Showing entry for Glucocorticoid receptor


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT006451
Protein NameGlucocorticoid receptor
Uniport IdP06536
GeneNr3c1
Gene Id24413
DomainGCR; Hormone_recep; zf-C4
Pfam PF02155   PF00104   PF00105  
OrganismRattus norvegicus (Rat)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0030325 adrenal gland development
Biological Process GO:0007568 aging
Biological Process GO:0008209 androgen metabolic process
Biological Process GO:0007420 brain development
Biological Process GO:0071549 cellular response to dexamethasone stimulus
Biological Process GO:0071385 cellular response to glucocorticoid stimulus
Biological Process GO:0071286 cellular response to magnesium ion
Biological Process GO:0071383 cellular response to steroid hormone stimulus
Biological Process GO:0071560 cellular response to transforming growth factor beta stimulus
Biological Process GO:0048096 chromatin-mediated maintenance of transcription
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0007623 circadian rhythm
Biological Process GO:0007565 female pregnancy
Biological Process GO:0008211 glucocorticoid metabolic process
Biological Process GO:0042921 glucocorticoid receptor signaling pathway
Biological Process GO:0030324 lung development
Biological Process GO:0060603 mammary gland duct morphogenesis
Biological Process GO:0042711 maternal behavior
Biological Process GO:0014889 muscle atrophy
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:1900170 negative regulation of glucocorticoid mediated signaling pathway
Biological Process GO:0031914 negative regulation of synaptic plasticity
Biological Process GO:0045892 negative regulation of transcription, DNA-templated
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0043116 negative regulation of vascular permeability
Biological Process GO:0061051 positive regulation of cell growth involved in cardiac muscle cell development
Biological Process GO:0060999 positive regulation of dendritic spine development
Biological Process GO:2000324 positive regulation of glucocorticoid receptor signaling pathway
Biological Process GO:0014049 positive regulation of glutamate secretion
Biological Process GO:0043525 positive regulation of neuron apoptotic process
Biological Process GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0065003 protein-containing complex assembly
Biological Process GO:0042127 regulation of cell population proliferation
Biological Process GO:0031946 regulation of glucocorticoid biosynthetic process
Biological Process GO:0006111 regulation of gluconeogenesis
Biological Process GO:0010906 regulation of glucose metabolic process
Biological Process GO:0006355 regulation of transcription, DNA-templated
Biological Process GO:0014823 response to activity
Biological Process GO:0046685 response to arsenic-containing substance
Biological Process GO:0051592 response to calcium ion
Biological Process GO:0051412 response to corticosterone
Biological Process GO:0071548 response to dexamethasone
Biological Process GO:0051602 response to electrical stimulus
Biological Process GO:0014854 response to inactivity
Biological Process GO:0032868 response to insulin
Biological Process GO:0046689 response to mercury ion
Biological Process GO:0009314 response to radiation
Biological Process GO:0006351 transcription, DNA-templated
molecular function GO:0003682 chromatin binding
molecular function GO:0001046 core promoter sequence-specific DNA binding
molecular function GO:0003677 DNA binding
molecular function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
molecular function GO:0003700 DNA-binding transcription factor activity
molecular function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
molecular function GO:0003690 double-stranded DNA binding
molecular function GO:0004883 glucocorticoid receptor activity
molecular function GO:0031072 heat shock protein binding
molecular function GO:0042562 hormone binding
molecular function GO:0030544 Hsp70 protein binding
molecular function GO:0051879 Hsp90 protein binding
molecular function GO:0042802 identical protein binding
molecular function GO:0004879 nuclear receptor activity
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0019901 protein kinase binding
molecular function GO:0030971 receptor tyrosine kinase binding
molecular function GO:0070491 repressing transcription factor binding
molecular function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
molecular function GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
molecular function GO:0043565 sequence-specific DNA binding
molecular function GO:0005496 steroid binding
molecular function GO:1990239 steroid hormone binding
molecular function GO:0003713 transcription coactivator activity
molecular function GO:0008134 transcription factor binding
molecular function GO:0008270 zinc ion binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0043197 dendritic spine
cellular component GO:0016020 membrane
cellular component GO:0005815 microtubule organizing center
cellular component GO:0005739 mitochondrion
cellular component GO:0043005 neuron projection
cellular component GO:0016607 nuclear speck
cellular component GO:0005634 nucleus
cellular component GO:0014069 postsynaptic density
cellular component GO:0032991 protein-containing complex
cellular component GO:0005819 spindle
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000130 Estradiol 272.38
BXGC0001325 Progesterone 314.46
BXGC0018491 Methylprednisolone 374.21
BXGC0020800 Testosterone 288.21
BXGC0024141 Hydrocortisone 362.21
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein