptor subunit gamma-2 2566 reviewed Ion channel
P20472 BXGT008578 Parvalbumin alpha 5816 reviewed Calcium-binding protein
P21579 BXGT008665 Synaptotagmin-1 6857 reviewed Transporter
P21675 BXGT008678 Transcription initiation factor TFIID subunit 1 6872 reviewed Kinase
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 54658 reviewed
P22897 BXGT008816 Macrophage mannose receptor 1 4360 reviewed
P23560 BXGT008883 Brain-derived neurotrophic factor 627 reviewed Signaling
P25101 BXGT009018 Endothelin-1 receptor 1909 reviewed G-protein coupled receptor
P26196 BXGT009089 Probable ATP-dependent RNA helicase DDX6 1656 reviewed
P26640 BXGT009123 Valine--tRNA ligase 7407 reviewed
P27635 BXGT009194 60S ribosomal protein L10 6134 reviewed Nucleic acid binding
P27797 BXGT009206 Calreticulin 811 reviewed Calcium-binding protein
P28472 BXGT009260 Gamma-aminobutyric acid receptor subunit beta-3 2562 reviewed Ion channel
P28907 BXGT009301 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 952 reviewed Enzyme
P29074 BXGT009313 Tyrosine-protein phosphatase non-receptor type 4 5775 reviewed
P30531 BXGT009432 Sodium- and chloride-dependent GABA transporter 1 6529 reviewed Transporter
P30559 BXGT009442 Oxytocin receptor 5021 reviewed G-protein coupled receptor
P30988 BXGT009491 Calcitonin receptor 799 reviewed G-protein coupled receptor
P31391 BXGT009535 Somatostatin receptor type 4 6754 reviewed G-protein coupled receptor
P32004 BXGT009594 Neural cell adhesion molecule L1 3897 reviewed
P33261 BXGT009707 Cytochrome P450 2C19 1557 reviewed
P34969 BXGT009777 5-hydroxytryptamine receptor 7 3363 reviewed G-protein coupled receptor
P35222 BXGT009799 Catenin beta-1 1499 reviewed
P35348 BXGT009814 Alpha-1A adrenergic receptor 148 reviewed G-protein coupled receptor
P35498 BXGT009838 Sodium channel protein type 1 subunit alpha 6323 reviewed Ion channel
P37840 BXGT010015 Alpha-synuclein 6622 reviewed Transporter
P41229 BXGT010239 Lysine-specific demethylase 5C 8242 reviewed
P41594 BXGT010266 Metabotropic glutamate receptor 5 2915 reviewed G-protein coupled receptor
P42262 BXGT010294 Glutamate receptor 2 2891 reviewed Ion channel
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5290 reviewed Kinase
P42338 BXGT010303 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 5291 reviewed Kinase
P42345 BXGT010304 Serine/threonine-protein kinase mTOR 2475 reviewed Kinase
P42658 BXGT010327 Dipeptidyl aminopeptidase-like protein 6 1804 reviewed Enzyme
P42858 BXGT010341 Huntingtin 3064 reviewed
P43007 BXGT010350 Neutral amino acid transporter A 6509 reviewed Transporter
P43354 BXGT010381 Nuclear receptor subfamily 4 group A member 2 4929 reviewed Nuclear receptor
P43681 BXGT010407 Neuronal acetylcholine receptor subunit alpha-4 1137 reviewed Ion channel
P46937 BXGT010554 Transcriptional coactivator YAP1 10413 reviewed Enzyme modulator
P47870 BXGT010591 Gamma-aminobutyric acid receptor subunit beta-2 2561 reviewed Ion channel
P48029 BXGT010606 Sodium- and chloride-dependent creatine transporter 1 6535 reviewed Transporter
P48058 BXGT010614 Glutamate receptor 4 2893 reviewed Ion channel
P48736 BXGT010658 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 5294 reviewed Kinase
P49711 BXGT010728 Transcriptional repressor CTCF 10664 reviewed Transcription factor
P50583 BXGT010813 Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] 318 reviewed Enzyme
P51531 BXGT010851 Probable global transcription activator SNF2L2 6595 reviewed Epigenetic regulator
P51532 BXGT010852 Transcription activator BRG1 6597 reviewed Epigenetic regulator
P52799 BXGT010956 Ephrin-B2 1948 reviewed Signaling
P53350 BXGT010984 Serine/threonine-protein kinase PLK1 5347 reviewed Kinase
P53667 BXGT011008 LIM domain kinase 1 3984 reviewed Kinase
P54136 BXGT011033 Arginine--tRNA ligase, cytoplasmic 5917 reviewed
P55055 BXGT011101 Oxysterols receptor LXR-beta 7376 reviewed Nuclear receptor
P55201 BXGT011109 Peregrin 7862 reviewed
P58400 BXGT011235 Neurexin-1-beta 9378 reviewed
P60484 BXGT011307 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 5728 reviewed Enzyme
P60709 BXGT011322 Actin, cytoplasmic 1 60 reviewed Cellular structure
P60763 BXGT011327 Ras-related C3 botulinum toxin substrate 3 5881 reviewed Enzyme modulator
P60842 BXGT011330 Eukaryotic initiation factor 4A-I 1973 reviewed
P60880 BXGT011335 Synaptosomal-associated protein 25 6616 reviewed Transporter
P61086 BXGT011357 Ubiquitin-conjugating enzyme E2 K 3093 reviewed
P62491 BXGT011430 Ras-related protein Rab-11A 8766 reviewed
P62805 BXGT011457 Histone H4 8370 reviewed
P63027 BXGT011487 Vesicle-associated membrane protein 2 6844 reviewed
P63244 BXGT011510 Receptor of activated protein C kinase 1 10399 reviewed
P67775 BXGT011563 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 5515 reviewed
P67870 BXGT011566 Casein kinase II subunit beta 1460 reviewed Kinase
P68400 BXGT011599 Casein kinase II subunit alpha 1457 reviewed Kinase
P78352 BXGT011836 Disks large homolog 4 1742 reviewed Receptor
Q00604 BXGT012538 Norrin 4693 reviewed
Q01484 BXGT012592 Ankyrin-2 287 reviewed
Q01668 BXGT012605 Voltage-dependent L-type calcium channel subunit alpha-1D 776 reviewed Ion channel
Q01959 BXGT012624 Sodium-dependent dopamine transporter 6531 reviewed Transporter
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A 4297 reviewed
Q04637 BXGT012771 Eukaryotic translation initiation factor 4 gamma 1 1981 reviewed Nucleic acid binding
Q05193 BXGT012810 Dynamin-1 1759 reviewed Enzyme modulator
Q06124 BXGT012856 Tyrosine-protein phosphatase non-receptor type 11 5781 reviewed
Q06787 BXGT012890 Synaptic functional regulator FMR1 2332 reviewed Nucleic acid binding
Q07075 BXGT012917 Glutamyl aminopeptidase 2028 reviewed Enzyme
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform 5530 reviewed
Q11203 BXGT013218 CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase 6487 reviewed
Q12791 BXGT013264 Calcium-activated potassium channel subunit alpha-1 3778 reviewed Ion channel
Q12830 BXGT013268 Nucleosome-remodeling factor subunit BPTF 2186 reviewed
Q12879 BXGT013275 Glutamate receptor ionotropic, NMDA 2A 2903 reviewed Ion channel
Q13002 BXGT013303 Glutamate receptor ionotropic, kainate 2 2898 reviewed Ion channel
Q13153 BXGT013319 Serine/threonine-protein kinase PAK 1 5058 reviewed Kinase
Q13155 BXGT013320 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 7965 reviewed
Q13224 BXGT013328 Glutamate receptor ionotropic, NMDA 2B 2904 reviewed Ion channel
Q13394 BXGT013347 Putative nucleotidyltransferase MAB21L1 4081 reviewed
Q13618 BXGT013382 Cullin-3 8452 reviewed
Q13627 BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A 1859 reviewed Kinase
Q13936 BXGT013404 Voltage-dependent L-type calcium channel subunit alpha-1C 775 reviewed Ion channel
Q14416 BXGT013468 Metabotropic glutamate receptor 2 2912 reviewed G-protein coupled receptor
Q14469 BXGT013473 Transcription factor HES-1 3280 reviewed Transcription factor
Q14643 BXGT013493 Inositol 1,4,5-trisphosphate receptor type 1 3708 reviewed Ion channel
Q14683 BXGT013500 Structural maintenance of chromosomes protein 1A 8243 reviewed
Q14721 BXGT013502 Potassium voltage-gated channel subfamily B member 1 3745 reviewed Ion channel
Q14831 BXGT013506 Metabotropic glutamate receptor 7 2917 reviewed G-protein coupled receptor
Q14839 BXGT013509 Chromodomain-helicase-DNA-binding protein 4 1108 reviewed
Q15047 BXGT013528 Histone-lysine N-methyltransferase SETDB1 9869 reviewed
Q15257 BXGT013554 Serine/threonine-protein phosphatase 2A activator 5524 reviewed Enzyme modulator
Q15303 BXGT013557 Receptor tyrosine-protein kinase erbB-4 2066 reviewed Kinase
Q15910 BXGT013612 Histone-lysine N-methyltransferase EZH2 2146 reviewed Epigenetic regulator
Q16774 BXGT013668 Guanylate kinase 2987 reviewed Kinase
Q6PI48 BXGT016471 Aspartate--tRNA ligase, mitochondrial 55157 reviewed Enzyme
Q7L7X3 BXGT016997 Serine/threonine-protein kinase TAO1 57551 reviewed Kinase
Q7RTN6 BXGT017085 STE20-related kinase adapter protein alpha 92335 reviewed Kinase
Q86UE8 BXGT017612 Serine/threonine-protein kinase tousled-like 2 11011 reviewed Kinase
Q8IWQ3 BXGT018355 Serine/threonine-protein kinase BRSK2 9024 reviewed Kinase
Q8IWS0 BXGT018356 PHD finger protein 6 84295 reviewed Nucleic acid binding
Q8IZS8 BXGT018372 Voltage-dependent calcium channel subunit alpha-2/delta-3 55799 reviewed Ion channel
Q8N0W4 BXGT018492 Neuroligin-4, X-linked 57502 reviewed
Q8NEB9 BXGT018553 Phosphatidylinositol 3-kinase catalytic subunit type 3 5289 reviewed Kinase
Q8NEM0 BXGT018555 Microcephalin 79648 reviewed Nucleic acid binding
Q8NFD5 BXGT018560 AT-rich interactive domain-containing protein 1B 57492 reviewed
Q8WW43 BXGT018998 Gamma-secretase subunit APH-1B 83464 reviewed Enzyme modulator
Q8WXF7 BXGT019011 Atlastin-1 51062 reviewed Enzyme modulator
Q8WZ19 BXGT019022 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 253980 reviewed
Q92731 BXGT019366 Estrogen receptor beta 2100 reviewed Nuclear receptor
Q92736 BXGT019367 Ryanodine receptor 2 6262 reviewed Ion channel
Q92793 BXGT019374 CREB-binding protein 1387 reviewed
Q92794 BXGT019375 Histone acetyltransferase KAT6A 7994 reviewed Enzyme
Q93009 BXGT019455 Ubiquitin carboxyl-terminal hydrolase 7 7874 reviewed Enzyme
Q96CW9 BXGT019634 Netrin-G2 84628 reviewed Enzyme modulator
Q96PU5 BXGT019711 E3 ubiquitin-protein ligase NEDD4-like 23327 reviewed Enzyme
Q96T60 BXGT019745 Bifunctional polynucleotide phosphatase/kinase 11284 reviewed
Q99250 BXGT019913 Sodium channel protein type 2 subunit alpha 6326 reviewed Ion channel
Q99496 BXGT019925 E3 ubiquitin-protein ligase RING2 6045 reviewed
Q99707 BXGT019952 Methionine synthase 4548 reviewed
Q99928 BXGT019975 Gamma-aminobutyric acid receptor subunit gamma-3 2567 reviewed Ion channel
Q9BXJ9 BXGT020170 N-alpha-acetyltransferase 15, NatA auxiliary subunit 80155 reviewed Enzyme
Q9BYW2 BXGT020192 Histone-lysine N-methyltransferase SETD2 29072 reviewed Epigenetic regulator
Q9H2X9 BXGT020459 Solute carrier family 12 member 5 57468 reviewed Transporter
Q9H4W6 BXGT020478 Transcription factor COE3 253738 reviewed
Q9H9B1 BXGT020501 Histone-lysine N-methyltransferase EHMT1 79813 reviewed Epigenetic regulator
Q9HAR2 BXGT020506 Adhesion G protein-coupled receptor L3 23284 reviewed G-protein coupled receptor
Q9HD40 BXGT020542 O-phosphoseryl-tRNA(Sec) selenium transferase 51091 reviewed
Q9NQX3 BXGT021172 Gephyrin 10243 reviewed
Q9NRF2 BXGT021185 SH2B adapter protein 1 25970 reviewed
Q9NWB1 BXGT021231 RNA binding protein fox-1 homolog 1 54715 reviewed Nucleic acid binding
Q9NY46 BXGT021248 Sodium channel protein type 3 subunit alpha 6328 reviewed Ion channel
Q9UBB5 BXGT021649 Methyl-CpG-binding domain protein 2 8932 reviewed Epigenetic regulator
Q9UBK8 BXGT021655 Methionine synthase reductase 4552 reviewed
Q9UGL1 BXGT021685 Lysine-specific demethylase 5B 10765 reviewed Epigenetic regulator
Q9UGM6 BXGT021687 Tryptophan--tRNA ligase, mitochondrial 10352 reviewed
Q9UKI8 BXGT021743 Serine/threonine-protein kinase tousled-like 1 9874 reviewed Kinase
Q9UL54 BXGT021755 Serine/threonine-protein kinase TAO2 9344 reviewed Kinase
Q9ULJ6 BXGT021761 Zinc finger MIZ domain-containing protein 1 57178 reviewed
Q9UPP1 BXGT021800 Histone lysine demethylase PHF8 23133 reviewed
Q9UQD0 BXGT021811 Sodium channel protein type 8 subunit alpha 6334 reviewed Ion channel
Q9Y233 BXGT022210 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 10846 reviewed
Q9Y2A7 BXGT022227 Nck-associated protein 1 10787 reviewed
Q9Y2I2 BXGT022236 Netrin-G1 22854 reviewed Enzyme modulator
Q9Y4D2 BXGT022274 Sn1-specific diacylglycerol lipase alpha 747 reviewed
Q9Y5L0 BXGT022296 Transportin-3 23534 reviewed Transporter
Q9Y5P4 BXGT022298 Collagen type IV alpha-3-binding protein 10087 reviewed Transporter
Q9Y5S2 BXGT022301 Serine/threonine-protein kinase MRCK beta 9578 reviewed Kinase
Q9Y646 BXGT022317 Carboxypeptidase Q 10404 reviewed Enzyme
Q15878 BXGT022659 Voltage-dependent R-type calcium channel subunit alpha-1E 777 reviewed Ion channel
Q7Z4S6 BXGT023001 Kinesin-like protein KIF21A 55605 reviewed Cellular structure
Q14678 BXGT023543 KN motif and ankyrin repeat domain-containing protein 1 23189 reviewed
O14490 BXGT023570 Disks large-associated protein 1 9229 reviewed Receptor
Q9UBP0 BXGT023601 Spastin 6683 reviewed Cellular structure
Q8IX03 BXGT024000 Protein KIBRA 23286 reviewed
Q8IYU8 BXGT024759 Calcium uptake protein 2, mitochondrial 221154 reviewed Calcium-binding protein
Q8NEZ4 BXGT024850 Histone-lysine N-methyltransferase 2C 58508 reviewed
P51608 BXGT025073 Methyl-CpG-binding protein 2 4204 reviewed Epigenetic regulator
P49366 BXGT025175 Deoxyhypusine synthase 1725 reviewed
Q05086 BXGT025648 Ubiquitin-protein ligase E3A 7337 reviewed
Q96C45 BXGT025705 Serine/threonine-protein kinase ULK4 54986 reviewed Kinase
Q8TAB3 BXGT025819 Protocadherin-19 57526 reviewed
Q9UQE7 BXGT025899 Structural maintenance of chromosomes protein 3 9126 reviewed
P19532 BXGT026110 Transcription factor E3 7030 reviewed
P09471 BXGT026153 Guanine nucleotide-binding protein G(o) subunit alpha 2775 reviewed Enzyme modulator
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease