Showing entry for Estradiol


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0000130
Compound NameEstradiol
Structure
FormulaC18H24O2
InchiKeyVOXZDWNPVJITMN-ZBRFXRBCSA-N
SMILES[H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@]1([H])C3=C(CC[C@@]21[H])C=C(O)C=C3
InchiInChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1
IUPAC(1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.02,?.011,1?]heptadeca-2(7),3,5-triene-5,14-diol
Molecular Weight272.38
Pubchem Id5757
Chembl IdCHEMBL135
Targets of Information Source
DrugBank DB00783
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 approved; investigational; vet_approved agonist
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 approved; investigational; vet_approved agonist
O75469 BXGT005128 Nuclear receptor subfamily 1 group I member 2 reviewed Nuclear receptor NR1I2 approved; investigational; vet_approved binder
P43681 BXGT010407 Neuronal acetylcholine receptor subunit alpha-4 reviewed Ion channel CHRNA4 approved; investigational; vet_approved binder
Q99527 BXGT019930 G-protein coupled estrogen receptor 1 reviewed G-protein coupled receptor GPER1 approved; investigational; vet_approved binder
P00846 BXGT005674 ATP synthase subunit a reviewed Transporter MT-ATP6 approved; investigational; vet_approved inhibitor
Q14457 BXGT013472 Beclin-1 reviewed Enzyme modulator BECN1 approved; investigational; vet_approved binder
PDB EST
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P14061 BXGT007979 Estradiol 17-beta-dehydrogenase 1 reviewed HSD17B1 Enzyme - - - -
P03372 BXGT006059 Estrogen receptor reviewed ESR1 Nuclear receptor - - - -
P49891 BXGT010757 Estrogen sulfotransferase, testis isoform reviewed Sult1e1 - - - - -
O70351 BXGT005064 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Hsd17b10 - - - - -
Q7TS98 BXGT017148 Anti-colorectal carcinoma light chain unreviewed - - - 2 -
Q99LC4 BXGT019989 Igh protein unreviewed Igh - - - - -
P04278 BXGT006182 Sex hormone-binding globulin reviewed SHBG - - - - -
P03372 BXGT006059 Estrogen receptor reviewed ESR1 Nuclear receptor - - 0.92 -
P50225 BXGT010781 Sulfotransferase 1A1 reviewed SULT1A1 - 83200 - - -
Q62986 BXGT016053 Estrogen receptor beta reviewed Esr2 - - - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed ESR2 Nuclear receptor - - - -
P49888 BXGT010756 Estrogen sulfotransferase reviewed SULT1E1 - - - - -
D5VCE0 BXGT024389 Enoyl-[acyl-carrier-protein] reductase [NADH] unreviewed fabI - - - - -
Binding DB 17292
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 1.2 - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - 1.4 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 10 - 0.59
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - 11 - 0.84
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 28 - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - 24 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 24 - 0.02
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - 24 - 0.07
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 0.65 - - -
reviewed BXGT019930 G-protein coupled estrogen receptor 1 reviewed G-protein coupled receptor GPER1 9 - - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 0.21 - - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 0.015 - - -
reviewed BXGT020668 Uncharacterized PhzA/B-like protein PA3332 reviewed PA3332 - - 19000 -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 1.9 - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - 1.7 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - - - 0.007
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 3 - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - - - 9.7
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - - - 2.4
reviewed BXGT004028 Estrogen receptor beta reviewed Esr2 - 2.3 - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - 2 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 2 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - - - 0.024
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - - - 0.085
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - 5.6 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 5.7 - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - 1.1 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 1.3 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - - - 0.16
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - - - 0.38
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - - - 0.0084
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - - - 0.3
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - - - 0.098
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - - - 0.019
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 0.75 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - - - 0.01
reviewed BXGT016053 Estrogen receptor beta reviewed Esr2 - - - 0.14
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - 1.18 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 1.35 - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - 1.2 - -
reviewed BXGT012869 Aldehyde oxidase reviewed Enzyme AOX1 4400 - - -
reviewed BXGT012869 Aldehyde oxidase reviewed Enzyme AOX1 870 - - -
reviewed BXGT010781 Sulfotransferase 1A1 reviewed SULT1A1 - - 2300 -
reviewed BXGT010781 Sulfotransferase 1A1 reviewed SULT1A1 - - 1200 -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - - 0.2 -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - - 0.5 -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 46 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 1.6 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 3.6 - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - 3.2 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 3.2 - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - 3.6 - -
reviewed BXGT013404 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed Ion channel CACNA1C - 50000 - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - 1 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 1 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 0.9 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 12 - - -
reviewed BXGT007710 Steroid hormone receptor ERR1 reviewed Nuclear receptor ESRRA - 3.6 - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 2 - - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 2 - - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 4 - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - 4 - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - - - 0.13
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - - - 0.7
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 2.2 - - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 3.5 - - -
reviewed BXGT016053 Estrogen receptor beta reviewed Esr2 - 2 - -
reviewed BXGT006424 Estrogen receptor reviewed Esr1 - 2 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 3.4 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 5.9 - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - - - 0.039
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - - - 0.018
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - - - 0.07
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - - - 0.8
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 100 - - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 100 - - -
reviewed BXGT008514 Estrogen receptor reviewed Esr1 - 2.2 - -
reviewed BXGT016053 Estrogen receptor beta reviewed Esr2 - 1.7 - -
reviewed BXGT006424 Estrogen receptor reviewed Esr1 - 1.9 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 1.7 - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - 3 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - - - 5.7
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - - - 5.6
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 4.4 - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - - - 0.5
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - - - 0.1
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 0.41 - -
reviewed BXGT013656 Cytochrome P450 1B1 reviewed Enzyme CYP1B1 - >50000 - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - 2.9 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - - - 1
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 0.01 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 0.7 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 0.5 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 0.16 - - -
reviewed BXGT019930 G-protein coupled estrogen receptor 1 reviewed G-protein coupled receptor GPER1 5.7 - - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 0.3 - - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 0.38 - - -
reviewed BXGT019930 G-protein coupled estrogen receptor 1 reviewed G-protein coupled receptor GPER1 - - - 0.3
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - - - 0.48
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - 19 - -
reviewed BXGT011910 Aldehyde oxidase 1 reviewed AOX1 - 40000 - -
reviewed BXGT015373 Aldehyde oxidase 1 reviewed AOX1 - 12000 - -
reviewed BXGT012869 Aldehyde oxidase reviewed Enzyme AOX1 - 80 - -
reviewed BXGT022402 Aldehyde oxidase 1 reviewed Aox1 3000 - - -
reviewed BXGT012856 Tyrosine-protein phosphatase non-receptor type 11 reviewed PTPN11 - >300000 - -
reviewed BXGT006424 Estrogen receptor reviewed Esr1 - - - 5.7
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - - - 1830
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - - - 2560
reviewed BXGT006424 Estrogen receptor reviewed Esr1 - - - 917
reviewed BXGT006424 Estrogen receptor reviewed Esr1 - - - 1830
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - - - 280
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - - - 130
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 18 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - - - 0.09
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - - - 0.72
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 0.57 - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - - - 0.25
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - - - 0.046
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - - - 0.15
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - - - 0.4
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - - - 0.123
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - - - 0.2
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - - - 3
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - - - 1.5
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - - - 0.56
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - - - 0.9
reviewed BXGT006830 Steryl-sulfatase reviewed Enzyme STS - 84000 - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - - - 0.67
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 11 - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - - - 2.1
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 1.4 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - - - 0.75
reviewed BXGT007552 Androgen receptor reviewed Nuclear receptor AR - 19.1 - -
reviewed BXGT006182 Sex hormone-binding globulin reviewed SHBG - 50 - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - 16.7 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 4.7 - -
reviewed BXGT007552 Androgen receptor reviewed Nuclear receptor AR - 26 - -
reviewed BXGT018814 G-protein coupled bile acid receptor 1 reviewed G-protein coupled receptor GPBAR1 - - - 38400
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - - - 0.37
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - - - 0.047
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 12.5 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - - - 3.2
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - - - 11
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - - - 1.05
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - - - 1.08
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - - - 50
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - - - 30
reviewed BXGT007710 Steroid hormone receptor ERR1 reviewed Nuclear receptor ESRRA - - - 5.9
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - - - 10
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - - - 1.4
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - - - 2.2
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - - - 0.05
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - - - 0.036
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - - - 0.01
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - - - 0.004
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - - - 0.49
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - - - 0.08
reviewed BXGT008096 Androgen receptor reviewed Ar - 407.38 - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - - - 0.458
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - - - 2.77
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - 10.74 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 21.04 - -
reviewed BXGT004141 Solute carrier family 22 member 1 reviewed Transporter SLC22A1 - 5730 - -
reviewed BXGT004140 Solute carrier family 22 member 2 reviewed Transporter SLC22A2 - >30000 - -
reviewed BXGT005150 Solute carrier family 22 member 3 reviewed Transporter SLC22A3 - 2880 - -
reviewed BXGT010535 Solute carrier organic anion transporter family member 1A1 reviewed Slco1a1 4700 - - -
reviewed BXGT006182 Sex hormone-binding globulin reviewed SHBG - - 1.5 -
reviewed BXGT007710 Steroid hormone receptor ERR1 reviewed Nuclear receptor ESRRA - 6 - -
CHEMBL CHEMBL135
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 1 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Selectivity ratio '=' 1 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Selectivity ratio '=' 1 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 1 nM
Q06520 BXGT012880 Bile salt sulfotransferase reviewed - SULT2A1 Activity - - -
P35503 BXGT009840 UDP-glucuronosyltransferase 1-3 reviewed - UGT1A3 Activity - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 0 nM
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 RBA '=' 100 %
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 RBA '=' 100 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Absolute ratio '=' 2 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Absolute ratio '=' 2 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ki '=' 2 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 0 nM
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a Ki - - -
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A Ki - - -
P15207 BXGT008096 Androgen receptor reviewed - Ar IC50 '=' 353 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ratio '=' 1 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ratio '=' 1 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Activity - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Activity - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 1 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Inhibition - - -
Q06124 BXGT012856 Tyrosine-protein phosphatase non-receptor type 11 reviewed - PTPN11 IC50 '>' 300000 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 1 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 1 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 1 nM
P10275 BXGT007552 Androgen receptor reviewed Nuclear receptor AR IC50 '=' 19 nM
Q99527 BXGT019930 G-protein coupled estrogen receptor 1 reviewed G-protein coupled receptor GPER1 Activity '=' 100 %
Q99527 BXGT019930 G-protein coupled estrogen receptor 1 reviewed G-protein coupled receptor GPER1 Activity '=' 3 %
Q9UNQ0 BXGT021792 ATP-binding cassette sub-family G member 2 reviewed Transporter ABCG2 Activity - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 0 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 32642 nM
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 Ki - - -
P31645 BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 IC50 '=' 10755 nM
P24557 BXGT008976 Thromboxane-A synthase reviewed - TBXAS1 Ki - - -
P25024 BXGT009005 C-X-C chemokine receptor type 1 reviewed G-protein coupled receptor CXCR1 IC50 - - -
P32238 BXGT009611 Cholecystokinin receptor type A reviewed G-protein coupled receptor CCKAR IC50 - - -
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 3 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 RBA '=' 48 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 0 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 0 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 ED50 '=' 1 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 28 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 24 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 - - -
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 Ki - - -
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed - PDE5A IC50 - - -
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 Ki - - -
P08311 BXGT006762 Cathepsin G reviewed Enzyme CTSG IC50 - - -
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b Ki - - -
P51679 BXGT010877 C-C chemokine receptor type 4 reviewed G-protein coupled receptor CCR4 IC50 - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ki '=' 100 nM
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Ki - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 RBA '=' 1 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 RBA '=' 1 -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Uterine weight '=' 41 -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Uterine weight '=' 41 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 RBA '=' 100 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 RBA '=' 100 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 1 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Activity '=' 100 %
P80456 BXGT011910 Aldehyde oxidase 1 reviewed - AOX1 IC50 '=' 40000 nM
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Max uterine weight '=' 76 mg
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Max uterine weight '=' 76 mg
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 MED '=' 0 M
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 MED '=' 0 M
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 2 nM
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 25118 nM
P49884 BXGT010754 Estrogen receptor reviewed - ESR1 RBA '=' 100 %
Q9XSB5 BXGT022188 Estrogen receptor beta reviewed - ESR2 RBA '=' 100 %
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 31622 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 46 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 0 nM
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 IC50 - - -
P41597 BXGT010268 C-C chemokine receptor type 2 reviewed - CCR2 Ki - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 1 nM
Q06278 BXGT012869 Aldehyde oxidase reviewed Enzyme AOX1 IC50 '=' 80 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Kd '=' 0 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 - - -
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 IC50 - - -
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 IC50 - - -
P30988 BXGT009491 Calcitonin receptor reviewed G-protein coupled receptor CALCR IC50 - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Ki - - -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Ki - - -
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 Ki - - -
P08588 BXGT006795 Beta-1 adrenergic receptor reviewed G-protein coupled receptor ADRB1 Ki - - -
P25024 BXGT009005 C-X-C chemokine receptor type 1 reviewed G-protein coupled receptor CXCR1 Ki - - -
P15289 BXGT008102 Arylsulfatase A reviewed Enzyme ARSA Potency - 2393 nM
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Inhibition - - -
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Activity - - -
P11474 BXGT007710 Steroid hormone receptor ERR1 reviewed Nuclear receptor ESRRA IC50 '=' 6 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 RBA '=' 100 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Activity '=' 160 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 0 nM
Q9UNQ0 BXGT021792 ATP-binding cassette sub-family G member 2 reviewed Transporter ABCG2 Activity '=' 50 %
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 IC50 - - -
P07943 BXGT006700 Aldo-keto reductase family 1 member B1 reviewed - Akr1b1 Ki - - -
P30988 BXGT009491 Calcitonin receptor reviewed G-protein coupled receptor CALCR Ki - - -
P25025 BXGT009006 C-X-C chemokine receptor type 2 reviewed G-protein coupled receptor CXCR2 Ki - - -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 IC50 - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 IC50 - - -
P32241 BXGT009613 Vasoactive intestinal polypeptide receptor 1 reviewed G-protein coupled receptor VIPR1 Ki - - -
O15439 BXGT004169 Multidrug resistance-associated protein 4 reviewed Transporter ABCC4 IC50 '=' 133000 nM
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 Ki - - -
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 IC50 - - -
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 reviewed Kinase ERBB2 IC50 - - -
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C reviewed Enzyme PTPRC IC50 - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 0 nM
Q99527 BXGT019930 G-protein coupled estrogen receptor 1 reviewed G-protein coupled receptor GPER1 Ki '=' 2 nM
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Reduction '=' 86 %
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Reduction '=' 86 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Activity '=' 1 %
P15207 BXGT008096 Androgen receptor reviewed - Ar Ki '=' 235 nM
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 reviewed Kinase FLT1 Ki - - -
P37288 BXGT009977 Vasopressin V1a receptor reviewed G-protein coupled receptor AVPR1A IC50 - - -
O75795 BXGT005152 UDP-glucuronosyltransferase 2B17 reviewed - UGT2B17 Activity '=' 0 pm/min/mg
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 5 nM
Q9R0W2 BXGT021408 Solute carrier family 22 member 2 reviewed - Slc22a2 IC50 '=' 84800 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 RBA '=' 1 -
P05181 BXGT006337 Cytochrome P450 2E1 reviewed - CYP2E1 IC50 - - -
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ki - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 30 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 RBA '=' 100 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 0 nM
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Control '=' 100 %
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Control '=' 100 %
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Ratio IC50 '<' 2 -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Activity - - -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Activity - - -
O95342 BXGT005373 Bile salt export pump reviewed Transporter ABCB11 IC50 '=' 133000 nM
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Relative binding affinity '=' 100 %
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Relative binding affinity '=' 100 %
O94956 BXGT005343 Solute carrier organic anion transporter family member 2B1 reviewed Transporter SLCO2B1 Activity - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Kd '=' 0 nM
Q99527 BXGT019930 G-protein coupled estrogen receptor 1 reviewed G-protein coupled receptor GPER1 Ki '=' 5 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Activity '=' 100 -
O60656 BXGT004889 UDP-glucuronosyltransferase 1-9 reviewed - UGT1A9 Activity '=' 0 pm/min/mg
P51681 BXGT010878 C-C chemokine receptor type 5 reviewed G-protein coupled receptor CCR5 Ki - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Selectivity '=' 1 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Selectivity '=' 1 -
P08588 BXGT006795 Beta-1 adrenergic receptor reviewed G-protein coupled receptor ADRB1 IC50 - - -
P23975 BXGT008935 Sodium-dependent noradrenaline transporter reviewed Transporter SLC6A2 Ki - - -
P50052 BXGT010768 Type-2 angiotensin II receptor reviewed G-protein coupled receptor AGTR2 Ki - - -
Q9BY64 BXGT020182 UDP-glucuronosyltransferase 2B28 reviewed - UGT2B28 Vmax '<' 1 pmol/min/mg protein
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 11 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 10 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Activity - - -
Q63449 BXGT016072 Progesterone receptor reviewed - Pgr Activity '=' 6 %
O88446 BXGT005272 Solute carrier family 22 member 3 reviewed - Slc22a3 IC50 '=' 1100 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 0 nM
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed - UGT1A1 Activity '=' 19 pm/min/mg
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 0 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 FC '=' 3 -
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 Ki - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ki '=' 0 nM
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 IC50 - - -
P04035 BXGT006129 3-hydroxy-3-methylglutaryl-coenzyme A reductase reviewed - HMGCR Ki - - -
P15127 BXGT008085 Insulin receptor reviewed - Insr IC50 - - -
P12530 BXGT007827 Arachidonate 15-lipoxygenase reviewed - ALOX15 Ki - - -
P41968 BXGT010275 Melanocortin receptor 3 reviewed G-protein coupled receptor MC3R IC50 - - -
P08173 BXGT006738 Muscarinic acetylcholine receptor M4 reviewed G-protein coupled receptor CHRM4 Ki - - -
P25929 BXGT009078 Neuropeptide Y receptor type 1 reviewed G-protein coupled receptor NPY1R IC50 - - -
Q690N0 BXGT016199 Progesterone receptor unreviewed - PGR Ki '=' 4247 nM
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C reviewed Enzyme PTPRC Ki - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Efficacy '=' 100 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 10 nM
P49888 BXGT010756 Estrogen sulfotransferase reviewed - SULT1E1 Km '=' 4 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ki '=' 0 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 130 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 FC '=' 16 -
P56937 BXGT011205 3-keto-steroid reductase reviewed - HSD17B7 Inhibition '=' 0 %
P07943 BXGT006700 Aldo-keto reductase family 1 member B1 reviewed - Akr1b1 IC50 - - -
P30411 BXGT009424 B2 bradykinin receptor reviewed G-protein coupled receptor BDKRB2 IC50 - - -
P32238 BXGT009611 Cholecystokinin receptor type A reviewed G-protein coupled receptor CCKAR Ki - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 3 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 E2 '=' 100 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 E2 '=' 100 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ki '=' 0 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ki '=' 0 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 3 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 3 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 3 nM
P49884 BXGT010754 Estrogen receptor reviewed - ESR1 RBA2 '=' 100 -
Q9XSB5 BXGT022188 Estrogen receptor beta reviewed - ESR2 RBA2 '=' 100 -
P49884 BXGT010754 Estrogen receptor reviewed - ESR1 Selectivity '=' 1 -
Q9XSB5 BXGT022188 Estrogen receptor beta reviewed - ESR2 Selectivity '=' 1 -
Q9BPX1 BXGT020103 17-beta-hydroxysteroid dehydrogenase 14 reviewed Enzyme HSD17B14 Delta Tm '=' 1 degrees C
P06401 BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR Ki - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 24 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Activity '=' 0 uM
P04278 BXGT006182 Sex hormone-binding globulin reviewed - SHBG RBA '=' 100 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Kd '=' 0 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Kd '=' 0 nM
Q92887 BXGT019389 Canalicular multispecific organic anion transporter 1 reviewed Transporter ABCC2 Activity '=' 123 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 3 nM
P15207 BXGT008096 Androgen receptor reviewed - Ar IC50 '=' 407 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 0 nM
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 IC50 - - -
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b IC50 - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Kd '=' 3 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Activity '=' 100 %
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 IC50 '=' 2 nM
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 IC50 '=' 2 nM
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Relative uterotrophic activity '=' 100 -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Relative uterotrophic activity '=' 100 -
P08185 BXGT006742 Corticosteroid-binding globulin reviewed Enzyme modulator SERPINA6 #NAME? '=' 4 -
P04278 BXGT006182 Sex hormone-binding globulin reviewed - SHBG #NAME? '=' 7 -
P15207 BXGT008096 Androgen receptor reviewed - Ar Activity '=' 0 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 RBA '=' 100 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IA - - -
Q9TU15 BXGT021625 Estrogen receptor beta reviewed - ESR2 RBA '=' 100 -
P49885 BXGT010755 Estrogen receptor reviewed - ESR1 RBA '=' 100 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Binding '=' 100 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Binding '=' 100 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 4 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 2 nM
O95718 BXGT005392 Steroid hormone receptor ERR2 reviewed Nuclear receptor ESRRB IC50 '=' 3 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 0 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Bmax '=' 35 fM mg-1
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Bmax '=' 35 fM mg-1
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 0 nM
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Uterine activity '=' 100 %
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Uterine activity '=' 100 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 0 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 0 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 2 nM
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 EC50 '=' 0 nM
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Control '=' 255 %
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Control '=' 255 %
P05181 BXGT006337 Cytochrome P450 2E1 reviewed - CYP2E1 Ki - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Response '=' 100 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Relative binding affinity '=' 380 -
P16473 BXGT008234 Thyrotropin receptor reviewed G-protein coupled receptor TSHR Potency '=' 39810 nM
Q5FB27 BXGT015373 Aldehyde oxidase 1 reviewed - AOX1 IC50 '=' 12000 nM
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 EC50 '=' 0 ug.mL-1
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 EC50 '=' 0 ug.mL-1
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Agonist '=' 100 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Agonist '=' 100 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 0 nM
Q9TU15 BXGT021625 Estrogen receptor beta reviewed - ESR2 RAC '=' 10 -
P49885 BXGT010755 Estrogen receptor reviewed - ESR1 RAC '=' 10 -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 RBA '=' 100 -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 RBA '=' 100 -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Uterine wet weight '=' 55 -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Uterine wet weight '=' 55 -
Q9TU15 BXGT021625 Estrogen receptor beta reviewed - ESR2 RAC '=' 100 -
P49885 BXGT010755 Estrogen receptor reviewed - ESR1 RAC '=' 100 -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Activity '=' 100 %
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Activity '=' 100 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 0 ug.mL-1
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 0 ug.mL-1
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 4 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 RBA '=' 0 -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Estrogenic potency '=' 27 -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Estrogenic potency '=' 27 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 1 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ratio IC50 '=' 0 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ratio IC50 '=' 0 -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Affinity '=' 100 %
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Affinity '=' 100 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 - - -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 EC50 '=' 5 nM
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 EC50 '=' 5 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 10 nM
P25101 BXGT009018 Endothelin-1 receptor reviewed G-protein coupled receptor EDNRA Ki - - -
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 IC50 '=' 41422 nM
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 IC50 - - -
P25105 BXGT009021 Platelet-activating factor receptor reviewed G-protein coupled receptor PTAFR Ki - - -
P12822 BXGT007850 Angiotensin-converting enzyme reviewed - ACE IC50 - - -
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 Ki - - -
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA Ki - - -
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 Ki - - -
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Ki - - -
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform reviewed - PPP3CA Ki - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 24 nM
O15245 BXGT004141 Solute carrier family 22 member 1 reviewed Transporter SLC22A1 Inhibition '=' 83 %
P02773 BXGT005958 Alpha-fetoprotein reviewed - Afp RBA '=' 100 -
Q8TDU6 BXGT018814 G-protein coupled bile acid receptor 1 reviewed G-protein coupled receptor GPBAR1 EC50 '=' 38400 nM
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 Ki - - -
P25025 BXGT009006 C-X-C chemokine receptor type 2 reviewed G-protein coupled receptor CXCR2 IC50 - - -
P14061 BXGT007979 Estradiol 17-beta-dehydrogenase 1 reviewed Enzyme HSD17B1 Km '=' 30 nM
O95718 BXGT005392 Steroid hormone receptor ERR2 reviewed Nuclear receptor ESRRB IC50 '=' 8 nM
P63319 BXGT011518 Protein kinase C gamma type reviewed - Prkcg Inhibition '=' 89 %
P68403 BXGT011600 Protein kinase C beta type reviewed - Prkcb Inhibition '=' 89 %
P05696 BXGT006379 Protein kinase C alpha type reviewed - Prkca Inhibition '=' 89 %
Q16637 BXGT013646 Survival motor neuron protein reviewed Epigenetic regulator SMN1 Potency '=' 1 nM
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Weight '=' -121 mg
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Weight '=' -121 mg
O95718 BXGT005392 Steroid hormone receptor ERR2 reviewed Nuclear receptor ESRRB Activity '=' 1 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Kd '=' 0 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Kd '=' 0 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Kd '=' 0 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Kd '=' 0 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 0 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Log IC50 - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Log IC50 - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 0 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 0 nM
P46720 BXGT010535 Solute carrier organic anion transporter family member 1A1 reviewed - Slco1a1 Activity - - -
O75751 BXGT005150 Solute carrier family 22 member 3 reviewed Transporter SLC22A3 IC50 '=' 2880 nM
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 IC50 '=' 0 nM
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 IC50 '=' 0 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 2 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ratio IC50 '=' 0 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ratio IC50 '=' 0 -
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 IC50 - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Ki - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 0 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 0 nM
Q9NY46 BXGT021248 Sodium channel protein type 3 subunit alpha reviewed Ion channel SCN3A Inhibition '=' 17 %
Q99250 BXGT019913 Sodium channel protein type 2 subunit alpha reviewed Ion channel SCN2A Inhibition '=' 17 %
P35498 BXGT009838 Sodium channel protein type 1 subunit alpha reviewed Ion channel SCN1A Inhibition '=' 17 %
Q9BY64 BXGT020182 UDP-glucuronosyltransferase 2B28 reviewed - UGT2B28 Activity - - -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 S/N '=' 13 -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 S/N '=' 13 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Relative activity '=' 100 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Relative activity '=' 100 -
P15207 BXGT008096 Androgen receptor reviewed - Ar RBA '=' 7 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 1 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 2 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ratio IC50 '=' 1 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ratio IC50 '=' 1 -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Inhibition '=' 100 %
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Inhibition '=' 100 %
P11509 BXGT007716 Cytochrome P450 2A6 reviewed - CYP2A6 Ki - - -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 Ki - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 1 nM
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Activity '=' 100 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 MFI '=' 190 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 0 nM
P24557 BXGT008976 Thromboxane-A synthase reviewed - TBXAS1 IC50 - - -
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 Ki - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 1 nM
P20781 BXGT008598 Glycine receptor subunit beta reviewed - Glrb IC50 - - -
P07727 BXGT006662 Glycine receptor subunit alpha-1 reviewed - Glra1 IC50 - - -
P24524 BXGT008974 Glycine receptor subunit alpha-3 reviewed - Glra3 IC50 - - -
P22771 BXGT008806 Glycine receptor subunit alpha-2 reviewed - Glra2 IC50 - - -
P12530 BXGT007827 Arachidonate 15-lipoxygenase reviewed - ALOX15 IC50 '=' 11295 nM
P29476 BXGT009354 Nitric oxide synthase, brain reviewed - Nos1 IC50 - - -
P29477 BXGT009355 Nitric oxide synthase, inducible reviewed - Nos2 IC50 - - -
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 Ki - - -
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 Ki - - -
P21452 BXGT008653 Substance-K receptor reviewed G-protein coupled receptor TACR2 Ki - - -
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 reviewed Kinase FLT1 IC50 - - -
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 6309 nM
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Uterine wet weight '=' 17 -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Uterine wet weight '=' 17 -
P08185 BXGT006742 Corticosteroid-binding globulin reviewed Enzyme modulator SERPINA6 Log 1/K '=' -5 -
P04278 BXGT006182 Sex hormone-binding globulin reviewed - SHBG Log 1/K '=' -8 -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 Inhibition - - -
P06133 BXGT006414 UDP-glucuronosyltransferase 2B4 reviewed - UGT2B4 Activity '=' 0 pm/min/mg
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Response '=' 100 %
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 Ki - - -
Q9Z0U5 BXGT022402 Aldehyde oxidase 1 reviewed - Aox1 Ki '=' 3000 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 ED50 '=' 0 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 0 nM
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 19952 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Activity '=' 0 %
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 4466 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Bmax '=' 37 fM mg-1
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Bmax '=' 37 fM mg-1
P84022 BXGT012027 Mothers against decapentaplegic homolog 3 reviewed Transcription factor SMAD3 Potency - 3162 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 0 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 RBA '=' 0 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 RBA '=' 0 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ki '=' 3 nM
P28564 BXGT009272 5-hydroxytryptamine receptor 1B reviewed - Htr1b Ki - - -
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B Ki - - -
P37288 BXGT009977 Vasopressin V1a receptor reviewed G-protein coupled receptor AVPR1A Ki - - -
P06536 BXGT006451 Glucocorticoid receptor reviewed - Nr3c1 Activity '=' 5 %
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 BSI '=' 100 -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 BSI '=' 100 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Activity '=' 50 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 0 nM
P02768 BXGT005955 Serum albumin reviewed Transporter ALB Log K' '=' 0 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 0 nM
P04278 BXGT006182 Sex hormone-binding globulin reviewed - SHBG IC50 '=' 50 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 0 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 18356 nM
Q9GK37 BXGT020404 Corticosteroid-binding globulin reviewed - Serpina6 Log K '=' 5 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IA - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 RA '=' 100 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Efficacy '=' 77 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Bmax '=' 33 fM mg-1
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Bmax '=' 33 fM mg-1
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Inhibition - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 RTP '=' 100 %
P08659 BXGT006805 Luciferin 4-monooxygenase reviewed - Potency - 26854 nM
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Uterotrophic activity - - -
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Uterotrophic activity - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ki '=' 100 nM
Q9TU15 BXGT021625 Estrogen receptor beta reviewed - ESR2 Relative binding affinity '=' 100 -
P49885 BXGT010755 Estrogen receptor reviewed - ESR1 Relative binding affinity '=' 100 -
P16662 BXGT008253 UDP-glucuronosyltransferase 2B7 reviewed - UGT2B7 Activity '=' 0 pm/min/mg
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 RBA '=' 100 -
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 RBA '=' 100 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Relative activity '=' 100 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Relative activity '=' 100 %
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Binding '=' 37 fM uterus-1
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Binding '=' 37 fM uterus-1
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 1 nM
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Relative binding affinity '=' 100 -
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Relative binding affinity '=' 100 -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 16360 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Relative binding affinity '=' 2100 -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Mean weight '=' 53 mg
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Mean weight '=' 53 mg
Q9TU15 BXGT021625 Estrogen receptor beta reviewed - ESR2 Kd '=' 100 -
P49885 BXGT010755 Estrogen receptor reviewed - ESR1 Kd '=' 100 -
P06536 BXGT006451 Glucocorticoid receptor reviewed - Nr3c1 RBA '=' 0 -
P22199 BXGT008741 Mineralocorticoid receptor reviewed - Nr3c2 Specific activity '=' 50 Ci mM-1
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 5 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 1 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Bmax '=' 32 fM mg-1
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Bmax '=' 32 fM mg-1
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Kd '=' 0 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Kd '=' 0 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 3 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Activity '=' 98 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Activity '=' 100 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Activity '=' 100 %
P06536 BXGT006451 Glucocorticoid receptor reviewed - Nr3c1 RBA '=' 0 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 4 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 0 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 0 nM
Q99527 BXGT019930 G-protein coupled estrogen receptor 1 reviewed G-protein coupled receptor GPER1 Activity '<' 10 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Inhibition '=' 78 %
P11474 BXGT007710 Steroid hormone receptor ERR1 reviewed Nuclear receptor ESRRA EC50 '=' 5 nM
P08185 BXGT006742 Corticosteroid-binding globulin reviewed Enzyme modulator SERPINA6 Ki '=' 10000 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Induction '=' 80 fM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Induction '=' 80 fM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 3 nM
P06133 BXGT006414 UDP-glucuronosyltransferase 2B4 reviewed - UGT2B4 Drug metabolism - - -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Uterine weight '=' 74 -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Uterine weight '=' 74 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Kd '=' 0 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Kd '=' 0 nM
Q9TU15 BXGT021625 Estrogen receptor beta reviewed - ESR2 Ratio '=' 1 -
P49885 BXGT010755 Estrogen receptor reviewed - ESR1 Ratio '=' 1 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ki '=' 0 nM
P22310 BXGT008754 UDP-glucuronosyltransferase 1-4 reviewed - UGT1A4 Drug metabolism - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 5 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 1000 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 RBA '=' 100 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ki '=' 2 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ki - - -
P20781 BXGT008598 Glycine receptor subunit beta reviewed - Glrb Ki - - -
P07727 BXGT006662 Glycine receptor subunit alpha-1 reviewed - Glra1 Ki - - -
P24524 BXGT008974 Glycine receptor subunit alpha-3 reviewed - Glra3 Ki - - -
P22771 BXGT008806 Glycine receptor subunit alpha-2 reviewed - Glra2 Ki - - -
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 IC50 - - -
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed - PDE5A Ki - - -
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 IC50 - - -
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 IC50 - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Ki - - -
P10828 BXGT007624 Thyroid hormone receptor beta reviewed Nuclear receptor THRB Potency - 15848 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ki '=' 2 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Inhibition '=' 75 %
P11474 BXGT007710 Steroid hormone receptor ERR1 reviewed Nuclear receptor ESRRA Activity - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Inhibition - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 0 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 0 nM
P14061 BXGT007979 Estradiol 17-beta-dehydrogenase 1 reviewed Enzyme HSD17B1 K app '=' 0 min-1
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 IC50 '=' 1 nM
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 ED50 '=' 0 nM
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 ED50 '=' 0 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ratio IC50 '=' 2 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ratio IC50 '=' 2 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Activity '=' 112 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Activity '=' 112 -
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Ki - - -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Uterine weight '=' 58 -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Uterine weight '=' 58 -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Effect '=' 100 %
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Effect '=' 100 %
Q9TU15 BXGT021625 Estrogen receptor beta reviewed - ESR2 RAC app '=' 100 -
P49885 BXGT010755 Estrogen receptor reviewed - ESR1 RAC app '=' 100 -
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Antiuterotrophic activity - - -
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Antiuterotrophic activity - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 REP '=' 100 %
P11474 BXGT007710 Steroid hormone receptor ERR1 reviewed Nuclear receptor ESRRA Activity '>' 100 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Activity '=' 0 uM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 1 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 1 nM
Q9TU15 BXGT021625 Estrogen receptor beta reviewed - ESR2 K ass '=' 2147483647 -
P49885 BXGT010755 Estrogen receptor reviewed - ESR1 K ass '=' 2147483647 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Relative binding affinity '=' 100 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Relative binding affinity '=' 100 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 21 nM
P08185 BXGT006742 Corticosteroid-binding globulin reviewed Enzyme modulator SERPINA6 Log K '=' 5 -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 IC50 '=' 1 nM
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 IC50 '=' 1 nM
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Estrogenic effect '=' 100 -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Estrogenic effect '=' 100 -
P08185 BXGT006742 Corticosteroid-binding globulin reviewed Enzyme modulator SERPINA6 Log 1/K '=' 5 -
P04278 BXGT006182 Sex hormone-binding globulin reviewed - SHBG Log 1/K '=' 8 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ki '=' 0 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ki '=' 0 nM
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Selectivity '=' 1 -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Selectivity '=' 1 -
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 RBA '=' 100 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Efficacy '=' 83 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 0 nM
P13945 BXGT007972 Beta-3 adrenergic receptor reviewed G-protein coupled receptor ADRB3 Ki - - -
P25100 BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D IC50 - - -
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B IC50 - - -
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Ki - - -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Inhibition - - -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Inhibition - - -
P30411 BXGT009424 B2 bradykinin receptor reviewed G-protein coupled receptor BDKRB2 Ki - - -
P41597 BXGT010268 C-C chemokine receptor type 2 reviewed - CCR2 IC50 - - -
P11509 BXGT007716 Cytochrome P450 2A6 reviewed - CYP2A6 IC50 - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Ki - - -
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Ki - - -
Q9HAW7 BXGT020508 UDP-glucuronosyltransferase 1-7 reviewed - UGT1A7 Activity '=' 0 pm/min/mg
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A IC50 - - -
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 Ki - - -
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B IC50 - - -
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 IC50 - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 0 nM
P22310 BXGT008754 UDP-glucuronosyltransferase 1-4 reviewed - UGT1A4 Activity '=' 7 pm/min/mg
P54855 BXGT011088 UDP-glucuronosyltransferase 2B15 reviewed - UGT2B15 Activity '=' 0 pm/min/mg
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 2 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 3 nM
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 Ki - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 280 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Activity '=' 24 %
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Binding '=' 501 fM uterus-1
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Binding '=' 501 fM uterus-1
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Induction '=' 81 fM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Induction '=' 81 fM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Activity '=' 5 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 3 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 33498 nM
Q9Y271 BXGT022222 Cysteinyl leukotriene receptor 1 reviewed G-protein coupled receptor CYSLTR1 Ki - - -
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA IC50 - - -
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 reviewed G-protein coupled receptor CHRM5 Ki - - -
P08311 BXGT006762 Cathepsin G reviewed Enzyme CTSG Ki - - -
P03956 BXGT006120 Interstitial collagenase reviewed Enzyme MMP1 Ki - - -
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA IC50 - - -
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR Ki - - -
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 IC50 - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 FC '=' 4 -
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 reviewed G-protein coupled receptor CHRM5 IC50 - - -
P29476 BXGT009354 Nitric oxide synthase, brain reviewed - Nos1 Ki - - -
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a IC50 - - -
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 IC50 - - -
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 IC50 - - -
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A Ki - - -
Q01959 BXGT012624 Sodium-dependent dopamine transporter reviewed Transporter SLC6A3 Ki '=' 11847 nM
P03956 BXGT006120 Interstitial collagenase reviewed Enzyme MMP1 IC50 - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 0 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 3 nM
P04278 BXGT006182 Sex hormone-binding globulin reviewed - SHBG RBA '=' 3 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Kd '=' 100 -
O15244 BXGT004140 Solute carrier family 22 member 2 reviewed Transporter SLC22A2 IC50 '>' 30000 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ki '=' 0 nM
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Control '=' 195 %
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Control '=' 195 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 1 nM
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 IC50 '=' 1 nM
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 IC50 '=' 2 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 3 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 3 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 RBA '=' 330 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 RBA '=' 330 -
O08756 BXGT026095 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed - Hsd17b10 IC50 '=' 770000 nM
P49884 BXGT010754 Estrogen receptor reviewed - ESR1 RBA '=' 100 -
Q9XSB5 BXGT022188 Estrogen receptor beta reviewed - ESR2 RBA '=' 100 -
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A IC50 - - -
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C IC50 - - -
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 Ki - - -
P25103 BXGT009020 Substance-P receptor reviewed G-protein coupled receptor TACR1 IC50 - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Induction '=' 14 fM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Induction '=' 14 fM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Induction '=' 70 fM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Induction '=' 70 fM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Kd '=' 0 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Kd '=' 0 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Kd '=' 0 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Kd '=' 0 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Relative binding affinity '=' 100 -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 NSB '=' 1 -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 NSB '=' 1 -
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 19952 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 0 nM
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 DOSE '=' 100 mg.kg-1
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 DOSE '=' 100 mg.kg-1
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Bmax '=' 34 fM mg-1
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Bmax '=' 34 fM mg-1
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 RAC '=' 100 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 RAC '=' 100 -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Uterine weight '=' 44 -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Uterine weight '=' 44 -
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Ki - - -
P23975 BXGT008935 Sodium-dependent noradrenaline transporter reviewed Transporter SLC6A2 IC50 - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Relative binding affinity '=' 1 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Relative binding affinity '=' 1 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Efficacy '=' 100 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 0 nM
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed - UGT1A1 Activity '=' 100 pm/min/mg
Q9HAW8 BXGT020509 UDP-glucuronosyltransferase 1-10 reviewed - UGT1A10 Activity '=' 48 pm/min/mg
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 1 nM
O15438 BXGT004168 Canalicular multispecific organic anion transporter 2 reviewed Transporter ABCC3 IC50 '=' 133000 nM
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 IC50 - - -
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a Ki - - -
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 IC50 - - -
Q01959 BXGT012624 Sodium-dependent dopamine transporter reviewed Transporter SLC6A3 IC50 '=' 14911 nM
P25101 BXGT009018 Endothelin-1 receptor reviewed G-protein coupled receptor EDNRA IC50 - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 - - -
P15127 BXGT008085 Insulin receptor reviewed - Insr Ki - - -
A6XA80 BXGT001522 Leukotriene C4 synthase reviewed - LTC4S Ki - - -
Q9Y271 BXGT022222 Cysteinyl leukotriene receptor 1 reviewed G-protein coupled receptor CYSLTR1 IC50 - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Kd '=' 0 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Kd '=' 0 nM
Q99527 BXGT019930 G-protein coupled estrogen receptor 1 reviewed G-protein coupled receptor GPER1 Activity - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 0 ug.mL-1
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 0 ug.mL-1
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 0 nM
P49884 BXGT010754 Estrogen receptor reviewed - ESR1 Relative affinity '=' 1 -
Q9XSB5 BXGT022188 Estrogen receptor beta reviewed - ESR2 Relative affinity '=' 1 -
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Potency - 7079 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 12 nM
Q99527 BXGT019930 G-protein coupled estrogen receptor 1 reviewed G-protein coupled receptor GPER1 T1/2 '<' 0 hr
P25100 BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D Ki - - -
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 Ki - - -
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 125 %
P62508 BXGT011431 Estrogen-related receptor gamma reviewed Nuclear receptor ESRRG Activity '=' 0 -
O95718 BXGT005392 Steroid hormone receptor ERR2 reviewed Nuclear receptor ESRRB Activity '=' 100 %
P54132 BXGT011032 Bloom syndrome protein reviewed - BLM Potency '=' 22 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ratio '=' 0 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ratio '=' 0 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 RBA '=' 100 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 RBA '=' 100 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 ED50 '=' 4 nM
P06536 BXGT006451 Glucocorticoid receptor reviewed - Nr3c1 RBA '=' 1 -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Uterine wet weight '=' 33 -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Uterine wet weight '=' 33 -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Uterine wet weight '=' 50 -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Uterine wet weight '=' 50 -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Control '=' 327 %
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Control '=' 327 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ki '=' 12 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 0 nM
P08842 BXGT006830 Steryl-sulfatase reviewed Enzyme STS IC50 '=' 84000 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 11 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 ED50 '=' 0 uM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ki '=' 0 nM
P25103 BXGT009020 Substance-P receptor reviewed G-protein coupled receptor TACR1 Ki - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 1 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 0 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ki '=' 0 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ki '=' 0 nM
P63319 BXGT011518 Protein kinase C gamma type reviewed - Prkcg Inhibition '=' 77 %
P68403 BXGT011600 Protein kinase C beta type reviewed - Prkcb Inhibition '=' 77 %
P05696 BXGT006379 Protein kinase C alpha type reviewed - Prkca Inhibition '=' 77 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 3 nM
Q194T2 BXGT013743 Non-structural protein 1 unreviewed - NS1 Potency '=' 7943 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ki '=' 0 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ki '=' 0 nM
P10275 BXGT007552 Androgen receptor reviewed Nuclear receptor AR Potency - 631 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 16 nM
P04278 BXGT006182 Sex hormone-binding globulin reviewed - SHBG Ka '=' 5 10'8/M
P11474 BXGT007710 Steroid hormone receptor ERR1 reviewed Nuclear receptor ESRRA IC50 '=' 3 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 10 nM
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 reviewed Kinase ERBB2 Ki - - -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Uterine weight '=' 54 -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Uterine weight '=' 54 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ratio IC50 '=' 1 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ratio IC50 '=' 1 -
Q8BW75 BXGT017924 Amine oxidase [flavin-containing] B reviewed - Maob Activity - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Relative binding affinity '=' 100 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ki '=' 3 nM
Q03181 BXGT012701 Peroxisome proliferator-activated receptor delta reviewed Nuclear receptor PPARD Potency - 15848 nM
P06536 BXGT006451 Glucocorticoid receptor reviewed - Nr3c1 RBA '=' 0 -
P06401 BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR RBA '=' 0 -
P10275 BXGT007552 Androgen receptor reviewed Nuclear receptor AR IC50 '=' 26 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 0 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 0 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 0 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ratio EC50 '=' 0 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ratio EC50 '=' 0 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 REP '=' 100 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Bmax '=' 34 fM mg-1
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Bmax '=' 34 fM mg-1
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 0 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 0 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ka '=' 2147483647 M-1
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ka '=' 2147483647 M-1
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ratio '=' 1 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ratio '=' 1 -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Binding '=' 100 %
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Binding '=' 100 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 0 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Activity '=' 100 -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 RBA '=' 10000 -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 RBA '=' 10000 -
P10275 BXGT007552 Androgen receptor reviewed Nuclear receptor AR Ki - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 0 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 11 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 0 nM
Q64133 BXGT016109 Amine oxidase [flavin-containing] A reviewed - Maoa Activity - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Inhibition - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 NT - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 0 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 0 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 1 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 1 nM
P49888 BXGT010756 Estrogen sulfotransferase reviewed - SULT1E1 Activity - - -
P15207 BXGT008096 Androgen receptor reviewed - Ar Relative binding affinity '=' 1 -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Efficacy '=' 0 %
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Efficacy '=' 0 %
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Uterine wet weight '=' 55 -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Uterine wet weight '=' 55 -
P11474 BXGT007710 Steroid hormone receptor ERR1 reviewed Nuclear receptor ESRRA Activity '=' 1 -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Uterine wet weight '=' 43 -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Uterine wet weight '=' 43 -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Control '=' 328 %
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Control '=' 328 %
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Relative activity '=' 100 -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Relative activity '=' 100 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ratio IC50 '=' 1 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ratio IC50 '=' 1 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ratio '=' 0 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ratio '=' 0 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ki '=' 0 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ki '=' 0 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ratio '=' 100 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ratio '=' 100 -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Relative potency '=' 100 -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Relative potency '=' 100 -
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 102 %
P46063 BXGT010501 ATP-dependent DNA helicase Q1 reviewed Enzyme RECQL Potency '=' 31622 nM
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Agonistic activity '=' 100 %
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Agonistic activity '=' 100 %
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C IC50 - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 HTS data '=' 100 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 FC '=' 2 -
O75874 BXGT005157 Isocitrate dehydrogenase [NADP] cytoplasmic reviewed - IDH1 Potency - 29092 nM
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 131 %
P06536 BXGT006451 Glucocorticoid receptor reviewed - Nr3c1 Relative activity '=' 6 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Fold selectivity '=' 1 -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 23109 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 26608 nM
P46720 BXGT010535 Solute carrier organic anion transporter family member 1A1 reviewed - Slco1a1 Activity '=' 40 %
P04278 BXGT006182 Sex hormone-binding globulin reviewed - SHBG Kd '=' 1 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 2 nM
Q9TU15 BXGT021625 Estrogen receptor beta reviewed - ESR2 RBA '=' 100 %
P49885 BXGT010755 Estrogen receptor reviewed - ESR1 RBA '=' 100 %
P50225 BXGT010781 Sulfotransferase 1A1 reviewed - SULT1A1 Kd '=' 2300 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 1 nM
P41968 BXGT010275 Melanocortin receptor 3 reviewed G-protein coupled receptor MC3R Ki - - -
P33032 BXGT009689 Melanocortin receptor 5 reviewed G-protein coupled receptor MC5R Ki - - -
P51681 BXGT010878 C-C chemokine receptor type 5 reviewed G-protein coupled receptor CCR5 IC50 - - -
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 Ki - - -
P51679 BXGT010877 C-C chemokine receptor type 4 reviewed G-protein coupled receptor CCR4 Ki - - -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 RBA '=' 100 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 RSA '=' 100 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 RSA '=' 100 %
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Uterine weight '=' 76 -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Uterine weight '=' 76 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ki '=' 1 nM
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 IC50 - - -
P49146 BXGT010681 Neuropeptide Y receptor type 2 reviewed G-protein coupled receptor NPY2R IC50 - - -
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 Ki - - -
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 IC50 - - -
P06241 BXGT006429 Tyrosine-protein kinase Fyn reviewed Kinase FYN IC50 - - -
P49146 BXGT010681 Neuropeptide Y receptor type 2 reviewed G-protein coupled receptor NPY2R Ki - - -
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 IC50 - - -
P25105 BXGT009021 Platelet-activating factor receptor reviewed G-protein coupled receptor PTAFR IC50 - - -
P12822 BXGT007850 Angiotensin-converting enzyme reviewed - ACE Ki - - -
P08246 BXGT006756 Neutrophil elastase reviewed Enzyme ELANE Ki - - -
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK IC50 - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 10 nM
P56937 BXGT011205 3-keto-steroid reductase reviewed - HSD17B7 Inhibition '=' 1 %
Q9NY46 BXGT021248 Sodium channel protein type 3 subunit alpha reviewed Ion channel SCN3A Inhibition '=' 53 %
Q99250 BXGT019913 Sodium channel protein type 2 subunit alpha reviewed Ion channel SCN2A Inhibition '=' 53 %
P35498 BXGT009838 Sodium channel protein type 1 subunit alpha reviewed Ion channel SCN1A Inhibition '=' 53 %
P50225 BXGT010781 Sulfotransferase 1A1 reviewed - SULT1A1 Activity - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 E2 response '=' 100 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 E2 response '=' 100 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Induction '=' 5 fM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Induction '=' 5 fM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Induction '=' 76 fM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Induction '=' 76 fM
P15207 BXGT008096 Androgen receptor reviewed - Ar Relative binding affinity '=' 1 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 FC '=' 5 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Bmax '=' 35 fM mg-1
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Bmax '=' 35 fM mg-1
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Ki '=' 18828 nM
P32245 BXGT009614 Melanocortin receptor 4 reviewed G-protein coupled receptor MC4R IC50 - - -
P32245 BXGT009614 Melanocortin receptor 4 reviewed G-protein coupled receptor MC4R Ki - - -
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 IC50 - - -
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 Ki - - -
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 IC50 - - -
P06241 BXGT006429 Tyrosine-protein kinase Fyn reviewed Kinase FYN Ki - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Kd '=' 100 -
P28564 BXGT009272 5-hydroxytryptamine receptor 1B reviewed - Htr1b IC50 - - -
O70528 BXGT005068 5-hydroxytryptamine receptor 4 reviewed - HTR4 IC50 - - -
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 IC50 - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Activity '=' 6 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 9 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 0 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 0 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 19 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 50 nM
P49884 BXGT010754 Estrogen receptor reviewed - ESR1 RBA1 '=' 100 -
Q9XSB5 BXGT022188 Estrogen receptor beta reviewed - ESR2 RBA1 '=' 100 -
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 IC50 '=' 2 nM
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Uterine weight '=' 70 -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Uterine weight '=' 70 -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Activity '=' 75 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 0 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ratio '=' 0 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ratio '=' 0 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Potency - 31622 nM
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Uterine weight '=' 74 -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Uterine weight '=' 74 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 FC '=' 1 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 FC '=' 1 -
P46720 BXGT010535 Solute carrier organic anion transporter family member 1A1 reviewed - Slco1a1 Ki '=' 4700 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 2 nM
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 EC50 '=' 0 ug.mL-1
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 EC50 '=' 0 ug.mL-1
P33032 BXGT009689 Melanocortin receptor 5 reviewed G-protein coupled receptor MC5R IC50 - - -
P08173 BXGT006738 Muscarinic acetylcholine receptor M4 reviewed G-protein coupled receptor CHRM4 IC50 - - -
P25929 BXGT009078 Neuropeptide Y receptor type 1 reviewed G-protein coupled receptor NPY1R Ki - - -
P29477 BXGT009355 Nitric oxide synthase, inducible reviewed - Nos2 Ki - - -
P08246 BXGT006756 Neutrophil elastase reviewed Enzyme ELANE IC50 - - -
Q63089 BXGT016060 Solute carrier family 22 member 1 reviewed - Slc22a1 Activity - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ki '=' 0 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 25929 nM
P50225 BXGT010781 Sulfotransferase 1A1 reviewed - SULT1A1 Km '=' 360 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Bmax '=' 36 fM mg-1
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Bmax '=' 36 fM mg-1
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Uterine weight '=' 25 mg
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Uterine weight '=' 25 mg
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 ED50 '=' 0 uM
Q9R1A7 BXGT021413 Nuclear receptor subfamily 1 group I member 2 reviewed - Nr1i2 Potency - 50118 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 1 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 1995 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 0 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 0 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Fold selectivity '=' 1 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 0 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 0 nM
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 IC50 - - -
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 Ki - - -
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 Ki - - -
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 Ki - - -
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a IC50 - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 RBA '=' 3 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Intrinsic activity '=' 100 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Intrinsic activity '=' 100 %
P31645 BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 Ki '=' 5714 nM
P21452 BXGT008653 Substance-K receptor reviewed G-protein coupled receptor TACR2 IC50 - - -
O95718 BXGT005392 Steroid hormone receptor ERR2 reviewed Nuclear receptor ESRRB EC50 '=' 4 nM
P19224 BXGT008468 UDP-glucuronosyltransferase 1-6 reviewed - UGT1A6 Activity '=' 0 pm/min/mg
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 3548 nM
P04035 BXGT006129 3-hydroxy-3-methylglutaryl-coenzyme A reductase reviewed - HMGCR IC50 - - -
A6XA80 BXGT001522 Leukotriene C4 synthase reviewed - LTC4S IC50 - - -
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C Ki - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 18 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 FC '=' 3 -
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 19952 nM
O75795 BXGT005152 UDP-glucuronosyltransferase 2B17 reviewed - UGT2B17 Drug metabolism - - -
Q01453 BXGT012588 Peripheral myelin protein 22 reviewed Cellular structure PMP22 Potency '=' 67455 nM
O70528 BXGT005068 5-hydroxytryptamine receptor 4 reviewed - HTR4 Ki - - -
P32241 BXGT009613 Vasoactive intestinal polypeptide receptor 1 reviewed G-protein coupled receptor VIPR1 IC50 - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 0 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 5 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 4 nM
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma reviewed Nuclear receptor PPARG Potency - 39810 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 37650 nM
Q9NSA0 BXGT021202 Solute carrier family 22 member 11 reviewed Transporter SLC22A11 Activity - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 0 nM
Q16637 BXGT013646 Survival motor neuron protein reviewed Epigenetic regulator SMN1 Potency '=' 794 nM
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 39 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 1 nM
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 IC50 - - -
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 IC50 - - -
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform reviewed - PPP3CA IC50 - - -
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR IC50 - - -
P10275 BXGT007552 Androgen receptor reviewed Nuclear receptor AR Potency - 25118 nM
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA Ki - - -
Q690N0 BXGT016199 Progesterone receptor unreviewed - PGR IC50 '=' 32559 nM
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK Ki - - -
P70502 BXGT011672 Solute carrier organic anion transporter family member 1A3 reviewed - Slco1a3 Activity - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 IC50 - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 IC50 - - -
P51449 BXGT010846 Nuclear receptor ROR-gamma reviewed Nuclear receptor RORC Potency - 33491 nM
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 12589 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Inhibition - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 4 nM
P49885 BXGT010755 Estrogen receptor reviewed - ESR1 RBA '=' 25 -
O15245 BXGT004141 Solute carrier family 22 member 1 reviewed Transporter SLC22A1 IC50 '=' 5730 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 1 nM
Q9GK37 BXGT020404 Corticosteroid-binding globulin reviewed - Serpina6 Log 1/K '=' 5 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 0 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 0 nM
O94956 BXGT005343 Solute carrier organic anion transporter family member 2B1 reviewed Transporter SLCO2B1 Inhibition '=' 47 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Inhibition '=' 100 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 0 nM
Q8TDU6 BXGT018814 G-protein coupled bile acid receptor 1 reviewed G-protein coupled receptor GPBAR1 Efficacy '=' 11 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Relative activation '=' 100 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 11 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 0 nM
P16662 BXGT008253 UDP-glucuronosyltransferase 2B7 reviewed - UGT2B7 Drug metabolism - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 1 nM
P50225 BXGT010781 Sulfotransferase 1A1 reviewed - SULT1A1 Vmax '=' 16 pmol/min/ug
P35503 BXGT009840 UDP-glucuronosyltransferase 1-3 reviewed - UGT1A3 Drug metabolism - - -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 16788 nM
Q99527 BXGT019930 G-protein coupled estrogen receptor 1 reviewed G-protein coupled receptor GPER1 Activity '=' 80 %
P20813 BXGT008603 Cytochrome P450 2B6 reviewed - CYP2B6 EC50 '=' 4100 nM
P0DTE4 BXGT022286 UDP-glucuronosyltransferase 2A1 reviewed - UGT2A1 Activity '=' 15 pm/min/mg
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 26608 nM
P10145 BXGT007542 Interleukin-8 reviewed Signaling CXCL8 Potency - 74978 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 0 nM
Q96RI1 BXGT019727 Bile acid receptor reviewed Nuclear receptor NR1H4 Potency - 39810 nM
Q06278 BXGT012869 Aldehyde oxidase reviewed Enzyme AOX1 Ratio Ki '=' 5 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 0 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 5 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Activity '=' 80 %
Q5T3U5 BXGT015846 Multidrug resistance-associated protein 7 reviewed Transporter ABCC10 Activity '=' 60 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 2 nM
P08659 BXGT006805 Luciferin 4-monooxygenase reviewed - Potency - 36125 nM
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A IC50 - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Activity '=' 163 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Activity '<' 10 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 0 nM
Q99527 BXGT019930 G-protein coupled estrogen receptor 1 reviewed G-protein coupled receptor GPER1 EC50 '=' 0 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 0 nM
P06536 BXGT006451 Glucocorticoid receptor reviewed - Nr3c1 RBA '=' 0 -
P22199 BXGT008741 Mineralocorticoid receptor reviewed - Nr3c2 RBA '=' 0 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 0 nM
Q13148 BXGT013318 TAR DNA-binding protein 43 reviewed - TARDBP Potency - 3162 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 0 nM
P50225 BXGT010781 Sulfotransferase 1A1 reviewed - SULT1A1 Kd '=' 1200 nM
P0DTE4 BXGT022286 UDP-glucuronosyltransferase 2A1 reviewed - UGT2A1 Drug metabolism - - -
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed - UGT1A1 Drug metabolism - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 0 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 56234 nM
P54855 BXGT011088 UDP-glucuronosyltransferase 2B15 reviewed - UGT2B15 Drug metabolism - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Efficacy '=' 3 nM
Q9HAW9 BXGT020510 UDP-glucuronosyltransferase 1-8 reviewed - UGT1A8 Drug metabolism - - -
P20813 BXGT008603 Cytochrome P450 2B6 reviewed - CYP2B6 Emax '=' 20 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 0 nM
Q16678 BXGT013656 Cytochrome P450 1B1 reviewed Enzyme CYP1B1 IC50 '>' 50000 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 0 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 1 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 0 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 0 nM
Q16678 BXGT013656 Cytochrome P450 1B1 reviewed Enzyme CYP1B1 Ki '=' 1900 nM
Q06278 BXGT012869 Aldehyde oxidase reviewed Enzyme AOX1 Ki '=' 870 nM
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Activity - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 1 nM
O95398 BXGT005378 Rap guanine nucleotide exchange factor 3 reviewed Enzyme modulator RAPGEF3 Potency - 125892 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 0 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 0 nM
Q92887 BXGT019389 Canalicular multispecific organic anion transporter 1 reviewed Transporter ABCC2 Activity - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 0 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 1 nM
Q06278 BXGT012869 Aldehyde oxidase reviewed Enzyme AOX1 Ki '=' 4400 nM
Q99527 BXGT019930 G-protein coupled estrogen receptor 1 reviewed G-protein coupled receptor GPER1 Efficacy '=' 75 %
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 Ki - - -
Q13936 BXGT013404 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed Ion channel CACNA1C IC50 '=' 50000 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 FC '=' 1 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 FC '=' 1 -
Q06278 BXGT012869 Aldehyde oxidase reviewed Enzyme AOX1 Ratio Ki '=' 10 -
O08756 BXGT026095 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed - Hsd17b10 IC50 '=' 155000 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 - - -
P50052 BXGT010768 Type-2 angiotensin II receptor reviewed G-protein coupled receptor AGTR2 IC50 - - -
P13945 BXGT007972 Beta-3 adrenergic receptor reviewed G-protein coupled receptor ADRB3 IC50 - - -
P50225 BXGT010781 Sulfotransferase 1A1 reviewed - SULT1A1 Km '=' 2400 nM
Q64669 BXGT016128 NAD(P)H dehydrogenase [quinone] 1 reviewed - Nqo1 CD - - -
Q16678 BXGT013656 Cytochrome P450 1B1 reviewed Enzyme CYP1B1 Inhibition '=' 12 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 0 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Emax '=' 137 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 0 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 0 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 0 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 0 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 6 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00134 Common bean Phaseolus vulgaris Pulses
BXGF00151 Pomegranate Punica granatum Fruits
BXGF01483 Onobrychis ebenoides Onobrychis ebenoides Others
BXGF02656 Dalbergia sissoo Dalbergia sissoo Medicinal Plant
BXGF03348 Panax notoginseng Panax notoginseng Medicinal Plant
BXGF03766 Drynaria fortunei Drynaria fortunei Medicinal Plant
BXGF04434 Iryanthera lancifolia Iryanthera lancifolia Others
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease