Showing entry for Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005281
Protein NamePotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
Uniport IdO88703
GeneHcn2
Gene Id15166
DomaincNMP_binding; Ion_trans; Ion_trans_N
Pfam PF00027   PF00520   PF08412  
OrganismMus musculus (Mouse)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0071320 cellular response to cAMP
Biological Process GO:0071321 cellular response to cGMP
Biological Process GO:1990573 potassium ion import across plasma membrane
Biological Process GO:0071805 potassium ion transmembrane transport
Biological Process GO:0034765 regulation of ion transmembrane transport
Biological Process GO:0042391 regulation of membrane potential
Biological Process GO:0098719 sodium ion import across plasma membrane
Biological Process GO:0035725 sodium ion transmembrane transport
molecular function GO:0030552 cAMP binding
molecular function GO:0042802 identical protein binding
molecular function GO:0005222 intracellular cAMP-activated cation channel activity
molecular function GO:0060090 molecular adaptor activity
molecular function GO:0030165 PDZ domain binding
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0005249 voltage-gated potassium channel activity
molecular function GO:0005248 voltage-gated sodium channel activity
cellular component GO:0030424 axon
cellular component GO:0005737 cytoplasm
cellular component GO:0032590 dendrite membrane
cellular component GO:0043198 dendritic shaft
cellular component GO:0098855 HCN channel complex
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0016020 membrane
cellular component GO:0043025 neuronal cell body
cellular component GO:0005886 plasma membrane
cellular component GO:0036477 somatodendritic compartment
cellular component GO:0045202 synapse
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000988 3' 5'-cyclic AMP 329.21
BXGC0036634 Cgmp 345.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein