Showing entry for 3' 5'-cyclic AMP


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0000988
Compound Name3' 5'-cyclic AMP
Structure
FormulaC10H12N5O6P
InchiKeyIVOMOUWHDPKRLL-KQYNXXCUSA-N
SMILESNC1=NC=NC2=C1N=CN2[C@@H]1O[C@@H]2COP(O)(=O)O[C@H]2[C@H]1O
InchiInChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
IUPAC(4aR,6R,7R,7aS)-6-(6-amino-9H-purin-9-yl)-2,7-dihydroxy-hexahydro-2?f?-furo[3,2-d][1,3,2]dioxaphosphinin-2-one
Molecular Weight329.21
Pubchem Id6076
Chembl IdCHEMBL316966
Targets of Information Source
DrugBank DB02527
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Q9UL51 BXGT021754 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 reviewed Ion channel HCN2 experimental -
P10644 BXGT007597 cAMP-dependent protein kinase type I-alpha regulatory subunit reviewed - PRKAR1A experimental -
P31323 BXGT009521 cAMP-dependent protein kinase type II-beta regulatory subunit reviewed - PRKAR2B experimental -
P94182 BXGT012127 Adenylate cyclase unreviewed - cyaB2 experimental -
Q98GN8 BXGT019897 Cyclic nucleotide-gated potassium channel mll3241 reviewed - mll3241 experimental -
P0ACJ8 BXGT007267 cAMP-activated global transcriptional regulator CRP reviewed - crp experimental -
PDB CMP
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P0ACJ8 BXGT007267 cAMP-activated global transcriptional regulator CRP reviewed crp - - - - -
P12369 BXGT007807 cAMP-dependent protein kinase type II-beta regulatory subunit reviewed Prkar2b - - - - -
P24476 BXGT008973 Antiviral protein DAP-30 reviewed - - - - -
P15266 BXGT008100 Nucleoside diphosphate kinase reviewed ndk - - - - -
O88703 BXGT005281 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 reviewed Hcn2 - - - - -
P00514 BXGT005565 cAMP-dependent protein kinase type I-alpha regulatory subunit reviewed PRKAR1A - - - - -
P40136 BXGT010159 Calmodulin-sensitive adenylate cyclase reviewed cya - - - - -
Q98GN8 BXGT019897 Cyclic nucleotide-gated potassium channel mll3241 reviewed mll3241 - - - - -
P94182 BXGT012127 Adenylate cyclase unreviewed cyaB2 - - - - -
Q540U1 BXGT015035 Class B acid phosphatase reviewed aphA - - - - -
Q9Y233 BXGT022210 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A reviewed PDE10A - - - - -
P55222 BXGT011114 Cyclic AMP receptor-like protein reviewed vfr - - - - -
O76977 BXGT005185 Hyperpolarization-activated (Ih) channel; Uncharacterized protein unreviewed - - - - -
Q08499 BXGT012988 cAMP-specific 3',5'-cyclic phosphodiesterase 4D reviewed PDE4D - - - - -
Q1GZZ4 BXGT013788 Cyclic nucleotide-binding domain (cNMP-BD) protein unreviewed Mfla_1926 - - - - -
P9WMH3 BXGT012388 CRP-like cAMP-activated global transcriptional regulator reviewed crp - - - - -
A0A384LKY8 BXGT000817 Adenylate cyclase 2 unreviewed cyaB - - - - -
Q13976 BXGT013409 cGMP-dependent protein kinase 1 reviewed PRKG1 Kinase - - 27 -
P07278 BXGT006590 cAMP-dependent protein kinase regulatory subunit reviewed BCY1 - - - - -
Q13976 BXGT013409 cGMP-dependent protein kinase 1 reviewed PRKG1 Kinase - - - -
Q9Y3Q4 BXGT022264 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 reviewed HCN4 Ion channel - - 830 -
Q79VI7 BXGT016899 CRP-like cAMP-activated global transcriptional regulator reviewed glxR - - - - -
P00516 BXGT005567 cGMP-dependent protein kinase 1 reviewed PRKG1 - - - - -
O88704 BXGT005282 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 reviewed Hcn1 - - - - -
Q9UL51 BXGT021754 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 reviewed HCN2 Ion channel - - - -
Q9Y3Q4 BXGT022264 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 reviewed HCN4 Ion channel - - - -
O05581 BXGT003977 Acetyltransferase Pat reviewed Rv0998 - - - - -
Q96PN6 BXGT019709 Adenylate cyclase type 10 reviewed ADCY10 - 54200 - - -
H7C677 BXGT003616 Crp family transcriptional regulator unreviewed APT58_01855 - - - 17000 -
E0RR11 BXGT003049 Uncharacterized protein unreviewed STHERM_c06300 - - - - -
Q5SID7 BXGT015712 Cyclic AMP receptor protein reviewed TTHA1437 - - - - -
Q9EQZ6 BXGT020303 Rap guanine nucleotide exchange factor 4 reviewed Rapgef4 - - - - -
A0QYW6 BXGT000925 Universal stress protein family protein, putative unreviewed MSMEG_3811 - - - 3320 -
Q13237 BXGT013331 cGMP-dependent protein kinase 2 reviewed PRKG2 Kinase - - 418 -
A0A0F7V8B2 BXGT000217 cAMP-dependent protein kinase regulatory subunit, putative unreviewed BN1205_095410 - - - - -
Q8ZKF6 BXGT019195 Acetyl-coenzyme A synthetase reviewed acs - - - - -
Q7KQK0 BXGT016984 cAMP-dependent protein kinase regulatory subunit unreviewed PF3D7_1223100 - - - 6 -
Q7KQK0 BXGT016984 cAMP-dependent protein kinase regulatory subunit unreviewed PF3D7_1223100 - - - 1.2 -
P10644 BXGT007597 cAMP-dependent protein kinase type I-alpha regulatory subunit reviewed PRKAR1A - - - - -
P73954 BXGT011731 Membrane-associated protein slr1513 reviewed slr1513 - - - 11000 -
O60741 BXGT004897 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 reviewed HCN1 - - - - -
Q72MQ6 BXGT016758 cGMP-specific phosphodiesterase unreviewed LIC_13137 - - - 240 -
P0ACK0 BXGT007268 cAMP-activated global transcriptional regulator CRP reviewed crp - - - - -
G0GA88 BXGT003361 Putative transcriptional regulator, Crp/Fnr family unreviewed Spith_0644 - - - - -
A0A384L3J4 BXGT000811 cAMP-regulatory protein unreviewed cap - - - - -
G4VPI6 BXGT003514 Phosphodiesterase unreviewed Smp_134140 - - - - -
P07900 BXGT006696 Heat shock protein HSP 90-alpha reviewed HSP90AA1 Chaperone - - - -
Q385V6 BXGT024138 Protein kinase A regulatory subunit unreviewed Tb11.02.2210 - - - - -
O95398 BXGT005378 Rap guanine nucleotide exchange factor 3 reviewed RAPGEF3 Enzyme modulator - - - -
Q6MLN6 BXGT024213 Uncharacterized protein unreviewed Bd1971 - - - - -
B5II98 BXGT024853 Uncharacterized protein unreviewed CPCC7001_1671 - - - - -
P0DTD1 BXGT023328 Replicase polyprotein 1ab reviewed rep - - - - -
Binding DB 50384264
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT019025 Rap guanine nucleotide exchange factor 4 reviewed Enzyme modulator RAPGEF4 - 40000 - -
reviewed BXGT019025 Rap guanine nucleotide exchange factor 4 reviewed Enzyme modulator RAPGEF4 - 48000 - -
CHEMBL CHEMBL316966
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 125 nM
P54132 BXGT011032 Bloom syndrome protein reviewed - BLM Potency '=' 3 nM
O15439 BXGT004169 Multidrug resistance-associated protein 4 reviewed Transporter ABCC4 Activity - - -
P10828 BXGT007624 Thyroid hormone receptor beta reviewed Nuclear receptor THRB Potency '=' 0 nM
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 5 nM
O15439 BXGT004169 Multidrug resistance-associated protein 4 reviewed Transporter ABCC4 Activity '=' 36 %
Q92830 BXGT019379 Histone acetyltransferase KAT2A reviewed - KAT2A Potency - 39810 nM
P00515 BXGT005566 cAMP-dependent protein kinase type II-alpha regulatory subunit reviewed - PRKAR2A K'a '=' 1 -
P31322 BXGT009520 cAMP-dependent protein kinase type II-beta regulatory subunit reviewed - PRKAR2B K'a '=' 1 -
P05131 BXGT006323 cAMP-dependent protein kinase catalytic subunit beta reviewed - PRKACB K'a '=' 1 -
P00517 BXGT005568 cAMP-dependent protein kinase catalytic subunit alpha reviewed - PRKACA K'a '=' 1 -
Q96J66 BXGT019680 ATP-binding cassette sub-family C member 11 reviewed Transporter ABCC11 Activity '=' 74 %
Q8TCC7 BXGT018794 Solute carrier family 22 member 8 reviewed Transporter SLC22A8 Activity - - -
O54735 BXGT004730 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed - Pde5a Km '=' 150000 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency '=' 22387 nM
Q76KC6 BXGT016863 Phosphodiesterase unreviewed - Pde8a Km '=' 50 nM
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Potency - 19952 nM
Q08493 BXGT012987 cAMP-specific 3',5'-cyclic phosphodiesterase 4C reviewed - PDE4C Hydrolysis '=' 1 -
Q07343 BXGT012926 cAMP-specific 3',5'-cyclic phosphodiesterase 4B reviewed - PDE4B Hydrolysis '=' 1 -
Q08499 BXGT012988 cAMP-specific 3',5'-cyclic phosphodiesterase 4D reviewed - PDE4D Hydrolysis '=' 1 -
P27815 BXGT009208 cAMP-specific 3',5'-cyclic phosphodiesterase 4A reviewed - PDE4A Hydrolysis '=' 1 -
P00328 BXGT005501 Alcohol dehydrogenase S chain reviewed - Ki '=' 780000 nM
P00327 BXGT005500 Alcohol dehydrogenase E chain reviewed - Ki '=' 780000 nM
Q13526 BXGT013369 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 reviewed - PIN1 Potency - 952 nM
E1BN64 BXGT003068 Phosphodiesterase unreviewed - PDE3B Km '=' 530 nM
Q8WZA2 BXGT019025 Rap guanine nucleotide exchange factor 4 reviewed Enzyme modulator RAPGEF4 IC50 '=' 40000 nM
O15439 BXGT004169 Multidrug resistance-associated protein 4 reviewed Transporter ABCC4 Km '=' 44500 nM
Q8WZA2 BXGT019025 Rap guanine nucleotide exchange factor 4 reviewed Enzyme modulator RAPGEF4 Ratio IC50 '=' 1 -
Q8WZA2 BXGT019025 Rap guanine nucleotide exchange factor 4 reviewed Enzyme modulator RAPGEF4 IC50 '=' 48000 nM
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 2818 nM
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 2377 nM
Q96J66 BXGT019680 ATP-binding cassette sub-family C member 11 reviewed Transporter ABCC11 Activity - - -
Q9Y253 BXGT022216 DNA polymerase eta reviewed - POLH Potency - 281 nM
O15439 BXGT004169 Multidrug resistance-associated protein 4 reviewed Transporter ABCC4 Activity '=' 39 %
Q9Y694 BXGT022321 Solute carrier family 22 member 7 reviewed Transporter SLC22A7 Activity - - -
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Potency - 366 nM
O15440 BXGT004170 Multidrug resistance-associated protein 5 reviewed Transporter ABCC5 Km '=' 379000 nM
O15439 BXGT004169 Multidrug resistance-associated protein 4 reviewed Transporter ABCC4 Activity '=' 48 %
P22629 BXGT008788 Streptavidin reviewed - Activity - - -
P49798 BXGT010745 Regulator of G-protein signaling 4 reviewed Enzyme modulator RGS4 Potency - 842 nM
O35956 BXGT004543 Solute carrier family 22 member 6 reviewed - Slc22a6 Activity - - -
Q6W5P4 BXGT016588 Neuropeptide S receptor reviewed - NPSR1 Potency '=' 1584 nM
O15440 BXGT004170 Multidrug resistance-associated protein 5 reviewed Transporter ABCC5 Activity '=' 35 %
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00072 Wild carrot Daucus carota Vegetables
BXGF00088 Barley Hordeum vulgare Cereals and cereal products
BXGF00134 Common bean Phaseolus vulgaris Pulses
BXGF00230 Carrot Daucus carota ssp. sativus Vegetables
BXGF00834 Yellow wax bean Phaseolus vulgaris Pulses
BXGF00835 Green bean Phaseolus vulgaris Pulses
BXGF04698 Isodon rubescens Isodon rubescens Others
BXGF05571 Ziziphus jujuba Ziziphus jujuba Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease