Showing entry for Progesterone


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0001325
Compound NameProgesterone
Structure
FormulaC21H30O2
InchiKeyRJKFOVLPORLFTN-LEKSSAKUSA-N
SMILES[H][C@@]12CC[C@H](C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C
InchiInChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
IUPAC(1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-6-en-5-one
Molecular Weight314.46
Pubchem Id5994
Chembl IdCHEMBL103
Targets of Information Source
DrugBank DB00396
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
P06401 BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR approved; vet_approved agonist
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 approved; vet_approved agonist,inhibitor,downregulator
P08235 BXGT006751 Mineralocorticoid receptor reviewed Nuclear receptor NR3C2 approved; vet_approved antagonist,agonist
P05093 BXGT006313 Steroid 17-alpha-hydroxylase/17,20 lyase reviewed - CYP17A1 approved; vet_approved substrate,inhibitor
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 approved; vet_approved activator,potentiator
P02763 BXGT005951 Alpha-1-acid glycoprotein 1 reviewed - ORM1 approved; vet_approved binder
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 approved; vet_approved partial agonist
P10275 BXGT007552 Androgen receptor reviewed Nuclear receptor AR approved; vet_approved agonist,potentiator
P04278 BXGT006182 Sex hormone-binding globulin reviewed - SHBG approved; vet_approved binder,potentiator
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 approved; vet_approved agonist,downregulator
PDB STR
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P06401 BXGT006436 Progesterone receptor reviewed PGR Nuclear receptor 5.1 - - -
P01868 BXGT005803 Ig gamma-1 chain C region secreted form reviewed Ighg1 - - - - -
P71278 BXGT011690 Pentaerythritol tetranitrate reductase unreviewed onr - - - 20000 -
Q04828 BXGT012787 Aldo-keto reductase family 1 member C1 reviewed AKR1C1 Enzyme - - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed CYP3A4 Enzyme - - - -
P08235 BXGT006751 Mineralocorticoid receptor reviewed NR3C2 Nuclear receptor - - - -
P71278 BXGT011690 Pentaerythritol tetranitrate reductase unreviewed onr - - - 700 -
P05090 BXGT006311 Apolipoprotein D reviewed APOD - - - ~1000 -
P51857 BXGT010899 Aldo-keto reductase family 1 member D1 reviewed AKR1D1 Enzyme - - - -
P08185 BXGT006742 Corticosteroid-binding globulin reviewed SERPINA6 Enzyme modulator - - - -
Q5YNS8 BXGT015917 Cytochrome P450 monooxygenase unreviewed NFA_53110 - - - - -
P52895 BXGT010961 Aldo-keto reductase family 1 member C2 reviewed AKR1C2 Enzyme - - - -
P05093 BXGT006313 Steroid 17-alpha-hydroxylase/17,20 lyase reviewed CYP17A1 - - - - -
A7U483 BXGT001615 Cytochrome P450 family 17 polypeptide 2 unreviewed cyp17a2 - - - - -
P08686 BXGT006813 Steroid 21-hydroxylase reviewed CYP21A2 - - - - -
P02701 BXGT005926 Avidin reviewed AVD - - - - -
D6N9X1 BXGT002980 Progesterone 5-beta-reductase unreviewed - - - - -
A9FDB7 BXGT001786 Cytochrome P450 CYP260A1 unreviewed sce1588 - - - - -
P01011 BXGT005715 Alpha-1-antichymotrypsin reviewed SERPINA3 Enzyme modulator - - - -
Binding DB 8903
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR - 1.6 - -
reviewed BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR - - - >10000
reviewed BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR 3.5 - - -
reviewed BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR - - - 1.8
reviewed BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR - - - 2.9
reviewed BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR - - - 0.92
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - >1000 - -
reviewed BXGT009855 Sterol O-acyltransferase 1 reviewed Enzyme SOAT1 - 17000 - -
reviewed BXGT006419 Progesterone receptor reviewed PGR 10.4 - - -
reviewed BXGT006751 Mineralocorticoid receptor reviewed Nuclear receptor NR3C2 - - 0.39 -
reviewed BXGT007552 Androgen receptor reviewed Nuclear receptor AR 8.5 - - -
reviewed BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 31 - - -
reviewed BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR - - - 1.5
reviewed BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR - 5 - -
reviewed BXGT021402 Sigma non-opioid intracellular receptor 1 reviewed Sigmar1 - - 239 -
reviewed BXGT006751 Mineralocorticoid receptor reviewed Nuclear receptor NR3C2 - 30 - -
reviewed BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 - >1000 - -
reviewed BXGT007552 Androgen receptor reviewed Nuclear receptor AR - 37 - -
reviewed BXGT006751 Mineralocorticoid receptor reviewed Nuclear receptor NR3C2 - 14 - -
reviewed BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 30.5 - - -
reviewed BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR - - - 2
reviewed BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR - - - 0.5
reviewed BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR - - - 2.2
reviewed BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR 3.4 - - -
reviewed BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR - 3.5 - -
reviewed BXGT006424 Estrogen receptor reviewed Esr1 - - 3.9 -
reviewed BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR - 0.2 - -
reviewed BXGT006419 Progesterone receptor reviewed PGR - 6 - -
reviewed BXGT008940 3-oxo-5-alpha-steroid 4-dehydrogenase 1 reviewed Srd5a1 - 2600 - -
reviewed BXGT008940 3-oxo-5-alpha-steroid 4-dehydrogenase 1 reviewed Srd5a1 - 1600 - -
reviewed BXGT008454 Androgen receptor reviewed Ar - 37 - -
reviewed BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR - 17 - -
reviewed BXGT006751 Mineralocorticoid receptor reviewed Nuclear receptor NR3C2 - >14 - -
reviewed BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR 3.8 - - -
reviewed BXGT007738 Cytochrome P450 2C9 reviewed CYP2C9 5500 - - -
reviewed BXGT013543 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase reviewed Enzyme EBP >100000 - - -
reviewed BXGT009627 C-8 sterol isomerase reviewed ERG2 4430 - - -
reviewed BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed SIGMAR1 260 - - -
reviewed BXGT013681 Lanosterol 14-alpha demethylase reviewed Enzyme CYP51A1 - >200000 - -
reviewed BXGT018814 G-protein coupled bile acid receptor 1 reviewed G-protein coupled receptor GPBAR1 - - - 2770
reviewed BXGT005921 Fatty acid-binding protein, liver reviewed Fabp1 27 - - -
reviewed BXGT007773 Fatty acid-binding protein, intestinal reviewed FABP2 20000 - - -
reviewed BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR - - - 0.9
reviewed BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR - - - 0.1
reviewed BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR - >10000 - -
reviewed BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR - - - 15.2
reviewed BXGT007552 Androgen receptor reviewed Nuclear receptor AR 35 - - -
reviewed BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR 5.1 - - -
reviewed BXGT015986 Sigma non-opioid intracellular receptor 1 reviewed SIGMAR1 660 - - -
reviewed BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 - - - 21200
reviewed BXGT008096 Androgen receptor reviewed Ar - 1548.82 - -
reviewed BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 - 48977882 - -
reviewed BXGT021792 ATP-binding cassette sub-family G member 2 reviewed Transporter ABCG2 - 125892.54 - -
reviewed BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 - 192200 - -
reviewed BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 - 88100 - -
reviewed BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 - 96200 - -
reviewed BXGT005373 Bile salt export pump reviewed Transporter ABCB11 - 17300 - -
reviewed BXGT005373 Bile salt export pump reviewed Transporter ABCB11 - 224600 - -
reviewed BXGT005150 Solute carrier family 22 member 3 reviewed Transporter SLC22A3 - 4280 - -
reviewed BXGT004140 Solute carrier family 22 member 2 reviewed Transporter SLC22A2 - 26700 - -
reviewed BXGT004141 Solute carrier family 22 member 1 reviewed Transporter SLC22A1 - 3050 - -
reviewed BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 - 47863 - -
reviewed BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 - 48978 - -
reviewed BXGT006182 Sex hormone-binding globulin reviewed SHBG - - 115 -
reviewed BXGT015986 Sigma non-opioid intracellular receptor 1 reviewed SIGMAR1 661 - - -
CHEMBL CHEMBL103
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P06401 BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR Efficacy '=' 100 %
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Efficacy '=' 39 %
P06401 BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR EC50 '=' 2 nM
P06401 BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR Ki '=' 3 nM
Q63449 BXGT016072 Progesterone receptor reviewed - Pgr ED50 '=' 5 mg.kg-1
P22199 BXGT008741 Mineralocorticoid receptor reviewed - Nr3c2 RBA - - -
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a Ki - - -
P10275 BXGT007552 Androgen receptor reviewed Nuclear receptor AR Potency - 25 nM
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 20596 nM
P06401 BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR Ki '=' 5 nM
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 Ki - - -
P06186 BXGT006419 Progesterone receptor reviewed - PGR log(RBA) '=' 2 -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 23715 nM
O95342 BXGT005373 Bile salt export pump reviewed Transporter ABCB11 IC50 '=' 17300 nM
Q6PSM0 BXGT016483 Multidrug resistance protein 1a unreviewed - Mdr1a Activity - - -
P25100 BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D IC50 - - -
P25100 BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D Ki - - -
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 IC50 - - -
P10275 BXGT007552 Androgen receptor reviewed Nuclear receptor AR Potency - 39810 nM
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 52 %
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Potency - 5011 nM
P10275 BXGT007552 Androgen receptor reviewed Nuclear receptor AR Efficacy '=' 46 %
P02692 BXGT005921 Fatty acid-binding protein, liver reviewed - Fabp1 Ki '=' 27 nM
P08235 BXGT006751 Mineralocorticoid receptor reviewed Nuclear receptor NR3C2 Kd '=' 0 nM
P06401 BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR Ki '=' 3 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '>' 1000 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 - 1000000 nM
P02791 BXGT005965 Ferritin light chain reviewed - FTL Potency '=' 17782 nM
P25929 BXGT009078 Neuropeptide Y receptor type 1 reviewed G-protein coupled receptor NPY1R IC50 - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 - - -
P41597 BXGT010268 C-C chemokine receptor type 2 reviewed - CCR2 Ki - - -
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 Ki - - -
P08311 BXGT006762 Cathepsin G reviewed Enzyme CTSG IC50 - - -
P25105 BXGT009021 Platelet-activating factor receptor reviewed G-protein coupled receptor PTAFR Ki - - -
O95149 BXGT005350 Snurportin-1 reviewed - SNUPN Potency - 32642 nM
Q14974 BXGT013516 Importin subunit beta-1 reviewed Transporter KPNB1 Potency - 32642 nM
P62826 BXGT011463 GTP-binding nuclear protein Ran reviewed Enzyme modulator RAN Potency - 32642 nM
P06401 BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR EC50 '=' 1 nM
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A IC50 - - -
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A Ki - - -
P08588 BXGT006795 Beta-1 adrenergic receptor reviewed G-protein coupled receptor ADRB1 IC50 - - -
P06401 BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR NSB '=' 0 -
P02791 BXGT005965 Ferritin light chain reviewed - FTL Potency '=' 35481 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 IC50 - - -
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 IC50 '=' 330 nM
P28564 BXGT009272 5-hydroxytryptamine receptor 1B reviewed - Htr1b Ki - - -
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 reviewed Kinase FLT1 IC50 - - -
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 IC50 - - -
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 Ki - - -
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 63 %
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 35481 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Activity '=' 34 %
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 IC50 '=' 47863 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 39810 nM
Q99700 BXGT019949 Ataxin-2 reviewed Nucleic acid binding ATXN2 Potency - 39810 nM
Q16637 BXGT013646 Survival motor neuron protein reviewed Epigenetic regulator SMN1 Potency '=' 15848 nM
P10275 BXGT007552 Androgen receptor reviewed Nuclear receptor AR IC50 '=' 37 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Efficacy '<' 20 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Efficacy '<' 20 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '>' 1000 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '>' 1000 nM
P16473 BXGT008234 Thyrotropin receptor reviewed G-protein coupled receptor TSHR Potency '=' 25118 nM
P10828 BXGT007624 Thyroid hormone receptor beta reviewed Nuclear receptor THRB Potency - 44668 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Inhibition - - -
P31214 BXGT009516 3-oxo-5-alpha-steroid 4-dehydrogenase 2 reviewed - Srd5a2 IC50 '=' 1600 nM
P24008 BXGT008940 3-oxo-5-alpha-steroid 4-dehydrogenase 1 reviewed - Srd5a1 IC50 '=' 1600 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Activity '=' 30 %
Q63449 BXGT016072 Progesterone receptor reviewed - Pgr Relative activity '=' 1 -
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 10318 nM
P06401 BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR EC50 '=' 2 nM
O75795 BXGT005152 UDP-glucuronosyltransferase 2B17 reviewed - UGT2B17 Activity '=' 0 pm/min/mg
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 Ki - - -
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform reviewed - PPP3CA IC50 - - -
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR IC50 - - -
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a Ki - - -
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 Ki - - -
P06401 BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR EC50 '=' 15 nM
Q194T2 BXGT013743 Non-structural protein 1 unreviewed - NS1 Potency '=' 28183 nM
P51679 BXGT010877 C-C chemokine receptor type 4 reviewed G-protein coupled receptor CCR4 IC50 - - -
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 Ki - - -
P04035 BXGT006129 3-hydroxy-3-methylglutaryl-coenzyme A reductase reviewed - HMGCR IC50 - - -
P33032 BXGT009689 Melanocortin receptor 5 reviewed G-protein coupled receptor MC5R Ki - - -
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Activity - - -
P12530 BXGT007827 Arachidonate 15-lipoxygenase reviewed - ALOX15 IC50 - - -
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 IC50 - - -
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C IC50 - - -
P29476 BXGT009354 Nitric oxide synthase, brain reviewed - Nos1 Ki - - -
P06186 BXGT006419 Progesterone receptor reviewed - PGR Ki '=' 10 nM
P02768 BXGT005955 Serum albumin reviewed Transporter ALB Log K' '=' 0 -
P16473 BXGT008234 Thyrotropin receptor reviewed G-protein coupled receptor TSHR Potency '=' 10000 nM
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Ki - - -
P08588 BXGT006795 Beta-1 adrenergic receptor reviewed G-protein coupled receptor ADRB1 Ki - - -
Q8TDU6 BXGT018814 G-protein coupled bile acid receptor 1 reviewed G-protein coupled receptor GPBAR1 EC50 '=' 2770 nM
P08235 BXGT006751 Mineralocorticoid receptor reviewed Nuclear receptor NR3C2 Efficacy '=' 83 %
P35610 BXGT009855 Sterol O-acyltransferase 1 reviewed Enzyme SOAT1 IC50 '=' 17000 nM
P06401 BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR IC50 '=' 3 nM
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 IC50 '>' 1000 nM
P06401 BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR IC50 - - -
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 39810 nM
Q63449 BXGT016072 Progesterone receptor reviewed - Pgr RBA '=' 100 %
P06401 BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR EC50 '=' 0 nM
P06186 BXGT006419 Progesterone receptor reviewed - PGR RBA '=' 100 -
P15207 BXGT008096 Androgen receptor reviewed - Ar RBA '=' 5 -
Q9GK37 BXGT020404 Corticosteroid-binding globulin reviewed - Serpina6 Log 1/K '=' 7 -
P25103 BXGT009020 Substance-P receptor reviewed G-protein coupled receptor TACR1 Ki - - -
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 reviewed Kinase FLT1 Ki - - -
P37288 BXGT009977 Vasopressin V1a receptor reviewed G-protein coupled receptor AVPR1A Ki - - -
P06401 BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR Efficacy '<' 20 %
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Ki '=' 30 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Activity '=' 25 %
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Inhibition - - -
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 IC50 '=' 88100 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 IC50 '=' 96200 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 IC50 '=' 192200 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 25118 nM
Q8TDU6 BXGT018814 G-protein coupled bile acid receptor 1 reviewed G-protein coupled receptor GPBAR1 Efficacy '=' 98 %
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha reviewed Transcription factor HIF1A Potency '=' 12589 nM
Q60492 BXGT015986 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 Ki '=' 660 nM
P04035 BXGT006129 3-hydroxy-3-methylglutaryl-coenzyme A reductase reviewed - HMGCR Ki - - -
P12104 BXGT007773 Fatty acid-binding protein, intestinal reviewed - FABP2 Ki '=' 20000 nM
Q96RI1 BXGT019727 Bile acid receptor reviewed Nuclear receptor NR1H4 Potency - 19952 nM
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 IC50 - - -
P08311 BXGT006762 Cathepsin G reviewed Enzyme CTSG Ki - - -
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 reviewed Kinase ERBB2 IC50 - - -
P31645 BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 Ki - - -
P06401 BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR RBA '=' 100 -
P06536 BXGT006451 Glucocorticoid receptor reviewed - Nr3c1 RBA '=' 17 -
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 17782 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 17782 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 11220 nM
P25105 BXGT009021 Platelet-activating factor receptor reviewed G-protein coupled receptor PTAFR IC50 - - -
P12822 BXGT007850 Angiotensin-converting enzyme reviewed - ACE Ki - - -
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 IC50 - - -
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK IC50 - - -
P25103 BXGT009020 Substance-P receptor reviewed G-protein coupled receptor TACR1 IC50 - - -
P31214 BXGT009516 3-oxo-5-alpha-steroid 4-dehydrogenase 2 reviewed - Srd5a2 IC50 '=' 2600 nM
P24008 BXGT008940 3-oxo-5-alpha-steroid 4-dehydrogenase 1 reviewed - Srd5a1 IC50 '=' 2600 nM
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Ki - - -
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Km '=' 30000 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 IC50 '=' 48977 nM
Q03181 BXGT012701 Peroxisome proliferator-activated receptor delta reviewed Nuclear receptor PPARD Potency - 25118 nM
P03956 BXGT006120 Interstitial collagenase reviewed Enzyme MMP1 IC50 - - -
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 Ki - - -
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA Ki - - -
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 IC50 - - -
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 IC50 '=' 3055 nM
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 Ki - - -
P06401 BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR Efficacy - - -
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 70794 nM
P08235 BXGT006751 Mineralocorticoid receptor reviewed Nuclear receptor NR3C2 IC50 '=' 30 nM
P06401 BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR EC50 '=' 0 nM
P19091 BXGT008454 Androgen receptor reviewed - Ar IC50 '=' 37 nM
P08173 BXGT006738 Muscarinic acetylcholine receptor M4 reviewed G-protein coupled receptor CHRM4 IC50 - - -
P15127 BXGT008085 Insulin receptor reviewed - Insr IC50 - - -
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 10000 nM
P08185 BXGT006742 Corticosteroid-binding globulin reviewed Enzyme modulator SERPINA6 Log Ki '=' 7 mM
P06536 BXGT006451 Glucocorticoid receptor reviewed - Nr3c1 RBA '=' 0 -
P23975 BXGT008935 Sodium-dependent noradrenaline transporter reviewed Transporter SLC6A2 IC50 - - -
P30411 BXGT009424 B2 bradykinin receptor reviewed G-protein coupled receptor BDKRB2 IC50 - - -
P06401 BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR EC50 '=' 2 nM
P51151 BXGT010837 Ras-related protein Rab-9A reviewed - RAB9A Potency '=' 115820 nM
Q9R1A7 BXGT021413 Nuclear receptor subfamily 1 group I member 2 reviewed - Nr1i2 Potency - 7943 nM
P08235 BXGT006751 Mineralocorticoid receptor reviewed Nuclear receptor NR3C2 IC50 '>' 14 nM
P37288 BXGT009977 Vasopressin V1a receptor reviewed G-protein coupled receptor AVPR1A IC50 - - -
P03956 BXGT006120 Interstitial collagenase reviewed Enzyme MMP1 Ki - - -
Q9UNQ0 BXGT021792 ATP-binding cassette sub-family G member 2 reviewed Transporter ABCG2 Activity - - -
P04278 BXGT006182 Sex hormone-binding globulin reviewed - SHBG Log 1/K '=' 6 -
Q15125 BXGT013543 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase reviewed Enzyme EBP Ki '>' 100000 nM
P08235 BXGT006751 Mineralocorticoid receptor reviewed Nuclear receptor NR3C2 IC50 '=' 14 nM
O35627 BXGT004535 Nuclear receptor subfamily 1 group I member 3 reviewed - Nr1i3 Remaining activity '=' 53 %
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 Ki - - -
P06401 BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR BSI '=' 16 -
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 Potency - 50118 nM
P50052 BXGT010768 Type-2 angiotensin II receptor reviewed G-protein coupled receptor AGTR2 IC50 - - -
P25025 BXGT009006 C-X-C chemokine receptor type 2 reviewed G-protein coupled receptor CXCR2 Ki - - -
P08185 BXGT006742 Corticosteroid-binding globulin reviewed Enzyme modulator SERPINA6 Log 1/K '=' -7 -
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A IC50 - - -
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Ki - - -
P06536 BXGT006451 Glucocorticoid receptor reviewed - Nr3c1 RBA '=' 0 -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 20596 nM
P04278 BXGT006182 Sex hormone-binding globulin reviewed - SHBG Log 1/K '=' -6 -
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 6309 nM
P56937 BXGT011205 3-keto-steroid reductase reviewed - HSD17B7 Inhibition '=' 19 %
P10275 BXGT007552 Androgen receptor reviewed Nuclear receptor AR Ki '=' 35 nM
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 Ki - - -
P06401 BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR EC50 '=' 0 nM
P06186 BXGT006419 Progesterone receptor reviewed - PGR IC50 '=' 6 nM
P10275 BXGT007552 Androgen receptor reviewed Nuclear receptor AR Ki '=' 8 nM
Q16850 BXGT013681 Lanosterol 14-alpha demethylase reviewed Enzyme CYP51A1 IC50 '>' 200000 nM
P10275 BXGT007552 Androgen receptor reviewed Nuclear receptor AR Potency - 31 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Efficacy - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Efficacy - - -
P22199 BXGT008741 Mineralocorticoid receptor reviewed - Nr3c2 RBA '=' 22 -
P06401 BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR Binding '=' 100 %
P40225 BXGT010168 Thrombopoietin reviewed - THPO Potency '=' 10000 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ki '>' 10000 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ki '>' 10000 nM
P07812 BXGT006678 Progesterone receptor reviewed - PGR Relative binding affinity '=' 100 %
P04278 BXGT006182 Sex hormone-binding globulin reviewed - SHBG Kd '=' 114 nM
P25101 BXGT009018 Endothelin-1 receptor reviewed G-protein coupled receptor EDNRA IC50 - - -
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 15848 nM
Q9R0C9 BXGT021402 Sigma non-opioid intracellular receptor 1 reviewed - Sigmar1 Kd '=' 239 nM
Q01453 BXGT012588 Peripheral myelin protein 22 reviewed Cellular structure PMP22 Potency '=' 84921 nM
P10275 BXGT007552 Androgen receptor reviewed Nuclear receptor AR Potency - 63 nM
P06401 BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR Activity - - -
O15244 BXGT004140 Solute carrier family 22 member 2 reviewed Transporter SLC22A2 IC50 '=' 26700 nM
P30988 BXGT009491 Calcitonin receptor reviewed G-protein coupled receptor CALCR IC50 - - -
Q690N0 BXGT016199 Progesterone receptor unreviewed - PGR IC50 '=' 28 nM
P10145 BXGT007542 Interleukin-8 reviewed Signaling CXCL8 Potency - 74978 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 21136 nM
Q03431 BXGT012714 Parathyroid hormone/parathyroid hormone-related peptide receptor reviewed G-protein coupled receptor PTH1R Potency - 44668 nM
P06536 BXGT006451 Glucocorticoid receptor reviewed - Nr3c1 RBA '=' 2 -
Q03181 BXGT012701 Peroxisome proliferator-activated receptor delta reviewed Nuclear receptor PPARD Potency - 44668 nM
P06401 BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR IC50 '<' 10000 nM
Q63449 BXGT016072 Progesterone receptor reviewed - Pgr RBA '=' 13 -
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 RBA '<' 0 -
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 RBA '<' 0 -
P49146 BXGT010681 Neuropeptide Y receptor type 2 reviewed G-protein coupled receptor NPY2R IC50 - - -
P08185 BXGT006742 Corticosteroid-binding globulin reviewed Enzyme modulator SERPINA6 #NAME? '=' 6 -
P06401 BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR Ki '=' 3 nM
P06401 BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR IC50 '=' 17 nM
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 Ki - - -
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b Ki - - -
P08482 BXGT006775 Muscarinic acetylcholine receptor M1 reviewed - Chrm1 Potency '=' 31622 nM
P15207 BXGT008096 Androgen receptor reviewed - Ar Relative binding affinity '=' 4 -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 - - -
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 IC50 - - -
P41968 BXGT010275 Melanocortin receptor 3 reviewed G-protein coupled receptor MC3R IC50 - - -
P33032 BXGT009689 Melanocortin receptor 5 reviewed G-protein coupled receptor MC5R IC50 - - -
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 IC50 - - -
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Ki - - -
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Ki - - -
P50052 BXGT010768 Type-2 angiotensin II receptor reviewed G-protein coupled receptor AGTR2 Ki - - -
P41597 BXGT010268 C-C chemokine receptor type 2 reviewed - CCR2 IC50 - - -
P51681 BXGT010878 C-C chemokine receptor type 5 reviewed G-protein coupled receptor CCR5 IC50 - - -
P32238 BXGT009611 Cholecystokinin receptor type A reviewed G-protein coupled receptor CCKAR Ki - - -
P05181 BXGT006337 Cytochrome P450 2E1 reviewed - CYP2E1 IC50 - - -
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA IC50 - - -
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK Ki - - -
P29477 BXGT009355 Nitric oxide synthase, inducible reviewed - Nos2 Ki - - -
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 Ki - - -
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 IC50 - - -
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 Ki - - -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 18356 nM
P41968 BXGT010275 Melanocortin receptor 3 reviewed G-protein coupled receptor MC3R Ki - - -
P32245 BXGT009614 Melanocortin receptor 4 reviewed G-protein coupled receptor MC4R IC50 - - -
P13945 BXGT007972 Beta-3 adrenergic receptor reviewed G-protein coupled receptor ADRB3 Ki - - -
P23975 BXGT008935 Sodium-dependent noradrenaline transporter reviewed Transporter SLC6A2 Ki - - -
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma reviewed Nuclear receptor PPARG Potency - 44668 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 30637 nM
P12530 BXGT007827 Arachidonate 15-lipoxygenase reviewed - ALOX15 Ki - - -
P51679 BXGT010877 C-C chemokine receptor type 4 reviewed G-protein coupled receptor CCR4 Ki - - -
P25025 BXGT009006 C-X-C chemokine receptor type 2 reviewed G-protein coupled receptor CXCR2 IC50 - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 IC50 - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Ki - - -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Ki - - -
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 IC50 - - -
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 IC50 - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Potency - 44668 nM
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 Ki - - -
P25101 BXGT009018 Endothelin-1 receptor reviewed G-protein coupled receptor EDNRA Ki - - -
Q96RI1 BXGT019727 Bile acid receptor reviewed Nuclear receptor NR1H4 Potency - 39810 nM
Q96RI1 BXGT019727 Bile acid receptor reviewed Nuclear receptor NR1H4 Potency - 44668 nM
P10828 BXGT007624 Thyroid hormone receptor beta reviewed Nuclear receptor THRB Potency - 50118 nM
P29477 BXGT009355 Nitric oxide synthase, inducible reviewed - Nos2 IC50 - - -
P25024 BXGT009005 C-X-C chemokine receptor type 1 reviewed G-protein coupled receptor CXCR1 Ki - - -
P11509 BXGT007716 Cytochrome P450 2A6 reviewed - CYP2A6 IC50 - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Ki - - -
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 IC50 - - -
Q01959 BXGT012624 Sodium-dependent dopamine transporter reviewed Transporter SLC6A3 Ki - - -
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 IC50 - - -
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a IC50 - - -
P21452 BXGT008653 Substance-K receptor reviewed G-protein coupled receptor TACR2 Ki - - -
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 Ki - - -
P05181 BXGT006337 Cytochrome P450 2E1 reviewed - CYP2E1 Ki - - -
P43220 BXGT010367 Glucagon-like peptide 1 receptor reviewed G-protein coupled receptor GLP1R Potency - 25118 nM
O94956 BXGT005343 Solute carrier organic anion transporter family member 2B1 reviewed Transporter SLCO2B1 Inhibition '=' -362 %
P08185 BXGT006742 Corticosteroid-binding globulin reviewed Enzyme modulator SERPINA6 Log K '=' 7 -
P06241 BXGT006429 Tyrosine-protein kinase Fyn reviewed Kinase FYN IC50 - - -
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed - PDE5A IC50 - - -
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR Ki - - -
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C reviewed Enzyme PTPRC IC50 - - -
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C reviewed Enzyme PTPRC Ki - - -
P10275 BXGT007552 Androgen receptor reviewed Nuclear receptor AR Binding '=' 1 %
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Potency - 6309 nM
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Potency - 14125 nM
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 Ki - - -
P32238 BXGT009611 Cholecystokinin receptor type A reviewed G-protein coupled receptor CCKAR IC50 - - -
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 IC50 - - -
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 IC50 - - -
P11509 BXGT007716 Cytochrome P450 2A6 reviewed - CYP2A6 Ki - - -
P30411 BXGT009424 B2 bradykinin receptor reviewed G-protein coupled receptor BDKRB2 Ki - - -
P19793 BXGT008515 Retinoic acid receptor RXR-alpha reviewed Nuclear receptor RXRA Potency - 35481 nM
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 Ki - - -
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ki - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 - - -
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 IC50 - - -
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA IC50 - - -
P06401 BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR Ki '=' 3 nM
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 IC50 - - -
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 Ki - - -
P28564 BXGT009272 5-hydroxytryptamine receptor 1B reviewed - Htr1b IC50 - - -
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A IC50 - - -
P49146 BXGT010681 Neuropeptide Y receptor type 2 reviewed G-protein coupled receptor NPY2R Ki - - -
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C IC50 - - -
P07943 BXGT006700 Aldo-keto reductase family 1 member B1 reviewed - Akr1b1 IC50 - - -
P08246 BXGT006756 Neutrophil elastase reviewed Enzyme ELANE Ki - - -
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 IC50 - - -
P08246 BXGT006756 Neutrophil elastase reviewed Enzyme ELANE IC50 - - -
P21452 BXGT008653 Substance-K receptor reviewed G-protein coupled receptor TACR2 IC50 - - -
P32241 BXGT009613 Vasoactive intestinal polypeptide receptor 1 reviewed G-protein coupled receptor VIPR1 IC50 - - -
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 reviewed G-protein coupled receptor CHRM5 Ki - - -
P06536 BXGT006451 Glucocorticoid receptor reviewed - Nr3c1 RBA '=' 12 -
Q194T2 BXGT013743 Non-structural protein 1 unreviewed - NS1 Potency '=' 1778 nM
P04278 BXGT006182 Sex hormone-binding globulin reviewed - SHBG #NAME? '=' 5 -
P06536 BXGT006451 Glucocorticoid receptor reviewed - Nr3c1 RBA '<' 0 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '<' 10000 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '<' 10000 nM
P51449 BXGT010846 Nuclear receptor ROR-gamma reviewed Nuclear receptor RORC Potency - 21131 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 IC50 '=' 2147483647 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '>' 10000 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '>' 10000 nM
P02791 BXGT005965 Ferritin light chain reviewed - FTL Potency '=' 31622 nM
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 Ki - - -
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 IC50 - - -
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 IC50 - - -
P51681 BXGT010878 C-C chemokine receptor type 5 reviewed G-protein coupled receptor CCR5 Ki - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Ki - - -
P15207 BXGT008096 Androgen receptor reviewed - Ar IC50 '=' 214 nM
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 IC50 - - -
P15207 BXGT008096 Androgen receptor reviewed - Ar Ki '=' 143 nM
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA Ki - - -
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 reviewed Kinase ERBB2 Ki - - -
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B IC50 - - -
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 IC50 - - -
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 Ki - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Inhibition - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Inhibition - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Inhibition - - -
P06401 BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR EC50 '=' 2 nM
P32352 BXGT009627 C-8 sterol isomerase reviewed - ERG2 Ki '=' 4430 nM
Q9R0W2 BXGT021408 Solute carrier family 22 member 2 reviewed - Slc22a2 IC50 '=' 1600 nM
P06401 BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR EC50 '>' 10000 nM
P29476 BXGT009354 Nitric oxide synthase, brain reviewed - Nos1 IC50 - - -
Q14973 BXGT013515 Sodium/bile acid cotransporter reviewed Transporter SLC10A1 Inhibition - - -
Q63089 BXGT016060 Solute carrier family 22 member 1 reviewed - Slc22a1 Activity - - -
O88446 BXGT005272 Solute carrier family 22 member 3 reviewed - Slc22a3 IC50 '=' 10500 nM
P56937 BXGT011205 3-keto-steroid reductase reviewed - HSD17B7 Inhibition '=' 7 %
P22199 BXGT008741 Mineralocorticoid receptor reviewed - Nr3c2 RBA '=' 8 -
P06401 BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR RBA '=' 13 -
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Efficacy '<' 20 %
P08185 BXGT006742 Corticosteroid-binding globulin reviewed Enzyme modulator SERPINA6 Log 1/K '=' 7 -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Ki '=' 5500 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 3981 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 EC50 '=' 21200 nM
P06401 BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR EC50 '=' 0 nM
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 25918 nM
P15207 BXGT008096 Androgen receptor reviewed - Ar Binding '=' 1 %
P15289 BXGT008102 Arylsulfatase A reviewed Enzyme ARSA Potency - 75 nM
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 Ki '=' 260 nM
Q03181 BXGT012701 Peroxisome proliferator-activated receptor delta reviewed Nuclear receptor PPARD Potency - 39810 nM
P15207 BXGT008096 Androgen receptor reviewed - Ar IC50 '=' 1548 nM
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Potency - 10000 nM
Q96RI1 BXGT019727 Bile acid receptor reviewed Nuclear receptor NR1H4 Potency - 12589 nM
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma reviewed Nuclear receptor PPARG Potency - 39810 nM
P06536 BXGT006451 Glucocorticoid receptor reviewed - Nr3c1 Relative activity '=' 6 %
P19091 BXGT008454 Androgen receptor reviewed - Ar Inhibition '=' 46 %
Q16637 BXGT013646 Survival motor neuron protein reviewed Epigenetic regulator SMN1 Potency '=' 14125 nM
P08482 BXGT006775 Muscarinic acetylcholine receptor M1 reviewed - Chrm1 Potency '=' 5623 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 23109 nM
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Potency '=' 39810 nM
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A Ki - - -
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B Ki - - -
O70528 BXGT005068 5-hydroxytryptamine receptor 4 reviewed - HTR4 Ki - - -
P24557 BXGT008976 Thromboxane-A synthase reviewed - TBXAS1 Ki - - -
P32241 BXGT009613 Vasoactive intestinal polypeptide receptor 1 reviewed G-protein coupled receptor VIPR1 Ki - - -
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 15848 nM
P06401 BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR EC50 '=' 1 nM
P06401 BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR IC50 '>' 10000 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ki - - -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 26608 nM
P06401 BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR IC50 '=' 5 nM
P08185 BXGT006742 Corticosteroid-binding globulin reviewed Enzyme modulator SERPINA6 Ki '=' 41 nM
O75874 BXGT005157 Isocitrate dehydrogenase [NADP] cytoplasmic reviewed - IDH1 Potency - 23109 nM
Q6W5P4 BXGT016588 Neuropeptide S receptor reviewed - NPSR1 Potency '=' 10000 nM
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 Ki - - -
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 Ki - - -
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform reviewed - PPP3CA Ki - - -
P06241 BXGT006429 Tyrosine-protein kinase Fyn reviewed Kinase FYN Ki - - -
O70528 BXGT005068 5-hydroxytryptamine receptor 4 reviewed - HTR4 IC50 - - -
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 Ki '=' 1284 nM
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Ki - - -
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 35481 nM
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b IC50 - - -
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B IC50 - - -
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 Ki - - -
P20781 BXGT008598 Glycine receptor subunit beta reviewed - Glrb IC50 - - -
P07727 BXGT006662 Glycine receptor subunit alpha-1 reviewed - Glra1 IC50 - - -
P24524 BXGT008974 Glycine receptor subunit alpha-3 reviewed - Glra3 IC50 - - -
P22771 BXGT008806 Glycine receptor subunit alpha-2 reviewed - Glra2 IC50 - - -
Q9Y271 BXGT022222 Cysteinyl leukotriene receptor 1 reviewed G-protein coupled receptor CYSLTR1 IC50 - - -
Q9Y271 BXGT022222 Cysteinyl leukotriene receptor 1 reviewed G-protein coupled receptor CYSLTR1 Ki - - -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Kd '=' 3 nM
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Kd '=' 3 nM
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 Inhibition - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 IC50 - - -
P33527 BXGT009728 Multidrug resistance-associated protein 1 reviewed Transporter ABCC1 Activity - - -
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 92 %
Q28590 BXGT013952 Progesterone receptor reviewed - PGR log(RBA) '=' 2 -
P06536 BXGT006451 Glucocorticoid receptor reviewed - Nr3c1 RBA '=' 42 -
P06401 BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR Efficacy '=' 100 -
P20781 BXGT008598 Glycine receptor subunit beta reviewed - Glrb Ki - - -
P07727 BXGT006662 Glycine receptor subunit alpha-1 reviewed - Glra1 Ki - - -
P24524 BXGT008974 Glycine receptor subunit alpha-3 reviewed - Glra3 Ki - - -
P22771 BXGT008806 Glycine receptor subunit alpha-2 reviewed - Glra2 Ki - - -
P08173 BXGT006738 Muscarinic acetylcholine receptor M4 reviewed G-protein coupled receptor CHRM4 Ki - - -
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Ki '=' 150 nM
P13945 BXGT007972 Beta-3 adrenergic receptor reviewed G-protein coupled receptor ADRB3 IC50 - - -
A6XA80 BXGT001522 Leukotriene C4 synthase reviewed - LTC4S IC50 - - -
Q01959 BXGT012624 Sodium-dependent dopamine transporter reviewed Transporter SLC6A3 IC50 - - -
P15127 BXGT008085 Insulin receptor reviewed - Insr Ki - - -
P30988 BXGT009491 Calcitonin receptor reviewed G-protein coupled receptor CALCR Ki - - -
Q690N0 BXGT016199 Progesterone receptor unreviewed - PGR Ki '=' 3 nM
P12822 BXGT007850 Angiotensin-converting enzyme reviewed - ACE IC50 - - -
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C Ki - - -
P31645 BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 IC50 - - -
P24557 BXGT008976 Thromboxane-A synthase reviewed - TBXAS1 IC50 - - -
P32245 BXGT009614 Melanocortin receptor 4 reviewed G-protein coupled receptor MC4R Ki - - -
P07943 BXGT006700 Aldo-keto reductase family 1 member B1 reviewed - Akr1b1 Ki - - -
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 IC50 - - -
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed - PDE5A Ki - - -
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 IC50 - - -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 29092 nM
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 reviewed G-protein coupled receptor CHRM5 IC50 - - -
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 Ki - - -
Q60492 BXGT015986 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 Ki '=' 661 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Km '=' 53600 nM
Q13148 BXGT013318 TAR DNA-binding protein 43 reviewed - TARDBP Potency - 17782 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 100000 nM
P51449 BXGT010846 Nuclear receptor ROR-gamma reviewed Nuclear receptor RORC Potency - 8412 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 25929 nM
P19793 BXGT008515 Retinoic acid receptor RXR-alpha reviewed Nuclear receptor RXRA Potency - 39810 nM
Q9R1A7 BXGT021413 Nuclear receptor subfamily 1 group I member 2 reviewed - Nr1i2 Potency - 79432 nM
P25929 BXGT009078 Neuropeptide Y receptor type 1 reviewed G-protein coupled receptor NPY1R Ki - - -
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 37578 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 44668 nM
P21447 BXGT008651 ATP-dependent translocase ABCB1 reviewed - Abcb1a Activity - - -
P56373 BXGT011164 P2X purinoceptor 3 reviewed Ion channel P2RX3 IC50 '=' 1600 nM
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 33 %
P06401 BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR RLU '=' 2 -
Q16637 BXGT013646 Survival motor neuron protein reviewed Epigenetic regulator SMN1 Potency '=' 1995 nM
P26435 BXGT009113 Sodium/bile acid cotransporter reviewed - Slc10a1 Activity - - -
P25024 BXGT009005 C-X-C chemokine receptor type 1 reviewed G-protein coupled receptor CXCR1 IC50 - - -
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 28183 nM
P02791 BXGT005965 Ferritin light chain reviewed - FTL Potency '=' 28183 nM
Q9UNQ0 BXGT021792 ATP-binding cassette sub-family G member 2 reviewed Transporter ABCG2 IC50 '=' 125892 nM
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 IC50 - - -
Q92887 BXGT019389 Canalicular multispecific organic anion transporter 1 reviewed Transporter ABCC2 Activity '=' 123 %
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a IC50 - - -
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Potency '=' 14125 nM
O95342 BXGT005373 Bile salt export pump reviewed Transporter ABCB11 IC50 '=' 224600 nM
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 1258 nM
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 IC50 - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 - - -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 11582 nM
O15245 BXGT004141 Solute carrier family 22 member 1 reviewed Transporter SLC22A1 IC50 '=' 3050 nM
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 IC50 - - -
O75751 BXGT005150 Solute carrier family 22 member 3 reviewed Transporter SLC22A3 IC50 '=' 4280 nM
O95342 BXGT005373 Bile salt export pump reviewed Transporter ABCB11 IC50 '<' 10000 nM
P06401 BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR log(RBA) '=' 2 -
A6XA80 BXGT001522 Leukotriene C4 synthase reviewed - LTC4S Ki - - -
O15245 BXGT004141 Solute carrier family 22 member 1 reviewed Transporter SLC22A1 Inhibition '=' 55 %
P19793 BXGT008515 Retinoic acid receptor RXR-alpha reviewed Nuclear receptor RXRA Potency - 22387 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ki - - -
Q13148 BXGT013318 TAR DNA-binding protein 43 reviewed - TARDBP Potency - 35481 nM
Q8WZA2 BXGT019025 Rap guanine nucleotide exchange factor 4 reviewed Enzyme modulator RAPGEF4 Potency - 28183 nM
P06401 BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR IC50 '=' 0 nM
Q8VCH6 BXGT018914 Delta(24)-sterol reductase reviewed - Dhcr24 Inhibition - - -
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00006 Garden onion Allium cepa Vegetables
BXGF00101 Flaxseed Linum usitatissimum Herbs and Spices
BXGF00105 Apple Malus pumila Fruits
BXGF00125 Rice Oryza sativa Cereals and cereal products
BXGF00141 Common pea Pisum sativum Pulses
BXGF00173 Garden tomato (var.) Solanum lycopersicum var. lycopersicum Vegetables
BXGF00175 Potato Solanum tuberosum Vegetables
BXGF00198 Adzuki bean Vigna angularis Pulses
BXGF00200 Mung bean Vigna radiata Pulses
BXGF01922 Senecio nemorensis Senecio nemorensis Medicinal Plant
BXGF01973 Lonicera japonica Lonicera japonica Medicinal Plant
BXGF02011 Boswellia carterii Boswellia carterii Medicinal Plant
BXGF04909 Hippophae fructus Hippophae fructus Others
BXGF05057 Helichrysum nitens Helichrysum nitens Others
BXGF05305 Alangium ridleyi Alangium ridleyi Human Edible Plant
BXGF05313 Hedysarum denticulatum Hedysarum denticulatum Others
BXGF05539 Ligularia songarica Ligularia songarica Others
BXGF06070 Perilla frutescens Perilla frutescens Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease